ES2546097T3 - Stent biodegradable con velocidad de degradación ajustable - Google Patents
Stent biodegradable con velocidad de degradación ajustable Download PDFInfo
- Publication number
- ES2546097T3 ES2546097T3 ES10733129.0T ES10733129T ES2546097T3 ES 2546097 T3 ES2546097 T3 ES 2546097T3 ES 10733129 T ES10733129 T ES 10733129T ES 2546097 T3 ES2546097 T3 ES 2546097T3
- Authority
- ES
- Spain
- Prior art keywords
- stent
- lactide
- weight
- plla
- poly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000015556 catabolic process Effects 0.000 title description 42
- 238000006731 degradation reaction Methods 0.000 title description 42
- 229920001432 poly(L-lactide) Polymers 0.000 claims abstract description 75
- 239000000178 monomer Substances 0.000 claims abstract description 33
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 14
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 claims abstract description 11
- 239000004793 Polystyrene Substances 0.000 claims abstract description 5
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- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 125000004122 cyclic group Chemical group 0.000 description 2
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- 210000002216 heart Anatomy 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 230000028709 inflammatory response Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000003698 laser cutting Methods 0.000 description 2
- 230000003902 lesion Effects 0.000 description 2
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- 229910052751 metal Inorganic materials 0.000 description 2
- 238000013146 percutaneous coronary intervention Methods 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
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- 230000002966 stenotic effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
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- JJTUDXZGHPGLLC-QWWZWVQMSA-N (3r,6r)-3,6-dimethyl-1,4-dioxane-2,5-dione Chemical compound C[C@H]1OC(=O)[C@@H](C)OC1=O JJTUDXZGHPGLLC-QWWZWVQMSA-N 0.000 description 1
- JJTUDXZGHPGLLC-ZXZARUISSA-N (3r,6s)-3,6-dimethyl-1,4-dioxane-2,5-dione Chemical compound C[C@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-ZXZARUISSA-N 0.000 description 1
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 1
- BYHQTRFJOGIQAO-GOSISDBHSA-N 3-(4-bromophenyl)-8-[(2R)-2-hydroxypropyl]-1-[(3-methoxyphenyl)methyl]-1,3,8-triazaspiro[4.5]decan-2-one Chemical compound C[C@H](CN1CCC2(CC1)CN(C(=O)N2CC3=CC(=CC=C3)OC)C4=CC=C(C=C4)Br)O BYHQTRFJOGIQAO-GOSISDBHSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000005764 Peripheral Arterial Disease Diseases 0.000 description 1
- 208000030831 Peripheral arterial occlusive disease Diseases 0.000 description 1
- 101100097991 Schizosaccharomyces pombe (strain 972 / ATCC 24843) rar1 gene Proteins 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000004026 adhesive bonding Methods 0.000 description 1
- 229920003232 aliphatic polyester Polymers 0.000 description 1
- 230000001028 anti-proliverative effect Effects 0.000 description 1
- 210000000709 aorta Anatomy 0.000 description 1
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- 210000000013 bile duct Anatomy 0.000 description 1
- 239000012867 bioactive agent Substances 0.000 description 1
- 239000003462 bioceramic Substances 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 230000008512 biological response Effects 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000001715 carotid artery Anatomy 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000002144 chemical decomposition reaction Methods 0.000 description 1
- 230000007073 chemical hydrolysis Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
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- 239000012141 concentrate Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 238000002788 crimping Methods 0.000 description 1
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- 239000000945 filler Substances 0.000 description 1
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- 210000002683 foot Anatomy 0.000 description 1
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- 238000013467 fragmentation Methods 0.000 description 1
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- 230000004927 fusion Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 210000003709 heart valve Anatomy 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 210000003090 iliac artery Anatomy 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
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- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 239000005267 main chain polymer Substances 0.000 description 1
