ES2442445T3 - Sistema de crioterapia - Google Patents
Sistema de crioterapia Download PDFInfo
- Publication number
- ES2442445T3 ES2442445T3 ES04702597.8T ES04702597T ES2442445T3 ES 2442445 T3 ES2442445 T3 ES 2442445T3 ES 04702597 T ES04702597 T ES 04702597T ES 2442445 T3 ES2442445 T3 ES 2442445T3
- Authority
- ES
- Spain
- Prior art keywords
- probe
- flow
- cryoprobes
- liquid
- cryoprobe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000315 cryotherapy Methods 0.000 title claims abstract description 61
- 239000007788 liquid Substances 0.000 claims abstract description 121
- 238000007710 freezing Methods 0.000 claims abstract description 108
- 230000008014 freezing Effects 0.000 claims abstract description 107
- 239000012530 fluid Substances 0.000 claims abstract description 68
- 238000004891 communication Methods 0.000 claims abstract description 22
- 238000003780 insertion Methods 0.000 claims abstract description 13
- 230000037431 insertion Effects 0.000 claims abstract description 13
- 238000010587 phase diagram Methods 0.000 claims abstract description 6
- 238000007906 compression Methods 0.000 claims description 26
- 230000006835 compression Effects 0.000 claims description 23
- 230000000903 blocking effect Effects 0.000 claims description 17
- 230000001105 regulatory effect Effects 0.000 claims description 16
- 239000000523 sample Substances 0.000 description 273
- 239000007789 gas Substances 0.000 description 121
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 106
- 238000001816 cooling Methods 0.000 description 86
- 229910052757 nitrogen Inorganic materials 0.000 description 52
- 210000001519 tissue Anatomy 0.000 description 52
- 238000000034 method Methods 0.000 description 50
- 206010028980 Neoplasm Diseases 0.000 description 40
- 238000013461 design Methods 0.000 description 36
- 238000002679 ablation Methods 0.000 description 27
- 238000002347 injection Methods 0.000 description 23
- 239000007924 injection Substances 0.000 description 23
- 238000011282 treatment Methods 0.000 description 20
- 238000010438 heat treatment Methods 0.000 description 19
- 238000003384 imaging method Methods 0.000 description 17
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 16
- 239000012808 vapor phase Substances 0.000 description 16
- 230000008569 process Effects 0.000 description 15
- 239000012071 phase Substances 0.000 description 14
- 230000008901 benefit Effects 0.000 description 13
- 230000000694 effects Effects 0.000 description 13
- 239000000463 material Substances 0.000 description 13
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 12
- 238000010257 thawing Methods 0.000 description 12
- 210000005036 nerve Anatomy 0.000 description 11
- 238000002604 ultrasonography Methods 0.000 description 11
- 230000004087 circulation Effects 0.000 description 10
- 238000002591 computed tomography Methods 0.000 description 10
- 230000006870 function Effects 0.000 description 9
- 239000001307 helium Substances 0.000 description 9
- 229910052734 helium Inorganic materials 0.000 description 9
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 9
- 229910052751 metal Inorganic materials 0.000 description 9
- 239000002184 metal Substances 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- 238000005481 NMR spectroscopy Methods 0.000 description 8
- 238000004458 analytical method Methods 0.000 description 8
- 229910052786 argon Inorganic materials 0.000 description 8
- 229910052802 copper Inorganic materials 0.000 description 8
- 239000010949 copper Substances 0.000 description 8
