ES2386859B1 - NATURAL COMPOSITION TO INCREASE VIGOR. - Google Patents
NATURAL COMPOSITION TO INCREASE VIGOR. Download PDFInfo
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- ES2386859B1 ES2386859B1 ES201130154A ES201130154A ES2386859B1 ES 2386859 B1 ES2386859 B1 ES 2386859B1 ES 201130154 A ES201130154 A ES 201130154A ES 201130154 A ES201130154 A ES 201130154A ES 2386859 B1 ES2386859 B1 ES 2386859B1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/20—Milk; Whey; Colostrum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
- A61K36/296—Epimedium
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- Engineering & Computer Science (AREA)
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- Alternative & Traditional Medicine (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere a una composición natural para aumentar el vigor que comprende entre 12-50 % en peso de extracto de Tribulus terrestris y excipientes aceptables.The present invention relates to a natural composition for increasing the strength comprising between 12-50% by weight of Tribulus terrestris extract and acceptable excipients.
Description
DESCRIPCIÓN Composición natural para aumentar el vigor CAMPO DE LA INVENCIÓN La presente invención se encuadra en general en el campo de los productos naturales y en particular se refiere a DESCRIPTION Natural composition for increasing vigor FIELD OF THE INVENTION The present invention is generally framed in the field of natural products and in particular refers to
una composición natural para aumentar el vigor. A natural composition to increase vigor.
El vigor se define como la fuerza y actividad del cuerpo humano. Una disminución del vigor representa una patología puesto que produce distintas alteraciones en el hombre, que puede variar desde una disfunción sexual hasta cansancio generalizado, disminución gradual de la fuerza muscular, insomnio, mal humor, disminución de la memoria, aumento de la grasa corporal en detrimento de la masa muscular. Vigor is defined as the strength and activity of the human body. A decrease in vigor represents a pathology since it produces different alterations in man, which can vary from sexual dysfunction to generalized tiredness, gradual decrease in muscle strength, insomnia, bad mood, decreased memory, increased body fat in detriment of muscle mass.
Existen en el mercado distintos tipos de tratamiento para tratar la disminución del vigor, sin embargo, la mayoría de ellos se refieren a productos químicos que producen efectos secundarios. There are different types of treatment on the market to treat decreased vigor, however, most of them refer to chemicals that produce side effects.
Existe por tanto la necesidad de un tratamiento natural que aumente el vigor del cuerpo humano sin producir efectos secundarios en el paciente. There is therefore a need for a natural treatment that increases the vigor of the human body without producing side effects in the patient.
Así pues, en un primer aspecto, la presente invención se refiere a una composición natural para aumentar el vigor que comprende entre 12-50 % en peso de extracto de Tribulus terrestris y excipientes aceptables. Thus, in a first aspect, the present invention relates to a natural composition for increasing the strength comprising between 12-50% by weight of Tribulus terrestris extract and acceptable excipients.
En la presente invención por aumento del vigor nos referimos a un aumento en la fuerza y/o actividad del cuerpo humano o partes del mismo. In the present invention by increased vigor we mean an increase in the strength and / or activity of the human body or parts thereof.
En una realización preferente, la composición natural de la presente invención comprende además de Tribulus terrestris, extracto de Epimedium sagittatum, extracto de Ginkgo biloba, ginseng y Avena sativa.Más preferentemente, la composición natural de la presente invención, comprende:In a preferred embodiment, the natural composition of the present invention further comprises Tribulus terrestris, Epimedium sagittatum extract, Ginkgo biloba extract, ginseng and Avena sativa.More preferably, the natural composition of the present invention comprises:
- 50 % en peso de extracto de Tribulus terrestris 50% by weight of Tribulus terrestris extract
- 12.5 % en peso de extracto de Epimedium sagittatum 12.5% by weight of Epimedium sagittatum extract
- 12.5 % en peso de extracto de Ginkgo biloba 12.5% by weight of Ginkgo biloba extract
- 12.5 % en peso de ginseng 12.5% by weight of ginseng
- 6.25 % en peso de Avena sativa 6.25% by weight Avena sativa
Más preferentemente, la composición natural que comprende 50 % en peso de extracto de Tribulus terrestris, 12.5 % en peso de extracto de Epimedium sagittatum, 12.5 % en peso de extracto de Ginkgo biloba, 12.5 % en peso de ginseng, 6.25 % en peso de Avena sativa, produce un aumento del vigor sanguíneo en la zona genital. More preferably, the natural composition comprising 50% by weight of Tribulus terrestris extract, 12.5% by weight of Epimedium sagittatum extract, 12.5% by weight of Ginkgo biloba extract, 12.5% by weight of ginseng, 6.25% by weight of Avena sativa, produces an increase in blood vigor in the genital area.
En la presente invención por aumento del vigor sanguíneo en la zona genital nos referimos a un aumento del flujo sanguíneo en el cuerpo cavernoso del pene que produce una mayor capacidad de almacenaje de sangre y aumenta la longitud y el grosor del pene. In the present invention, due to increased blood vigor in the genital area, we refer to an increase in blood flow in the cavernous body of the penis that produces a greater capacity for blood storage and increases the length and thickness of the penis.