- 238000010128 melt processing Methods 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 244000309715 mini pig Species 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
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- 231100000331 toxic Toxicity 0.000 description 1
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- 210000001635 urinary tract Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000013585 weight reducing agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K26/00—Working by laser beam, e.g. welding, cutting or boring
- B23K26/36—Removing material
- B23K26/40—Removing material taking account of the properties of the material involved
- B23K26/402—Removing material taking account of the properties of the material involved involving non-metallic material, e.g. isolators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K2103/00—Materials to be soldered, welded or cut
- B23K2103/30—Organic material
- B23K2103/42—Plastics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23K—SOLDERING OR UNSOLDERING; WELDING; CLADDING OR PLATING BY SOLDERING OR WELDING; CUTTING BY APPLYING HEAT LOCALLY, e.g. FLAME CUTTING; WORKING BY LASER BEAM
- B23K2103/00—Materials to be soldered, welded or cut
- B23K2103/50—Inorganic material, e.g. metals, not provided for in B23K2103/02 – B23K2103/26
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Optics & Photonics (AREA)
- Plasma & Fusion (AREA)
- Mechanical Engineering (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/506,973 US9889238B2 (en) | 2009-07-21 | 2009-07-21 | Biodegradable stent with adjustable degradation rate |
| US506973 | 2009-07-21 | ||
| PCT/US2010/041998 WO2011011242A2 (en) | 2009-07-21 | 2010-07-14 | Biodegradable stent with adjustable degradation rate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2546097T3 true ES2546097T3 (es) | 2015-09-18 |
Family
ID=42731897
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10733129.0T Active ES2546097T3 (es) | 2009-07-21 | 2010-07-14 | Stent biodegradable con velocidad de degradación ajustable |
| ES15162569.6T Active ES2626604T3 (es) | 2009-07-21 | 2010-07-14 | Estent biodegradable con velocidad de degradación ajustable |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES15162569.6T Active ES2626604T3 (es) | 2009-07-21 | 2010-07-14 | Estent biodegradable con velocidad de degradación ajustable |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9889238B2 (enExample) |
| EP (2) | EP2949351B1 (enExample) |
| JP (2) | JP5735505B2 (enExample) |
| CY (1) | CY1116668T1 (enExample) |
| DK (1) | DK2456480T3 (enExample) |
| ES (2) | ES2546097T3 (enExample) |
| HU (1) | HUE025457T2 (enExample) |
| PL (1) | PL2456480T3 (enExample) |
| PT (1) | PT2456480E (enExample) |
| SI (1) | SI2456480T1 (enExample) |
| WO (1) | WO2011011242A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9889238B2 (en) | 2009-07-21 | 2018-02-13 | Abbott Cardiovascular Systems Inc. | Biodegradable stent with adjustable degradation rate |
| US8889823B2 (en) | 2009-07-21 | 2014-11-18 | Abbott Cardiovascular Systems Inc. | Method to make poly(L-lactide) stent with tunable degradation rate |
| US8966868B2 (en) * | 2011-05-09 | 2015-03-03 | Abbott Cardiovascular Systems Inc. | Methods of stabilizing molecular weight of polymer stents after sterilization |
| US8834776B2 (en) | 2011-05-10 | 2014-09-16 | Abbott Cardiovascular Systems Inc. | Control of degradation profile of bioabsorbable poly(l-lactide) scaffold |
| US8709070B2 (en) | 2011-05-10 | 2014-04-29 | Abbott Cardiovascular Systems Inc. | Bioabsorbable scaffold with particles providing delayed acceleration of degradation |
| US8545546B2 (en) * | 2011-05-13 | 2013-10-01 | Abbott Cardiovascular Systems Inc. | Bioabsorbable scaffolds made from composites |
| CN102499999B (zh) * | 2011-11-22 | 2014-06-18 | 深圳市信立泰生物医疗工程有限公司 | 一种形变后的聚合物管材和由其制备的完全可生物降解聚合物支架 |
| US20130338700A1 (en) * | 2012-06-13 | 2013-12-19 | Matheny Enterprises, Llc | Biodegradable, Active Ingredient-Eluting Structural Support |
| US9205456B2 (en) * | 2012-07-24 | 2015-12-08 | Abbott Cardiovascular Systems Inc. | Modifying polymer properties with penetrants in the fabrication of bioresorbable scaffolds |
| WO2015020527A1 (en) | 2013-08-09 | 2015-02-12 | Maastricht University | Biodegradable radiopaque stents and other implants |
| US10207449B2 (en) | 2014-06-24 | 2019-02-19 | Cook Medical Technologies Llc | Sequential biaxial strain of semi-crystalline tubes |
| JPWO2016114216A1 (ja) * | 2015-01-13 | 2017-10-19 | テルモ株式会社 | 生分解性ステント |
| EP3303445B1 (en) * | 2015-06-05 | 2020-12-16 | Council of Scientific and Industrial Research | A one step process for the pelletisation of poly lactic acid without melt processing |