- 238000001704 evaporation Methods 0.000 description 8
- 230000008020 evaporation Effects 0.000 description 8
- 238000005259 measurement Methods 0.000 description 8
- 238000003860 storage Methods 0.000 description 8
- 238000004861 thermometry Methods 0.000 description 8
- 238000009835 boiling Methods 0.000 description 7
- 230000008859 change Effects 0.000 description 7
- 239000012535 impurity Substances 0.000 description 7
- 239000003507 refrigerant Substances 0.000 description 7
- 229910045601 alloy Inorganic materials 0.000 description 6
- 239000000956 alloy Substances 0.000 description 6
- 239000004020 conductor Substances 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 6
- 238000000520 microinjection Methods 0.000 description 6
- 230000000638 stimulation Effects 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 230000004075 alteration Effects 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 5
- 239000002131 composite material Substances 0.000 description 5
- 238000002681 cryosurgery Methods 0.000 description 5
- 231100000518 lethal Toxicity 0.000 description 5
- 230000001665 lethal effect Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000012986 modification Methods 0.000 description 5
- 230000004048 modification Effects 0.000 description 5
- 230000007383 nerve stimulation Effects 0.000 description 5
- 230000007704 transition Effects 0.000 description 5
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
- 229910000831 Steel Inorganic materials 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 230000015572 biosynthetic process Effects 0.000 description 4
- 238000010276 construction Methods 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 230000007547 defect Effects 0.000 description 4
- 238000009826 distribution Methods 0.000 description 4
- 238000009429 electrical wiring Methods 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- 238000005457 optimization Methods 0.000 description 4
- 230000001953 sensory effect Effects 0.000 description 4
- 239000010959 steel Substances 0.000 description 4
- UCTWMZQNUQWSLP-VIFPVBQESA-N (R)-adrenaline Chemical compound CNC[C@H](O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-VIFPVBQESA-N 0.000 description 3
- 229930182837 (R)-adrenaline Natural products 0.000 description 3
- 229910001275 Niobium-titanium Inorganic materials 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 239000000919 ceramic Substances 0.000 description 3
- 238000002512 chemotherapy Methods 0.000 description 3
- 231100000433 cytotoxic Toxicity 0.000 description 3
- 230000001472 cytotoxic effect Effects 0.000 description 3
- 229960005139 epinephrine Drugs 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
- 150000002430 hydrocarbons Chemical class 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 238000009413 insulation Methods 0.000 description 3
- 230000001788 irregular Effects 0.000 description 3
- 239000003345 natural gas Substances 0.000 description 3
- RJSRQTFBFAJJIL-UHFFFAOYSA-N niobium titanium Chemical compound [Ti].[Nb] RJSRQTFBFAJJIL-UHFFFAOYSA-N 0.000 description 3
- 230000003439 radiotherapeutic effect Effects 0.000 description 3
- 238000001959 radiotherapy Methods 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 206010015866 Extravasation Diseases 0.000 description 2
- 229910000760 Hardened steel Inorganic materials 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 206010019695 Hepatic neoplasm Diseases 0.000 description 2
- 208000008839 Kidney Neoplasms Diseases 0.000 description 2
