ES2462553A1 - Composition for improvement of sexual well-being (Machine-translation by Google Translate, not legally binding) - Google Patents
Composition for improvement of sexual well-being (Machine-translation by Google Translate, not legally binding) Download PDFInfo
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- ES2462553A1 ES2462553A1 ES201430039A ES201430039A ES2462553A1 ES 2462553 A1 ES2462553 A1 ES 2462553A1 ES 201430039 A ES201430039 A ES 201430039A ES 201430039 A ES201430039 A ES 201430039A ES 2462553 A1 ES2462553 A1 ES 2462553A1
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Abstract
Description
Composición para mejora del bienestar sexual Composition to improve sexual well-being
La presente invención se enmarca dentro del campo farmacéutico y alimenticio, concretamente en el campo de la mejora de la capacidad y bienestar sexual de ambos sexos, de la actividad sexual masculina, el tratamiento de la disfunción sexual y la salud del sistema vascular sexual de ambos sexos. The present invention is framed within the pharmaceutical and nutritional field, specifically in the field of the improvement of sexual capacity and well-being of both sexes, of male sexual activity, the treatment of sexual dysfunction and the health of the sexual vascular system of both sexes
Concretamente la presente invención se refiere a una composición oral formulada como comprimidos, granulados y soluciones, entre otros, que comprende una mezcla de extractos de origen natural y otros ingredientes alimenticios. La presente invención también se refiere al uso de la misma para la preparación de un medicamento para tratamiento de la disfunción eréctil y la disfunción sexual femenina. Specifically, the present invention relates to an oral composition formulated as tablets, granules and solutions, among others, comprising a mixture of extracts of natural origin and other food ingredients. The present invention also relates to the use thereof for the preparation of a medicament for the treatment of erectile dysfunction and female sexual dysfunction.
La disfunción eréctil (DE) es una enfermedad frecuente que afecta a muchos hombres. Puede que empiece en las relaciones de pareja, pero también puede interferir en muchos otros aspectos de la vida, por ejemplo en la autoestima. La definición técnica de DE es la incapacidad de lograr o mantener una erección suficiente como para tener una relación sexual satisfactoria (Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol. 1994;151:54-61). Erectile dysfunction (ED) is a common disease that affects many men. It may start in relationships, but it can also interfere in many other aspects of life, for example in self-esteem. The technical definition of ED is the inability to achieve or maintain an erection sufficient to have a satisfactory sexual relationship (Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol. 1994; 151: 54-61).
La erección es un proceso complejo que requiere cambios en los músculos, los nervios y los vasos sanguíneos del pene. Pero para simplificar, la DE aparece cuando la sangre no puede entrar o permanecer en cantidad suficiente en el pene y durante el tiempo suficiente para mantener la erección (National Kidney and Urologic Diseases Information Clearinghouse. Erectile Dysfunction. Bethesda, MD: US Department of Health and Human Services, National Institutes of Health; 2009). Erection is a complex process that requires changes in the muscles, nerves and blood vessels of the penis. But to simplify, ED appears when blood cannot enter or remain in sufficient quantity in the penis and for long enough to maintain an erection (National Kidney and Urologic Diseases Information Clearinghouse. Erectile Dysfunction. Bethesda, MD: US Department of Health and Human Services, National Institutes of Health; 2009).
El proceso de erección exige una secuencia de acontecimientos y la DE puede suceder cuando se interrumpe cualquiera de ellos. Los eventos necesarios incluyen impulsos nerviosos en el cerebro, la médula espinal y la zona que rodea el pene, así como diversas respuestas en los músculos, tejidos fibrosos, venas y arterias del cuerpo cavernoso y cercanas. The erection process requires a sequence of events and ED can happen when any of them is interrupted. The necessary events include nerve impulses in the brain, spinal cord and the area surrounding the penis, as well as various responses in the muscles, fibrous tissues, veins and arteries of the cavernous and nearby body.
En ocasiones la disfunción eréctil está asociada a diferentes enfermedades, como la diabetes, renopatía, alcoholismo crónico, esclerosis múltiple, arteriosclerosis, enfermedad vascular o enfermedad neurológica, pero también puede ser un efecto secundario de la medicación (p. ej., un efecto secundario de un antihipertensivo, antihistamínico, antidepresivo, tranquilizante, supresor del apetito entre otros). Otras causas incluyen los traumatismos, incluyendo la cirugía (en particular, cirugía prostática) que provoca daños nerviosos o limita el flujo sanguíneo en el pene. En ausencia de cualquier causa orgánica, se puede determinar que la DE tiene un origen psicológico (DEP), como la depresión, la ansiedad, el estrés, la tensión o la culpabilidad. La DE no es una consecuencia normal del envejecimiento, pero su incidencia aumenta con la edad. Sometimes erectile dysfunction is associated with different diseases, such as diabetes, renopathy, chronic alcoholism, multiple sclerosis, arteriosclerosis, vascular disease or neurological disease, but it can also be a side effect of the medication (e.g., a side effect of an antihypertensive, antihistamine, antidepressant, tranquilizer, appetite suppressant among others). Other causes include trauma, including surgery (particularly prostate surgery) that causes nerve damage or limits blood flow in the penis. In the absence of any organic cause, it can be determined that ED has a psychological origin (DEP), such as depression, anxiety, stress, tension or guilt. ED is not a normal consequence of aging, but its incidence increases with age.
Cerca del 52% de los hombres de entre 40 y 70 años tiene DE (National Kidney and Urologic Diseases Information Clearinghouse. Erectile Dysfunction. Bethesda, MD: US Department of Health and Human Services, National Institutes of Health; 2009). About 52% of men in their 40s and 70s have ED (National Kidney and Urologic Diseases Information Clearinghouse. Erectile Dysfunction. Bethesda, MD: US Department of Health and Human Services, National Institutes of Health; 2009).
Los tratamientos farmacológicos estándar para la DE incluyen una clase de fármacos conocidos como inhibidores de la fosfodiesterasa tipo 5 (PDE-5), como el citrato de sildenafilo (Viagra®). A pesar de que estos fármacos pueden ser muy efectivos, alrededor del 30% del total de los pacientes tratados sufren efectos secundarios. Los inhibidores de PDE-5 están asociados con efectos secundarios que incluyen cefalea, enrojecimiento del rostro, molestias estomacales, congestión nasal, infección del tracto urinario, cambios visuales, como cambios leves y temporales en los colores azul/verde o aumento de la sensibilidad a la luz y diarrea. Por otra parte, estos fármacos están contraindicados en pacientes que están tomando fármacos a base de nitratos para la angina de pecho, como nitroglicerina (Nitro-Bid™, entre otros), mononitrato de isosorbida (Imdur™) y dinitrato de isosorbida (Isordil™); anticoagulantes y determinados Standard pharmacological treatments for ED include a class of drugs known as phosphodiesterase type 5 (PDE-5) inhibitors, such as sildenafil citrate (Viagra®). Although these drugs can be very effective, about 30% of the total treated patients suffer from side effects. PDE-5 inhibitors are associated with side effects that include headache, redness of the face, stomach discomfort, nasal congestion, urinary tract infection, visual changes, such as mild and temporary changes in blue / green colors or increased sensitivity to Light and diarrhea. On the other hand, these drugs are contraindicated in patients who are taking nitrate-based drugs for angina pectoris, such as nitroglycerin (Nitro-Bid ™, among others), isosorbide mononitrate (Imdur ™) and isosorbide dinitrate (Isordil ™ ); anticoagulants and certain
tipos de bloqueadores alfa para la próstata agrandada (hiperplasia prostática benigna) o tensión arterial elevada. types of alpha blockers for enlarged prostate (benign prostatic hyperplasia) or high blood pressure.
