ES2541684T3 - Crioconservación de material biocompatible - Google Patents
Crioconservación de material biocompatible Download PDFInfo
- Publication number
- ES2541684T3 ES2541684T3 ES06772165.4T ES06772165T ES2541684T3 ES 2541684 T3 ES2541684 T3 ES 2541684T3 ES 06772165 T ES06772165 T ES 06772165T ES 2541684 T3 ES2541684 T3 ES 2541684T3
- Authority
- ES
- Spain
- Prior art keywords
- cells
- endothelial
- cell
- implantable material
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000560 biocompatible material Substances 0.000 title 1
- 238000005138 cryopreservation Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract description 46
- 239000000463 material Substances 0.000 abstract description 13
- 239000000203 mixture Substances 0.000 abstract description 11
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 239000011159 matrix material Substances 0.000 abstract description 4
- 230000035899 viability Effects 0.000 abstract description 2
- 239000012595 freezing medium Substances 0.000 abstract 2
- 150000004676 glycans Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 abstract 1
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 14
- 230000003511 endothelial effect Effects 0.000 description 9
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 7
- 239000003636 conditioned culture medium Substances 0.000 description 7
- 239000002609 medium Substances 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 238000007789 sealing Methods 0.000 description 7
- 210000001519 tissue Anatomy 0.000 description 7
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 description 6
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 6
- 229920002971 Heparan sulfate Polymers 0.000 description 6
- 102000046299 Transforming Growth Factor beta1 Human genes 0.000 description 6
- 101800002279 Transforming growth factor beta-1 Proteins 0.000 description 6
- 229920001287 Chondroitin sulfate Polymers 0.000 description 5
- 210000002889 endothelial cell Anatomy 0.000 description 5
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 4
- 229940059329 chondroitin sulfate Drugs 0.000 description 4
- 239000000565 sealant Substances 0.000 description 4
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 3
- 238000012286 ELISA Assay Methods 0.000 description 3
- 229910002651 NO3 Inorganic materials 0.000 description 3
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 210000000130 stem cell Anatomy 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
- 229920000045 Dermatan sulfate Polymers 0.000 description 2
- 238000006595 Griess deamination reaction Methods 0.000 description 2
- 102000004142 Trypsin Human genes 0.000 description 2
- 108090000631 Trypsin Proteins 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- DLGJWSVWTWEWBJ-HGGSSLSASA-N chondroitin Chemical compound CC(O)=N[C@@H]1[C@H](O)O[C@H](CO)[C@H](O)[C@@H]1OC1[C@H](O)[C@H](O)C=C(C(O)=O)O1 DLGJWSVWTWEWBJ-HGGSSLSASA-N 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- IPZJQDSFZGZEOY-UHFFFAOYSA-N dimethylmethylene Chemical group C[C]C IPZJQDSFZGZEOY-UHFFFAOYSA-N 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 238000013411 master cell bank Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000012588 trypsin Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 102000029816 Collagenase Human genes 0.000 description 1
- 108060005980 Collagenase Proteins 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 108090000913 Nitrate Reductases Proteins 0.000 description 1
- BELBBZDIHDAJOR-UHFFFAOYSA-N Phenolsulfonephthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2S(=O)(=O)O1 BELBBZDIHDAJOR-UHFFFAOYSA-N 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 230000003872 anastomosis Effects 0.000 description 1
- 239000000987 azo dye Substances 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000007975 buffered saline Substances 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000013553 cell monolayer Substances 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229960002424 collagenase Drugs 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 description 1