- 208000034158 bleeding Diseases 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000973 chemotherapeutic effect Effects 0.000 description 2
- 230000015271 coagulation Effects 0.000 description 2
- 238000005345 coagulation Methods 0.000 description 2
- 238000007596 consolidation process Methods 0.000 description 2
- 230000003013 cytotoxicity Effects 0.000 description 2
- 231100000135 cytotoxicity Toxicity 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 229910001873 dinitrogen Inorganic materials 0.000 description 2
- 230000036251 extravasation Effects 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 239000011810 insulating material Substances 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 230000002452 interceptive effect Effects 0.000 description 2
- 239000003949 liquefied natural gas Substances 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 208000014018 liver neoplasm Diseases 0.000 description 2
- 108010013207 macro aggregates of albumin Proteins 0.000 description 2
- 238000002595 magnetic resonance imaging Methods 0.000 description 2
- 238000013507 mapping Methods 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 230000001338 necrotic effect Effects 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 210000002307 prostate Anatomy 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 230000001172 regenerating effect Effects 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000013526 supercooled liquid Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 208000018084 Bone neoplasm Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 206010062713 Haemorrhagic diathesis Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 235000019687 Lamb Nutrition 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 230000005679 Peltier effect Effects 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 238000003491 array Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000002051 biphasic effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 238000009529 body temperature measurement Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 239000011889 copper foil Substances 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 239000012777 electrically insulating material Substances 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 210000000609 ganglia Anatomy 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000017525 heat dissipation Effects 0.000 description 1
- 208000031169 hemorrhagic disease Diseases 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000000076 hypertonic saline solution Substances 0.000 description 1
- 230000001024 immunotherapeutic effect Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 208000037841 lung tumor Diseases 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000002906 medical waste Substances 0.000 description 1
- 229910052754 neon Inorganic materials 0.000 description 1
- GKAOGPIIYCISHV-UHFFFAOYSA-N neon atom Chemical compound [Ne] GKAOGPIIYCISHV-UHFFFAOYSA-N 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 201000002528 pancreatic cancer Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 210000000578 peripheral nerve Anatomy 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 208000023958 prostate neoplasm Diseases 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000036573 scar formation Effects 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000010583 slow cooling Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000004781 supercooling Methods 0.000 description 1
- 210000000331 sympathetic ganglia Anatomy 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000002470 thermal conductor Substances 0.000 description 1