Además, los inhibidores de PDE-5 pueden no ser adecuados para los pacientes que sufren una cardiopatía grave, fallo cardíaco, hipotensión, hipertensión, diabetes incontrolada o que han sufrido un accidente cerebro vascular, así como para los pacientes con trastornos hematológicos que pueden estar asociados con el priapismo (por ejemplo, anemia de células falciformes, mieloma múltiple o leucemia). In addition, PDE-5 inhibitors may not be suitable for patients suffering from severe heart disease, heart failure, hypotension, hypertension, uncontrolled diabetes or who have suffered a stroke, as well as for patients with hematologic disorders that may be associated with priapism (for example, sickle cell anemia, multiple myeloma or leukemia).
Por consiguiente, existe una constante necesidad de terapias seguras y efectivas para el tratamiento de la DE. Así como de una composición que sea también efectiva para mujeres, en particular para el tratamiento de la disfunción sexual femenina. Therefore, there is a constant need for safe and effective therapies for the treatment of ED. As well as a composition that is also effective for women, in particular for the treatment of female sexual dysfunction.
Existen diferentes documentos del estado de la técnica que se refieren a patentes dirigidas a formulaciones para mejora del bienestar sexual. Entre estos documentos encontramos la solicitud de patente WO2011161655, relativa a una formulación para mejorar la condición física o el bienestar sexual de mujeres y hombres, para realzar el vigor masculino, y para el tratamiento de la disfunción sexual y la salud del sistema vascular sexual de ambos sexos con ingredientes que incluyen una fuente de proantocianidinas, una fuente de arginina, extracto de rosa mosqueta y / o extracto de Quercus robur. La fuente de proantocianidinas puede ser un extracto vegetal y la fuente de la arginina puede ser aspartato de arginina. There are different state-of-the-art documents that refer to patents aimed at formulations to improve sexual well-being. Among these documents are patent application WO2011161655, concerning a formulation to improve the physical condition or sexual well-being of women and men, to enhance male vigor, and for the treatment of sexual dysfunction and the health of the sexual vascular system of both sexes with ingredients that include a source of proanthocyanidins, a source of arginine, rosehip extract and / or Quercus robur extract. The source of proanthocyanidins can be a plant extract and the source of arginine can be arginine aspartate.
También encontramos el documento de solicitud de patente WO2013093096, que se refiere a composiciones pueden aumentar el bienestar sexual de hombres sanos y mujeres sanos. La ingestión de la composición objeto de esta solicitud proporciona mejora en los resultados de la función sexual tanto en hombres como en mujeres, mejorando el deseo sexual, la excitación sexual y la respuesta sexual tanto en hombres sanos y mujeres sanos. We also found patent application document WO2013093096, which refers to compositions that can increase the sexual well-being of healthy men and healthy women. Ingestion of the composition object of this application provides improvement in the results of sexual function in both men and women, improving sexual desire, sexual arousal and sexual response in both healthy men and healthy women.
Sin embargo, la mayoría del estado de la técnica se centra en numerosas patentes relativas a diferentes fórmulas farmacéuticas para tratamiento de la disfunción eréctil (DE). However, most of the state of the art focuses on numerous patents relating to different pharmaceutical formulas for the treatment of erectile dysfunction (ED).
Así, tenemos por ejemplo la patente internacional WO2009083808 se refiere a polipéptidos activos desde un punto de vista terapéutico y originalmente obtenidos de la araña chilena Latrodectus mactans, así como métodos para su purificación y uso en el tratamiento de la disfunción eréctil (DE). Por otro lado, la patente internacional WO2008100926 se refiere al tratamiento de la eyaculación precoz y la disfunción eréctil co-mórbidas en un hombre, que comprende administrar un material de tramadol como un inhibidor de fosfodiesterasa al hombre. La invención se refiere específicamente a una composición farmacéutica que comprende un material de tramadol y un inhibidor de fosfodiesterasa. Thus, we have for example the international patent WO2009083808 refers to polypeptides active from a therapeutic point of view and originally obtained from the Chilean spider Latrodectus mactans, as well as methods for their purification and use in the treatment of erectile dysfunction (ED). On the other hand, the international patent WO2008100926 refers to the treatment of premature ejaculation and co-morbid erectile dysfunction in a man, which comprises administering a tramadol material as a phosphodiesterase inhibitor to man. The invention specifically relates to a pharmaceutical composition comprising a tramadol material and a phosphodiesterase inhibitor.
Por otro lado, la patente internacional WO2009121687 se refiere a L-citrulina a una dosis igual a 6 g/día y su composición farmacéutica para tratar la disfunción eréctil. On the other hand, the international patent WO2009121687 refers to L-citrulline at a dose equal to 6 g / day and its pharmaceutical composition for treating erectile dysfunction.
La patente europea EP1315502 se refiere al uso de un gel hidroalcohólico que comprende un esteroide en la ruta sintética de la testosterona, uno o más alcoholes C1-C4, un agente potenciador de la penetración, un espesante y agua, para la fabricación de un medicamento para mejorar la eficacia de un producto farmacéutico útil para tratar la disfunción eréctil en un sujeto masculino, en el que el medicamento se administra por vía percutánea a un sujeto, en el que el producto farmacéutico es un inhibidor de fosfodiesterasa tipo 5. European patent EP1315502 refers to the use of a hydroalcoholic gel comprising a steroid in the synthetic route of testosterone, one or more C1-C4 alcohols, a penetration enhancing agent, a thickener and water, for the manufacture of a medicament. to improve the efficacy of a pharmaceutical product useful for treating erectile dysfunction in a male subject, in which the medication is administered percutaneously to a subject, in which the pharmaceutical product is a phosphodiesterase type 5 inhibitor.
La patente española ES2318023 se refiere a al empleo de derivados de ácidos 2,5-dihidroxibencenosulfónicos de fórmula general (I), en la elaboración de medicamentos útiles en terapéutica para potenciar los efectos de los inhibidores de la fosfodiesterasa-5 incluyendo sildenafilo, vardenafilo y IC-351, de apomorfina, de los donadores de óxido nítrico incluyendo nitrato de amilo, nitroglicerina, nitroprusiato, nitrosotioles y nicorandilo, de los compuestos que aumentan el nivel de GMP cíclico en el tejido peneano y de otros compuestos destinados a promover la erección del pene en el hombre. The Spanish patent ES2318023 refers to the use of derivatives of 2,5-dihydroxybenzenesulfonic acids of general formula (I), in the elaboration of drugs useful in therapeutics to enhance the effects of phosphodiesterase-5 inhibitors including sildenafil, vardenafil and IC-351, of apomorphine, of nitric oxide donors including amyl nitrate, nitroglycerin, nitroprusside, nitrosothiols and nicorandyl, of compounds that increase the level of cyclic GMP in penile tissue and other compounds intended to promote erection of penis in man.
