ES2533256T3 - Uso de resiniferatoxina (RTX) para la fabricación de un medicamento para el tratamiento del dolor - Google Patents
Uso de resiniferatoxina (RTX) para la fabricación de un medicamento para el tratamiento del dolor Download PDFInfo
- Publication number
- ES2533256T3 ES2533256T3 ES04802396.4T ES04802396T ES2533256T3 ES 2533256 T3 ES2533256 T3 ES 2533256T3 ES 04802396 T ES04802396 T ES 04802396T ES 2533256 T3 ES2533256 T3 ES 2533256T3
- Authority
- ES
- Spain
- Prior art keywords
- pain
- case
- bone
- treatment
- tooth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 208000002193 Pain Diseases 0.000 title abstract 8
- 239000003814 drug Substances 0.000 title abstract 5
- 229940079593 drug Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- DSDNAKHZNJAGHN-MXTYGGKSSA-N resiniferatoxin Chemical compound C1=C(O)C(OC)=CC(CC(=O)OCC=2C[C@]3(O)C(=O)C(C)=C[C@H]3[C@@]34[C@H](C)C[C@@]5(O[C@@](O4)(CC=4C=CC=CC=4)O[C@@H]5[C@@H]3C=2)C(C)=C)=C1 DSDNAKHZNJAGHN-MXTYGGKSSA-N 0.000 title abstract 2
- 210000000988 bone and bone Anatomy 0.000 abstract 4
- 238000002347 injection Methods 0.000 abstract 4
- 239000007924 injection Substances 0.000 abstract 4
- 208000006820 Arthralgia Diseases 0.000 abstract 3
- 206010006002 Bone pain Diseases 0.000 abstract 3
- 206010003246 arthritis Diseases 0.000 abstract 3
- 208000000112 Myalgia Diseases 0.000 abstract 2
- 206010028851 Necrosis Diseases 0.000 abstract 2
- 206010034464 Periarthritis Diseases 0.000 abstract 2
- 201000010603 frozen shoulder Diseases 0.000 abstract 2
- 230000017074 necrotic cell death Effects 0.000 abstract 2
- 208000004371 toothache Diseases 0.000 abstract 2
- 206010002153 Anal fissure Diseases 0.000 abstract 1
- 208000016583 Anus disease Diseases 0.000 abstract 1
- 206010058029 Arthrofibrosis Diseases 0.000 abstract 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract 1
- 206010007710 Cartilage injury Diseases 0.000 abstract 1
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 208000009531 Fissure in Ano Diseases 0.000 abstract 1
- 206010061159 Foot deformity Diseases 0.000 abstract 1
- 208000001963 Hallux Valgus Diseases 0.000 abstract 1
- 208000004575 Infectious Arthritis Diseases 0.000 abstract 1
- 206010061246 Intervertebral disc degeneration Diseases 0.000 abstract 1
- 206010023230 Joint stiffness Diseases 0.000 abstract 1
- 208000002472 Morton Neuroma Diseases 0.000 abstract 1
- 208000005890 Neuroma Diseases 0.000 abstract 1
- 201000009859 Osteochondrosis Diseases 0.000 abstract 1
- 208000004983 Phantom Limb Diseases 0.000 abstract 1
- 206010056238 Phantom pain Diseases 0.000 abstract 1
- 206010035623 Pleuritic pain Diseases 0.000 abstract 1
- 206010068771 Soft tissue neoplasm Diseases 0.000 abstract 1
- 208000000491 Tendinopathy Diseases 0.000 abstract 1
- 206010043255 Tendonitis Diseases 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 229910001424 calcium ion Inorganic materials 0.000 abstract 1
- 159000000007 calcium salts Chemical class 0.000 abstract 1
- 208000002849 chondrocalcinosis Diseases 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 208000002925 dental caries Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 210000002391 femur head Anatomy 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 208000014617 hemorrhoid Diseases 0.000 abstract 1
- 239000007943 implant Substances 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 210000000936 intestine Anatomy 0.000 abstract 1
- 238000010255 intramuscular injection Methods 0.000 abstract 1
- 239000007927 intramuscular injection Substances 0.000 abstract 1
- 230000003902 lesion Effects 0.000 abstract 1
- 210000003041 ligament Anatomy 0.000 abstract 1
- 239000003589 local anesthetic agent Substances 0.000 abstract 1