- 230000019432 tissue death Effects 0.000 description 1
- 238000013334 tissue model Methods 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
- A61B2018/0231—Characteristics of handpieces or probes
- A61B2018/0262—Characteristics of handpieces or probes using a circulating cryogenic fluid
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Otolaryngology (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Surgical Instruments (AREA)
- Thermotherapy And Cooling Therapy Devices (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44054103P | 2003-01-15 | 2003-01-15 | |
| US44066203P | 2003-01-15 | 2003-01-15 | |
| US440662P | 2003-01-15 | ||
| US440541P | 2003-01-15 | ||
| US10/757,768 US7410484B2 (en) | 2003-01-15 | 2004-01-14 | Cryotherapy probe |
| US757768 | 2004-01-14 | ||
| US10/757,769 US7083612B2 (en) | 2003-01-15 | 2004-01-14 | Cryotherapy system |
| US757769 | 2004-01-14 | ||
| PCT/US2004/001402 WO2004064914A2 (en) | 2003-01-15 | 2004-01-15 | Cryotherapy probe and system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2442445T3 true ES2442445T3 (es) | 2014-02-11 |
Family
ID=32777227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES04702597.8T Expired - Lifetime ES2442445T3 (es) | 2003-01-15 | 2004-01-15 | Sistema de crioterapia |
Country Status (7)
| Country | Link |
|---|---|
| EP (3) | EP2904986B1 (https=) |
| JP (2) | JP4572193B2 (https=) |
| AU (2) | AU2004206911B2 (https=) |
| CA (2) | CA2931693C (https=) |
| ES (1) | ES2442445T3 (https=) |
| MX (1) | MXPA05007622A (https=) |
| WO (1) | WO2004064914A2 (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7083612B2 (en) | 2003-01-15 | 2006-08-01 | Cryodynamics, Llc | Cryotherapy system |
| US7273479B2 (en) * | 2003-01-15 | 2007-09-25 | Cryodynamics, Llc | Methods and systems for cryogenic cooling |
| US7410484B2 (en) | 2003-01-15 | 2008-08-12 | Cryodynamics, Llc | Cryotherapy probe |
| JP4703724B2 (ja) | 2006-04-28 | 2011-06-15 | ゼルティック エステティックス インコーポレイテッド | 皮下の脂質リッチ細胞の冷却が改善された治療装置に使用する凍結防止剤 |
| WO2008099490A1 (ja) * | 2007-02-15 | 2008-08-21 | Dgs Computer | 凍結治療に使う治療具及び治療装置 |
| US8814850B2 (en) * | 2008-04-24 | 2014-08-26 | Cryomedix, Llc | Method and system for cryoablation treatment |
| US9089316B2 (en) * | 2009-11-02 | 2015-07-28 | Endocare, Inc. | Cryogenic medical system |
| US8475441B2 (en) | 2008-12-23 | 2013-07-02 | Cryomedix, Llc | Isotherm-based tissue ablation control system |
| CA2756263A1 (en) * | 2009-04-06 | 2010-10-14 | Cryomedix Llc | Single phase liquid refrigerant cryoablation system with multitubular distal section and related method |
| US8888768B2 (en) | 2009-04-30 | 2014-11-18 | Cryomedix, Llc | Cryoablation system having docking station for charging cryogen containers and related method |
| US9662162B2 (en) | 2010-06-01 | 2017-05-30 | Afreeze Gmbh | Leakage protection system, pressure balancing system, and precipitator with valve function for ablation applications |
| US9095320B2 (en) | 2010-09-27 | 2015-08-04 | CyroMedix, LLC | Cryo-induced renal neuromodulation devices and methods |
| CN104159534B (zh) | 2012-01-13 | 2017-02-22 | 肌肉科技股份有限公司 | 用于美容和其他处理的皮下低温重塑的皮肤保护 |
| WO2013106857A1 (en) * | 2012-01-13 | 2013-07-18 | Myoscience, Inc. | Skin protection for subdermal cryogenic remodeling for cosmetic and other treatments |
| HK1220342A1 (zh) | 2013-03-15 | 2017-05-05 | Varian Medical Systems, Inc. | 冷冻系统及方法 |
| FR3004115B1 (fr) * | 2013-04-04 | 2016-05-06 | Nestis | Catheter d'injection de fluide a deux gaines coulissantes |