En otra realización preferente, la composición natural de la presente invención comprende además de extracto de Epimedium sagittatum, extracto de Maca del Perú, extracto de Muira puama, extracto de Catuaba y ginseng. Más preferentemente, la composición natural de la presente invención comprendeIn another preferred embodiment, the natural composition of the present invention further comprises Epimedium sagittatum extract, Maca extract from Peru, Muira puama extract, Catuaba extract and ginseng. More preferably, the natural composition of the present invention comprises
25 % en peso de extracto de Tribulus terrestris 25% by weight of Tribulus terrestris extract
25 % en peso de extracto de Maca del Perú, 25% by weight of Maca extract from Peru,
12.5 % en peso de extracto de Catuaba 12.5% by weight of Catuaba extract
12.25 % en peso de ginseng Más preferentemente, la composición natural que comprende 25 % en peso de extracto de Tribulus terrestris, 25 % en peso de extracto de Maca del Perú, 18.75 % en peso de extracto de Muira puama, 12.5 % en peso de extracto de Catuaba y 12.25 % en peso de ginseng, produce un aumento del vigor sexual. 12.25% by weight of ginseng More preferably, the natural composition comprising 25% by weight of Tribulus terrestris extract, 25% by weight of Maca extract from Peru, 18.75% by weight of Muira puama extract, 12.5% by weight of Catuaba extract and 12.25% by weight of ginseng, produces an increase in sexual vigor.
En la presente invención por aumento del vigor sexual nos referimos a un aumento en la fuerza y actividad sexual, o un aumento de la libido. In the present invention by increased sexual vigor we mean an increase in sexual strength and activity, or an increase in libido.
En otra realización preferente, la composición natural de la presente invención, comprende además de de Tribulus terrestris calostro, extracto de Mucuna pruriens, Coleus forskohlii, crisina, Avena sativa y zinc. In another preferred embodiment, the natural composition of the present invention also comprises of Tribulus terrestris colostrum, Mucuna pruriens extract, Coleus forskohlii, chrysin, Avena sativa and zinc.
Más preferentemente, la composición natural de la presente invención, comprende: More preferably, the natural composition of the present invention comprises:
42.5 % en peso de extracto de Tribulus terrestris 42.5% by weight of Tribulus terrestris extract
18.75 % en peso de calostro 18.75% by weight of colostrum
12.5 % en peso de extracto de Mucuna pruriens, 12.5% by weight of Mucuna pruriens extract,
3.75 % en peso de extracto de Coleus forskohlii, 3.75% by weight of Coleus forskohlii extract,
2.5 % en peso de crisina, 2.5% by weight of chrysin,
12.5 % en peso de Avena sativa 12.5% by weight Avena sativa
1 % en peso de zinc 1% zinc weight
Más preferentemente, la composición natural de la presente invención que comprende 42.5 % en peso de extracto de Tribulus terrestris, 18.75 % en peso de calostro, 12.5 % en peso de extracto de Mucuna pruriens, 3.75 % en peso de extracto de Coleus forskohlii, 2.5 % en peso de crisina, 12.5 % en peso de Avena sativa, 1 % en peso de zinc, produce un aumento del vigor corporal. More preferably, the natural composition of the present invention comprising 42.5% by weight of Tribulus terrestris extract, 18.75% by weight of colostrum, 12.5% by weight of Mucuna pruriens extract, 3.75% by weight of Coleus forskohlii extract, 2.5 % by weight of chrysin, 12.5% by weight of Avena sativa, 1% by weight of zinc, produces an increase in body vigor.
En la presente invención por vigor corporal nos referimos a un aumento de la fuerza y la masa muscular. In the present invention by body vigor we refer to an increase in muscle strength and mass.
En otra realización preferente, la composición natural de la presente invención, comprende además de extracto de Tribulus terrestris, calostro, L-arginina, naringinina, L-ornitina, L-lisina, L-glutamina y ácido gamma aminobutírico (GABA). In another preferred embodiment, the natural composition of the present invention further comprises Tribulus terrestris extract, colostrum, L-arginine, naringinine, L-ornithine, L-lysine, L-glutamine and gamma aminobutyric acid (GABA).
Más preferentemente, la composición natural de la presente invención comprende: More preferably, the natural composition of the present invention comprises:
12.5 % en peso de extracto de Tribulus terrestris 25 % en peso de calostro 20 % en peso de L-arginina 12.5% by weight of Tribulus terrestris extract 25% colostrum by weight 20% by weight of L-arginine
2.5 % en peso de naringinina 5 % en peso de L-ornitina 2.5% by weight of naringinine 5% by weight of L-Ornithine
12.5 % en peso de L-lisina 12.5% by weight of L-lysine
5 % en peso de ácido gamma aminobutírico 5% by weight of gamma aminobutyric acid
Más preferentemente, la composición natural que comprende 12.5 % en peso de extracto de Tribulus terrestris, 25 % en peso de calostro, 20 % en peso de L-arginina, 2.5 % en peso de naringinina, 5 % en peso de L-ornitina, 12.5 % en peso de L-lisina, 12.5 % en peso de L-glutamina, 5 % en peso de ácido gamma aminobutírico además de vigor sexual y/o corporal, produce un aumento del vigor físico y mental. More preferably, the natural composition comprising 12.5% by weight of Tribulus terrestris extract, 25% by weight of colostrum, 20% by weight of L-arginine, 2.5% by weight of naringinine, 5% by weight of L-ornithine, 12.5% by weight of L-lysine, 12.5% by weight of L-glutamine, 5% by weight of gamma aminobutyric acid in addition to sexual and / or body vigor, produces an increase in physical and mental vigor.
En la presente invención por aumento del vigor físico y mental nos referimos a un aumento de la fuerza y función física y un aumento del flujo sanguíneo cerebral que produce una mayor actividad mental, en concreto aumenta el efecto anti-envejecimiento. In the present invention, by increasing physical and mental vigor, we refer to an increase in physical strength and function and an increase in cerebral blood flow that produces greater mental activity, in particular, increases the anti-aging effect.
En otra realización preferente, la composición natural de la presente invención comprende como excipientes, estearato de magnesio, y/o celulosa microcristalina. In another preferred embodiment, the natural composition of the present invention comprises excipients, magnesium stearate, and / or microcrystalline cellulose.