La patente europea EP1458389 se refiere a una formulación acuosa de moxaverina, así como a la utilización de moxaverina para la preparación de medicamentos. Moxaverina es un desarrollo perfeccionado del principio activo papaverina y actúa como espasmolítico musculotrópico, el cual es 2,5 veces más eficaz que la sustancia madre papaverina. European patent EP1458389 refers to an aqueous formulation of moxaverine, as well as the use of moxaverine for the preparation of medicaments. Moxaverina is an improved development of the active substance papaverine and acts as a musculotropic spasmolytic, which is 2.5 times more effective than the mother substance papaverine.
Sin embargo ninguna de las composiciones anteriormente citadas se refiere a una composición de productos naturales 100%, que se muestra eficaz y segura para tratar la disfunción eréctil ni para el bienestar de ambos sexos. However, none of the aforementioned compositions refers to a 100% natural product composition, which is shown to be effective and safe for treating erectile dysfunction or for the well-being of both sexes.
El objetivo de la presente invención es la obtención de una composición administrada por vía oral con acción farmacológica y nutricional para la mejora del bienestar sexual de personas de ambos sexos. En particular la invención se refiere a una composición para mejorar la capacidad y bienestar sexual de personas de ambos sexos, en particular para la mejora de la actividad sexual masculina, para el tratamiento de la disfunción sexual y la salud del sistema vascular sexual de ambos sexos. La presente composición es capaz de aumentar el bienestar sexual de hombres y mujeres sanos. La ingestión por vía oral de la presente composición mejora la excitación sexual y la respuesta sexual tanto en hombres sanos y mujeres sanos, dando como resultado un mayor bienestar sexual. The objective of the present invention is to obtain a composition administered orally with pharmacological and nutritional action to improve the sexual well-being of people of both sexes. In particular, the invention relates to a composition for improving the sexual capacity and well-being of people of both sexes, in particular for the improvement of male sexual activity, for the treatment of sexual dysfunction and the health of the sexual vascular system of both sexes. . The present composition is capable of increasing the sexual well-being of healthy men and women. Oral ingestion of the present composition improves sexual arousal and sexual response in both healthy men and healthy women, resulting in greater sexual well-being.
La composición de la presente invención es una composición farmacéutica y alimenticia en forma de comprimido masticable, u otras formas de administración oral, para tratamiento de la disfunción eréctil que comprende una cantidad efectiva de Angelica sinensis, Cornus officinalis, Curcuma longa, Epimedium, Lycium barbarum, Punica granatum, The composition of the present invention is a pharmaceutical and food composition in the form of a chewable tablet, or other forms of oral administration, for the treatment of erectile dysfunction comprising an effective amount of Angelica sinensis, Cornus officinalis, Curcuma longa, Epimedium, Lycium barbarum , Punica granatum,
Schisandra chinensis, Trigonella foenum-graecum, Tribulus terrestris, Rhodiola rosea, Eleutherococcus senticosus, Panax ginseng, Cuscuta sinensis, Arginina, Cafeína, Carbonato de magnesio, Taurina, Oxido de zinc, Vitamina B6 y Borato sódico. Schisandra chinensis, Trigonella foenum-graecum, Tribulus terrestris, Rhodiola rosea, Eleutherococcus senticosus, Panax ginseng, Cuscuta sinensis, Arginine, Caffeine, Magnesium carbonate, Taurine, Zinc oxide, Vitamin B6 and Sodium borate.
Los ingredientes activos que componen la formulación objeto de la presente invención, tienen las siguientes propiedades, considerando cinco grupos de ingredientes con acciones complementarias y sinérgicas para atender a las necesidades masculinas: The active ingredients that make up the formulation object of the present invention have the following properties, considering five groups of ingredients with complementary and synergistic actions to meet the male needs:
Plantas vigorizantes sexuales: -Angelica sinensis: liberación de óxido nítrico con la consiguiente relajación de la musculatura lisa del cuerpo Sexual invigorating plants: -Angelica sinensis: release of nitric oxide with the consequent relaxation of the smooth muscles of the body
cavernoso. -Cornus officinalis: incrementa la presión del cuerpo cavernoso mejorando la erección. -Curcuma longa: mejora de la erección elevando el c-GMP. -Cuscuta sinensis: estimula la secreción de testosterona. -Epimedium: inhibe la PED-5 y aumenta la producción de NO, conllevando a una mayor producción de testosterona cavernous. -Cornus officinalis: increases the pressure of the cavernous body improving erection. -Curcuma longa: improvement of the erection by raising the c-GMP. -Cuscuta sinensis: stimulates the secretion of testosterone. -Epimedium: inhibits PED-5 and increases NO production, leading to increased testosterone production
y a una mejora de la erección. -Lycium barbarum: acción antioxidante que protege frente al daño testicular. -Punica granatum: aumenta los niveles de testosterona, mejora la erección via la producción de NO y posee acción and to an erection improvement. -Lycium barbarum: antioxidant action that protects against testicular damage. -Punica granatum: increases testosterone levels, improves erection via NO production and has action
antioxidante. -Schisandra chinensis: actúa a nivel de contractilidad de la musculatura lisa del corpus cavernoso y el metabolismo antioxidant -Schisandra chinensis: acts at the level of contractility of the smooth musculature of the corpora cavernosa and metabolism
del calcio, mejorando la erección. -Trigonella foenum-graecum: mantenimiento de los niveles de testosterona y aumento del deseo sexual y la libido. -Tribulus terrestris: aumento de los niveles de testosterona e incremento del deseo sexual. of calcium, improving erection. -Trigonella foenum-graecum: maintenance of testosterone levels and increased sexual desire and libido. -Tribulus terrestris: increased testosterone levels and increased sexual desire.