| US10035009B2 (en) | 2013-04-15 | 2018-07-31 | The Board Of Trustees Of The Leland Stanford Junior University | Systems and methods for treating pancreatic cancer |
| BR112016006214B1 (pt) | 2013-09-24 | 2022-09-13 | Adagio Medical, Inc | Cateter de crioablação |
| US10952676B2 (en) | 2013-10-14 | 2021-03-23 | Adagio Medical, Inc. | Endoesophageal balloon catheter, system, and related method |
| WO2015117036A2 (en) | 2014-01-30 | 2015-08-06 | Zeltiq Aesthetics, Inc. | Treatment systems, methods, and apparatuses for improving the appearance of skin and providing for other treatments |
| WO2015160574A1 (en) | 2014-04-17 | 2015-10-22 | Adagio Medical, Inc. | Endovascular near critical fluid based cryoablation catheter having plurality of preformed treatment shapes |
| US10543032B2 (en) | 2014-11-13 | 2020-01-28 | Adagio Medical, Inc. | Pressure modulated cryoablation system and related methods |
| US11051867B2 (en) | 2015-09-18 | 2021-07-06 | Adagio Medical, Inc. | Tissue contact verification system |
| RU2602795C1 (ru) * | 2015-11-03 | 2016-11-20 | Валентин Николаевич Павлов | Криохирургический аппарат |
| US10864031B2 (en) | 2015-11-30 | 2020-12-15 | Adagio Medical, Inc. | Ablation method for creating elongate continuous lesions enclosing multiple vessel entries |
| RU2624347C1 (ru) * | 2016-01-22 | 2017-07-03 | Общество с ограниченной ответственностью "Международный Институт криомедицины" (ООО "Международный Институт криомедицины") | Криомедицинский аппарат |
| BR112018073275A2 (pt) * | 2016-05-10 | 2020-10-27 | Zeltiq Aesthetics, Inc | sistema e método cosmético para congelar previsivelmente a pele do indivíduo, método cosmético para tratar a pele e método cosmético para tratar tecido alvo de um indivíduo |
| US20170326346A1 (en) * | 2016-05-10 | 2017-11-16 | Zeltiq Aesthetics, Inc. | Permeation enhancers and methods of cryotherapy |
| US11382790B2 (en) | 2016-05-10 | 2022-07-12 | Zeltiq Aesthetics, Inc. | Skin freezing systems for treating acne and skin conditions |
| CA3054037A1 (en) | 2017-01-19 | 2018-07-26 | The General Hospital Corporation | Medical device including an evaporative structure therein |
| US12226139B2 (en) | 2017-01-19 | 2025-02-18 | The General Hospital Corporation | Systems and methods for thermal treatment of tissue |
| ES2994230T3 (en) * | 2017-02-04 | 2025-01-20 | Vessi Medical Ltd | Cryotherapy device flow control |
| US20180310977A1 (en) * | 2017-04-28 | 2018-11-01 | Kyphon SÀRL | Introducer and cryoprobe |
| KR101840346B1 (ko) * | 2017-08-08 | 2018-05-04 | 주식회사 비엠텍월드와이드 | 냉각 기체 회수 장치를 갖는 극저온 치료기 및 이의 제어방법 |
| KR102736370B1 (ko) | 2017-09-05 | 2024-11-29 | 아다지오 메디컬, 인크. | 형상 기억 스타일렛을 갖는 절제 카테터 |
| CN107485443A (zh) * | 2017-09-21 | 2017-12-19 | 北京阳光易帮医疗科技有限公司 | 一种冷冻微波复合消融系统 |
| TW201916863A (zh) * | 2017-10-18 | 2019-05-01 | 美商加利爾醫療股份有限公司 | 冷凍外科術系統 |
| CN111836593B (zh) | 2018-01-10 | 2024-12-17 | 艾达吉欧医疗公司 | 具有传导性衬套的冷冻消融元件 |
| EP3787539A4 (en) | 2018-05-01 | 2022-01-26 | The Johns Hopkins University | CARBON DIOXIDE BASED PERCUTANEOUS CRYOSURGERY SYSTEM |
| CA3107932A1 (en) | 2018-07-31 | 2020-02-06 | Zeltiq Aesthetics, Inc. | Methods, devices, and systems for improving skin characteristics |
| EP3849447A4 (en) * | 2019-01-14 | 2021-11-17 | Cryoelectric Science Ltd. | PROCESSES, SYSTEMS AND APPARATUS FOR CRYOSURGERY, COLD SURGERY AND ELECTROLYSIS |
| US11633224B2 (en) | 2020-02-10 | 2023-04-25 | Icecure Medical Ltd. | Cryogen pump |
| CN111134832B (zh) * | 2020-02-24 | 2024-07-05 | 上海导向医疗系统有限公司 | 流量调节组件以及流量可调节的冷冻探针 |