EJEMPLO 1: Composición para aumentar el vigor sanguíneo en la zona genital masculina. EXAMPLE 1: Composition to increase blood vigor in the male genital area.
- INGREDIENTES INGREDIENTS
- (mg) (mg)
- Extracto deTribulus Terrestris Tribulus Terrestris Extract
- 200 200
- Extracto de Epimedium Sagittatum Epimedium Sagittatum Extract
- 50 fifty
- Extracto de Ginkko Biloba Ginkko Biloba Extract
- 50 fifty
- Ginseng rojo coreano Korean Red Ginseng
- 50 fifty
- Avena sativa Avena sativa
- 25 25
- Estearato de magnesio Magnesium stearate
- 13 13
- Celulosa microcristalina Microcrystalline cellulose
- 12 12
- TOTAL TOTAL
- 400 400
Los extractos naturales descritos en el ejemplo 1, fueron mezclados con los excipientes mediante los procedimientos 5 conocidos en el estado de la técnica, y posteriormente fueron prensados para comprimirlos. The natural extracts described in example 1, were mixed with the excipients by the methods known in the state of the art, and subsequently pressed to compress them.
Para demostrar los efectos de la composición del ejemplo 1, se hizo un ensayo con 60 sujetos, a 30 de los cuales se les administró la composición descrita en el ejemplo 1 dos veces al día, y a 30 sujetos se les administró un placebo. Posteriormente se midieron los siguientes parámetros: rigidez y grosor del pene. Los resultados mostraron que transcurrido 1 mes, los pacientes que habían recibido la composición del ejemplo 1 presentaban una mejoría de los To demonstrate the effects of the composition of Example 1, a trial was done with 60 subjects, 30 of whom were given the composition described in Example 1 twice daily, and 30 subjects were given a placebo. Subsequently, the following parameters were measured: stiffness and thickness of the penis. The results showed that after 1 month, the patients who had received the composition of Example 1 had an improvement in the
10 parámetros medidos en el ensayo, (plt;0.05), demostrando la eficacia de la composición. 10 parameters measured in the test, (plt; 0.05), demonstrating the effectiveness of the composition.
EJEMPLO 2: Composición para aumentar el vigor sexual EXAMPLE 2: Composition to increase sexual vigor
- INGREDIENTES INGREDIENTS
- (mg) (mg)
- Extracto deTribulus Terrestris Tribulus Terrestris Extract
- 100 100
- Extracto de Maca del Perú Maca Extract from Peru
- 100 100
- Extracto de Muira Puama Muira Puama Extract
- 75 75
- Extracto de Catuaba Catuaba Extract
- 50 fifty
- Ginseng rojo coreano Korean Red Ginseng
- 50 fifty
- Estearato de magnesio Magnesium stearate
- 13 13
- Celulosa microcristalina Microcrystalline cellulose
- 12 12
- Total Total
- 400 400
Los extractos naturales descritos en el ejemplo 2, fueron mezclados con los excipientes mediante los procedimientos conocidos en el estado de la técnica, y posteriormente fueron prensados para comprimirlos. The natural extracts described in Example 2, were mixed with the excipients by the procedures known in the state of the art, and subsequently pressed to compress them.
15 En este estudio se muestra que las pastillas del ejemplo 4 aumentan la concentración de DHEA-S en el epidídimo. Para ello, se administraron las pastillas tipo 2 (dos pastillas al día durante 3 semanas) a 30 pacientes no diabéticos, diagnosticados con disfunción eréctil, a 15 pacientes diabéticos, diagnosticados con disfunción eréctil y fueron comparados con 30 personas no diabéticas y sin disfunción eréctil. Los niveles de DHEA-S en sangre fueron medidos antes y después del tratamiento, además de otros parámetros (testosterona, FSH, LH, prolactina, 15 This study shows that the pills in Example 4 increase the concentration of DHEA-S in the epididymis. For this, type 2 pills (two pills a day for 3 weeks) were administered to 30 non-diabetic patients, diagnosed with erectile dysfunction, to 15 diabetic patients, diagnosed with erectile dysfunction and were compared with 30 non-diabetic people without erectile dysfunction . Blood DHEA-S levels were measured before and after treatment, in addition to other parameters (testosterone, FSH, LH, prolactin,
20 colesterol, triglicéridos, creatinina, HB, glucosa, función renal y hepática). Los resultados se muestran en la tabla 1: Como muestran los datos, las pastillas tipo 2 aumentaron los niveles de DHEA-S significativamente en todos los pacientes, además, en un 60% de los pacientes (diabéticos y no diabéticos) la frecuencia de las relaciones sexuales aumentaron significativamente a partir de los 10 días de tratamiento. 20 cholesterol, triglycerides, creatinine, HB, glucose, renal and hepatic function). The results are shown in Table 1: As the data show, type 2 pills increased DHEA-S levels significantly in all patients, in addition, in 60% of patients (diabetic and non-diabetic) the frequency of Sexual intercourse increased significantly after 10 days of treatment.
- DHEA-S antes(µg/dl) DHEA-S before (µg / dl)
- del tratamiento DHEA-S después (µg/dl) del tratamiento of the treatment DHEA-S after (µg / dl) of the treatment
- ND con DE ND with DE
- 41.8 ± 22.6 77.6 ± 25.9 41.8 ± 22.6 77.6 ± 25.9
- D con DE D with DE
- 32.2 ± 24.8 50.0 ± 32.0 32.2 ± 24.8 50.0 ± 32.0
EJEMPLO 3: Composición para aumentar el vigor corporal EXAMPLE 3: Composition to increase body vigor
- INGREDIENTES INGREDIENTS
- (mg) (mg)
- Calostro Colostrum
- 75 75
- Extracto deTribulus Terrestris Tribulus Terrestris Extract
- 170 170
- Extracto de Mucuna Pruriens Avena Sativa Mucuna Pruriens Avena Sativa Extract
- 50 50 50 50
- Extracto de Coleus Forskohlii Coleus Forskohlii Extract
- 15 fifteen
- Crisina Zinc Zinc Crisina
- 10 4 10 4
- Estearato de magnesio Magnesium stearate
- 13 13
- Celulosa microcristalina Microcrystalline cellulose
- 13 13
- Total Total
- 400 400
Los extractos naturales descritos en el ejemplo 7, fueron mezclados con los excipientes mediante los procedimientos conocidos en el estado de la técnica, y posteriormente fueron prensados para comprimirlos. The natural extracts described in Example 7, were mixed with the excipients by the procedures known in the state of the art, and subsequently pressed to compress them.
