ES2542694T3 - Composición que comprende ácidos grasos omega 3 y un sal de cobre enmascarada o recubierta - Google Patents
Composición que comprende ácidos grasos omega 3 y un sal de cobre enmascarada o recubierta Download PDFInfo
- Publication number
- ES2542694T3 ES2542694T3 ES08718009.7T ES08718009T ES2542694T3 ES 2542694 T3 ES2542694 T3 ES 2542694T3 ES 08718009 T ES08718009 T ES 08718009T ES 2542694 T3 ES2542694 T3 ES 2542694T3
- Authority
- ES
- Spain
- Prior art keywords
- omega
- fatty acids
- masked
- copper
- copper salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
- A23P20/10—Coating with edible coatings, e.g. with oils or fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/30—Copper compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Inorganic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nanotechnology (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Botany (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Una composición farmacéutica que comprende uno o más ácidos grasos omega 3 sensibles al cobre y una sal de cobre enmascarada o recubierta para estabilizar la composición farmacéutica frente a la descomposición dependiente de la sal de cobre.
Description
E08718009
15-07-2015
Gelatina 175 bloom bovina Glicerol al 99 %,USP Aceite de soja en copos (hidrogenado), NF Aceite de soja USP y
Colorantes (si es necesario) orgánicos y/o inorgánicos, por ejemplo, dióxido de titanio USP, óxido de hierro negro E172 y/o óxido de hierro rojo E172
La estabilidad de la composición anterior se investiga en un entorno donde el cobre no está enmascarado y en una
5 situación en la que el cobre está enmascarado en la cubierta y que, por consiguiente, no está en contacto directo con los ingredientes sensibles al cobre. La estabilidad del procedimiento de enmascaramiento/recubrimiento descrito se correlaciona con el grado de descomposición de tal compuesto y/o composición sensibles al cobre.
Ejemplo 3
240 mg de aceite de pescado con DHA al 70 % etiquetado 160 mg de ácidos grasos omega 3Ácido docosahexaenoico (DHA) etiquetado 130 mg de DHAÁcido eicosapentaenoico (EPA) como parte del aceite de pescado etiquetado 11 mg 91,5 mg de ascorbato de calcio etiquetado 60 mg de vitamina C 31,343 mg de acetato de d,l-alfa-tocoferol etiquetado 20 mg de vitamina E 55 mg de luteína al 20 % en aceite de alazor etiquetado 10 mg de luteína 12,447 mg de óxido de cinc etiquetado 10 mg de cinc 0,45 mg de carbonato cúprico básico etiquetado 0,25 mg de cobre Zeaxantina como parte de la luteína etiquetado 0,8 mg
La composición anterior puede contener otros excipientes para la producción de una formulación galénica deseada, 10 por ejemplo, para fabricar una cubierta de una cápsula o similar.
Ejemplo 4
Estabilidad de ácidos grasos omega 3 en cápsulas blandas de gelatina después de 2 días de almacenamiento a 80 [grados] C. (Humedad ambiental, es decir, humedad relativa del 50-70 %)
(Cambio en el contenido de los componentes de ácido graso omega 3)
15 Los ensayos para cuantificar el porcentaje en peso de EPA y DHA después del almacenamiento se llevan a cabo por cromatografía de gases por el procedimiento habitual descrito en la Farmacopea Europea 5.4.
