ES2529180T3 - Formulación multietapa que contiene una biguanida y un derivado de tiazolidinodiona - Google Patents
Formulación multietapa que contiene una biguanida y un derivado de tiazolidinodiona Download PDFInfo
- Publication number
- ES2529180T3 ES2529180T3 ES03754689.2T ES03754689T ES2529180T3 ES 2529180 T3 ES2529180 T3 ES 2529180T3 ES 03754689 T ES03754689 T ES 03754689T ES 2529180 T3 ES2529180 T3 ES 2529180T3
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- Prior art keywords
- tablet
- coating
- core
- weight
- semipermeable membrane
- Prior art date
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- Expired - Lifetime
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- IEPRKVQEAMIZSS-AATRIKPKSA-N diethyl fumarate Chemical compound CCOC(=O)\C=C\C(=O)OCC IEPRKVQEAMIZSS-AATRIKPKSA-N 0.000 description 1
- VKNUORWMCINMRB-UHFFFAOYSA-N diethyl malate Chemical compound CCOC(=O)CC(O)C(=O)OCC VKNUORWMCINMRB-UHFFFAOYSA-N 0.000 description 1
- WYACBZDAHNBPPB-UHFFFAOYSA-N diethyl oxalate Chemical compound CCOC(=O)C(=O)OCC WYACBZDAHNBPPB-UHFFFAOYSA-N 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 230000003292 diminished effect Effects 0.000 description 1
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- 239000002270 dispersing agent Substances 0.000 description 1
- MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
- 229940043264 dodecyl sulfate Drugs 0.000 description 1
- 238000007908 dry granulation Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 229940095884 glucophage Drugs 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000010651 grapefruit oil Substances 0.000 description 1
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- 239000000017 hydrogel Substances 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- OXVFDZYQLGRLCD-UHFFFAOYSA-N hydroxypioglitazone Chemical compound N1=CC(C(O)C)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 OXVFDZYQLGRLCD-UHFFFAOYSA-N 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
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- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229940068041 phytic acid Drugs 0.000 description 1
- 235000002949 phytic acid Nutrition 0.000 description 1
- 239000000467 phytic acid Substances 0.000 description 1
- 229920000193 polymethacrylate Polymers 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 229960004586 rosiglitazone Drugs 0.000 description 1
- 229940116351 sebacate Drugs 0.000 description 1
- CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 description 1
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- 235000011803 sesame oil Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41218102P | 2002-09-20 | 2002-09-20 | |
| US41218002P | 2002-09-20 | 2002-09-20 | |
| US412181P | 2002-09-20 | ||
| PCT/US2003/029292 WO2004026241A2 (en) | 2002-09-20 | 2003-09-19 | Multistage formulation containing a biguanide and thiazolidindione derivatives |
| US412180P | 2010-11-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2529180T3 true ES2529180T3 (es) | 2015-02-17 |
Family
ID=32033587
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES03754689.2T Expired - Lifetime ES2529180T3 (es) | 2002-09-20 | 2003-09-19 | Formulación multietapa que contiene una biguanida y un derivado de tiazolidinodiona |
Country Status (8)
| Country | Link |
|---|---|
| EP (2) | EP1539144B1 (https=) |
| JP (1) | JP4694841B2 (https=) |