| EP4196027A4 (en) * | 2020-08-14 | 2024-08-28 | Adagio Medical, Inc. | NEW FLOW COLLECTOR FOR CRYO-ABLATION CATHETER |
| IL307869A (en) * | 2021-04-21 | 2023-12-01 | NEDLIN Yakov | Method and apparatus for high intensity ablation |
| CN113729916B (zh) * | 2021-10-18 | 2022-12-09 | 佳木斯大学 | 基于大数据的肿瘤冷冻探针系统及组装设备 |
| US12426934B2 (en) | 2022-02-28 | 2025-09-30 | Icecure Medical Ltd. | Cryogen flow control |
| US12215811B2 (en) | 2022-07-18 | 2025-02-04 | Icecure Medical Ltd. | Cryogenic system connector |
| US12591258B2 (en) * | 2023-02-15 | 2026-03-31 | Varian Medical Systems, Inc. | System and method to measure temperature and generate heat using a resistive material |
| US12527613B2 (en) | 2023-09-11 | 2026-01-20 | Icecure Medical Ltd. | Cryoprobe |
| EP4529872A1 (de) | 2023-09-28 | 2025-04-02 | Erbe Elektromedizin GmbH | Gasdosiereinheit zur gasversorgung eines kryoinstruments |
| CN119950010B (zh) * | 2024-10-22 | 2026-03-10 | 海杰亚（北京）医疗器械有限公司 | 复合式高低温冷热消融系统 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3800552A (en) | 1972-03-29 | 1974-04-02 | Bendix Corp | Cryogenic surgical instrument |
| GB1438759A (en) | 1972-06-02 | 1976-06-09 | Spembly Ltd | Cryo-surgical apparatus |
| GB1422535A (en) * | 1972-06-16 | 1976-01-28 | Spembly Ltd | Cryogenic apparatus |
| ZA917281B (en) | 1990-09-26 | 1992-08-26 | Cryomedical Sciences Inc | Cryosurgical instrument and system and method of cryosurgery |
| US5254116A (en) | 1991-09-06 | 1993-10-19 | Cryomedical Sciences, Inc. | Cryosurgical instrument with vent holes and method using same |
| US5520682A (en) * | 1991-09-06 | 1996-05-28 | Cryomedical Sciences, Inc. | Cryosurgical instrument with vent means and method using same |
| GB9123415D0 (en) * | 1991-11-05 | 1991-12-18 | Clarke Brian K R | Cryosurgical apparatus |
| US5531742A (en) * | 1992-01-15 | 1996-07-02 | Barken; Israel | Apparatus and method for computer controlled cryosurgery |
| US5424288A (en) | 1992-02-28 | 1995-06-13 | Order; Stanley E. | Method of treating solid tumor cancers utilizing macro aggregated proteins and colloidal radioactive phosphorous |
| EP0627941A1 (en) | 1992-02-28 | 1994-12-14 | ORDER, Stanley E. | Use of aggregated proteins to prolong retention time of a therapeutic agent adjacent a targeted site such as a tumor |
| US5275595A (en) * | 1992-07-06 | 1994-01-04 | Dobak Iii John D | Cryosurgical instrument |
| IL104506A (en) | 1993-01-25 | 1997-11-20 | Israel State | Fast changing heating- cooling device and method, particularly for cryogenic and/or surgical use |
| GB2283678B (en) * | 1993-11-09 | 1998-06-03 | Spembly Medical Ltd | Cryosurgical catheter probe |
| JP3528931B2 (ja) * | 1993-11-17 | 2004-05-24 | 株式会社前川製作所 | 液体冷媒の供給・排出方法及びその装置 |
| GB9405818D0 (en) | 1994-03-24 | 1994-05-11 | Royal Doulton Ltd | Method and device for controlling belt tracking |
| IL110176A (en) | 1994-06-30 | 1999-12-31 | Israel State | Multiprobe surgical cryogenic apparatus |
| US5452582A (en) | 1994-07-06 | 1995-09-26 | Apd Cryogenics, Inc. | Cryo-probe |
| US5901783A (en) * | 1995-10-12 | 1999-05-11 | Croyogen, Inc. | Cryogenic heat exchanger |
| US6039730A (en) * | 1996-06-24 | 2000-03-21 | Allegheny-Singer Research Institute | Method and apparatus for cryosurgery |
| US5800488A (en) | 1996-07-23 | 1998-09-01 | Endocare, Inc. | Cryoprobe with warming feature |
| US5899897A (en) * | 1996-09-26 | 1999-05-04 | Allegheny-Singer Research Institute | Method and apparatus for heating during cryosurgery |
| US5910104A (en) | 1996-12-26 | 1999-06-08 | Cryogen, Inc. | Cryosurgical probe with disposable sheath |
