ES2547579T3 - Un aparato para tratamiento sanguíneo extracorpóreo - Google Patents
Un aparato para tratamiento sanguíneo extracorpóreo Download PDFInfo
- Publication number
- ES2547579T3 ES2547579T3 ES12712734.8T ES12712734T ES2547579T3 ES 2547579 T3 ES2547579 T3 ES 2547579T3 ES 12712734 T ES12712734 T ES 12712734T ES 2547579 T3 ES2547579 T3 ES 2547579T3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1603—Regulation parameters
- A61M1/1605—Physical characteristics of the dialysate fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1601—Control or regulation
- A61M1/1603—Regulation parameters
- A61M1/1611—Weight of the patient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
- A61M1/3406—Physical characteristics of the filtrate, e.g. urea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3403—Regulation parameters
- A61M1/341—Regulation parameters by measuring the filtrate rate or volume
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3424—Substitution fluid path
- A61M1/3431—Substitution fluid path upstream of the filter
- A61M1/3434—Substitution fluid path upstream of the filter with pre-dilution and post-dilution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3424—Substitution fluid path
- A61M1/3437—Substitution fluid path downstream of the filter, e.g. post-dilution with filtrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3441—Substitution rate control as a function of the ultrafiltration rate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3455—Substitution fluids
- A61M1/3462—Circuits for the preparation thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/342—Adding solutions to the blood, e.g. substitution solutions
- A61M1/3455—Substitution fluids
- A61M1/3465—Substitution fluids using dialysate as substitution fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
- A61M1/3413—Diafiltration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- External Artificial Organs (AREA)
- Surgical Instruments (AREA)
Abstract
Un aparato para tratamiento sanguíneo extracorpóreo, que comprende: al menos una unidad de tratamiento (2) que tiene al menos una primera cámara (3) y al menos una segunda cámara (4) separadas entre sí por una membrana semipermeable (5); al menos una vía de extracción de sangre (6) conectada a un orificio de entrada de la primera cámara y predispuesta para extraer sangre de un paciente, al menos una vía de retorno de sangre (7) conectada con un orificio de salida de la primera cámara y predispuesta para devolver sangre tratada al paciente, formando la vía de extracción de sangre (6), la vía de retorno de sangre (7) y la primera cámara parte de un circuito sanguíneo extracorpóreo (8); al menos una vía de infusión (9; 9a ,9b) de un fluido de sustitución conectada con el circuito extracorpóreo o conectable directamente con un paciente; al menos una vía de diálisis conectada en la entrada a la segunda cámara (4); al menos una vía de evacuación de fluido (10) conectada a un orificio de salida de la segunda cámara; medios sensores para determinar: - un primer parámetro relativo a un volumen de sangre (BV%) del paciente; - al menos un segundo y un tercer parámetro relativos seleccionados entre: un caudal de ultrafiltración (UFR) a través de la membrana, una velocidad de pérdida de peso (WLR) del paciente, un caudal de infusión (QINF) del fluido de sustitución que atraviesa la vía de infusión (9; 9a, 9b); - un cuarto parámetro relativo a una presión transmembrana (TMP) entre la primera cámara y la segunda cámara; un primer dispositivo regulador (20) activo en al menos uno del circuito extracorpóreo (8) y la vía de evacuación de fluido (10) y configurado para regular un caudal del ultrafiltración (UFR) o una presión transmembrana (TMP) entre la primera y la segunda cámara de la unidad de tratamiento, una unidad de control (15) conectada a los medios sensores y al primer dispositivo regulador (20) y configurada para realizar: a) al menos en un instante de control (t), un procedimiento de control que comprende: - recibir de los medios sensores valores medidos del primer parámetro (BV%mes(t)) y el segundo y tercer parámetro (UFRmes(t), WLRmes(t), QINFmes(t)), y - calcular, tomando como base dichos valores medidos y al menos un valor de prescripción de la variación del volumen de sangre (BV%target), un valor de control relativo a la velocidad de pérdida de peso (WLR(t)) que el aparato debe imponer, - imponer el valor de control (WLR(t)) en la velocidad de pérdida de peso, y para realizar: b) al menos en un instante de ajuste (π) una secuencia de ajuste de la presión transmembrana, comprendiendo dicha secuencia de ajuste: - imponer en un primer valor de la presión transmembrana (TMPn) un primer incremento (δTMPn) para alcanzar un segundo valor de presión transmembrana (TMPn+1); - determinar una variación (ΔUFR(n)) entre el flujo de ultrafiltración a través de la membrana (5) en el primer valor de presión transmembrana (TMPn) y el flujo de ultrafiltración en el segundo valor de presión transmembrana (TMPn +1), en el que la variación del caudal de ultrafiltración se determina mediante medición directa del flujo de ultrafiltración o indirectamente, teniendo en cuenta tanto la variación de flujo de líquido de sustitución (ΔQINF(n)) a lo largo de la vía de infusión como las variaciones de velocidad de pérdida de peso (ΔWLR(n)) debidas al procedimiento de control; - comparar la variación de ultrafiltración (ΔUFR(n)) con un valor de referencia y, si el valor de la variación (ΔUFR(n)) es mayor que el valor de referencia, ordenar al primer dispositivo de regulación, imponer un segundo incremento (δTMPn+1) en la segunda presión transmembrana para alcanzar un tercer valor de la presión transmembrana (TMPn+2).
