ES2569123T3 - Infusión lenta de sulcardina y sus sales - Google Patents
Infusión lenta de sulcardina y sus sales Download PDFInfo
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- ES2569123T3 ES2569123T3 ES10832056.5T ES10832056T ES2569123T3 ES 2569123 T3 ES2569123 T3 ES 2569123T3 ES 10832056 T ES10832056 T ES 10832056T ES 2569123 T3 ES2569123 T3 ES 2569123T3
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- 235000011164 potassium chloride Nutrition 0.000 description 1
- 235000010259 potassium hydrogen sulphite Nutrition 0.000 description 1
- 239000004293 potassium hydrogen sulphite Substances 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000010410 reperfusion Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
- 229960001860 salicylate Drugs 0.000 description 1
- MOODSJOROWROTO-UHFFFAOYSA-N salicylsulfuric acid Chemical compound OC(=O)C1=CC=CC=C1OS(O)(=O)=O MOODSJOROWROTO-UHFFFAOYSA-N 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 231100000075 skin burn Toxicity 0.000 description 1
- CBXWGGFGZDVPNV-UHFFFAOYSA-N so4-so4 Chemical compound OS(O)(=O)=O.OS(O)(=O)=O CBXWGGFGZDVPNV-UHFFFAOYSA-N 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
- CSMWJXBSXGUPGY-UHFFFAOYSA-L sodium dithionate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)S([O-])(=O)=O CSMWJXBSXGUPGY-UHFFFAOYSA-L 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 235000010265 sodium sulphite Nutrition 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- ZBMZVLHSJCTVON-UHFFFAOYSA-N sotalol Chemical compound CC(C)NCC(O)C1=CC=C(NS(C)(=O)=O)C=C1 ZBMZVLHSJCTVON-UHFFFAOYSA-N 0.000 description 1
- 229960002370 sotalol Drugs 0.000 description 1
- 229940114926 stearate Drugs 0.000 description 1
- 239000008223 sterile water Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000008362 succinate buffer Substances 0.000 description 1
- DHCDFWKWKRSZHF-UHFFFAOYSA-N sulfurothioic S-acid Chemical compound OS(O)(=O)=S DHCDFWKWKRSZHF-UHFFFAOYSA-N 0.000 description 1
- 235000010269 sulphur dioxide Nutrition 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 125000002640 tocopherol group Chemical class 0.000 description 1
- 239000000541 tocopherol-rich extract Substances 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 239000012929 tonicity agent Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 238000007492 two-way ANOVA Methods 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26192709P | 2009-11-17 | 2009-11-17 | |
| US261927P | 2009-11-17 | ||
| PCT/US2010/056849 WO2011062903A2 (en) | 2009-11-17 | 2010-11-16 | Slow infusion of sulcardine and its salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2569123T3 true ES2569123T3 (es) | 2016-05-06 |
Family
ID=44060289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10832056.5T Active ES2569123T3 (es) | 2009-11-17 | 2010-11-16 | Infusión lenta de sulcardina y sus sales |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8637566B2 (https=) |
| EP (1) | EP2501380B1 (https=) |
| JP (2) | JP6116907B2 (https=) |
| CN (1) | CN102869357A (https=) |
| ES (1) | ES2569123T3 (https=) |
| PL (1) | PL2501380T3 (https=) |
| WO (1) | WO2011062903A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2501381B1 (en) * | 2009-11-17 | 2017-07-26 | Huya Bioscience International LLC | Treatment of atrial fibrillation |
| EP2501380B1 (en) * | 2009-11-17 | 2016-01-27 | Huya Bioscience International LLC | Slow infusion of sulcardine and its salts |
| CN113453677A (zh) | 2018-12-13 | 2021-09-28 | 沪亚生物国际有限责任公司 | 用于治疗急性心房颤动的舒卡定施用 |
| SG11202108160YA (en) * | 2019-01-29 | 2021-08-30 | Huya Bioscience International Llc | Sulcardine salts |
| CN112516136B (zh) * | 2019-09-17 | 2024-03-01 | 中国科学院上海药物研究所 | 硫酸舒欣啶在制备抗心衰产品中的应用 |
| IL298907A (en) * | 2020-06-12 | 2023-02-01 | Huyabio Int Llc | Administering sulcardin for the treatment of acute atrial fibrillation |
| CN114984004B (zh) * | 2022-05-25 | 2023-09-12 | 扬州中宝药业股份有限公司 | 硫酸舒欣啶在制备抗脓毒症药物中的应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1172908C (zh) * | 1999-12-10 | 2004-10-27 | 中国科学院上海药物研究所 | N-取代苄基或苯基芳香磺酰胺化合物及其用途 |
| EP2501381B1 (en) * | 2009-11-17 | 2017-07-26 | Huya Bioscience International LLC | Treatment of atrial fibrillation |
| EP2501380B1 (en) * | 2009-11-17 | 2016-01-27 | Huya Bioscience International LLC | Slow infusion of sulcardine and its salts |
-
2010
- 2010-11-16 EP EP10832056.5A patent/EP2501380B1/en active Active
- 2010-11-16 PL PL10832056T patent/PL2501380T3/pl unknown
- 2010-11-16 ES ES10832056.5T patent/ES2569123T3/es active Active
- 2010-11-16 US US13/509,739 patent/US8637566B2/en active Active
- 2010-11-16 WO PCT/US2010/056849 patent/WO2011062903A2/en not_active Ceased
- 2010-11-16 JP JP2012539070A patent/JP6116907B2/ja active Active
- 2010-11-16 CN CN2010800519066A patent/CN102869357A/zh active Pending
-
2015
- 2015-08-10 JP JP2015157843A patent/JP6173391B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011062903A2 (en) | 2011-05-26 |
| US8637566B2 (en) | 2014-01-28 |
| EP2501380A2 (en) | 2012-09-26 |
| US20120245214A1 (en) | 2012-09-27 |
| JP6116907B2 (ja) | 2017-04-19 |
| WO2011062903A9 (en) | 2011-09-09 |
| CN102869357A (zh) | 2013-01-09 |
| EP2501380A4 (en) | 2013-05-22 |
| JP2013511472A (ja) | 2013-04-04 |
| EP2501380B1 (en) | 2016-01-27 |
| JP2016014034A (ja) | 2016-01-28 |
| JP6173391B2 (ja) | 2017-08-02 |
| PL2501380T3 (pl) | 2016-08-31 |
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