| US5885276A (en) * | 1997-12-02 | 1999-03-23 | Galil Medical Ltd. | Method and device for transmyocardial cryo revascularization |
| US5978697A (en) | 1998-01-05 | 1999-11-02 | Galil Medical Ltd. | System and method for MRI-guided cryosurgery |
| US6251105B1 (en) * | 1998-03-31 | 2001-06-26 | Endocare, Inc. | Cryoprobe system |
| US6142991A (en) | 1998-03-31 | 2000-11-07 | Galil Medical, Ltd. | High resolution cryosurgical method and apparatus |
| US6592577B2 (en) * | 1999-01-25 | 2003-07-15 | Cryocath Technologies Inc. | Cooling system |
| US6179831B1 (en) | 1999-04-29 | 2001-01-30 | Galil Medical Ltd. | Method of cryoablating benign prostate hyperplasia |
| US6139544A (en) | 1999-05-26 | 2000-10-31 | Endocare, Inc. | Computer guided cryosurgery |
| US6471694B1 (en) * | 2000-08-09 | 2002-10-29 | Cryogen, Inc. | Control system for cryosurgery |
| US6235018B1 (en) * | 1999-10-29 | 2001-05-22 | Cryoflex, Inc. | Method and apparatus for monitoring cryosurgical operations |
| US6706037B2 (en) * | 2000-10-24 | 2004-03-16 | Galil Medical Ltd. | Multiple cryoprobe apparatus and method |
-
2004
- 2004-01-15 CA CA2931693A patent/CA2931693C/en not_active Expired - Fee Related
- 2004-01-15 EP EP15157656.8A patent/EP2904986B1/en not_active Expired - Lifetime
- 2004-01-15 WO PCT/US2004/001402 patent/WO2004064914A2/en not_active Ceased
- 2004-01-15 MX MXPA05007622A patent/MXPA05007622A/es active IP Right Grant
- 2004-01-15 CA CA2516122A patent/CA2516122C/en not_active Expired - Fee Related
- 2004-01-15 AU AU2004206911A patent/AU2004206911B2/en not_active Ceased
- 2004-01-15 JP JP2006501041A patent/JP4572193B2/ja not_active Expired - Fee Related
- 2004-01-15 ES ES04702597.8T patent/ES2442445T3/es not_active Expired - Lifetime
- 2004-01-15 EP EP10184565.9A patent/EP2311398B1/en not_active Expired - Lifetime
- 2004-01-15 EP EP04702597.8A patent/EP1592357B1/en not_active Expired - Lifetime
-
2009
- 2009-10-14 AU AU2009225359A patent/AU2009225359B2/en not_active Ceased
- 2009-12-08 JP JP2009278973A patent/JP5295937B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010051827A (ja) | 2010-03-11 |
| EP2904986B1 (en) | 2022-07-06 |
| WO2004064914A2 (en) | 2004-08-05 |
| EP2904986A1 (en) | 2015-08-12 |
| MXPA05007622A (es) | 2006-02-22 |
| EP1592357A4 (en) | 2007-10-31 |
| EP1592357A2 (en) | 2005-11-09 |
| CA2931693C (en) | 2017-03-14 |
| JP2006517118A (ja) | 2006-07-20 |
| AU2004206911B2 (en) | 2009-07-16 |
| AU2009225359B2 (en) | 2012-06-07 |
| CA2931693A1 (en) | 2004-08-05 |
| EP1592357B1 (en) | 2013-11-13 |
| JP4572193B2 (ja) | 2010-10-27 |
| AU2009225359A1 (en) | 2009-11-05 |
| CA2516122A1 (en) | 2004-08-05 |
| JP5295937B2 (ja) | 2013-09-18 |
| EP2311398A1 (en) | 2011-04-20 |
| EP2311398B1 (en) | 2015-04-15 |
| AU2004206911A1 (en) | 2004-08-05 |
| CA2516122C (en) | 2016-07-26 |
| WO2004064914A3 (en) | 2005-03-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2442445T3 (es) | Sistema de crioterapia | |
| US11197707B2 (en) | Cryotherapy probe | |
| US7507233B2 (en) | Cryotherapy system | |
| AU660500B2 (en) | Cryosurgical instrument with vent holes and method | |
| EP3075337B1 (en) | Systems for cryogenic cooling | |
| JP5490218B2 (ja) | 多管の遠位部を有する単相液体冷媒冷凍アブレーション・システム及び関連する方法 | |
| ES3011732T3 (en) | Pressure modulated cryoablation system | |
| CA2261177C (en) | Cryoprobe | |
| US5520682A (en) | Cryosurgical instrument with vent means and method using same | |
| US11026737B2 (en) | Cryogenic system and methods | |
| Qi et al. | Performance evaluation of a novel liquid nitrogen cryoprobe | |
| HK1122484B (en) | Methods and systems for cryogenic cooling |