Plantas energizantes-adaptógenas. Poseen acción ergogénica, potenciando la predisposición, el deseo y la potencia sexual: Energizing-adaptogenic plants. They have ergogenic action, promoting predisposition, desire and sexual potency:
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- Rhodiola rosea -Eleutherococcus senticosus -Panax ginseng Rhodiola rosea -Eleutherococcus senticosus -Panax ginseng
Elementos fortificantes y estimulantes. Sustancias de efecto ergogénico y cognitivo, resultando un incremento de la potencia sexual: Fortifying and stimulating elements. Substances with an ergogenic and cognitive effect, resulting in an increase in sexual potency:
- --
- cafeína -taurina caffeine-taurine
Aminoácidos activos: Active amino acids:
- --
- Arginina: la L-Arginina es un aminoácido semi-esencial, es decir, el organismo lo sintetiza en cantidad adecuada, pero hay determinadas situaciones en las que sus necesidades son mayores y hay que suplementarlo. Interviene en la primera fase de la respuesta erectiva. Por acción de la enzima óxido-sintetasa, se convierte en óxido nítrico (gas vasodilatador) que produce el comienzo del proceso de vasodilatación en los cuerpos cavernosos del pene aumentando la capacidad eréctil. Estudios iniciales en el estado del arte proponen que los hombres con bajos niveles de nitrato en sangre o en orina pueden hallar que los suplementos de arginina son útiles para el manejo de la disfunción eréctil. Arginine: L-Arginine is a semi-essential amino acid, that is, the body synthesizes it in adequate quantity, but there are certain situations in which its needs are greater and must be supplemented. It intervenes in the first phase of the erectile response. By the action of the enzyme oxide synthetase, it is converted into nitric oxide (vasodilator gas) that produces the beginning of the vasodilation process in the cavernous bodies of the penis, increasing the erectile capacity. Initial studies in the state of the art propose that men with low levels of nitrate in blood or urine may find that arginine supplements are useful for the management of erectile dysfunction.
Minerales y vitaminas: -Zinc: mineral esencial para el sistema reproductor masculino, ya que está implicado en el crecimiento y desarrollo de los órganos sexuales, la cantidad y movilidad de los espermatozoides y los niveles de testosterona -Magnesio: aumenta los niveles de testosterona libre, aumenta la concentración de óxido nítrico y disminuye los Minerals and vitamins: -Zinc: essential mineral for the male reproductive system, since it is involved in the growth and development of sexual organs, the amount and mobility of sperm and testosterone levels -Magnesium: increases free testosterone levels , increases the concentration of nitric oxide and decreases the
niveles de calcio intracelular, con la consiguiente mejora de la respuesta sexual. -Boro: aumenta los niveles de testosterona. -Vitamina B6 (piridoxina): incrementa la absorción de magnesio intracellular calcium levels, with the consequent improvement of the sexual response. -Boro: increases testosterone levels. -Vitamin B6 (pyridoxine): increases magnesium absorption
La composición de la siguiente invención comprende al menos los siguientes ingredientes en los siguientes intervalos de cantidad, expresada en milígramos (mg): La formulación objeto de la presente invención se administra por vía oral (por ejemplo en forma de comprimidos, granulados, soluciones, etc.). De forma preferida es en forma de comprimido masticable de 2500 mg cada comprimido. De forma preferida, la posología adecuada de la presente formulación es de dos comprimidos al menos tres horas antes de comenzar la actividad. De forma preferida se deben tomar fuera de las comidas para mejorar los resultados. The composition of the following invention comprises at least the following ingredients in the following quantity ranges, expressed in milligrams (mg): The formulation object of the present invention is administered orally (for example in the form of tablets, granules, solutions, etc.). Preferably, it is in the form of a chewable tablet of 2500 mg each tablet. Preferably, the appropriate dosage of the present formulation is two tablets at least three hours before starting the activity. Preferably, they should be taken outside of meals to improve results.
- Ingredientes Ingredients
- mg mg
- Tribulus terrestris Tribulus Terrestris
- 250-750 mg 250-750 mg
- Arginina Arginine
- 125- 1000 mg 125-1000 mg
- Taurina Taurine
- 125- 1000 mg 125-1000 mg
- Trigonella foenum-graecum Trigonella foenum-graecum
- 75-300 mg 75-300 mg
- Epimedium Epimedium
- 75-205 mg 75-205 mg
- Carbonato de magnesio Magnesium carbonate
- 100- 200 mg 100-200 mg
- Schisandra sinensis Schisandra sinensis
- 50- 150 mg 50-150 mg
- Angelica sinensis Angelica sinensis
- 50-100 mg 50-100 mg
- Lycium barbarum Lycium barbarum
- 30-500 mg 30-500 mg
- Cuscuta sinensisCuscuta sinensis
- 25-200 mg 25-200 mg
- Punica granatum Punica granatum
- 25-500 mg 25-500 mg
- Rhodiola rosea Rhodiola rosea
- 25-500 mg 25-500 mg
- Eleutherococcus senticosus Eleutherococcus senticosus
- 25-500 mg 25-500 mg
- Panax ginseng Panax ginseng
- 25-500 mg 25-500 mg
- Borato sódico Sodium borate
- 25-50 mg 25-50 mg
- Curcuma longa Curcuma longa
- 20-100 mg 20-100 mg
- Cornus officinalis Cornus officinalis
- 10-40 mg 10-40 mg
- Cafeína Caffeine
- 10-300mg 10-300mg
- Oxido de Zinc Zinc oxide
- 5-13 mg 5-13 mg
- Vitamina B6-piridoxina Vitamin B6-Pyridoxine
- 3-6 mg 3-6 mg
Según otro aspecto, la composición objeto de la presente invención adicionalmente comprende excipientes, tales como agentes hidratantes, agentes antioxidantes, agentes emulgentes, agentes estabilizantes, agentes emolientes y agentes antimicrobianos. According to another aspect, the composition object of the present invention additionally comprises excipients, such as moisturizing agents, antioxidant agents, emulsifying agents, stabilizing agents, emollient agents and antimicrobial agents.
Según otro aspecto la composición está formulada como comprimido masticable. According to another aspect, the composition is formulated as a chewable tablet.
Una composición preferida de la siguiente invención comprende al menos los siguientes elementos en las siguientes cantidades: A preferred composition of the following invention comprises at least the following elements in the following amounts:
- Ingredientes Ingredients
- mg/composición mg / composition
- Tribulus terrestris Tribulus Terrestris
- 500 mg 500 mg
- Arginina Arginine
- 250,00 mg 250.00 mg
- Taurina Taurine
- 250,00 mg 250.00 mg
- Trigonella foenum-graecum Trigonella foenum-graecum
- 150,00 mg 150.00 mg
- Epimedium Epimedium
- 125,00 mg 125.00 mg
- Carbonato de magnesio Magnesium carbonate
- 125,00 mg 125.00 mg
- Schisandra sinensis Schisandra sinensis
- 100,00 mg 100.00 mg
- Angelica sinensis Angelica sinensis
- 75,00 mg 75.00 mg
- Lycium barbarum Lycium barbarum
- 60,00 mg 60.00 mg
- Cuscuta sinensis Cuscuta sinensis
- 50,00 mg 50.00 mg
- Punica granatum Punica granatum
- 50,00 mg 50.00 mg
- Rhodiola rosea Rhodiola rosea
- 50,00 mg 50.00 mg
- Eleutherococcus senticosus Eleutherococcus senticosus
- 50,00 mg 50.00 mg
- Panax ginseng Panax ginseng
- 50,00 mg 50.00 mg
- Borato sódico Sodium borate
- 44,10 mg 44.10 mg
- Curcuma longa Curcuma longa
- 32,50 mg 32.50 mg
- Cornus officinalis Cornus officinalis
- 20,00 mg 20.00 mg
- Cafeína Caffeine
- 15,00 mg 15.00 mg
- Oxido de zinc Zinc oxide
- 6,25 mg 6.25 mg
- Vitamina B6-piridoxina Vitamin B6-Pyridoxine
- 3,00 mg 3.00 mg
- Excipientes Excipients
- 491,15 mg 491.15 mg
De acuerdo con otro aspecto la presente invención se refiere al uso de la composición anteriormente citada para la preparación de un medicamento para aumentar el bienestar sexual de hombres y mujeres sanos. According to another aspect, the present invention relates to the use of the aforementioned composition for the preparation of a medicament to increase the sexual well-being of healthy men and women.
