ES2544808T3 - Miméticos sintéticos de LTA y uso de los mismos como componente de vacuna para la terapia y/o profilaxis de infecciones gram-positivas - Google Patents
Miméticos sintéticos de LTA y uso de los mismos como componente de vacuna para la terapia y/o profilaxis de infecciones gram-positivas Download PDFInfo
- Publication number
- ES2544808T3 ES2544808T3 ES11157947.0T ES11157947T ES2544808T3 ES 2544808 T3 ES2544808 T3 ES 2544808T3 ES 11157947 T ES11157947 T ES 11157947T ES 2544808 T3 ES2544808 T3 ES 2544808T3
- Authority
- ES
- Spain
- Prior art keywords
- lta
- prophylaxis
- gram
- therapy
- vaccine component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 208000015181 infectious disease Diseases 0.000 title 1
- 238000011321 prophylaxis Methods 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 229940124856 vaccine component Drugs 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000837 carbohydrate group Chemical group 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/11—Esters of phosphoric acids with hydroxyalkyl compounds without further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un mimético sintético de ácido lipoteicoico (LTA) que tiene la siguiente fórmula general (III)**Fórmula** en donde z es un número entero seleccionado de 1 a 40, y preferiblemente seleccionado de 4 a 6, en donde R1 se selecciona de H o un resto carbohidrato, y L es un resto enlazador para conectar dicho mimético a una proteína de soporte adecuada, o sales o solvatos del mismo.
Description
E11157947
06-08-2015
J. Huebner, Y. Wang, W. A. Krueger, L. C. Madoff, G. Martirosian, S. Boisot, D. A. Goldmann, D. L. Kasper, A. O. Tzianabos y G. B. Pier (1999). "Isolation and chemical characterization of a capsular polysaccharide antigen shared by clinical isolates of Enterococcus faecalis and vancomycin-resistant Enterococcus faecium." Infect Immun 67(3): 1213-1219.
5 J. Huebner, A. Quaas, W. A. Krueger, D. A. Goldmann y G. B. Pier (2000). "Prophylactic and therapeutic efficacy of antibodies to a capsular polysaccharide shared among vancomycin-sensitive and -resistant enterococci." Infect Immun 68(8): 4631-4636.
C. Theilacker, Z. Kaczynski, A. Kropec, F. Fabretti, T. Sange, O. Holst y J. Huebner (2006). "Opsonic antibodies to Enterococcus faecalis strain 12030 are directed against lipoteichoic acid." Infect Immun 74(10): 5703-5712.
10 I. G. Sava, E. Heikens y J. Huebner (2010). "Pathogenesis and immunity in enterococcal infections." Clin Microbiol Infect 16(6): 533-540.
W. F. Hogendorf, L. J. Bos, H. S. Overkleeft, J. D. Codee y G. A. Marel (2010). "Synthesis of an alpha-kojibiosyl substituted glycerol teichoic acid hexamer." Bioorg Med Chem 18(11): 3668-3678.
9
Claims (1)
-
imagen1 imagen2
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20110157947 EP2500349B1 (en) | 2011-03-11 | 2011-03-11 | Synthetic LTA mimetics and use thereof as vaccine component for therapy and/or prophylaxis against gram-positive infections |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2544808T3 true ES2544808T3 (es) | 2015-09-04 |
Family
ID=43828266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES11157947.0T Active ES2544808T3 (es) | 2011-03-11 | 2011-03-11 | Miméticos sintéticos de LTA y uso de los mismos como componente de vacuna para la terapia y/o profilaxis de infecciones gram-positivas |
Country Status (7)
Country | Link |
---|---|
US (1) | US9290531B2 (es) |
EP (1) | EP2500349B1 (es) |
JP (1) | JP6154751B2 (es) |
CA (1) | CA2829126A1 (es) |
ES (1) | ES2544808T3 (es) |
HK (1) | HK1175786A1 (es) |
WO (1) | WO2012119846A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2780351B1 (en) * | 2011-11-18 | 2019-12-18 | National Research Council of Canada (NRC) | Clostridium difficile lipoteichoic acid and uses thereof |
WO2018013999A1 (en) | 2016-07-15 | 2018-01-18 | Am Chemicals Llc | Non-nucleosidic solid supports and phosphoramidite building blocks for oligonucleotide synthesis |
KR101950881B1 (ko) * | 2017-08-10 | 2019-02-22 | 서울대학교산학협력단 | 리포테이코익산(Lipoteichoic acid(LTA))을 함유하는 피부 재생 및 창상 치유용 약학 조성물 |
BR112020004471A8 (pt) * | 2017-09-07 | 2022-11-01 | Merck Sharp & Dohme | Polissacarídeos pneumocócicos e uso dos mesmos em conjugados imunogênicos polissacarídeo-proteína carreadora |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996023896A1 (en) * | 1995-01-30 | 1996-08-08 | Peter Truog | Antitumor and anticholesterol preparations containing a lipoteichoic acid from steptococcus |
AUPQ137699A0 (en) | 1999-07-02 | 1999-07-22 | University Of New England, The | Control of acidosis |
CA2474709A1 (en) * | 2002-02-04 | 2003-08-14 | Biomira, Inc. | Immunostimulatory, covalently lipidated oligonucleotides |
-
2011
- 2011-03-11 ES ES11157947.0T patent/ES2544808T3/es active Active
- 2011-03-11 EP EP20110157947 patent/EP2500349B1/en not_active Not-in-force
-
2012
- 2012-02-17 US US14/002,459 patent/US9290531B2/en not_active Expired - Fee Related
- 2012-02-17 JP JP2013557032A patent/JP6154751B2/ja not_active Expired - Fee Related
- 2012-02-17 WO PCT/EP2012/052801 patent/WO2012119846A1/en active Application Filing
- 2012-02-17 CA CA2829126A patent/CA2829126A1/en not_active Abandoned
-
2013
- 2013-03-12 HK HK13103062.2A patent/HK1175786A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP2500349A1 (en) | 2012-09-19 |
JP2014507450A (ja) | 2014-03-27 |
WO2012119846A1 (en) | 2012-09-13 |
US20140050741A1 (en) | 2014-02-20 |
EP2500349B1 (en) | 2015-05-06 |
HK1175786A1 (en) | 2013-07-12 |
JP6154751B2 (ja) | 2017-06-28 |
CA2829126A1 (en) | 2012-09-13 |
US9290531B2 (en) | 2016-03-22 |
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