- Componentes de ácidos grasos omega 3
- Formulación con cobre no enmascarado Formulaciones con cobre enmascarado
- Formulaciones desveladas en el ejemplo 3: (con carbonato cúprico básico). La cubierta es idéntica a la cubierta desvelada en el ejemplo 2, pero no contiene cobre
- Formulación como se desvela en el ejemplo 3, en la que se reemplaza el carbonato cúprico básico con 2,250 mg de DESCOTE® (gluconato de cobre recubierto), que corresponden a 0,25 mg de cobre. La cubierta es idéntica a la cubierta desvelada en el ejemplo 2, pero no contiene cobre Formulación desvelada en el ejemplo 3, si bien se omite el cobre de dicha formulación. No obstante hay cobre en la cubierta, a saber, 0,45 mg de carbonato cúprico básico (que corresponden a 0,25 mg de cobre), como se desvela en el ejemplo 2
- EPA en % en peso
- disminución del 5,0 % disminución del 1,7 % sin cambios (sin disminución)
- DHA en % en peso
- Sin cambios detectables Sin cambios detectables sin cambios (sin disminución)
- Otros ácidos grasos omega 3** distintos de EPA y DHA en % en peso
- disminución del 1,9 % disminución del 0,4 % sin cambios (sin disminución)
- **Otros ácidos grasos omega 3 denota la suma de ácido alfa-linolénico (ALA), ácido estearidónico (SA), ácido eicosatetraenoico (ETA) y ácido docosapentaenoico (DPA).
3
Claims (1)
-
imagen1
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07104792 | 2007-03-23 | ||
EP07104792A EP1974733A1 (en) | 2007-03-23 | 2007-03-23 | Use of a masked or coated copper salt for the treatment of macular degeneration |
EP07111322 | 2007-06-28 | ||
EP07111322 | 2007-06-28 | ||
PCT/EP2008/053283 WO2008116806A1 (en) | 2007-03-23 | 2008-03-19 | Use of a masked or coated copper salt for the treatment of macular degeneration |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2542694T3 true ES2542694T3 (es) | 2015-08-10 |
Family
ID=39477329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES08718009.7T Active ES2542694T3 (es) | 2007-03-23 | 2008-03-19 | Composición que comprende ácidos grasos omega 3 y un sal de cobre enmascarada o recubierta |
Country Status (26)
Country | Link |
---|---|
US (1) | US20080233182A1 (es) |
EP (1) | EP2124973B1 (es) |
JP (1) | JP2010521534A (es) |
KR (1) | KR101688656B1 (es) |
AR (1) | AR065791A1 (es) |
AU (1) | AU2008231847B2 (es) |
BR (1) | BRPI0809258B8 (es) |
CA (1) | CA2681514C (es) |
CL (1) | CL2008000804A1 (es) |
CO (1) | CO6230993A2 (es) |
DK (1) | DK2124973T3 (es) |
EC (1) | ECSP099700A (es) |
ES (1) | ES2542694T3 (es) |
GT (1) | GT200900251A (es) |
IL (1) | IL201109A (es) |
MA (1) | MA31293B1 (es) |
MX (1) | MX2009010244A (es) |
MY (1) | MY164520A (es) |
NZ (1) | NZ579852A (es) |
PE (1) | PE20090186A1 (es) |
PL (1) | PL2124973T3 (es) |
PT (1) | PT2124973E (es) |
RU (1) | RU2009139002A (es) |
TN (1) | TN2009000387A1 (es) |
TW (1) | TW200904456A (es) |
WO (1) | WO2008116806A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PH12019500030A1 (en) * | 2009-03-09 | 2020-02-10 | Pronova Biopharma Norge As | Compositions comprising a fatty acid oil mixture and a surfactant, and methods and uses thereof |
KR101759255B1 (ko) | 2015-09-18 | 2017-07-18 | 한국산업기술대학교산학협력단 | 무촉매 방식 가변경사각을 갖는 나노 구조물 성장 방법 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2043487A1 (es) * | 1969-05-28 | 1971-02-19 | Commissariat Energie Atomique | |
US5298237A (en) * | 1992-01-24 | 1994-03-29 | The Trustees Of Columbia University In The City Of New York | Gel composition for reduction of gingival inflammation and retardation of dental plaque |