10 Las composición del ejemplo 3 fue probada en 18 sujetos sanos, a 9 de ellos se les administro dos pastillas al día de la composición descrita en el ejemplo 3 durante 3 semanas, y a los otros 9 se les administró un placebo. Al cabo de 3 semanas se comprobó los siguientes parámetros: masa muscular mediante la excreción de creatinina, potasio total y síntesis de proteína muscular. Los resultados mostraron que en todos los sujetos aumentó la creatinina (plt;0.02), todos los sujetos mostraron un aumento de potasio toatl (plt;0.0001) y la síntesis de proteína muscular aumentó 10 The composition of Example 3 was tested in 18 healthy subjects, 9 of them were given two pills a day of the composition described in Example 3 for 3 weeks, and the other 9 were given a placebo. After 3 weeks, the following parameters were checked: muscle mass by excretion of creatinine, total potassium and muscle protein synthesis. The results showed that in all subjects creatinine increased (plt; 0.02), all subjects showed an increase in toatl potassium (plt; 0.0001) and muscle protein synthesis increased
15 también en todos los sujetos (plt;0.05). 15 also in all subjects (plt; 0.05).
EJEMPLO 4: Composición para aumentar el vigor físico y mental. EXAMPLE 4: Composition to increase physical and mental vigor.
- INGREDIENTES INGREDIENTS
- (mg) (mg)
- calostro colostrum
- 100 100
- Extracto de Tribulus Terrestris Tribulus Terrestris Extract
- 50 fifty
- Naringinina Naringinine
- 10 10
- L-Arginina L-Arginine
- 80 80
- L-Ornitina L-Ornithine
- 20 twenty
- L-Lisina L-Lysine
- 50 fifty
- L-Glutamina L-Glutamine
- 50 fifty
- GABA GABA
- 20 twenty
- Estearato de magnesio Magnesium stearate
- 10 10
- Celulosa microcristalina Microcrystalline cellulose
- 10 10
- Total Total
- 390 390
Los extractos naturales descritos en el ejemplo 4, fueron mezclados con los excipientes mediante los procedimientos conocidos en el estado de la técnica, y posteriormente fueron prensados para comprimirlos. The natural extracts described in example 4, were mixed with the excipients by the procedures known in the state of the art, and subsequently pressed to compress them.
5 El efecto de las pastillas dl ejemplo 4 fue probado en 60 sujetos con una edad comprendida entre 60-72 años, a 30 de los cuales se les administró la composición descrita en el ejemplo 1 dos veces al día, y a 30 sujetos se les administró un placebo. Posteriormente se midió si existía o no aumento de la hormona del crecimiento (GH). Los resultados mostraron que transcurrido 1 mes, los pacientes que habían recibido la composición del ejemplo 1 presentaban un aumento de la secreción de dicha hormona (plt;0.05). 5 The effect of the tablets in Example 4 was tested on 60 subjects aged between 60-72 years, 30 of whom were given the composition described in Example 1 twice a day, and 30 subjects were administered a placebo Subsequently, it was measured whether or not there was an increase in growth hormone (GH). The results showed that after 1 month, patients who had received the composition of example 1 had an increase in the secretion of said hormone (plt; 0.05).
Claims (33)
- 1.one.
- Composición natural para aumentar el vigor que comprende entre 12-50 % en peso de extracto de Tribulus terrestris y excipientes aceptables. Natural composition to increase vigor comprising between 12-50% by weight of Tribulus terrestris extract and acceptable excipients.
- 2.2.
- Composición natural según la reivindicación 1, que comprende extracto de Epimedium sagittatum, extracto de Ginkgo biloba, ginseng y Avena sativa. Natural composition according to claim 1, comprising Epimedium sagittatum extract, Ginkgo biloba extract, ginseng and Avena sativa.
- 3.3.
- Composición natural según cualquiera de las reivindicaciones anteriores caracterizada por que comprende: 50 % en peso de extracto de Tribulus terrestris Natural composition according to any of the preceding claims characterized in that it comprises: 50% by weight of Tribulus terrestris extract
- 4.Four.
- Composición natural según cualquiera de las reivindicaciones anteriores caracterizada por que produce un aumento del vigor sanguíneo de la zona genital masculina. Natural composition according to any of the preceding claims characterized in that it produces an increase in blood vigor of the male genital area.
- 5.5.
- Composición natural según la reivindicación 1, que comprende extracto de Maca del Perú, extracto de Muira puama, extracto de Catuaba y ginseng. Natural composition according to claim 1, comprising Maca extract from Peru, Muira puama extract, Catuaba extract and ginseng.
- 6. 6.
- Composición natural según la reivindicación 5, caracterizada por que comprende: 25 % en peso de extracto de Tribulus terrestris 25 % en peso de extracto de Maca del Perú, Natural composition according to claim 5, characterized in that it comprises: 25% by weight of Tribulus terrestris extract 25% by weight of Maca extract from Peru,
- 7. 7.
