ES2547579T3 - Un aparato para tratamiento sanguíneo extracorpóreo - Google Patents

Un aparato para tratamiento sanguíneo extracorpóreo Download PDF

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Publication number
ES2547579T3
ES2547579T3 ES12712734.8T ES12712734T ES2547579T3 ES 2547579 T3 ES2547579 T3 ES 2547579T3 ES 12712734 T ES12712734 T ES 12712734T ES 2547579 T3 ES2547579 T3 ES 2547579T3
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chamber
value
transmembrane pressure
path
blood
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Francesco Fontanazzi
Alessandro SURACE
Francesco Paolini
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Gambro Lundia AB
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Gambro Lundia AB
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601Control or regulation
    • A61M1/1603Regulation parameters
    • A61M1/1605Physical characteristics of the dialysate fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601Control or regulation
    • A61M1/1603Regulation parameters
    • A61M1/1611Weight of the patient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403Regulation parameters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403Regulation parameters
    • A61M1/3406Physical characteristics of the filtrate, e.g. urea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3403Regulation parameters
    • A61M1/341Regulation parameters by measuring the filtrate rate or volume
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342Adding solutions to the blood, e.g. substitution solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3424Substitution fluid path
    • A61M1/3431Substitution fluid path upstream of the filter
    • A61M1/3434Substitution fluid path upstream of the filter with pre-dilution and post-dilution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3424Substitution fluid path
    • A61M1/3437Substitution fluid path downstream of the filter, e.g. post-dilution with filtrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3441Substitution rate control as a function of the ultrafiltration rate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3455Substitution fluids
    • A61M1/3462Circuits for the preparation thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/342Adding solutions to the blood, e.g. substitution solutions
    • A61M1/3455Substitution fluids
    • A61M1/3465Substitution fluids using dialysate as substitution fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3413Diafiltration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/33Controlling, regulating or measuring
    • A61M2205/3331Pressure; Flow
    • A61M2205/3334Measuring or controlling the flow rate

Landscapes

  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Emergency Medicine (AREA)
  • External Artificial Organs (AREA)
  • Surgical Instruments (AREA)

Abstract

Un aparato para tratamiento sanguíneo extracorpóreo, que comprende: al menos una unidad de tratamiento (2) que tiene al menos una primera cámara (3) y al menos una segunda cámara (4) separadas entre sí por una membrana semipermeable (5); al menos una vía de extracción de sangre (6) conectada a un orificio de entrada de la primera cámara y predispuesta para extraer sangre de un paciente, al menos una vía de retorno de sangre (7) conectada con un orificio de salida de la primera cámara y predispuesta para devolver sangre tratada al paciente, formando la vía de extracción de sangre (6), la vía de retorno de sangre (7) y la primera cámara parte de un circuito sanguíneo extracorpóreo (8); al menos una vía de infusión (9; 9a ,9b) de un fluido de sustitución conectada con el circuito extracorpóreo o conectable directamente con un paciente; al menos una vía de diálisis conectada en la entrada a la segunda cámara (4); al menos una vía de evacuación de fluido (10) conectada a un orificio de salida de la segunda cámara; medios sensores para determinar: - un primer parámetro relativo a un volumen de sangre (BV%) del paciente; - al menos un segundo y un tercer parámetro relativos seleccionados entre: un caudal de ultrafiltración (UFR) a través de la membrana, una velocidad de pérdida de peso (WLR) del paciente, un caudal de infusión (QINF) del fluido de sustitución que atraviesa la vía de infusión (9; 9a, 9b); - un cuarto parámetro relativo a una presión transmembrana (TMP) entre la primera cámara y la segunda cámara; un primer dispositivo regulador (20) activo en al menos uno del circuito extracorpóreo (8) y la vía de evacuación de fluido (10) y configurado para regular un caudal del ultrafiltración (UFR) o una presión transmembrana (TMP) entre la primera y la segunda cámara de la unidad de tratamiento, una unidad de control (15) conectada a los medios sensores y al primer dispositivo regulador (20) y configurada para realizar: a) al menos en un instante de control (t), un procedimiento de control que comprende: - recibir de los medios sensores valores medidos del primer parámetro (BV%mes(t)) y el segundo y tercer parámetro (UFRmes(t), WLRmes(t), QINFmes(t)), y - calcular, tomando como base dichos valores medidos y al menos un valor de prescripción de la variación del volumen de sangre (BV%target), un valor de control relativo a la velocidad de pérdida de peso (WLR(t)) que el aparato debe imponer, - imponer el valor de control (WLR(t)) en la velocidad de pérdida de peso, y para realizar: b) al menos en un instante de ajuste (π) una secuencia de ajuste de la presión transmembrana, comprendiendo dicha secuencia de ajuste: - imponer en un primer valor de la presión transmembrana (TMPn) un primer incremento (δTMPn) para alcanzar un segundo valor de presión transmembrana (TMPn+1); - determinar una variación (ΔUFR(n)) entre el flujo de ultrafiltración a través de la membrana (5) en el primer valor de presión transmembrana (TMPn) y el flujo de ultrafiltración en el segundo valor de presión transmembrana (TMPn +1), en el que la variación del caudal de ultrafiltración se determina mediante medición directa del flujo de ultrafiltración o indirectamente, teniendo en cuenta tanto la variación de flujo de líquido de sustitución (ΔQINF(n)) a lo largo de la vía de infusión como las variaciones de velocidad de pérdida de peso (ΔWLR(n)) debidas al procedimiento de control; - comparar la variación de ultrafiltración (ΔUFR(n)) con un valor de referencia y, si el valor de la variación (ΔUFR(n)) es mayor que el valor de referencia, ordenar al primer dispositivo de regulación, imponer un segundo incremento (δTMPn+1) en la segunda presión transmembrana para alcanzar un tercer valor de la presión transmembrana (TMPn+2).