US5641512A (en) * | 1995-03-29 | 1997-06-24 | The Procter & Gamble Company | Soft gelatin capsule compositions |
US20030004043A1 (en) * | 2001-06-27 | 2003-01-02 | Deola James A. | Pivoting backrest for exercise apparatus |
US20030104043A1 (en) * | 2001-12-03 | 2003-06-05 | Brown Beverly Ann | Topical cream for alleviating spider veins |
US20050249820A1 (en) * | 2004-05-04 | 2005-11-10 | Akorn, Inc. | Nutritional supplement for the treatment and prevention of macular degeneration |
WO2005110375A1 (en) * | 2004-05-08 | 2005-11-24 | Paul Edward L Jr | Nutritional supplement for treatment of ocular diseases |
US7449196B2 (en) * | 2004-07-09 | 2008-11-11 | Robert Sabin | Anti tumor compositions and methods of use |
EP1614414A3 (en) * | 2004-07-09 | 2008-07-09 | Robert Sabin | Compositions comprising a copper compound for treatment of mammalian diseases |
AU2005306320B2 (en) * | 2004-11-19 | 2011-09-08 | Martek Biosciences Corporation | Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same |
-
2008
- 2008-03-19 EP EP08718009.7A patent/EP2124973B1/en active Active
- 2008-03-19 PE PE2008000520A patent/PE20090186A1/es not_active Application Discontinuation
- 2008-03-19 AU AU2008231847A patent/AU2008231847B2/en active Active
- 2008-03-19 KR KR1020097022078A patent/KR101688656B1/ko active IP Right Grant
- 2008-03-19 WO PCT/EP2008/053283 patent/WO2008116806A1/en active Application Filing
- 2008-03-19 AR ARP080101138A patent/AR065791A1/es not_active Application Discontinuation
- 2008-03-19 CA CA2681514A patent/CA2681514C/en active Active
- 2008-03-19 JP JP2010500223A patent/JP2010521534A/ja active Pending
- 2008-03-19 MY MYPI20093944A patent/MY164520A/en unknown
- 2008-03-19 PT PT87180097T patent/PT2124973E/pt unknown
- 2008-03-19 RU RU2009139002/15A patent/RU2009139002A/ru not_active Application Discontinuation
- 2008-03-19 DK DK08718009.7T patent/DK2124973T3/da active
- 2008-03-19 BR BRPI0809258A patent/BRPI0809258B8/pt active IP Right Grant
- 2008-03-19 MX MX2009010244A patent/MX2009010244A/es not_active Application Discontinuation
- 2008-03-19 PL PL08718009T patent/PL2124973T3/pl unknown
- 2008-03-19 ES ES08718009.7T patent/ES2542694T3/es active Active
- 2008-03-19 NZ NZ579852A patent/NZ579852A/en not_active IP Right Cessation
- 2008-03-20 US US12/052,016 patent/US20080233182A1/en not_active Abandoned
- 2008-03-20 CL CL200800804A patent/CL2008000804A1/es unknown
- 2008-03-21 TW TW097110250A patent/TW200904456A/zh unknown
-
2009
- 2009-09-22 IL IL201109A patent/IL201109A/en active IP Right Grant
- 2009-09-22 TN TNP2009000387A patent/TN2009000387A1/fr unknown
- 2009-09-22 GT GT200900251A patent/GT200900251A/es unknown
- 2009-09-23 CO CO09103873A patent/CO6230993A2/es not_active Application Discontinuation
- 2009-10-02 MA MA32248A patent/MA31293B1/fr unknown
- 2009-10-23 EC EC2009009700A patent/ECSP099700A/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL201109A0 (en) | 2010-05-17 |
EP2124973A1 (en) | 2009-12-02 |
EP2124973B1 (en) | 2015-05-27 |
TW200904456A (en) | 2009-02-01 |
MY164520A (en) | 2017-12-29 |
KR101688656B1 (ko) | 2016-12-21 |
GT200900251A (es) | 2018-10-08 |
AR065791A1 (es) | 2009-07-01 |
JP2010521534A (ja) | 2010-06-24 |
CL2008000804A1 (es) | 2008-10-24 |
CA2681514A1 (en) | 2008-10-02 |
CO6230993A2 (es) | 2010-12-20 |
BRPI0809258B8 (pt) | 2021-05-25 |
RU2009139002A (ru) | 2011-04-27 |
MX2009010244A (es) | 2009-10-26 |
TN2009000387A1 (en) | 2010-12-31 |
MA31293B1 (fr) | 2010-04-01 |
AU2008231847A1 (en) | 2008-10-02 |
PE20090186A1 (es) | 2009-03-20 |
US20080233182A1 (en) | 2008-09-25 |
DK2124973T3 (da) | 2015-06-22 |