| KR (4) | KR20100137023A (https=) |
| CN (2) | CN101623274B (https=) |
| AU (1) | AU2003272504A1 (https=) |
| CA (1) | CA2499597C (https=) |
| ES (1) | ES2529180T3 (https=) |
| WO (1) | WO2004026241A2 (https=) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8323692B2 (en) * | 2002-02-21 | 2012-12-04 | Valeant International Bermuda | Controlled release dosage forms |
| US7785627B2 (en) * | 2002-09-20 | 2010-08-31 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US9060941B2 (en) | 2002-09-20 | 2015-06-23 | Actavis, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| MXPA05007883A (es) * | 2003-01-29 | 2005-09-21 | Takeda Pharmaceutical | Proceso para producir una preparacion recubierta. |
| PE20061245A1 (es) * | 2005-03-30 | 2007-01-06 | Generex Pharm Inc | Composiciones para la transmision transmucosa oral de la metformina |
| CN101365432B (zh) * | 2005-12-16 | 2011-06-22 | 默沙东公司 | 二肽基肽酶-4抑制剂与二甲双胍的组合的药物组合物 |
| US8747897B2 (en) * | 2006-04-27 | 2014-06-10 | Supernus Pharmaceuticals, Inc. | Osmotic drug delivery system |
| MY146781A (en) | 2006-05-23 | 2012-09-28 | Takeda Pharmaceutical | Oral preparation comprising pioglitazone |
| DE102008059206A1 (de) * | 2008-11-27 | 2010-06-10 | Bayer Schering Pharma Aktiengesellschaft | Pharmazeutische Darreichungsform enthaltend Nifedipin oder Nisoldipin und einen Angiotensin-II Antagonisten und/oder ein Diuretikum |
| US9416098B2 (en) | 2010-01-06 | 2016-08-16 | Immunomet Therapeutics Inc. | Biguanide derivative, a preparation method thereof and a pharmaceutical composition containing the biguanide derivative as an active ingredient |
| CA2802335A1 (en) * | 2010-06-22 | 2011-12-29 | Twi Pharmaceuticals, Inc. | Controlled release compositions with reduced food effect |
| EP2611434A1 (en) | 2010-09-01 | 2013-07-10 | Lupin Limited | Pharmaceutical composition comprising metformin and pioglitazone |
| CN102008472B (zh) * | 2010-10-18 | 2012-08-22 | 中国科学院上海药物研究所 | 一种复方盐酸吡格列酮/盐酸二甲双胍双层渗透泵控释制剂及其制备方法 |
| CN101984974B (zh) * | 2010-11-15 | 2013-04-17 | 山东新华制药股份有限公司 | 一种用于治疗2型糖尿病的药物组合物的制备方法 |
| CN105663130B (zh) * | 2011-04-15 | 2019-08-09 | 江苏豪森药业集团有限公司 | 一种具有第一和第二活性药物的制剂 |
| AU2012326976B2 (en) | 2011-10-21 | 2017-08-17 | Takeda Pharmaceutical Company Limited | Sustained-release preparation |
| UY35006A (es) * | 2012-09-06 | 2014-03-31 | Bayer Healthcare Llc | Composición farmacéutica recubierta que contiene regorafenib |
| CN102920704A (zh) * | 2012-11-05 | 2013-02-13 | 上海现代药物制剂工程研究中心有限公司 | 含有双胍和噻唑烷二酮衍生物的药物制剂 |
| WO2014184742A1 (en) | 2013-05-13 | 2014-11-20 | Ranbaxy Laboratories Limited | Pharmaceutical compositions containing a biguanide and a low dose antidiabetic agent |
| CN106458868A (zh) | 2014-04-17 | 2017-02-22 | 伊谬诺米特医疗有限公司 | 胍化合物及其用途 |
| EP3025707A1 (en) * | 2014-11-27 | 2016-06-01 | Arven Ilac Sanayi Ve Ticaret A.S. | A multilayer tablet comprising metformin and pioglitazone |
| CN104473894A (zh) * | 2014-12-18 | 2015-04-01 | 浙江华海药业股份有限公司 | 一种盐酸吡格列酮载药包衣制剂及其制备方法 |
| CN106137999A (zh) * | 2015-03-31 | 2016-11-23 | 深圳翰宇药业股份有限公司 | 一种复方吡格列酮二甲双胍缓释片及其制备方法 |
| KR101750690B1 (ko) * | 2015-10-28 | 2017-06-27 | 주식회사 종근당 | 메트포르민 및 로베글리타존을 포함하는 약제학적 조성물 |
| CN108478537A (zh) * | 2018-05-03 | 2018-09-04 | 南京易亨制药有限公司 | 一种含普瑞巴林的单室渗透泵控释片剂 |
| WO2021242040A1 (ko) * | 2020-05-29 | 2021-12-02 | 한국유나이티드제약 주식회사 | 삼투압에 의해 방출 조절되는 서방성 메트포르민 코팅 정제 및 이의 제조방법 |