De acuerdo con otro aspecto la presente invención se refiere al uso de la composición anteriormente citada para la preparación de un medicamento para el tratamiento de la disfunción eréctil. In accordance with another aspect the present invention relates to the use of the aforementioned composition for the preparation of a medicament for the treatment of erectile dysfunction.
De acuerdo con otro aspecto la presente invención se refiere al uso de la composición anteriormente citada para la preparación de un medicamento en forma de comprimido masticable. De forma preferida el medicamento está en forma de comprimido masticable de 2500 mg. In accordance with another aspect the present invention relates to the use of the aforementioned composition for the preparation of a medicament in the form of a chewable tablet. Preferably, the medicament is in the form of a chewable tablet of 2500 mg.
De acuerdo con otro aspecto la presente invención se refiere al uso de la composición anteriormente citada para la preparación de un medicamento administrado en pautas de posología de dos comprimidos por vía oral al menos tres horas antes del acto sexual. According to another aspect, the present invention relates to the use of the aforementioned composition for the preparation of a medicament administered in dosing guidelines of two tablets orally at least three hours before sexual intercourse.
EJEMPLOS DE REALIZACIÓN: EXAMPLES OF REALIZATION:
Los siguientes ejemplos específicos que se proporcionan aquí sirven para ilustrar la naturaleza de la presente invención. Estos ejemplos se incluyen solamente con fines ilustrativos y no han de ser interpretados como limitaciones a la invención que aquí se reivindica. The following specific examples provided herein serve to illustrate the nature of the present invention. These examples are included for illustrative purposes only and should not be construed as limitations on the invention claimed herein.
Ejemplo 1: Evaluación de la actividad farmacológica para hombres y mujeres Example 1: Evaluation of pharmacological activity for men and women
Mediante un proceso de mezclado, estabilización y compresión se obtiene el comprimido masticable objeto de la presente invención. The chewable tablet object of the present invention is obtained by means of a mixing, stabilization and compression process.
Este comprimido comprende los siguientes elementos: Esta composición se administró tres horas antes del acto sexual, tomando dos comprimidos masticables en una población de 10 varones y 10 mujeres. Al cabo de un mes se les facilitó una encuesta para valorar la actividad y satisfacción con el producto y se apreció satisfactoriamente que los resultados fueron claramente positivos en un 100% de los pacientes encuestados. This tablet comprises the following elements: This composition was administered three hours before sexual intercourse, taking two chewable tablets in a population of 10 men and 10 women. After a month they were given a survey to assess the activity and satisfaction with the product and it was satisfactorily appreciated that the results were clearly positive in 100% of the patients surveyed.
- Ingredientes Ingredients
- mg/composición mg / composition
- Tribulus terrestris Tribulus Terrestris
- 500 mg 500 mg
- Arginina Arginine
- 250,00 mg 250.00 mg
- Taurina Taurine
- 250,00 mg 250.00 mg
- Trigonella foenum-graecum Trigonella foenum-graecum
- 150,00 mg 150.00 mg
- Epimedium Epimedium
- 125,00 mg 125.00 mg
- Carbonato de magnesio Magnesium carbonate
- 125,00 mg 125.00 mg
- Schisandra sinensis Schisandra sinensis
- 100,00 mg 100.00 mg
- Angelica sinensis Angelica sinensis
- 75,00 mg 75.00 mg
- Lycium barbarum Lycium barbarum
- 60,00 mg 60.00 mg
- Cuscuta sinensis Cuscuta sinensis
- 50,00 mg 50.00 mg
- Punica granatum Punica granatum
- 50,00 mg 50.00 mg
- Rhodiola rosea Rhodiola rosea
- 50,00 mg 50.00 mg
- Eleutherococcus senticosus Eleutherococcus senticosus
- 50,00 mg 50.00 mg
- Panax ginseng Panax ginseng
- 50,00 mg 50.00 mg
- Borato sódico Sodium borate
- 44,10 mg 44.10 mg
- Curcuma longa Curcuma longa
- 32,50 mg 32.50 mg
- Cornus officinalis Cornus officinalis
- 20,00 mg 20.00 mg
- Cafeína Caffeine
- 15,00 mg 15.00 mg
- Oxido de zinc Zinc oxide
- 6,25 mg 6.25 mg
- Vitamina B6-piridoxina Vitamin B6-Pyridoxine
- 3,00 mg 3.00 mg
- Excipientes Excipients
- 491,15 mg 491.15 mg
Los parámetros más positivamente aceptados por los pacientes fueron: The most positively accepted parameters by the patients were:
- --
- Vitalidad masculina: bienestar de la fisiología masculina para el adecuado funcionamiento a nivel sexual. -Actividad energizante: aumenta la resistencia y potencia masculina, el deseo sexual y la claridad mental. -Factor psicológico: mejora la superación de situaciones de estrés y desgano físico, específicamente en el plano Male vitality: well-being of male physiology for proper functioning at the sexual level. -Energizing activity: increases male endurance and potency, sexual desire and mental clarity. - Psychological factor: improves the overcoming of situations of stress and physical reluctance, specifically in the plane
sexual. -Calidad de la función sexual. -Aumento del deseo sexual en mujeres. sexual. -Quality of sexual function. -Increase of sexual desire in women.
Ejemplo 2: Actividad Biológica sobre la inhibición de la enzima PDE5A Example 2: Biological Activity on the inhibition of the PDE5A enzyme
Parte del proceso fisiológico de la erección incluye al sistema nervioso parasimpático causando la liberación de óxido nítrico (NO) en el cuerpo cavernoso del pene. El NO se une a los receptores de la enzima guanilato ciclasa, lo que deriva en niveles aumentados de guanosín monofosfato cíclico (GMPc), llevando a una relajación del músculo liso del cuerpo cavernoso, mediante vasodilatación de las arterias helicinas del interior del pene. La vasodilatación incrementa el flujo de sangre en el interior del pene, causando así la erección. Robert F. Furchgott ganó el Premio Nobel de Fisiología y Medicina en 1998 por el descubrimiento y el análisis del factor de relajación derivado del endotelio (EDRF en siglas en inglés: endothelium-derived relaxing factor), que posteriormente fue identificado como óxido nítrico o algún otro compuesto relacionado muy cercano. Part of the physiological process of erection includes the parasympathetic nervous system causing the release of nitric oxide (NO) in the cavernous body of the penis. NO binds to the guanylate cyclase enzyme receptors, resulting in increased levels of cyclic guanosine monophosphate (cGMP), leading to a relaxation of the smooth muscle of the cavernous body, by vasodilation of the helicin arteries inside the penis. Vasodilation increases the flow of blood inside the penis, thus causing erection. Robert F. Furchgott won the Nobel Prize in Physiology and Medicine in 1998 for the discovery and analysis of the endothelium-derived relaxation factor (EDRF), which was subsequently identified as nitric oxide or some Another related compound very close.