| CN108289747B (zh) * | 2015-11-26 | 2020-11-27 | 株式会社日本医疗机器技研 | 生物体吸收性支架 |
| CN115219655A (zh) * | 2022-06-14 | 2022-10-21 | 南京浩衍鼎业科技技术有限公司 | 一种聚合物产品降解速率控制方法 |
| WO2023250246A2 (en) * | 2022-06-24 | 2023-12-28 | Razmodics Llc | Implantable scaffolds having biodegradable components and methods of manufacturing and use thereof |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4539981A (en) | 1982-11-08 | 1985-09-10 | Johnson & Johnson Products, Inc. | Absorbable bone fixation device |
| DE4014974A1 (de) | 1990-05-10 | 1991-11-14 | Boehringer Ingelheim Kg | Verfahren zur herstellung von loesungsmittel- und restmonomerenfreien in spritzgiess-, extrusions- und schmelzspinnverfahren einsetzbaren polymeren |
| JPH04166165A (ja) | 1990-10-30 | 1992-06-12 | Shimadzu Corp | 骨固定用材料 |
| JPH04282337A (ja) | 1991-03-08 | 1992-10-07 | Fuji Photo Film Co Ltd | ２−アリールオキシ−１−クロルプロパンの製造方法 |
| US5357034A (en) | 1992-09-08 | 1994-10-18 | Camelot Technologies Inc. | Lactide polymerization |
| US5338822A (en) * | 1992-10-02 | 1994-08-16 | Cargill, Incorporated | Melt-stable lactide polymer composition and process for manufacture thereof |
| US5747637A (en) | 1995-09-07 | 1998-05-05 | Mitsui Toatsu Chemicals, Inc. | Bioabsorbable polymer and process for preparing the same |
| US6174330B1 (en) * | 1997-08-01 | 2001-01-16 | Schneider (Usa) Inc | Bioabsorbable marker having radiopaque constituents |
| US5824059A (en) * | 1997-08-05 | 1998-10-20 | Wijay; Bandula | Flexible stent |
| US6206883B1 (en) | 1999-03-05 | 2001-03-27 | Stryker Technologies Corporation | Bioabsorbable materials and medical devices made therefrom |
| EP1184008B9 (en) | 2000-03-13 | 2012-09-19 | Kabushiki Kaisha Kyoto Iryo Sekkei | Wire rods for vascular stents and vascular stents with the use of the same |
| KR100354828B1 (ko) * | 2001-03-12 | 2002-10-05 | 주식회사 씨엠리서치 | 생분해성 폴리에스테르의 제조방법 및 그에 의해 제조된생분해성 폴리에스테르 |
| US20030069629A1 (en) | 2001-06-01 | 2003-04-10 | Jadhav Balkrishna S. | Bioresorbable medical devices |
| GB0116341D0 (en) | 2001-07-04 | 2001-08-29 | Smith & Nephew | Biodegradable polymer systems |
| US7731890B2 (en) | 2006-06-15 | 2010-06-08 | Advanced Cardiovascular Systems, Inc. | Methods of fabricating stents with enhanced fracture toughness |
| US8747879B2 (en) | 2006-04-28 | 2014-06-10 | Advanced Cardiovascular Systems, Inc. | Method of fabricating an implantable medical device to reduce chance of late inflammatory response |
| US20060041102A1 (en) | 2004-08-23 | 2006-02-23 | Advanced Cardiovascular Systems, Inc. | Implantable devices comprising biologically absorbable polymers having constant rate of degradation and methods for fabricating the same |
| US8778375B2 (en) | 2005-04-29 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Amorphous poly(D,L-lactide) coating |
| US7291166B2 (en) * | 2005-05-18 | 2007-11-06 | Advanced Cardiovascular Systems, Inc. | Polymeric stent patterns |
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-
2009
- 2009-07-21 US US12/506,973 patent/US9889238B2/en active Active
-
2010
- 2010-07-14 EP EP15162569.6A patent/EP2949351B1/en not_active Not-in-force
- 2010-07-14 DK DK10733129.0T patent/DK2456480T3/en active
- 2010-07-14 ES ES10733129.0T patent/ES2546097T3/es active Active
- 2010-07-14 EP EP10733129.0A patent/EP2456480B2/en active Active
- 2010-07-14 ES ES15162569.6T patent/ES2626604T3/es active Active
- 2010-07-14 PT PT107331290T patent/PT2456480E/pt unknown
- 2010-07-14 HU HUE10733129A patent/HUE025457T2/en unknown
- 2010-07-14 JP JP2012521678A patent/JP5735505B2/ja active Active
- 2010-07-14 PL PL10733129T patent/PL2456480T3/pl unknown
- 2010-07-14 SI SI201030992T patent/SI2456480T1/sl unknown
- 2010-07-14 WO PCT/US2010/041998 patent/WO2011011242A2/en not_active Ceased
-
2015
- 2015-04-16 JP JP2015084280A patent/JP6017617B2/ja not_active Expired - Fee Related
- 2015-09-01 CY CY20151100765T patent/CY1116668T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2456480B1 (en) | 2015-06-03 |
| EP2456480A2 (en) | 2012-05-30 |
| PL2456480T3 (pl) | 2015-11-30 |
| DK2456480T3 (en) | 2015-08-31 |
| SI2456480T1 (sl) | 2015-11-30 |
| ES2626604T3 (es) | 2017-07-25 |
| JP2015154957A (ja) | 2015-08-27 |
| CY1116668T1 (el) | 2017-03-15 |
| HK1216303A1 (en) | 2016-11-04 |
| HUE025457T2 (en) | 2016-02-29 |
| JP5735505B2 (ja) | 2015-06-17 |
| WO2011011242A2 (en) | 2011-01-27 |
| US20110022155A1 (en) | 2011-01-27 |
| JP6017617B2 (ja) | 2016-11-02 |
| JP2012533408A (ja) | 2012-12-27 |
| US9889238B2 (en) | 2018-02-13 |
| PT2456480E (pt) | 2015-09-23 |
| WO2011011242A3 (en) | 2011-04-07 |
| EP2949351B1 (en) | 2017-04-05 |
| EP2949351A1 (en) | 2015-12-02 |
| EP2456480B2 (en) | 2018-03-07 |
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