ES2528673A1 - Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y sus aplicaciones - Google Patents
Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y sus aplicaciones Download PDFInfo
- Publication number
- ES2528673A1 ES2528673A1 ES201331060A ES201331060A ES2528673A1 ES 2528673 A1 ES2528673 A1 ES 2528673A1 ES 201331060 A ES201331060 A ES 201331060A ES 201331060 A ES201331060 A ES 201331060A ES 2528673 A1 ES2528673 A1 ES 2528673A1
- Authority
- ES
- Spain
- Prior art keywords
- peptide
- activity
- quorum
- species
- encodes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 230000018612 quorum sensing Effects 0.000 title abstract 3
- 230000002401 inhibitory effect Effects 0.000 title 1
- 102000040430 polynucleotide Human genes 0.000 title 1
- 108091033319 polynucleotide Proteins 0.000 title 1
- 239000002157 polynucleotide Substances 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 101000693619 Starmerella bombicola Lactone esterase Proteins 0.000 abstract 2
- 241000894007 species Species 0.000 abstract 2
- UKAUYVFTDYCKQA-UHFFFAOYSA-N -2-Amino-4-hydroxybutanoic acid Natural products OC(=O)C(N)CCO UKAUYVFTDYCKQA-UHFFFAOYSA-N 0.000 abstract 1
- 108090000317 Chymotrypsin Proteins 0.000 abstract 1
- 108010067770 Endopeptidase K Proteins 0.000 abstract 1
- 241001496920 Tenacibaculum Species 0.000 abstract 1
- 241000618895 Tenacibaculum sp. Species 0.000 abstract 1
- 239000003782 beta lactam antibiotic agent Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000012512 characterization method Methods 0.000 abstract 1
- 229960002376 chymotrypsin Drugs 0.000 abstract 1
- 238000010367 cloning Methods 0.000 abstract 1
- 230000000593 degrading effect Effects 0.000 abstract 1
- 238000010791 quenching Methods 0.000 abstract 1
- 230000000171 quenching effect Effects 0.000 abstract 1
- 238000012163 sequencing technique Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/50—Isolated enzymes; Isolated proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Péptido con actividad inhibidora de Quorum Sensing, polinucleótido que codifica dicho péptido y sus aplicaciones. Se describe la donación, secuenciación y caracterización del gen responsable de la actividad Quorum Quenching (QQ) frente a señales de Quorum Sensing (QS) de la cepa Tenacibacuium sp. 20J (CECT7426). Dicho gen codifica un péptido que presenta al menos actividad lactonasa con un porcentaje de identidad inferior al 38% con las lactonasas descritas hasta el momento para otras especies, así como las secuencias de los genes homólogos presentes en otras especies del género Tenacibacuium. Dicho péptido muestra un amplio espectro de actividad degradando N-acil-homoserin lactonas (AHLs) de 4-14 átomos de carbono en su cadena lateral, opcionalmente sustituidas, es activo a pH comprendido entre 3 y 9, resistente a proteinasa K y quimiotripsina y no interactúa con antibióticos 13β-lactámicos.
Description
β-
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201331060A ES2528673B1 (es) | 2013-07-11 | 2013-07-11 | Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y sus aplicaciones |
PCT/ES2014/070569 WO2015004305A1 (es) | 2013-07-11 | 2014-07-10 | Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y sus aplicaciones |
US14/904,278 US10316302B2 (en) | 2013-07-11 | 2014-07-10 | Peptide with quorum-sensing inhibitory activity, polynucleotide that encodes said peptide, and the uses thereof |
EP14822500.6A EP3020814B1 (en) | 2013-07-11 | 2014-07-10 | Peptide with quorum-sensing inhibitory activity, polynucleotide that encodes said peptide, and the uses thereof |
ES14822500T ES2742307T3 (es) | 2013-07-11 | 2014-07-10 | Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y los usos de los mismos |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES201331060A ES2528673B1 (es) | 2013-07-11 | 2013-07-11 | Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y sus aplicaciones |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2528673A1 true ES2528673A1 (es) | 2015-02-11 |
ES2528673B1 ES2528673B1 (es) | 2015-11-24 |
Family
ID=52279385
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES201331060A Expired - Fee Related ES2528673B1 (es) | 2013-07-11 | 2013-07-11 | Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y sus aplicaciones |
ES14822500T Active ES2742307T3 (es) | 2013-07-11 | 2014-07-10 | Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y los usos de los mismos |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES14822500T Active ES2742307T3 (es) | 2013-07-11 | 2014-07-10 | Péptido con actividad inhibidora de quorum sensing, polinucleótido que codifica dicho péptido y los usos de los mismos |
Country Status (4)
Country | Link |
---|---|
US (1) | US10316302B2 (es) |
EP (1) | EP3020814B1 (es) |
ES (2) | ES2528673B1 (es) |
WO (1) | WO2015004305A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10081800B1 (en) * | 2017-08-03 | 2018-09-25 | Fornia Biosolutions, Inc. | Lactonase enzymes and methods of using same |
CN114302959A (zh) * | 2019-06-17 | 2022-04-08 | 米加尔-加利里研究院有限公司 | 群体感应淬灭内酯酶的稳定突变体及其在病原体的治疗中的用途 |
CN112481236B (zh) * | 2020-11-25 | 2023-06-06 | 武汉理工大学 | 一种重组蛋白INP-AidH及其制备方法和应用 |
WO2022238627A1 (fr) | 2021-05-12 | 2022-11-17 | Museum National D'histoire Naturelle | Inhibiteurs de quorum sensing et composition les contenant |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1470221B1 (en) | 2002-01-23 | 2007-03-21 | Agency for Science, Technology and Research | Ralstonia ahl-acylase gene |
ES2342807B2 (es) | 2008-08-01 | 2011-03-18 | Universidade De Santiago De Compostela | Uso de bacterias del genero tenacibaculum para quorum quenching. |
-
2013
- 2013-07-11 ES ES201331060A patent/ES2528673B1/es not_active Expired - Fee Related
-
2014
- 2014-07-10 EP EP14822500.6A patent/EP3020814B1/en active Active
- 2014-07-10 ES ES14822500T patent/ES2742307T3/es active Active
- 2014-07-10 WO PCT/ES2014/070569 patent/WO2015004305A1/es active Application Filing
- 2014-07-10 US US14/904,278 patent/US10316302B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
ES2742307T3 (es) | 2020-02-13 |
EP3020814A1 (en) | 2016-05-18 |
US20160244735A1 (en) | 2016-08-25 |
WO2015004305A1 (es) | 2015-01-15 |
ES2528673B1 (es) | 2015-11-24 |
US10316302B2 (en) | 2019-06-11 |
EP3020814A4 (en) | 2016-11-30 |
EP3020814B1 (en) | 2019-05-22 |
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FG2A | Definitive protection |
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Effective date: 20211004 |