- Composición natural según cualquiera de las reivindicaciones 5-6, caracterizada por que aumenta el vigor sexual. Natural composition according to any of claims 5-6, characterized in that it increases sexual vigor.
- 8.8.
- Composición natural según la reivindicación 1, que comprende calostro, extracto de Mucuna pruriens, Coleus forskohlii, crisina, Avena sativa y zinc. Natural composition according to claim 1, comprising colostrum, Mucuna pruriens extract, Coleus forskohlii, chrysin, Avena sativa and zinc.
- 9.9.
- Composición natural según la reivindicación 8, caracterizada por que comprende: Natural composition according to claim 8, characterized in that it comprises:
- 10.10.
- Composición natural según cualquiera de las reivindicaciones 8-9, caracterizada por que aumenta el vigor corporal. Natural composition according to any of claims 8-9, characterized in that it increases body vigor.
- 11.eleven.
- Composición natural según la reivindicación 1, que comprende calostro, L-arginina, naringinina, L-ornitina, Llisina, L-glutamina y ácido gamma aminobutírico (GABA). Natural composition according to claim 1, comprising colostrum, L-arginine, naringinine, L-ornithine, Llisin, L-glutamine and gamma aminobutyric acid (GABA).
- 12.12.
- Composición natural según la reivindicación 11, caracterizada por que comprende: Natural composition according to claim 11, characterized in that it comprises:
- 15.fifteen.
- Uso de una composición natural según cualquiera de las reivindicaciones 1-4 para el aumento del vigor sanguíneo de la zona genital masculina. Use of a natural composition according to any of claims 1-4 for the increase of blood vigor of the male genital area.
- 16.16.
- Uso de una composición natural según cualquiera de las reivindicaciones 5-7 para el aumento del vigor sexual. Use of a natural composition according to any of claims 5-7 for increasing sexual vigor.
- Categoría Category
- 56 Documentos citados Reivindicaciones afectadas 56 Documents cited Claims Affected
- X X
- DE 202008006741 U1 (LANGHOFF, G) 05.11.2009, página 2, [0001]-[0003],[0007],[0010]; página 3, [0013]-[0019]; página 4, [0020],[0024]; página 5, [0031],[0035],[0037]; reivindicaciones 1,6,10,11,19. 1,14 DE 202008006741 U1 (LANGHOFF, G) 05.11.2009, page 2, [0001] - [0003], [0007], [0010]; page 3, [0013] - [0019]; page 4, [0020], [0024]; page 5, [0031], [0035], [0037]; claims 1,6,10,11,19. 1.14
- Y Y
- 1,2-4,10,14-18 1,2-4,10,14-18
- X X
- ES 2259139 T3 (INDENA S.p.A.) 16.09.2006, página 3; página 4, ejemplos 1-3. 1,14,15 EN 2259139 T3 (INDENA S.p.A.) 16.09.2006, page 3; page 4, examples 1-3. 1.14.15
- X X
- ES 2259144 T3 (INDENA S.p.A.) 16.09.2006, página 3; página 4, ejemplos 1-3. 1,14,15 ES 2259144 T3 (INDENA S.p.A.) 16.09.2006, page 3; page 4, examples 1-3. 1.14.15
- X X
- WO 2008051170 A2 (DANISKA, V.) 02.05.2008 página 3; reivindicaciones 1,6. 1,16-18 WO 2008051170 A2 (DANISKA, V.) 02.05.2008 page 3; claims 1.6. 1.16-18
- X X
- WO 2006111830 A2 (COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH) 26.10.2006, páginas 9,10: página 14, F3; reivindicaciones 1,3,6. 1,15 WO 2006111830 A2 (COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH) 26.10.2006, pages 9.10: page 14, F3; claims 1,3,6. 1.15
- Y Y
- US 2008026082 A1 (OLALDE RANGEL, J. A.) 31.01.2008, página 2, [0016],[0017]; página 4, [0023],[0024]; ejemplo 2; reivindicaciones 1,2,4,5. 2-4,15 US 2008026082 A1 (OLALDE RANGEL, J. A.) 31.01.2008, page 2, [0016], [0017]; page 4, [0023], [0024]; example 2; claims 1,2,4,5. 2-4.15
- Y Y
- WO 2006021930 A2 (FEMI-X A/S) 02.03.2006, 5-7,16 WO 2006021930 A2 (FEMI-X A / S) 02.03.2006, 5-7.16
- página 2, [0010]; página 3, [0017]; página 4, [0020]-[0022]; página 5, [0025]-[0027]; reivindicaciones 1,2,4. page 2, [0010]; page 3, [0017]; page 4, [0020] - [0022]; page 5, [0025] - [0027]; claims 1,2,4.