Description
Claims (1)
-
imagen1 imagen2 imagen3 imagen4
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT000442A ITMI20110442A1 (it) | 2011-03-21 | 2011-03-21 | Apparecchiatura per il trattamento extracorporeo di sangue. |
ITMI20110442 | 2011-03-21 | ||
PCT/IB2012/000537 WO2012127298A1 (en) | 2011-03-21 | 2012-03-20 | An apparatus for extracorporeal blood treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2547579T3 true ES2547579T3 (es) | 2015-10-07 |
Family
ID=43977108
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES12712734.8T Active ES2547579T3 (es) | 2011-03-21 | 2012-03-20 | Un aparato para tratamiento sanguíneo extracorpóreo |
Country Status (9)
Country | Link |
---|---|
US (1) | US9220830B2 (es) |
EP (1) | EP2688600B1 (es) |
KR (1) | KR101531457B1 (es) |
CN (1) | CN103547299B (es) |
AU (1) | AU2012232839B2 (es) |
CA (1) | CA2830039C (es) |
ES (1) | ES2547579T3 (es) |
IT (1) | ITMI20110442A1 (es) |
WO (1) | WO2012127298A1 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2590696B1 (en) | 2010-07-05 | 2017-03-08 | Gambro Lundia AB | An ambulatory ultrafiltration device, related methods and a computer program product |
ES2561461T3 (es) | 2010-09-30 | 2016-02-26 | Gambro Lundia Ab | Aparato para el tratamiento extracorpóreo de la sangre |
ES2525666T3 (es) | 2012-07-18 | 2014-12-29 | Gambro Lundia Ab | Aparato y método para determinar un parámetro indicativo del avance de un tratamiento de sangre extracorpóreo |
WO2014076519A1 (fr) * | 2012-10-29 | 2014-05-22 | Debiotech S.A. | Dispositif de traitement extra corporel du sang |
EP2732834B1 (en) | 2012-11-14 | 2015-07-29 | Gambro Lundia AB | Apparatus for determining a parameter indicative of the progress of an extracorporeal blood treatment |
ITMO20120285A1 (it) * | 2012-11-21 | 2014-05-22 | Monica Zanotti | Apparato di emodiafiltrazione |
EP2745863B9 (en) | 2012-12-20 | 2017-08-30 | Gambro Lundia AB | An apparatus for extracorporeal blood treatment |
EP3015123B1 (en) * | 2014-10-29 | 2017-03-22 | B. Braun Avitum AG | Acute renal replacement therapy apparatus |
US10688233B2 (en) | 2014-12-19 | 2020-06-23 | Fenwal, Inc. | Method and system for the automated processing of biological fluid during low level alert condition |
CN107666918B (zh) | 2015-05-25 | 2021-01-15 | 甘布罗伦迪亚股份公司 | 用于体外血液处理的设备 |
WO2016188951A1 (en) | 2015-05-25 | 2016-12-01 | Gambro Lundia Ab | Apparatus for extracorporeal blood treatment ii |
WO2016188950A1 (en) | 2015-05-25 | 2016-12-01 | Gambro Lundia Ab | Apparatus for extracorporeal blood treatment i |
EP3865160A1 (en) * | 2015-11-09 | 2021-08-18 | Gambro Lundia AB | Apparatus for extracorporeal blood treatment |
CN105363084B (zh) * | 2015-12-10 | 2018-06-26 | 威海威高血液净化制品有限公司 | 一种血液净化装置的液体平衡系统及应用 |
JP6646733B2 (ja) * | 2016-03-31 | 2020-02-14 | 旭化成メディカル株式会社 | 血液浄化システム、及びそのプライミング方法 |
CN110392585B (zh) | 2016-11-25 | 2022-04-26 | 甘布罗伦迪亚股份公司 | 用于体外血液处理的装置 |
ES2938579T3 (es) | 2016-11-25 | 2023-04-12 | Gambro Lundia Ab | Aparato para el tratamiento extracorpóreo de sangre |
WO2018095691A1 (en) | 2016-11-25 | 2018-05-31 | Gambro Lundia Ab | Apparatus for extracorporeal blood treatment |
US10881347B2 (en) | 2017-12-29 | 2021-01-05 | Fresenius Medical Care Holdings, Inc. | Closed loop dialysis treatment using adaptive ultrafiltration rates |