Description

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Claims (1)

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ES12712734.8T 2011-03-21 2012-03-20 Un aparato para tratamiento sanguíneo extracorpóreo Active ES2547579T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT000442A ITMI20110442A1 (it) 2011-03-21 2011-03-21 Apparecchiatura per il trattamento extracorporeo di sangue.
ITMI20110442 2011-03-21
PCT/IB2012/000537 WO2012127298A1 (en) 2011-03-21 2012-03-20 An apparatus for extracorporeal blood treatment

Publications (1)

Publication Number Publication Date
ES2547579T3 true ES2547579T3 (es) 2015-10-07

Family

ID=43977108

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12712734.8T Active ES2547579T3 (es) 2011-03-21 2012-03-20 Un aparato para tratamiento sanguíneo extracorpóreo

Country Status (9)

Country Link
US (1) US9220830B2 (es)
EP (1) EP2688600B1 (es)
KR (1) KR101531457B1 (es)
CN (1) CN103547299B (es)
AU (1) AU2012232839B2 (es)
CA (1) CA2830039C (es)
ES (1) ES2547579T3 (es)
IT (1) ITMI20110442A1 (es)
WO (1) WO2012127298A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2590696B1 (en) 2010-07-05 2017-03-08 Gambro Lundia AB An ambulatory ultrafiltration device, related methods and a computer program product
ES2561461T3 (es) 2010-09-30 2016-02-26 Gambro Lundia Ab Aparato para el tratamiento extracorpóreo de la sangre
ES2525666T3 (es) 2012-07-18 2014-12-29 Gambro Lundia Ab Aparato y método para determinar un parámetro indicativo del avance de un tratamiento de sangre extracorpóreo
WO2014076519A1 (fr) * 2012-10-29 2014-05-22 Debiotech S.A. Dispositif de traitement extra corporel du sang
EP2732834B1 (en) 2012-11-14 2015-07-29 Gambro Lundia AB Apparatus for determining a parameter indicative of the progress of an extracorporeal blood treatment
ITMO20120285A1 (it) * 2012-11-21 2014-05-22 Monica Zanotti Apparato di emodiafiltrazione
EP2745863B9 (en) 2012-12-20 2017-08-30 Gambro Lundia AB An apparatus for extracorporeal blood treatment
EP3015123B1 (en) * 2014-10-29 2017-03-22 B. Braun Avitum AG Acute renal replacement therapy apparatus
US10688233B2 (en) 2014-12-19 2020-06-23 Fenwal, Inc. Method and system for the automated processing of biological fluid during low level alert condition
CN107666918B (zh) 2015-05-25 2021-01-15 甘布罗伦迪亚股份公司 用于体外血液处理的设备
WO2016188951A1 (en) 2015-05-25 2016-12-01 Gambro Lundia Ab Apparatus for extracorporeal blood treatment ii
WO2016188950A1 (en) 2015-05-25 2016-12-01 Gambro Lundia Ab Apparatus for extracorporeal blood treatment i
EP3865160A1 (en) * 2015-11-09 2021-08-18 Gambro Lundia AB Apparatus for extracorporeal blood treatment
CN105363084B (zh) * 2015-12-10 2018-06-26 威海威高血液净化制品有限公司 一种血液净化装置的液体平衡系统及应用
JP6646733B2 (ja) * 2016-03-31 2020-02-14 旭化成メディカル株式会社 血液浄化システム、及びそのプライミング方法
CN110392585B (zh) 2016-11-25 2022-04-26 甘布罗伦迪亚股份公司 用于体外血液处理的装置