- Y Y
- WO 2009045505 A2 (LIBIDINOL LLC) 09.04.2009, página 4, líneas 23-26; páginas 10,11, ejemplos 1,2; página 13, líneas 8-14; página 14, líneas 1-10; página 15, línea 23 – página 16, línea 25; reivindicación 30. 1,5-7 WO 2009045505 A2 (LIBIDINOL LLC) 04.04.2009, page 4, lines 23-26; pages 10.11, examples 1.2; page 13, lines 8-14; page 14, lines 1-10; page 15, line 23 - page 16, line 25; claim 30. 1.5-7
- Y Y
- US 2009175936 A1 (RÖHR, W.) 09.07.2009, página 2, [0029]-[0032]. 8,9,11-13 US 2009175936 A1 (RÖHR, W.) 09.07.2009, page 2, [0029] - [0032]. 8,9,11-13
- Categoría de los documentos citados X: de particular relevancia Y: de particular relevancia combinado con otro/s de la misma categoría A: refleja el estado de la técnica O: referido a divulgación no escrita P: publicado entre la fecha de prioridad y la de presentación de la solicitud E: documento anterior, pero publicado después de la fecha de presentación de la solicitud Category of the documents cited X: of particular relevance Y: of particular relevance combined with other / s of the same category A: reflects the state of the art O: refers to unwritten disclosure P: published between the priority date and the date of priority submission of the application E: previous document, but published after the date of submission of the application
- El presente informe ha sido realizado • para todas las reivindicaciones • para las reivindicaciones nº: This report has been prepared • for all claims • for claims no:
- Fecha de realización del informe 02.04.2012 Date of realization of the report 02.04.2012
- Examinador A. Sukhwani Página 1/6 Examiner A. Sukhwani Page 1/6
- Categoría Category
- 56 Documentos citados Reivindicaciones afectadas 56 Documents cited Claims Affected
- Y Y
- PHARMIA. Pharmia Anti-Aging -L-Arginine, GABA & Glutamine To Rejuvenate Skin, 2010. [en línea] [recuperado el 07.03.2012] Recuperado de Internet: lt;URL: http://www.pharmialabs.com/pharmiaantiaging/components.htm 11,12 PHARMIA Pharmia Anti-Aging -L-Arginine, GABA & Glutamine To Rejuvenate Skin, 2010. [online] [retrieved on 07.03.2012] Recovered from the Internet: <URL: http://www.pharmialabs.com/pharmiaantiaging/components .htm 11.12
- Y Y
- US 2009068300 A1 (EDALAT, P. P.) 12.03.2009, página 1, [0003],[0004],[0009],[0010]), página 2, [0018]; reivindicaciones 1,2,4,5,7. 10,13,14,17,18 US 2009068300 A1 (EDALAT, P. P.) 12.03.2009, page 1, [0003], [0004], [0009], [0010]), page 2, [0018]; claims 1,2,4,5,7. 10,13,14,17,18
- Y Y
- EP 1344529 A1 (BRYANT, A.E.) 17.09.2003, [0020],[0027],[0030],[0031],[0036]. 8,9 EP 1344529 A1 (BRYANT, A.E.) 17.09.2003, [0020], [0027], [0030], [0031], [0036]. 8.9
- Categoría de los documentos citados X: de particular relevancia Y: de particular relevancia combinado con otro/s de la misma categoría A: refleja el estado de la técnica O: referido a divulgación no escrita P: publicado entre la fecha de prioridad y la de presentación de la solicitud E: documento anterior, pero publicado después de la fecha de presentación de la solicitud Category of the documents cited X: of particular relevance Y: of particular relevance combined with other / s of the same category A: reflects the state of the art O: refers to unwritten disclosure P: published between the priority date and the date of priority submission of the application E: previous document, but published after the date of submission of the application
- El presente informe ha sido realizado • para todas las reivindicaciones • para las reivindicaciones nº: This report has been prepared • for all claims • for claims no:
- Fecha de realización del informe 02.04.2012 Date of realization of the report 02.04.2012
- Examinador A. Sukhwani Página 2/6 Examiner A. Sukhwani Page 2/6
- Novedad (Art. 6.1 LP 11/1986) Novelty (Art. 6.1 LP 11/1986)
- Reivindicaciones Reivindicaciones 2 -13 1, 14 -18 SI NO Claims Claims 2 -13 1, 14 -18 IF NOT
- Actividad inventiva (Art. 8.1 LP11/1986) Inventive activity (Art. 8.1 LP11 / 1986)
- Reivindicaciones Reivindicaciones 1 -18 SI NO Claims Claims 1-18 IF NOT
- Documento Document
- Número Publicación o Identificación Fecha Publicación Publication or Identification Number publication date
- D01 D01
- DE 202008006741 U1 (LANGHOFF, G) 05.11.2009 DE 202008006741 U1 (LANGHOFF, G) 05.11.2009
- D02 D02
- ES 2259139 T3 (INDENA S.p.A.) 16.09.2006 ES 2259139 T3 (INDENA S.p.A.) 16.09.2006
- D03 D03
- ES 2259144 (INDENA S.p.A.) 16.09.2006 ES 2259144 (INDENA S.p.A.) 16.09.2006
- D04 D04
- WO 2008051170 A2 (DANISKA, V) 02.05.2008 WO 2008051170 A2 (DANISKA, V) 05.02.2008
- D05 D05
- WO 2006111830 A2 (COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH) 26.10.2006 WO 2006111830 A2 (COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH) 10.26.2006
- D06 D06
- US 2008026082 A1 (OLALDE RANGEL, J. A.) 31.01.2008 US 2008026082 A1 (OLALDE RANGEL, J. A.) 01.31.2008
- D07 D07
- WO 2006021930 A2 (FEMI-X A/S) 02.03.2006 WO 2006021930 A2 (FEMI-X A / S) 02.03.2006
- D08 D08
- WO 2009045505 A2 (LIBIDINOL LLC) 09.04.2009 WO 2009045505 A2 (LIBIDINOL LLC) 04.09.2009
- D09 D09
- US 2009175936 A1 (RÖHR, W.) 09.07.2009 US 2009175936 A1 (RÖHR, W.) 07.07.2009
- D10 D10
- PHARMIA. Pharmia Anti-Aging, 2010. [en línea] [recuperado el 07.03.2012] Recuperado de Internet: lt;URL: http://www.pharmialabs.com/pharmiaantiaging/components.htm 2010 PHARMIA Pharmia Anti-Aging, 2010. [online] [retrieved on 07.03.2012] Recovered from the Internet: <URL: http://www.pharmialabs.com/pharmiaantiaging/components.htm 2010
- D11 D11
- US 2009068300 A1 (EDALAT, P. P.) 12.03.2009 US 2009 068300 A1 (EDALAT, P. P.) 03/12/2009
- D12 D12
- EP 1344529 A1 (BRYANT, A.E.) 17.09.2003 EP 1344529 A1 (BRYANT, A.E.) 09.17.2003
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- D01 divulga composiciones con efecto revitalizador para el tratamiento y profilaxis de disfunciones eréctiles (página 2, [0001]-[0003], [0010]. Entre los componentes destaca el Tribulus terrestris (página 2, [0007]) en la cantidad de 30% (página 4, [0024]) dentro del intervalo previsto en la solicitud reivindicada. Además, combina esta planta con maca (Lepidium meyenii), Muira puama, ginseng y catuaba (página 3, [0013]) anticipando las características técnicas de las reivindicaciones 1, 15. D01 discloses revitalizing compositions for the treatment and prophylaxis of erectile dysfunctions (page 2, [0001] - [0003], [0010]. Among the components, Tribulus terrestris (page 2, [0007]) stands out in the amount of 30 % (page 4, [0024]) within the interval provided for in the claimed application In addition, combine this plant with maca (Lepidium meyenii), Muira puama, ginseng and catuaba (page 3, [0013]) anticipating the technical characteristics of the claims 1, 15.