| US11684596B2 (en) * | 2020-09-22 | 2023-06-27 | Elite Pharmaceuticals Solution Inc. | Antidiabetic pharmaceutical compositions and preparation method thereof |
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| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| FR2243684B1 (https=) | 1973-09-19 | 1977-01-28 | Semb | |
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| US4892739A (en) | 1988-04-25 | 1990-01-09 | Ciba-Geigy Corporation | Osmotic continuous dispensing oral delivery system containing a pharmaceutically acceptable active agent having a improved core membrane adhesion properties |
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| TWI238064B (en) * | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
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| ATE355840T1 (de) * | 1997-06-18 | 2007-03-15 | Smithkline Beecham Plc | Behandlung der diabetes mit thiazolidindione und metformin |
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| US6780432B1 (en) * | 2000-05-01 | 2004-08-24 | Aeropharm Technology, Inc. | Core formulation |
| US6451342B2 (en) | 2000-05-01 | 2002-09-17 | Aeropharm Technology Incorporated | Core formulation comprised of troglitazone and a biguanide |
| DE10025946A1 (de) * | 2000-05-26 | 2001-11-29 | Gruenenthal Gmbh | Wirkstoffkombination |
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| US20030224046A1 (en) * | 2002-06-03 | 2003-12-04 | Vinay Rao | Unit-dose combination composition for the simultaneous delivery of a short-acting and a long-acting oral hypoglycemic agent |
-
2003
- 2003-09-19 KR KR1020107027556A patent/KR20100137023A/ko not_active Ceased
- 2003-09-19 ES ES03754689.2T patent/ES2529180T3/es not_active Expired - Lifetime
- 2003-09-19 EP EP03754689.2A patent/EP1539144B1/en not_active Expired - Lifetime
- 2003-09-19 WO PCT/US2003/029292 patent/WO2004026241A2/en not_active Ceased
- 2003-09-19 KR KR1020127002220A patent/KR20120034211A/ko not_active Ceased
- 2003-09-19 AU AU2003272504A patent/AU2003272504A1/en not_active Abandoned
- 2003-09-19 CN CN2009101611482A patent/CN101623274B/zh not_active Expired - Fee Related
- 2003-09-19 KR KR1020137005362A patent/KR101363679B1/ko not_active Expired - Fee Related
- 2003-09-19 CN CNB038223627A patent/CN100544717C/zh not_active Expired - Fee Related
- 2003-09-19 EP EP13001210.7A patent/EP2604266A1/en not_active Withdrawn
- 2003-09-19 CA CA2499597A patent/CA2499597C/en not_active Expired - Fee Related
- 2003-09-19 KR KR1020057004787A patent/KR20050053677A/ko not_active Ceased
- 2003-09-19 JP JP2004537943A patent/JP4694841B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR20130039344A (ko) | 2013-04-19 |
| KR101363679B1 (ko) | 2014-02-14 |
| HK1136780A1 (en) | 2010-07-09 |
| AU2003272504A1 (en) | 2004-04-08 |
| CA2499597C (en) | 2012-01-17 |
| CN1681496A (zh) | 2005-10-12 |
| KR20100137023A (ko) | 2010-12-29 |
| EP2604266A1 (en) | 2013-06-19 |
| CN101623274B (zh) | 2012-06-27 |
| CA2499597A1 (en) | 2004-04-01 |
| KR20120034211A (ko) | 2012-04-10 |
| HK1078783A1 (zh) | 2006-03-24 |
| CN100544717C (zh) | 2009-09-30 |
| EP1539144A2 (en) | 2005-06-15 |
| EP1539144B1 (en) | 2014-12-24 |
| AU2003272504A8 (en) | 2004-04-08 |
| JP2006502187A (ja) | 2006-01-19 |
| KR20050053677A (ko) | 2005-06-08 |
| EP1539144A4 (en) | 2010-06-09 |
| WO2004026241A2 (en) | 2004-04-01 |
| WO2004026241A3 (en) | 2004-06-10 |
| CN101623274A (zh) | 2010-01-13 |
| JP4694841B2 (ja) | 2011-06-08 |
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