- 229940051593 dermatan sulfate Drugs 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 244000052637 human pathogen Species 0.000 description 1
- 210000003090 iliac artery Anatomy 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229960003531 phenolsulfonphthalein Drugs 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
- 238000012207 quantitative assay Methods 0.000 description 1
- 238000012113 quantitative test Methods 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 238000009331 sowing Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 229940099456 transforming growth factor beta 1 Drugs 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3808—Endothelial cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Botany (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- External Artificial Organs (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69270805P | 2005-06-21 | 2005-06-21 | |
| US692708P | 2005-06-21 | ||
| WOPCT/US2005/043967 | 2005-12-06 | ||
| PCT/US2005/043967 WO2006062909A2 (en) | 2004-12-08 | 2005-12-06 | Methods and compositions for enhancing vascular access |
| PCT/US2006/021755 WO2007001744A2 (en) | 2005-06-21 | 2006-06-05 | Methods and compositions for enhancing vascular access |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2541684T3 true ES2541684T3 (es) | 2015-07-23 |
Family
ID=39892157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06772165.4T Active ES2541684T3 (es) | 2005-06-21 | 2006-06-05 | Crioconservación de material biocompatible |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20090035346A1 (https=) |
| EP (2) | EP2361591A3 (https=) |
| JP (2) | JP5632580B2 (https=) |
| CN (3) | CN101878757A (https=) |
| AU (1) | AU2006262682B2 (https=) |
| CA (2) | CA2818182C (https=) |
| ES (1) | ES2541684T3 (https=) |
| IL (2) | IL188263A (https=) |
| SG (2) | SG161258A1 (https=) |
| WO (1) | WO2007001744A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2926510B2 (ja) | 1990-08-09 | 1999-07-28 | 京都電子工業株式会社 | アンモニア濃度測定装置 |
| CA2605080A1 (en) | 2005-04-21 | 2006-11-02 | Massachusetts Institute Of Technology | Materials and methods for altering an immune response to exogenous and endogenous immunogens, including syngeneic and non-syngeneic cells, tissues or organs |
| EP2361591A3 (en) | 2005-06-21 | 2011-12-21 | Pervasis Therapeutics, Inc. | Methods and compositions for enhancing vascular access |
| JP5372764B2 (ja) * | 2006-11-07 | 2013-12-18 | シャイア リジェネラティブ メディシン， インコーポレイテッド | 血管形成関連疾患の治療および管理のための材料および方法 |
| WO2008057590A2 (en) * | 2006-11-07 | 2008-05-15 | Pervasis Therapeutics, Inc. | Methods and compositions for modulating tissue modeling |
| EP2240116B1 (en) | 2008-01-28 | 2015-07-01 | Biomet 3I, LLC | Implant surface with increased hydrophilicity |
| KR101970342B1 (ko) * | 2011-04-28 | 2019-04-18 | 아브락시스 바이오사이언스, 엘엘씨 | 나노입자 조성물의 혈관내 전달 및 그의 용도 |
| CN102763642B (zh) * | 2012-08-14 | 2014-04-02 | 郑州赛英科干细胞技术有限公司 | 一种冷冻保护液以及冷冻保存人胎盘羊膜和绒毛膜的方法 |
| AU2015265954A1 (en) * | 2014-05-27 | 2017-01-12 | Novahep Ab | Bioengineered allogeneic valve |
| CA3222892A1 (en) * | 2015-03-10 | 2016-09-15 | Stent Tek Limited | Surgical system, device and methods of use thereof for the percutaneous creation of an arteriovenous fistula (avf) |
| US11389622B1 (en) * | 2017-11-13 | 2022-07-19 | Simon B. Rayhanabad | Patch for providing dialysis |
| US12017032B1 (en) | 2017-11-13 | 2024-06-25 | Sbr Innovations, Llc | Arteriovenous graft and method of using thereof |
| WO2019152799A1 (en) | 2018-02-02 | 2019-08-08 | University Of Louisville Research Foundation, Inc. | Sutureless graft anastomotic quick connect system |
| JP7669266B2 (ja) * | 2018-08-31 | 2025-04-28 | ウィスコンシン アラムニ リサーチ ファンデーション | 動脈内皮細胞を播種した血管移植片の生成 |
| US12310836B2 (en) | 2020-03-03 | 2025-05-27 | Akeo Hagiwara | Vein cover |
| CN115376392B (zh) * | 2022-08-18 | 2024-04-26 | 昆明理工大学 | 主动脉老化对血管生物力学影响的模拟装置及方法 |
| EP4439070B1 (de) * | 2023-03-27 | 2025-12-03 | Siemens Healthcare Diagnostics Products GmbH | Automatisches analysesystem |