Hay compuestos conocidos en el estado de técnica como el sildenafilo, cuyo mecanismo de acción consiste en la inhibición específica de la fosfodiesterasa tipo 5 (PDE5) que es responsable de la degradación del GMPc en el cuerpo cavernoso. La estructura molecular del sildenafilo es similar a la del GMPc compitiendo por la unión de éste a PDE5. El resultado es que el cGMP permanece más tiempo en el interior del pene, produciéndose erecciones más potentes y mantenidas. Los principios activos como el tadalafilo y el vardenafilo actúan siguiendo el mismo mecanismo. There are compounds known in the state of the art as sildenafil, whose mechanism of action consists in the specific inhibition of phosphodiesterase type 5 (PDE5) that is responsible for the degradation of cGMP in the corpora cavernosa. The molecular structure of sildenafil is similar to that of cGMP competing for its binding to PDE5. The result is that the cGMP remains longer inside the penis, producing more powerful and maintained erections. The active substances such as tadalafil and vardenafil act according to the same mechanism.
Pues bien, para evaluar biológicamente la efectividad de la composición de la presente invención tal y como se ha citado en el ejemplo 1 se han realizado estudios de actividad enzimática sobre la PDE5A aislado utilizando un método de detección de fluorescencia. Well, to biologically evaluate the effectiveness of the composition of the present invention as cited in example 1, enzymatic activity studies have been performed on the isolated PDE5A using a fluorescence detection method.
Para este ejemplo comparativo se utilizó el compuesto Zaprinast (inhibidor selectivo de PDE5A) para evaluar la For this comparative example the compound Zaprinast (selective PDE5A inhibitor) was used to evaluate the
actividad frente a la composición objeto de la presente invención (codificada como “Producto HT”). activity against the composition object of the present invention (encoded as "HT Product").
Se realizaron estudios de actividad (inhibición de PDE5A) frente a un control sin administración de agente activo de ambas composiciones a las siguientes concentraciones: Activity studies (PDE5A inhibition) were performed against a control without active agent administration of both compositions at the following concentrations:
- • •
- Zaprinast: 300 nM a 1000 nM Zaprinast: 300 nM to 1000 nM
- • •
- Producto HT: 0,16 µg/ml, 0,8 µg/ml, 4 µg/ml, 20 µg/ml, 100 µg/ml y 500 µg/ml. HT product: 0.16 µg / ml, 0.8 µg / ml, 4 µg / ml, 20 µg / ml, 100 µg / ml and 500 µg / ml.
Se valoró la actividad de inhibición enzimática de PDE5A y se observó que el porcentaje de inhibición de PDE5A con el The enzymatic inhibition activity of PDE5A was assessed and it was observed that the percentage of inhibition of PDE5A with the
Producto HT para aquellas concentraciones ≥ a 100 μg/ml oscila entre 44% y 77%, dando un resultado claramente HT product for those concentrations ≥ 100 μg / ml ranges between 44% and 77%, giving a clear result
positivo. Los valores obtenidos con la administración de Zaprinast para las concentraciones de 300 nM a 1000 nM fueron de 57% y 65% respectivamente. positive. The values obtained with the administration of Zaprinast for concentrations of 300 nM to 1000 nM were 57% and 65% respectively.
Por ello, en base a este estudio experimental, se observa que la composición objeto de la presente invención (también llamada Producto HT) es claramente eficaz frente a la disfunción eréctil. Therefore, based on this experimental study, it is observed that the composition object of the present invention (also called HT Product) is clearly effective against erectile dysfunction.
De forma importante la presente invención se refiere a una composición por vía oral para la mejora del bienestar sexual de personas de ambos sexos que comprende una cantidad efectiva de: Angelica sinensis, Cornus officinalis, Curcuma longa, Epimedium, Lycium barbarum, Punica granatum, Schisandra chinensis, Trigonella foenum-graecum, Tribulus terrestris, Rhodiola rosea, Eleutherococcus senticosus, Panax ginseng, Cuscuta sinensis, Arginina, Cafeína, Carbonato de magnesio, Taurina, Oxido de zinc, Vitamina B6 y Borato sódico. Importantly, the present invention relates to an oral composition for the improvement of sexual well-being of people of both sexes comprising an effective amount of: Angelica sinensis, Cornus officinalis, Curcuma longa, Epimedium, Lycium barbarum, Punica granatum, Schisandra chinensis, Trigonella foenum-graecum, Tribulus terrestris, Rhodiola rosea, Eleutherococcus senticosus, Panax ginseng, Cuscuta sinensis, Arginine, Caffeine, Magnesium carbonate, Taurine, Zinc oxide, Vitamin B6 and Sodium borate.
De forma preferida la composición se administra en forma de comprimido masticable. Preferably, the composition is administered as a chewable tablet.
La presente invención también se refiere al uso de la composición anteriormente citada para la preparación de un medicamento para el tratamiento de la disfunción eréctil y aumentar el bienestar sexual de hombres y mujeres sanos. The present invention also relates to the use of the aforementioned composition for the preparation of a medicament for the treatment of erectile dysfunction and to increase the sexual well-being of healthy men and women.
De forma preferida la composición de la presente invención se administra en forma de comprimido masticable. De forma preferida de 2500 mg. La presente invención también se refiere al uso de la composición anteriormente citada administrando dos comprimidos por vía oral al menos tres horas antes del acto sexual. Preferably, the composition of the present invention is administered as a chewable tablet. Preferably 2500 mg. The present invention also relates to the use of the aforementioned composition by administering two tablets orally at least three hours before sexual intercourse.