EP3542707A1 (en) * | 2018-03-20 | 2019-09-25 | Gambro Lundia AB | Sensor and apparatus for determining at least one parameter of blood circulating in an extracorporeal blood circuit |
DE102019126048A1 (de) * | 2019-09-26 | 2021-04-01 | B.Braun Avitum Ag | Blutbehandlungsvorrichtung mit automatischer Substitutionsvolumenkompensation |
CA3160327A1 (en) * | 2019-12-10 | 2021-06-17 | John Ramez Zacharia | Combined extracorporeal and drug delivery system and method |
US20210237064A1 (en) * | 2020-01-31 | 2021-08-05 | Astrin Biosciences, Inc. | Biological Fluid Filtration System |
EP3892313B1 (en) * | 2020-04-09 | 2023-01-11 | Gambro Lundia AB | Apparatus for extracorporeal blood treatment |
EP3915608B1 (en) * | 2020-05-29 | 2024-06-26 | Gambro Lundia AB | Apparatus for extracorporeal blood treatment |
US20220355012A1 (en) * | 2021-05-07 | 2022-11-10 | Terumo Cardiovascular Systems Corporation | Heart-lung machine with semi-autonomous initiation mode |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5486286A (en) * | 1991-04-19 | 1996-01-23 | Althin Medical, Inc. | Apparatus for performing a self-test of kidney dialysis membrane |
JP2930418B2 (ja) * | 1992-11-12 | 1999-08-03 | アルシン・メディカル・インコーポレーテッド | 腎臓透析法及び装置 |
IT1276468B1 (it) * | 1995-07-04 | 1997-10-31 | Hospal Dasco Spa | Metodo e apparecchiatura di dialisi automatica |
DE60204883T3 (de) * | 2002-09-05 | 2013-10-24 | Gambro Lundia Ab | Steuerung für eine Blutbehandlungsvorrichtung |
ITMO20040191A1 (it) * | 2004-07-23 | 2004-10-23 | Gambro Lundia Ab | Macchina e metodo per il trattamento extracorporeo di sangue. |
US8372025B2 (en) * | 2005-09-22 | 2013-02-12 | Baxter International Inc. | Automation and optimization of CRRT treatment using regional citrate anticoagulation |
JP4822258B2 (ja) * | 2005-11-11 | 2011-11-24 | 日機装株式会社 | 血液透析装置 |
WO2008064174A1 (en) * | 2006-11-17 | 2008-05-29 | National Quality Care, Inc. | Enhanced clearance in an artificial kidney incorporating a pulsatile pump |
IT1391086B1 (it) * | 2008-07-09 | 2011-11-18 | Gambro Lundia Ab | Apparato trattamento extracorporeo sangue |
-
2011
- 2011-03-21 IT IT000442A patent/ITMI20110442A1/it unknown
-
2012
- 2012-03-20 CN CN201280024654.7A patent/CN103547299B/zh active Active
- 2012-03-20 CA CA2830039A patent/CA2830039C/en active Active
- 2012-03-20 AU AU2012232839A patent/AU2012232839B2/en active Active
- 2012-03-20 ES ES12712734.8T patent/ES2547579T3/es active Active
- 2012-03-20 WO PCT/IB2012/000537 patent/WO2012127298A1/en active Application Filing
- 2012-03-20 KR KR1020137027172A patent/KR101531457B1/ko active IP Right Grant
- 2012-03-20 US US14/006,612 patent/US9220830B2/en active Active
- 2012-03-20 EP EP12712734.8A patent/EP2688600B1/en active Active
Also Published As
Publication number | Publication date |
---|---|
CA2830039C (en) | 2016-02-16 |
AU2012232839B2 (en) | 2014-12-04 |
KR20130135958A (ko) | 2013-12-11 |
EP2688600A1 (en) | 2014-01-29 |
ITMI20110442A1 (it) | 2012-09-22 |
CA2830039A1 (en) | 2012-09-27 |
EP2688600B1 (en) | 2015-07-15 |
US9220830B2 (en) | 2015-12-29 |
AU2012232839A1 (en) | 2013-10-31 |
CN103547299A (zh) | 2014-01-29 |
WO2012127298A1 (en) | 2012-09-27 |
US20140074008A1 (en) | 2014-03-13 |
KR101531457B1 (ko) | 2015-06-24 |
CN103547299B (zh) | 2015-08-26 |
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