ES2528673B1 - Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y sus aplicaciones - Google Patents

Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y sus aplicaciones Download PDF

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Publication number
ES2528673B1
ES2528673B1 ES201331060A ES201331060A ES2528673B1 ES 2528673 B1 ES2528673 B1 ES 2528673B1 ES 201331060 A ES201331060 A ES 201331060A ES 201331060 A ES201331060 A ES 201331060A ES 2528673 B1 ES2528673 B1 ES 2528673B1
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ES
Spain
Prior art keywords
peptide
quorum sensing
activity
applications
polinucleótido
Prior art date
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Active
Application number
ES201331060A
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English (en)
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ES2528673A1 (es
Inventor
Ana María Otero Casal
Manuel Romero Bernárdez
Celia MAYER MAYER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade de Santiago de Compostela
Fundacion Pedro Barrie de la Maza Conde De Fenosa
Original Assignee
Universidade de Santiago de Compostela
Fundacion Pedro Barrie de la Maza Conde De Fenosa
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Application filed by Universidade de Santiago de Compostela, Fundacion Pedro Barrie de la Maza Conde De Fenosa filed Critical Universidade de Santiago de Compostela
Priority to ES201331060A priority Critical patent/ES2528673B1/es
Publication of ES2528673A1 publication Critical patent/ES2528673A1/es
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18Carboxylic ester hydrolases (3.1.1)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • A01N63/10Animals; Substances produced thereby or obtained therefrom
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/18Peptides; Protein hydrolysates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Abstract

Péptido con actividad inhibidora de Quorum Sensing, polinucleótido que codifica dicho péptido y sus aplicaciones.#Se describe la donación, secuenciación y caracterización del gen responsable de la actividad Quorum Quenching (QQ) frente a señales de Quorum Sensing (QS) de la cepa Tenacibacuium sp. 20J (CECT7426). Dicho gen codifica un péptido que presenta al menos actividad lactonasa con un porcentaje de identidad inferior al 38% con las lactonasas descritas hasta el momento para otras especies, así como las secuencias de los genes homólogos presentes en otras especies del género Tenacibacuium. Dicho péptido muestra un amplio espectro de actividad degradando N-acil-homoserin lactonas (AHLs) de 4-14 átomos de carbono en su cadena lateral, opcionalmente sustituidas, es activo a pH comprendido entre 3 y 9, resistente a proteinasa K y quimiotripsina y no interactúa con antibióticos 13{be}-lactámicos.

Description

β-

Claims (1)

ES201331060A 2013-07-11 2013-07-11 Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y sus aplicaciones Active ES2528673B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES201331060A ES2528673B1 (es) 2013-07-11 2013-07-11 Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y sus aplicaciones

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
ES201331060A ES2528673B1 (es) 2013-07-11 2013-07-11 Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y sus aplicaciones
PCT/ES2014/070569 WO2015004305A1 (es) 2013-07-11 2014-07-10 Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y sus aplicaciones
EP14822500.6A EP3020814B1 (en) 2013-07-11 2014-07-10 Peptide with quorum-sensing inhibitory activity, polynucleotide that encodes said peptide, and the uses thereof
ES14822500T ES2742307T3 (es) 2013-07-11 2014-07-10 Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y los usos de los mismos
US14/904,278 US10316302B2 (en) 2013-07-11 2014-07-10 Peptide with quorum-sensing inhibitory activity, polynucleotide that encodes said peptide, and the uses thereof

Publications (2)

Publication Number Publication Date
ES2528673A1 ES2528673A1 (es) 2015-02-11
ES2528673B1 true ES2528673B1 (es) 2015-11-24

Family

ID=52279385

Family Applications (2)

Application Number Title Priority Date Filing Date
ES201331060A Active ES2528673B1 (es) 2013-07-11 2013-07-11 Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y sus aplicaciones
ES14822500T Active ES2742307T3 (es) 2013-07-11 2014-07-10 Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y los usos de los mismos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES14822500T Active ES2742307T3 (es) 2013-07-11 2014-07-10 Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y los usos de los mismos

Country Status (4)

Country Link
US (1) US10316302B2 (es)
EP (1) EP3020814B1 (es)
ES (2) ES2528673B1 (es)
WO (1) WO2015004305A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10081800B1 (en) 2017-08-03 2018-09-25 Fornia Biosolutions, Inc. Lactonase enzymes and methods of using same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002225585A1 (en) 2002-01-23 2003-09-04 Agency For Science, Technology And Research Ralstonia ahl-acylase gene
ES2342807B2 (es) 2008-08-01 2011-03-18 Universidade De Santiago De Compostela Uso de bacterias del genero tenacibaculum para quorum quenching.

Also Published As

Publication number Publication date
ES2742307T3 (es) 2020-02-13
US10316302B2 (en) 2019-06-11
ES2528673A1 (es) 2015-02-11
EP3020814A1 (en) 2016-05-18
WO2015004305A1 (es) 2015-01-15
EP3020814B1 (en) 2019-05-22
EP3020814A4 (en) 2016-11-30
US20160244735A1 (en) 2016-08-25

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