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- D02 se refiere a formulaciones útiles en el tratamiento de la impotencia masculina y femenina que contienen Tribulus terrestris (página 3) divulgado ejemplos en que la cantidad de esta planta está en el intervalo previsto, además de emplear Ginkgo biloba, estearato de magnesio y celulosa microcristalina (página 4, ejemplos 1-3), anticipando las reivindicaciones 1, 14, 15. D02 refers to formulations useful in the treatment of male and female impotence containing Tribulus terrestris (page 3) disclosed examples in which the amount of this plant is in the expected range, in addition to using Ginkgo biloba, magnesium stearate and microcrystalline cellulose (page 4, examples 1-3), anticipating claims 1, 14, 15.
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- D03 divulga formulaciones útiles en el tratamiento de la impotencia masculina y femenina que contienen Tribulus terrestris (página 3) divulgado ejemplos en que la cantidad de esta planta está en el intervalo, además de emplear Epimedium, estearato de magnesio y celulosa microcristalina (página 4, ejemplos 1-3), anticipando las reivindicaciones 1, 14, 15. D03 discloses formulations useful in the treatment of male and female impotence that contain Tribulus terrestris (page 3), disclosing examples in which the amount of this plant is in the range, in addition to using Epimedium, magnesium stearate and microcrystalline cellulose (page 4, Examples 1-3), anticipating claims 1, 14, 15.
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- D04 se refiere a una bebida con efectos energéticos que comprende entre otros Tribulus terrestris entre un 20 a 60% en peso, preferentemente 45% (página 3; reivindicaciones 1, 6) entrando estos porcentajes dentro del intervalo previsto en la reivindicación 1, 16-18. D04 refers to a drink with energy effects comprising among others Tribulus terrestris between 20 to 60% by weight, preferably 45% (page 3; claims 1, 6) entering these percentages within the range provided in claim 1, 16- 18.
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- D05 divulga formulaciones que comprenden Mucuna pruriens y Tribulus terrestris, en el que esta última planta está en la proporción 5-15% (páginas 9, 10; reivindicaciones 1, 3), formulaciones efectivas para la disfunción eréctil (reivindicación 6). En la página 14, F3, el Tribulus terrestris está en el porcentaje de 15%, dentro del intervalo previsto, anticipando también las reivindicaciones 1, 15. D05 discloses formulations comprising Mucuna pruriens and Tribulus terrestris, in which the latter plant is in the proportion 5-15% (pages 9, 10; claims 1, 3), effective formulations for erectile dysfunction (claim 6). On page 14, F3, Tribulus terrestris is in the percentage of 15%, within the expected range, also anticipating claims 1, 15.
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- D01 además de ser relevantes para la novedad por divulgar la composición con Tribulus terrestris, resulta el documento más relevante para la actividad inventiva de las otras reivindicaciones puesto que divulga la combinación de esta planta con otras como maca (Lepidium meyenii), Muira puama, ginseng, catuaba (página 3, [0013] -[0019]; reivindicaciones 1, 19), y con otros componentes como L-arginina, L-lisina, glutamina (página 5, [0031]; reiv. 6), naringinina y crisina ([0035]), zinc ([0037]; reivs. 10, 11), por lo que afecta a la actividad inventiva de las reivindicaciones 1, 2-4, 10, 14-18, sobre todo al tener en cuenta otros documentos como: D01 in addition to being relevant to the novelty for disclosing the composition with Tribulus terrestris, is the most relevant document for the inventive activity of the other claims since it discloses the combination of this plant with others such as maca (Lepidium meyenii), Muira puama, ginseng , catuaba (page 3, [0013] - [0019]; claims 1, 19), and with other components such as L-arginine, L-lysine, glutamine (page 5, [0031]; reiv. 6), naringinine and chrysin ([0035]), zinc ([0037]; reivs. 10, 11), as regards the inventive activity of claims 1, 2-4, 10, 14-18, especially when considering other documents how:
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- D06 que se refiere a una composición sinergética para la disfunción eréctil que comprende Tribulus terrestris (página 4, [0023]), con Ginkgo biloba ([0024]), maca ([0016]), ginseng [0017] y Epimedium (ejemplo 2; reivindicaciones 1, 2, 4, 5) afectando a la actividad inventiva de las reivindicaciones 2-4, 15. D06 which refers to a synergistic composition for erectile dysfunction comprising Tribulus terrestris (page 4, [0023]), with Ginkgo biloba ([0024]), maca ([0016]), ginseng [0017] and Epimedium (example 2 ; claims 1, 2, 4, 5) affecting the inventive activity of claims 2-4, 15.