NZ579852A (en) | 2012-03-30 |
KR20100015799A (ko) | 2010-02-12 |
CA2681514C (en) | 2016-11-08 |
WO2008116806A1 (en) | 2008-10-02 |
BRPI0809258A2 (pt) | 2014-09-23 |
IL201109A (en) | 2016-10-31 |
AU2008231847B2 (en) | 2012-12-06 |
PT2124973E (pt) | 2015-09-01 |
ECSP099700A (es) | 2009-11-30 |
PL2124973T3 (pl) | 2015-10-30 |
BRPI0809258B1 (pt) | 2019-10-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Elagizi et al. | Omega-3 polyunsaturated fatty acids and cardiovascular health: a comprehensive review | |
de Barboza et al. | Oxidative stress, antioxidants and intestinal calcium absorption | |
Barcelos et al. | Effects of ω-3 essential fatty acids (ω-3 EFAs) on motor disorders and memory dysfunction typical neuroleptic-induced: behavioral and biochemical parameter | |
Trebatická et al. | Cardiovascular diseases, depression disorders and potential effects of omega-3 fatty acids | |
Kumar et al. | Hesperidin potentiates the neuroprotective effects of diazepam and gabapentin against pentylenetetrazole-induced convulsions in mice: Possible behavioral, biochemical and mitochondrial alterations | |
RU2009126735A (ru) | Композиция питательной добавки, предназначенной для лечения глазных болезней | |
MXPA06008352A (es) | Una composicion farmaceutica. | |
EP3738586A1 (en) | Enteric soft capsules comprising polyunsaturated fatty acids | |
CO6470839A2 (es) | Composiciones farmacéuticas que contienen epa y un agente cardiovascular y métodos de emplearlas | |
EA200100895A1 (ru) | Незаменимые жирные кислоты для предотвращения сердечно-сосудистых приступов | |
RU2008103281A (ru) | Способы и композиции для профилактики и лечения воспалительного заболевания | |
EP2217220B1 (en) | Lipoic acid pellet composition | |
RU2007117803A (ru) | Композиция для лечения глаз, содержащая омега-3 жирные кислоты и омега-6 жирные кислоты | |
EP1714658B1 (fr) | Complément alimentaire comprenant une association d'agents antioxydants et de la carnitine ou un précurseur de la carnitine, comme aide à la fertilité chez l'homme et chez la femme | |
ES2542694T3 (es) | Composición que comprende ácidos grasos omega 3 y un sal de cobre enmascarada o recubierta | |
Jabłońska-Trypuć et al. | Traumatic acid toxicity mechanisms in human breast cancer MCF-7 cells | |
Nasadyuk et al. | Thymohexin exhibits cytoprotective effect in experimental gastric lesions in rats both through the inhibition of inducible nitric oxide synthase and reduction of oxidative mucosal damage | |
Tenore et al. | Canned bluefin tuna, an in vitro cardioprotective functional food potentially safer than commercial fish oil based pharmaceutical formulations | |
FR3068603A1 (fr) | Complement alimentaire pour proteger la fertilite feminine et masculine | |
Das | Bioactive lipids as mediators of the beneficial actions of statins | |
AR070405A1 (es) | Composiciones para la prevencion y/o el tratamiento de la degeneracion macular y/o la perdida de la agudeza visual | |
Mohamed et al. | Effects of simultaneous melatonin administration on the testis of the experimentally induced hyper-and hypothyroidism in the adult male albino rat | |
Siriviriyakul et al. | The vascular effect of genistein: What is its mechanism, nitric oxide or PGI 2? | |
FR2760358A1 (fr) | Composition cosmetique et pharmaceutique revigorante, notamment permettant d'eviter aux cheveux de devenir blancs avec l'âge, et aussi de reprendre leur couleur d'origine s'ils sont deja blancs | |
ITFI20120288A1 (it) | Formulazione farmaceutica comprendente inositolo e selenio, sua preparazione ed uso. |