- 230000005499 meniscus Effects 0.000 abstract 1
- 210000001087 myotubule Anatomy 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- 208000007538 neurilemmoma Diseases 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
- 201000001245 periodontitis Diseases 0.000 abstract 1
- 210000003281 pleural cavity Anatomy 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 231100000241 scar Toxicity 0.000 abstract 1
- 206010039667 schwannoma Diseases 0.000 abstract 1
- 201000001223 septic arthritis Diseases 0.000 abstract 1
- 230000001148 spastic effect Effects 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
- 201000004595 synovitis Diseases 0.000 abstract 1
- 201000004415 tendinitis Diseases 0.000 abstract 1
- 206010044652 trigeminal neuralgia Diseases 0.000 abstract 1
- 210000000689 upper leg Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CH2004/000756 WO2006069451A1 (de) | 2004-12-28 | 2004-12-28 | Verwendung von resiniferatoxin (rtx) für die herstellung eines mittels zur behandlung von gelenkschmerzen und verfahren zur applikation dieses mittels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2533256T3 true ES2533256T3 (es) | 2015-04-08 |
Family
ID=34959549
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES04802396.4T Expired - Lifetime ES2533256T3 (es) | 2004-12-28 | 2004-12-28 | Uso de resiniferatoxina (RTX) para la fabricación de un medicamento para el tratamiento del dolor |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20080139641A1 (OSRAM) |
| EP (1) | EP1838301B1 (OSRAM) |
| JP (1) | JP5775246B2 (OSRAM) |
| CA (1) | CA2594202C (OSRAM) |
| DK (1) | DK1838301T3 (OSRAM) |
| ES (1) | ES2533256T3 (OSRAM) |
| PL (1) | PL1838301T3 (OSRAM) |
| WO (1) | WO2006069451A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2089023A2 (en) | 2006-11-02 | 2009-08-19 | Aestus Therapeutics, Inc. | Methods of treating neuropathic pain with agonists of ppar-gamma |
| US8697155B2 (en) * | 2008-07-22 | 2014-04-15 | Mayo Foundation For Medical Education And Research | Treatment of obesity and related disorders |
| US8870876B2 (en) | 2009-02-13 | 2014-10-28 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| US8277459B2 (en) | 2009-09-25 | 2012-10-02 | Tarsus Medical Inc. | Methods and devices for treating a structural bone and joint deformity |
| US8652141B2 (en) | 2010-01-21 | 2014-02-18 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| US8696719B2 (en) | 2010-06-03 | 2014-04-15 | Tarsus Medical Inc. | Methods and devices for treating hallux valgus |
| WO2012168450A1 (en) | 2011-06-10 | 2012-12-13 | Queen Mary & Westfield College | Artemisinin and its derivatives for use in the treatment of trauma haemorrhage and associated conditions |
| JP2015523401A (ja) * | 2012-08-03 | 2015-08-13 | メステックス・アー・ゲー | レシニフェラトキシン溶液 |
| JP6144775B2 (ja) | 2012-12-12 | 2017-06-07 | クイーン マリー アンド ウエストフィールド カレッジ， ユニバーシティー オブ ロンドン | 腎臓病の治療に使用されるアーテミシニンおよびその誘導体 |
| US10076384B2 (en) | 2013-03-08 | 2018-09-18 | Symple Surgical, Inc. | Balloon catheter apparatus with microwave emitter |
| ES3066533T3 (en) | 2016-11-02 | 2026-05-13 | Centrexion Therapeutics Corp | Stable aqueous capsaicin injectable formulations and medical uses thereof |
| US11400136B2 (en) * | 2017-06-19 | 2022-08-02 | President And Fellows Of Harvard College | Methods and compositions for treating a microbial infection |
| US20200206166A1 (en) | 2017-07-20 | 2020-07-02 | Centrexion Therapeutics Corporation | Methods and compositions for treatment of pain using capsaicin |
| MX2020002692A (es) * | 2017-09-11 | 2020-10-14 | Sorrento Therapeutics Inc | Formulacion de resiniferatoxina. |
| CA3123222A1 (en) | 2018-12-21 | 2020-06-25 | Sorrento Therapeutics, Inc. | Perineural administration of resiniferatoxin for treatment of maladaptive pain |