Claims (11)
- Ingredientes Ingredients
- miligramos milligrams
- Tribulus terrestris Tribulus Terrestris
- 250-750 mg 250-750 mg
- Arginina Arginine
- 125- 1000 mg 125-1000 mg
- Taurina Taurine
- 125- 1000 mg 125-1000 mg
- Trigonella foenum-graecum Trigonella foenum-graecum
- 75-300 mg 75-300 mg
- Epimedium Epimedium
- 75-205 mg 75-205 mg
- Carbonato de magnesio Magnesium carbonate
- 100- 200 mg 100-200 mg
- Schisandra sinensis Schisandra sinensis
- 50- 150 mg 50-150 mg
- Angelica sinensis Angelica sinensis
- 50-100 mg 50-100 mg
- Lycium barbarum Lycium barbarum
- 30-500 mg 30-500 mg
- Cuscuta sinensisCuscuta sinensis
- 25-200 mg 25-200 mg
- Punica granatum Punica granatum
- 25-500 mg 25-500 mg
- Rhodiola rosea Rhodiola rosea
- 25-500 mg 25-500 mg
- Eleutherococcus senticosus Eleutherococcus senticosus
- 25-500 mg 25-500 mg
- Panax ginseng Panax ginseng
- 25-500 mg 25-500 mg
- Borato sódico Sodium borate
- 25-50 mg 25-50 mg
- Curcuma longa Curcuma longa
- 20-100 mg 20-100 mg
- Cornus officinalis Cornus officinalis
- 10-40 mg 10-40 mg
- Cafeína Caffeine
- 10-300mg 10-300mg
- Oxido de zinc Zinc oxide
- 5-13 mg 5-13 mg
- Vitamina B6-piridoxina Vitamin B6-Pyridoxine
- 3-6 mg 3-6 mg
- Ingredientes Ingredients
- miligramos milligrams
- Tribulus terrestris Tribulus Terrestris
- 500 mg 500 mg
- Arginina Arginine
- 250,00 mg 250.00 mg
- Taurina Taurine
- 250,00 mg 250.00 mg
- Trigonella foenum-graecum Trigonella foenum-graecum
- 150,00 mg 150.00 mg
- Epimedium Epimedium
- 125,00 mg 125.00 mg
- Carbonato de magnesio Magnesium carbonate
- 125,00 mg 125.00 mg
- Schisandra sinensis Schisandra sinensis
- 100,00 mg 100.00 mg
- Angelica sinensis Angelica sinensis
- 75,00 mg 75.00 mg
- Lycium barbarum Lycium barbarum
- 60,00 mg 60.00 mg
- Cuscuta sinensis Cuscuta sinensis
- 50,00 mg 50.00 mg
- Punica granatum Punica granatum
- 50,00 mg 50.00 mg
- Rhodiola rosea Rhodiola rosea
- 50,00 mg 50.00 mg
- Eleutherococcus senticosus Eleutherococcus senticosus
- 50,00 mg 50.00 mg
- Panax ginseng Panax ginseng
- 50,00 mg 50.00 mg
- Borato sódico Sodium borate
- 44,10 mg 44.10 mg
- Curcuma longa Curcuma longa
- 32,50 mg 32.50 mg
- Cornus officinalis Cornus officinalis
- 20,00 mg 20.00 mg
- Cafeína Caffeine
- 15,00 mg 15.00 mg
- Oxido de zinc Zinc oxide
- 6,25 mg 6.25 mg
- Vitamina B6-piridoxina Vitamin B6-Pyridoxine
- 3,00 mg 3.00 mg
- Excipientes Excipients
- 491,15 mg 491.15 mg
- Categoría Category
- 56 Documentos citados Reivindicaciones afectadas 56 Documents cited Claims Affected
- A TO
- US 2009175936 A1 (RÖHR, W.) 09.07.2009, página 2, [0028]-[0030],[0032]. 1-4 US 2009175936 A1 (RÖHR, W.) 09.07.2009, page 2, [0028] - [0030], [0032]. 1-4
- A TO
- JP 2004305089 A (TAISHO PHARM CO LTD) 04.11.2004 & Resumen de base de datos WPI. Recuperado de EPOQUE; Número de acceso 2004-778402. 1-4 JP 2004305089 A (TAISHO PHARM CO LTD) 04.11.2004 & WPI database summary. Recovered from EPOQUE; Accession number 2004-778402. 1-4
- A TO
- US 2008026082 A1 (OLALDE RANGEL, J. A.) 31.01.2008, página 2, [0015],[0017]; página 4, [0023]; páginas 5-6, Ejemplo 2, Tabla 1. 1,4-7 US 2008026082 A1 (OLALDE RANGEL, J. A.) 31.01.2008, page 2, [0015], [0017]; page 4, [0023]; pages 5-6, Example 2, Table 1. 1.4-7
- A TO
- WO 2009045505 A2 (LIBIDINOL LLC) 09.04.2009, página 3; página 4, líneas 23-29; página 5; páginas 10-12, Ejemplos 1,2; página 13, líneas 8-14; página 14, líneas 1-10; página 15, línea 22 – página 16, línea 25. 1-4 WO 2009045505 A2 (LIBIDINOL LLC) 04.04.2009, page 3; page 4, lines 23-29; page 5; pages 10-12, Examples 1,2; page 13, lines 8-14; page 14, lines 1-10; page 15, line 22 - page 16, line 25. 1-4
- A TO
- CN 101317940 A (YUEJIN WANG) 10.12.2008 & Resumen de base de datos EPODOC. Recuperado de EPOQUE; Número de acceso CN-200810140557-A. 1,4-7 CN 101317940 A (YUEJIN WANG) 10.12.2008 & EPODOC database summary. Recovered from EPOQUE; Accession number CN-200810140557-A. 1.4-7
- A TO
- CN 102949521 A (XI AN TAIKOMED MEDICAL TECHNOLOGY CO LTD) 06.03.2013 & Resumen de base de datos EPODOC. Recuperado de EPOQUE; Número de acceso CN-201210481208-A. 1,4-7 CN 102949521 A (XI AN TAIKOMED MEDICAL TECHNOLOGY CO LTD) 06.03.2013 & EPODOC database summary. Recovered from EPOQUE; Accession number CN-201210481208-A. 1.4-7
- A TO
- LOW, W. Y; TAN, H. M. Asian traditional medicine for erectile dysfunction. The Journal of Men's Health & Gender, 2007. Vol. 4, nº 3, páginas 245-250. ISSN 1571-8913. Doi:10.1016/j.jmhg.2007.05.010 1,4-7 LOW, W. Y; TAN, H. M. Asian traditional medicine for erectile dysfunction. The Journal of Men's Health & Gender, 2007. Vol. 4, No. 3, pages 245-250. ISSN 1571-8913. Doi: 10.1016 / j.jmhg. 2007.05.010 1.4-7
- A TO
- WO 2006021930 A2 (FEMI-X A/S) 02.03.2006, página 4, [0019],[0020]; página 5, [0024]. 1,4-7 WO 2006021930 A2 (FEMI-X A / S) 02.03.2006, page 4, [0019], [0020]; page 5, [0024]. 1.4-7
- A TO
- ES 2386859 B1 (GOMEZ DE DIEGO, E. A.) 22.03.2013, páginas 2,4. 1,4-7 EN 2386859 B1 (GOMEZ DE DIEGO, E. A.) 03.23.2013, pages 2.4. 1.4-7
- Categoría de los documentos citados X: de particular relevancia Y: de particular relevancia combinado con otro/s de la misma categoría A: refleja el estado de la técnica O: referido a divulgación no escrita P: publicado entre la fecha de prioridad y la de presentación de la solicitud E: documento anterior, pero publicado después de la fecha de presentación de la solicitud Category of the documents cited X: of particular relevance Y: of particular relevance combined with other / s of the same category A: reflects the state of the art O: refers to unwritten disclosure P: published between the priority date and the date of priority submission of the application E: previous document, but published after the date of submission of the application
- El presente informe ha sido realizado • para todas las reivindicaciones • para las reivindicaciones nº: This report has been prepared • for all claims • for claims no:
- Fecha de realización del informe 14.05.2014 Date of realization of the report 14.05.2014
- Examinador A. Sukhwani Página 1/4 Examiner A. Sukhwani Page 1/4
- Documento Document
- Número Publicación o Identificación Fecha Publicación Publication or Identification Number publication date
- D01 D01
- US 2009175936 A1 (RÖHR, W.) 09.07.2009 US 2009175936 A1 (RÖHR, W.) 07.07.2009
- D02 D02
- JP 2004305089 A (TAISHO PHARM CO LTD) 04.11.2004 JP 2004305089 A (TAISHO PHARM CO LTD) 04.11.2004
- D03 D03
- US 2008026082 A1 (OLALDE RANGEL, J. A.) 31.01.2008 US 2008026082 A1 (OLALDE RANGEL, J. A.) 01.31.2008
- D04 D04
- WO 2009045505 A2 (LIBIDINOL LLC) 09.04.2009 WO 2009045505 A2 (LIBIDINOL LLC) 04.09.2009
- D05 D05
- CN 101317940 A (YUEJIN WANG) 10.12.2008 CN 101317940 A (YUEJIN WANG) 10.12.2008
- D06 D06
- CN 102949521 A (XI AN TAIKOMED MEDICAL TECHNOLOGY CO LTD) 06.03.2013 CN 102949521 A (XI AN TAIKOMED MEDICAL TECHNOLOGY CO LTD) 06.03.2013
- D07 D07
- LOW, W. Y; TAN, H. M. Asian traditional medicine for erectile dysfunction. The Journal of Men's Health & Gender, 2007. Vol. 4, nº 3, páginas 245-250. 2007 LOW, W. Y; TAN, H. M. Asian traditional medicine for erectile dysfunction. The Journal of Men's Health & Gender, 2007. Vol. 4, No. 3, pages 245-250. 2007
- D08 D08
- WO 2006021930 A2 (FEMI-X A/S) 02.03.2006 WO 2006021930 A2 (FEMI-X A / S) 02.03.2006
- D09 D09
- ES 2386859 B1 (GOMEZ DE DIEGO, E. A.) 22.03.2013 ES 2386859 B1 (GOMEZ DE DIEGO, E. A.) 03/22/2013
- --
- D01 se refiere a preparaciones farmacéuticas que comprenden vitaminas como la B6 piridoxina (página 2, [0028]), minerales como el boro, magnesio y zinc (página 2, [0029]), aminoácidos como la L-arginina (página 2, [0030]), y extractos de plantas enumerando más de cien, y entre ellas 11 de las reivindicadas como Angelica sinensis, Curcuma longa (turmeric), Epimedium, Lycium barbarum (wolfberry), Punica granatum (pomegranate), Schisandra chinensis, Trigonella foenum-graecum (fenufreek), Tribulus terrestris, Rhodiola rosea, Eleutherococcus senticosus, Panax ginseng, (página 2, [0032]), citando dieciséis de los veinte componentes, sin especificar si están todos en la misma composición por lo que no anticipa la invención. D01 refers to pharmaceutical preparations comprising vitamins such as B6 pyridoxine (page 2, [0028]), minerals such as boron, magnesium and zinc (page 2, [0029]), amino acids such as L-arginine (page 2, [ 0030]), and plant extracts listing more than one hundred, and among them 11 of those claimed as Angelica sinensis, Curcuma longa (turmeric), Epimedium, Lycium barbarum (wolfberry), Punica granatum (pomegranate), Schisandra chinensis, Trigonella foenum- graecum (fenufreek), Tribulus terrestris, Rhodiola rosea, Eleutherococcus senticosus, Panax ginseng, (page 2, [0032]), citing sixteen of the twenty components, without specifying whether they are all in the same composition and therefore do not anticipate the invention.
- --
- D02 divulga en una bebida siete plantas, entre ellas la Cuscuta y el Cornus officinalis junto con Angelica, Schisandra, ginseng, Epimedium, Eleutherococcus, además de cafeína y taurina (resumen) pero no todos los componentes reivindicados.D02 discloses in a drink seven plants, including Cuscuta and Cornus officinalis along with Angelica, Schisandra, ginseng, Epimedium, Eleutherococcus, as well as caffeine and taurine (summary) but not all of the claimed components.
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Cited By (8)
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CN104887809A (en) * | 2015-06-15 | 2015-09-09 | 平阴县中医医院 | Medicine for treating gynecologic inflammation and preparation method thereof |
CN104906229A (en) * | 2015-06-08 | 2015-09-16 | 山东大学齐鲁医院 | Traditional Chinese medicine gel preparation for treating cervicitis |
CN107890473A (en) * | 2017-11-27 | 2018-04-10 | 中国科学院兰州化学物理研究所 | A kind of composition with fatigue-relieving and Yang strengthening function |
CN108653644A (en) * | 2018-07-20 | 2018-10-16 | 成都润馨堂药业有限公司 | A kind of pharmaceutical composition of warming kidney and enhancing yang and its preparation method and application |
EP3610882A1 (en) * | 2018-06-11 | 2020-02-19 | Mohammad S. Majid | Herbal combination product |
WO2020068964A3 (en) * | 2018-09-26 | 2020-04-30 | Aretha Duncan | Synergistic herbal stimulant compositions |
WO2022175981A1 (en) * | 2021-02-18 | 2022-08-25 | Sipwise Beverages Pvt. Ltd | A synergistic herbal composition for improving sexual wellness in females |
WO2022175980A1 (en) * | 2021-02-18 | 2022-08-25 | Sipwise Beverages Pvt. Ltd | A synergistic herbal composition for improving male sexual wellness |
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104906229A (en) * | 2015-06-08 | 2015-09-16 | 山东大学齐鲁医院 | Traditional Chinese medicine gel preparation for treating cervicitis |
CN104887809A (en) * | 2015-06-15 | 2015-09-09 | 平阴县中医医院 | Medicine for treating gynecologic inflammation and preparation method thereof |
CN107890473A (en) * | 2017-11-27 | 2018-04-10 | 中国科学院兰州化学物理研究所 | A kind of composition with fatigue-relieving and Yang strengthening function |
EP3610882A1 (en) * | 2018-06-11 | 2020-02-19 | Mohammad S. Majid | Herbal combination product |
CN108653644A (en) * | 2018-07-20 | 2018-10-16 | 成都润馨堂药业有限公司 | A kind of pharmaceutical composition of warming kidney and enhancing yang and its preparation method and application |
WO2020068964A3 (en) * | 2018-09-26 | 2020-04-30 | Aretha Duncan | Synergistic herbal stimulant compositions |
WO2022175981A1 (en) * | 2021-02-18 | 2022-08-25 | Sipwise Beverages Pvt. Ltd | A synergistic herbal composition for improving sexual wellness in females |
WO2022175980A1 (en) * | 2021-02-18 | 2022-08-25 | Sipwise Beverages Pvt. Ltd | A synergistic herbal composition for improving male sexual wellness |
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