ES2938579T3 (es) 2016-11-25 2023-04-12 Gambro Lundia Ab Aparato para el tratamiento extracorpóreo de sangre
WO2018095691A1 (en) 2016-11-25 2018-05-31 Gambro Lundia Ab Apparatus for extracorporeal blood treatment
US10881347B2 (en) 2017-12-29 2021-01-05 Fresenius Medical Care Holdings, Inc. Closed loop dialysis treatment using adaptive ultrafiltration rates
EP3542707A1 (en) * 2018-03-20 2019-09-25 Gambro Lundia AB Sensor and apparatus for determining at least one parameter of blood circulating in an extracorporeal blood circuit
DE102019126048A1 (de) * 2019-09-26 2021-04-01 B.Braun Avitum Ag Blutbehandlungsvorrichtung mit automatischer Substitutionsvolumenkompensation
CA3160327A1 (en) * 2019-12-10 2021-06-17 John Ramez Zacharia Combined extracorporeal and drug delivery system and method
US20210237064A1 (en) * 2020-01-31 2021-08-05 Astrin Biosciences, Inc. Biological Fluid Filtration System
EP3892313B1 (en) * 2020-04-09 2023-01-11 Gambro Lundia AB Apparatus for extracorporeal blood treatment
EP3915608B1 (en) * 2020-05-29 2024-06-26 Gambro Lundia AB Apparatus for extracorporeal blood treatment
US20220355012A1 (en) * 2021-05-07 2022-11-10 Terumo Cardiovascular Systems Corporation Heart-lung machine with semi-autonomous initiation mode

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US5486286A (en) * 1991-04-19 1996-01-23 Althin Medical, Inc. Apparatus for performing a self-test of kidney dialysis membrane
JP2930418B2 (ja) * 1992-11-12 1999-08-03 アルシン・メディカル・インコーポレーテッド 腎臓透析法及び装置
IT1276468B1 (it) * 1995-07-04 1997-10-31 Hospal Dasco Spa Metodo e apparecchiatura di dialisi automatica
DE60204883T3 (de) * 2002-09-05 2013-10-24 Gambro Lundia Ab Steuerung für eine Blutbehandlungsvorrichtung
ITMO20040191A1 (it) * 2004-07-23 2004-10-23 Gambro Lundia Ab Macchina e metodo per il trattamento extracorporeo di sangue.
US8372025B2 (en) * 2005-09-22 2013-02-12 Baxter International Inc. Automation and optimization of CRRT treatment using regional citrate anticoagulation
JP4822258B2 (ja) * 2005-11-11 2011-11-24 日機装株式会社 血液透析装置
WO2008064174A1 (en) * 2006-11-17 2008-05-29 National Quality Care, Inc. Enhanced clearance in an artificial kidney incorporating a pulsatile pump
IT1391086B1 (it) * 2008-07-09 2011-11-18 Gambro Lundia Ab Apparato trattamento extracorporeo sangue

Also Published As

Publication number Publication date
CA2830039C (en) 2016-02-16
AU2012232839B2 (en) 2014-12-04
KR20130135958A (ko) 2013-12-11
EP2688600A1 (en) 2014-01-29
ITMI20110442A1 (it) 2012-09-22
CA2830039A1 (en) 2012-09-27
EP2688600B1 (en) 2015-07-15
US9220830B2 (en) 2015-12-29
AU2012232839A1 (en) 2013-10-31
CN103547299A (zh) 2014-01-29
WO2012127298A1 (en) 2012-09-27
US20140074008A1 (en) 2014-03-13
KR101531457B1 (ko) 2015-06-24
CN103547299B (zh) 2015-08-26

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