| CN120227529B (zh) * | 2025-05-29 | 2025-08-12 | 鼎科医疗技术（苏州）有限公司 | 一种血管外支架 |
Family Cites Families (88)
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| US4418691A (en) * | 1981-10-26 | 1983-12-06 | Massachusetts Institute Of Technology | Method of promoting the regeneration of tissue at a wound |
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| US4820626A (en) * | 1985-06-06 | 1989-04-11 | Thomas Jefferson University | Method of treating a synthetic or naturally occuring surface with microvascular endothelial cells, and the treated surface itself |
| IL78950A (en) | 1985-06-06 | 1991-12-15 | Univ Jefferson | Coating for prosthetic devices |
| US4732155A (en) * | 1985-08-27 | 1988-03-22 | The Children's Medical Center Corporation | Implantable chemoattractant system |
| US5863531A (en) * | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
| US6309635B1 (en) * | 1986-11-20 | 2001-10-30 | Children's Medical Center Corp. | Seeding parenchymal cells into compression resistant porous scaffold after vascularizing in vivo |
| CA1340581C (en) * | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
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| US5073492A (en) * | 1987-01-09 | 1991-12-17 | The Johns Hopkins University | Synergistic composition for endothelial cell growth |
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| US5202120A (en) * | 1987-09-11 | 1993-04-13 | Case Western Reserve University | Methods of reducing glial scar formation and promoting axon and blood vessel growth and/or regeneration through the use of activated immature astrocytes |
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- 2006-06-05 US US11/922,729 patent/US20090035346A1/en not_active Abandoned
- 2006-06-05 CN CN2010102362140A patent/CN101878757A/zh active Pending
- 2006-06-05 CN CN2006800279776A patent/CN101257861B/zh not_active Expired - Fee Related
- 2006-06-05 SG SG201002482-6A patent/SG161258A1/en unknown
- 2006-06-05 AU AU2006262682A patent/AU2006262682B2/en not_active Ceased
- 2006-06-05 EP EP20060772165 patent/EP1901680B1/en not_active Not-in-force
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- 2006-06-05 JP JP2008518189A patent/JP5632580B2/ja not_active Expired - Fee Related
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- 2006-06-05 WO PCT/US2006/021755 patent/WO2007001744A2/en not_active Ceased
- 2006-06-05 CN CN201210246619.1A patent/CN102743792B/zh not_active Expired - Fee Related
- 2006-06-05 ES ES06772165.4T patent/ES2541684T3/es active Active
- 2006-06-05 CA CA 2612751 patent/CA2612751A1/en not_active Abandoned
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2007
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2012
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- 2012-07-05 IL IL220806A patent/IL220806A/en not_active IP Right Cessation
- 2012-11-02 US US13/667,227 patent/US9023377B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN102743792A (zh) | 2012-10-24 |
| WO2007001744A2 (en) | 2007-01-04 |
| EP2361591A2 (en) | 2011-08-31 |
| EP1901680A2 (en) | 2008-03-26 |
| EP2361591A3 (en) | 2011-12-21 |
| JP5632580B2 (ja) | 2014-11-26 |
| EP1901680B1 (en) | 2015-04-15 |
| IL188263A (en) | 2014-05-28 |
| IL220806A (en) | 2014-05-28 |
| CN102743792B (zh) | 2014-09-24 |
| AU2006262682B2 (en) | 2012-07-05 |
| AU2006262682A1 (en) | 2007-01-04 |
| JP2012166084A (ja) | 2012-09-06 |
| SG161258A1 (en) | 2010-05-27 |
| WO2007001744B1 (en) | 2007-12-21 |
| CN101257861A (zh) | 2008-09-03 |
| SG195537A1 (en) | 2013-12-30 |
| IL188263A0 (en) | 2009-02-11 |
| IL220806A0 (en) | 2012-08-30 |
| WO2007001744A3 (en) | 2007-10-04 |
| JP2008546406A (ja) | 2008-12-25 |
| US20090035346A1 (en) | 2009-02-05 |
| US20130210142A1 (en) | 2013-08-15 |
| CA2818182C (en) | 2015-04-14 |
| CA2818182A1 (en) | 2007-01-04 |
| CN101257861B (zh) | 2012-12-05 |
| CN101878757A (zh) | 2010-11-10 |
| CA2612751A1 (en) | 2007-01-04 |
| US9023377B2 (en) | 2015-05-05 |
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