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- D07 se refiere a composiciones afrodisíacas de hierbas que comprenden Tribulus terrestris, Ginkgo biloba, catuaba, maca y Epimedium (página 2, [10,], página 3, [0017], página 4, [0020]-[0022], página 5, [0025]-[0027]; reivindicaciones 1, 2, 4 afectando a la reivindicación 5-7, 16. D07 refers to aphrodisiac herbal compositions comprising Tribulus terrestris, Ginkgo biloba, catuaba, maca and Epimedium (page 2, [10,], page 3, [0017], page 4, [0020] - [0022], page 5 , [0025] - [0027], claims 1, 2, 4 affecting claim 5-7, 16.
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- D08 divulga composiciones para mantener el estado de bienestar sexual que pueden comprender Tribulus terrestris, ginseng, maca, Muira puama, además de L-arginina y GABA (página 4, líneas 23-26; páginas 10, 11, Ejemplos 1, 2; página 13, líneas 8-14: página 14, líneas 1-10; página 15, línea 23-página 16, línea 25; reivindicación 30), afectando a las reivindicaciones 1, 5-7. D08 discloses compositions to maintain the state of sexual well-being that may comprise Tribulus terrestris, ginseng, maca, Muira puama, in addition to L-arginine and GABA (page 4, lines 23-26; pages 10, 11, Examples 1, 2; page 13, lines 8-14: page 14, lines 1-10; page 15, line 23-page 16, line 25; claim 30), affecting claims 1, 5-7.
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- D09 divulga preparaciones farmacéuticas que comprenden minerales como el zinc (página 2, [0029]), aminoácidos como la L-arginina, L-lisina, L-ornitina, L-glutamina [0030], calostro [0031], extractos de plantas como catuaba, Ginkgo biloba, ginseng, Epimedium, Mucuna pruriens, Muira puama, Tribulus terrestris ([0032] afectando a las reivindicaciones 8, 9, 11-13. D09 discloses pharmaceutical preparations comprising minerals such as zinc (page 2, [0029]), amino acids such as L-arginine, L-lysine, L-ornithine, L-glutamine [0030], colostrum [0031], plant extracts such as catuaba, Ginkgo biloba, ginseng, Epimedium, Mucuna pruriens, Muira puama, Tribulus terrestris ([0032] affecting claims 8, 9, 11-13.
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- D10 divulga todos los componentes previstos en la reivindicación 11, 12. D10 discloses all the components provided in claim 11, 12.
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- D11 se refiere a formulaciones para los que efectúan ejercicios físicos que comprenden Tribulus terrestris, Epimedium, Avena sativa, zinc, glutamina, lisina, estearato de magnesio (página 1, [0003], [0004], [0009], [0010]), página 2, [0018]; reivindicaciones 1, 2, 4, 5, 7, afectando a las reivindicaciones 10, 13, 14. 17, 18. D11 refers to formulations for those who perform physical exercises comprising Tribulus terrestris, Epimedium, Avena sativa, zinc, glutamine, lysine, magnesium stearate (page 1, [0003], [0004], [0009], [0010]) , page 2, [0018]; claims 1, 2, 4, 5, 7, affecting claims 10, 13, 14. 17, 18.
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- D12 divulga una composición para la calvicie masculina pero que también se puede utilizar para aumentar el vigor sexual ([0027]) que comprende zinc [0020], crisina [0030], Tribulus terrestris, Miura puama, Avena sativa ([0031], [0036]), afectando a las reivindicaciones 8, 9. D12 discloses a composition for male baldness but which can also be used to increase sexual vigor ([0027]) comprising zinc [0020], chrysin [0030], Tribulus terrestris, Miura puama, Avena sativa ([0031], [ 0036]), affecting claims 8, 9.
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| ES2462553A1 (en) * | 2014-01-16 | 2014-05-23 | Gepnes Hattrick Sl | Composition for improvement of sexual well-being (Machine-translation by Google Translate, not legally binding) |
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| GB0205826D0 (en) * | 2002-03-13 | 2002-04-24 | Bryant Andrew E | Therapeutic compositions and methods |
| ITMI20020994A1 (en) * | 2002-05-10 | 2003-11-10 | Indena Spa | USEFUL FORMULATIONS IN THE TREATMENT OF MALE AND FEMALE IMPOTENCE |
| ITMI20020990A1 (en) * | 2002-05-10 | 2003-11-10 | Indena Spa | USEFUL FORMULATIONS IN THE TREATMENT OF MALE AND FEMALE IMPOTENCE |
| WO2006021930A2 (en) * | 2004-08-25 | 2006-03-02 | Femi-X A/S | Aphrodisiac herbal composition for a female comprising epimedium grandiflorum, turnera diffusa var. aphrodisiaca, ilex paraguariensis and smilax spp |
| WO2006111830A2 (en) * | 2005-04-20 | 2006-10-26 | Council Of Scientific And Industrial Research | Functional aphrodisiac rolled herbal bidis and cigarettes |
| DE102006006532B4 (en) * | 2006-02-10 | 2007-11-08 | Biogenerics Pharma Gmbh | Pharmaceutical preparation |
| US7658956B2 (en) * | 2006-07-28 | 2010-02-09 | Jose Angel Olalde Rangel | Erectile dysfunction phyto-nutraceutical synergistic composition |
| SK287407B6 (en) * | 2006-10-24 | 2010-09-07 | Mtv Invest, S.R.O. | Beverage having a stimulative effect |
| US20090068300A1 (en) * | 2007-09-07 | 2009-03-12 | Veripak, Inc. | Pre- and post-workout formulations processes and supplement products thereby |
| US20090092687A1 (en) * | 2007-10-03 | 2009-04-09 | Stein Daniel S | Prhormone composition and method of use thereof |
| DE202008006741U1 (en) * | 2008-05-19 | 2009-10-01 | Langhoff, Gertrud | Nutrient composition for vitalization |
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