ES251430A1 - Procedimiento para la obtenciën de nuevos derivados fosforosos de indol - Google Patents
Procedimiento para la obtenciën de nuevos derivados fosforosos de indolInfo
- Publication number
- ES251430A1 ES251430A1 ES0251430A ES251430A ES251430A1 ES 251430 A1 ES251430 A1 ES 251430A1 ES 0251430 A ES0251430 A ES 0251430A ES 251430 A ES251430 A ES 251430A ES 251430 A1 ES251430 A1 ES 251430A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compounds
- alkyl
- nitrogen atom
- addition salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 229910052698 phosphorus Inorganic materials 0.000 title 1
- 239000011574 phosphorus Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000003386 piperidinyl group Chemical group 0.000 abstract 2
- OHHYMKDBKJPILO-UHFFFAOYSA-N 3-[2-(diethylamino)ethyl]-1h-indol-4-ol Chemical compound C1=CC(O)=C2C(CCN(CC)CC)=CNC2=C1 OHHYMKDBKJPILO-UHFFFAOYSA-N 0.000 abstract 1
- NLMQHXUGJIAKTH-UHFFFAOYSA-N 4-hydroxyindole Chemical class OC1=CC=CC2=C1C=CN2 NLMQHXUGJIAKTH-UHFFFAOYSA-N 0.000 abstract 1
- HDFFVHSMHLDSLO-UHFFFAOYSA-N Dibenzyl phosphate Chemical class C=1C=CC=CC=1COP(=O)(O)OCC1=CC=CC=C1 HDFFVHSMHLDSLO-UHFFFAOYSA-N 0.000 abstract 1
- SMVXYBYTGKEHCS-UHFFFAOYSA-N [benzyl(chloro)phosphoryl]methylbenzene Chemical compound C=1C=CC=CC=1CP(=O)(Cl)CC1=CC=CC=C1 SMVXYBYTGKEHCS-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
- SPCIYGNTAMCTRO-UHFFFAOYSA-N psilocin Chemical compound C1=CC(O)=C2C(CCN(C)C)=CNC2=C1 SPCIYGNTAMCTRO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedimiento para la obtención de nuevos derivados fosforosos de indol de la fórmula general I **(Ver fórmula)** donde R1 y R2 significan grupos alquílicos iguales o distintos con 1 hasta 4 átomos de carbono o junto con el átomo de nitrógeno un anillo piperidínicocaracterizadoporque un derivado del 4-hidroxi-indol de la fórmula general II **(Ver fórmula)** donde R1 y R2 tienen el significado arriba indicadoen forma de su sal con una base inorgánicase transforma en un disolvente inertepor tratamiento con derivados reaccionables del ácido fosfórico en el éster del ácido fosfórico.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH6387558A CH370409A (de) | 1958-09-12 | 1958-09-12 | Verfahren zur Herstellung von neuen, phosphorhaltigen Indol-Derivaten |
| CH6842459A CH375359A (de) | 1959-01-16 | 1959-01-16 | Verfahren zur Herstellung von neuen, phosphorhaltigen Indol-Derivaten |
| CH7074259 | 1959-03-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES251430A1 true ES251430A1 (es) | 1960-04-01 |
Family
ID=27178509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0251430A Expired ES251430A1 (es) | 1958-09-12 | 1959-08-13 | Procedimiento para la obtenciën de nuevos derivados fosforosos de indol |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE582353A (es) |
| DE (1) | DE1211645B (es) |
| ES (1) | ES251430A1 (es) |
| FR (1) | FR1311106A (es) |
| GB (1) | GB912714A (es) |
| LU (1) | LU37646A1 (es) |
| NL (2) | NL243249A (es) |
| OA (1) | OA01253A (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| WO2020212952A1 (en) | 2019-04-17 | 2020-10-22 | Compass Pathfinder Limited | Treatment of depression and other various disorders with psilocybin |
| KR20240096817A (ko) | 2020-05-19 | 2024-06-26 | 사이빈 아이알엘 리미티드 | 중수소화된 트립타민 유도체 및 사용 방법 |
-
0
- LU LU37646D patent/LU37646A1/xx unknown
- NL NL121067D patent/NL121067C/xx active
- NL NL243249D patent/NL243249A/xx unknown
- BE BE582353D patent/BE582353A/xx unknown
-
1959
- 1959-08-13 ES ES0251430A patent/ES251430A1/es not_active Expired
- 1959-08-24 GB GB28884/59A patent/GB912714A/en not_active Expired
- 1959-09-08 DE DES64818A patent/DE1211645B/de active Pending
- 1959-09-10 FR FR804443A patent/FR1311106A/fr not_active Expired
-
1964
- 1964-12-31 OA OA51500A patent/OA01253A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE582353A (es) | |
| NL243249A (es) | |
| DE1211645B (de) | 1966-03-03 |
| OA01253A (fr) | 1969-01-25 |
| LU37646A1 (es) | |
| NL121067C (es) | |
| GB912714A (en) | 1962-12-12 |
| FR1311106A (fr) | 1962-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR2697524B1 (fr) | Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments. | |
| DK34793A (da) | Vandoploeseligt, farmaceutisk acceptabelt salt af et monoacylderivat af rapamycin, fremgangsmaade til dets fremstilling og injicerbart, farmaceutisk praeparat indeholdende det | |
| JPH01230516A (ja) | ３−アミノプロポキシアリール誘導体を含有する薬剤 | |
| GB873925A (en) | Improvements in or relating to aralkylbenzmorphan derivatives | |
| GB1055055A (en) | Improvements in or relating to 4-[1-lower alkyl piperidylidene-(4)]-9,10-dihydro-4h-benzo[4,5]-cyclohepta[1,2-b]thiophene derivatives | |
| ES251430A1 (es) | Procedimiento para la obtenciën de nuevos derivados fosforosos de indol | |
| HUP9700810A2 (hu) | Diozmetinsavak és -észterek, és a vegyületeket tartalmazó gyógyszerkészítmények | |
| GB1415471A (en) | Phenylethylamine derivatives | |
| GB1188159A (en) | Process for the production of New N-Substituted Amides and Esteramides of Phosphoric and Thiophosphoric Acid | |
| GB1500063A (en) | Indolinone and fluorenone derivatives | |
| US3637759A (en) | Chromanes | |
| GB1206572A (en) | New basically substituted coumarin derivatives and process for the production thereof | |
| GB1365770A (en) | Basically substituted 1/2h/-phtalazinone derivatives and proce sses for the production thereof | |
| ES437790A1 (es) | Procedimiento para preparar composiciones farmaceuticas y veterinarias. | |
| US3426017A (en) | Sulfonylurea compounds | |
| US4855445A (en) | Substituted-8-alkenyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids | |
| HUT38907A (en) | Process for preparing 2-pyridine-thiol-derivatives | |
| US3882143A (en) | 4-(2-hydroxy-3-aminopropoxy)oxindole derivatives | |
| GB1324687A (en) | 3-amino-delta2-pyrazoline derivatives and process for the preparation thereof | |
| GB856587A (en) | Substituted piperidines | |
| GB1003645A (en) | Indolo-indolizine compounds | |
| GB925723A (en) | Novel thebaine derivatives | |
| ES406768A1 (es) | Procedimiento para la preparacion de nuevos derivados de indol. | |
| GB1216947A (en) | Norbornene-2,3-dicarboximide and norbornane-2,3-dicarboximide derivatives and method for preparing them | |
| FI831051L (fi) | Foerfarande foer framstaellning av terapeutiskt anvaendbara 2-pyrrolin-2-karbonitril-derivat |