| US11254659B1 (en) | 2019-01-18 | 2022-02-22 | Centrexion Therapeutics Corporation | Capsaicinoid prodrug compounds and their use in treating medical conditions |
| US11447444B1 (en) | 2019-01-18 | 2022-09-20 | Centrexion Therapeutics Corporation | Capsaicinoid prodrug compounds and their use in treating medical conditions |
| SG11202107815UA (en) * | 2019-01-22 | 2021-08-30 | Sorrento Therapeutics Inc | Method for treating osteoarthritis pain by administering resiniferatoxin |
| CN110123833A (zh) * | 2019-05-31 | 2019-08-16 | 龚啸元 | 一种关节镜手术用灌流液及其制备方法 |
| CA3172784A1 (en) * | 2020-04-15 | 2021-10-21 | Grunenthal Gmbh | Resiniferatoxin compositions |
| WO2025153517A1 (en) | 2024-01-15 | 2025-07-24 | Grünenthal GmbH | Treating knee joint pain by injecting resiniferatoxin at ultra low doses |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3104085A (en) | 1960-07-18 | 1963-09-17 | Ind Paper Log Inc | Compressed fibrous articles |
| US4939149A (en) * | 1988-10-24 | 1990-07-03 | The United States Of America As Represented By The Department Of Health And Human Services | Resiniferatoxin and analogues thereof to cause sensory afferent C-fiber and thermoregulatory desensitization |
| US4997853A (en) * | 1988-12-02 | 1991-03-05 | Galenpharma, Inc. | Method and compositions utilizing capsaicin as an external analgesic |
| WO1990014083A1 (en) * | 1989-05-15 | 1990-11-29 | Afferon Corporation | Composition and method for neural desensitization |
| DE69841907D1 (de) | 1997-03-13 | 2010-11-04 | James N Campbell | Zusammensetzungen enthaltend Capsaicin oder Capsaicin Analoge und ein Anästhetikum |
| GB9711962D0 (en) | 1997-06-10 | 1997-08-06 | Reckitt & Colmann Prod Ltd | Therapeutically active compositions |
| WO2002033411A1 (en) * | 2000-10-16 | 2002-04-25 | Ortho-Mcneil Pharmaceutical, Inc. | Improved ligand binding assays for vanilloid receptors |
| JP2004521112A (ja) * | 2001-01-24 | 2004-07-15 | メステックス アクチエンゲゼルシャフト | 関節痛治療薬を製造することへの神経毒性物質の使用 |
| CA2442049C (en) | 2001-03-22 | 2010-06-01 | Michael J. Iadarola | Selective ablation of pain-sensing neurons by administration of a vanilloid receptor agonist |
| US20030104085A1 (en) * | 2001-12-05 | 2003-06-05 | Yeomans David C. | Methods and compositions for treating back pain |
| CN102205127A (zh) | 2002-12-18 | 2011-10-05 | 阿尔乔医疗公司 | 类辣椒素的给药 |
| ATE489086T1 (de) * | 2004-12-22 | 2010-12-15 | Mestex Ag | Mischung eines vanilloidrezeptoragonisten mit einer nervenregenerationshemmenden substanz, ihre verwendung für die herstellung eines schmerzmittels und verfahren zur applikation dieses mittels |
-
2004
- 2004-12-28 WO PCT/CH2004/000756 patent/WO2006069451A1/de not_active Ceased
- 2004-12-28 ES ES04802396.4T patent/ES2533256T3/es not_active Expired - Lifetime
- 2004-12-28 PL PL04802396T patent/PL1838301T3/pl unknown
- 2004-12-28 DK DK04802396.4T patent/DK1838301T3/en active
- 2004-12-28 JP JP2007548653A patent/JP5775246B2/ja not_active Expired - Lifetime
- 2004-12-28 US US11/722,779 patent/US20080139641A1/en not_active Abandoned
- 2004-12-28 CA CA 2594202 patent/CA2594202C/en not_active Expired - Lifetime
- 2004-12-28 EP EP04802396.4A patent/EP1838301B1/de not_active Expired - Lifetime
-
2010
- 2010-04-07 US US12/755,994 patent/US9044452B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2594202C (en) | 2013-12-03 |
| WO2006069451A1 (de) | 2006-07-06 |
| JP5775246B2 (ja) | 2015-09-09 |
| JP2008525504A (ja) | 2008-07-17 |
| EP1838301B1 (de) | 2015-01-28 |
| CA2594202A1 (en) | 2006-07-06 |
| PL1838301T3 (pl) | 2015-08-31 |
| US9044452B2 (en) | 2015-06-02 |
| EP1838301A1 (de) | 2007-10-03 |
| US20100196281A1 (en) | 2010-08-05 |
| DK1838301T3 (en) | 2015-04-27 |
| US20080139641A1 (en) | 2008-06-12 |
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