ES2440393R1 - Un método para aumentar el efecto de una forma activada potenciada de un anticuerpo - Google Patents
Un método para aumentar el efecto de una forma activada potenciada de un anticuerpo Download PDFInfo
- Publication number
- ES2440393R1 ES2440393R1 ES201390006A ES201390006A ES2440393R1 ES 2440393 R1 ES2440393 R1 ES 2440393R1 ES 201390006 A ES201390006 A ES 201390006A ES 201390006 A ES201390006 A ES 201390006A ES 2440393 R1 ES2440393 R1 ES 2440393R1
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- Spain
- Prior art keywords
- activated form
- antibody
- effect
- antibody against
- increasing
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0004—Homeopathy; Vitalisation; Resonance; Dynamisation, e.g. esoteric applications; Oxygenation of blood
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
Abstract
Un método para aumentar el efecto de una forma activada potenciada de un anticuerpo. La presente invención proporciona un método para aumentar el efecto de una forma activada potenciada de un anticuerpo contra una molécula biológica endógena que se selecciona del grupo de la proteína S-100, el antígeno prostático específico, el receptor de la insulina y el receptor de la angiotensina II, mediante la combinación de una forma activada potenciada de un anticuerpo contra dicha molécula biológica endógena, con una forma activada potenciada de un anticuerpo contra la NO sintasa endotelial. La presente invención proporciona también una composición farmacéutica que comprende a) una forma activada potenciada de un anticuerpo contra una molécula biológica endógena que se selecciona del grupo de la proteína S-100, el antígeno prostático específico, el receptor de la insulina y el receptor de la angiotensina II, y b) una forma activada potenciada de un anticuerpo contra la NO sintasa endotelial.
Applications Claiming Priority (37)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010129295/15A RU2531049C2 (ru) | 2010-07-15 | 2010-07-15 | Лекарственное средство для лечения заболеваний предстательной железы и способ лечения заболеваний предстательной железы |
| RU2010129298 | 2010-07-15 | ||
| RU2010129292 | 2010-07-15 | ||
| RU2010129292/15A RU2523557C2 (ru) | 2010-07-15 | 2010-07-15 | Способ лечения вегетососудистой дистонии и фармацевтическая композиция для лечения вегетососудистой дистонии |
| RU2010129291 | 2010-07-15 | ||
| RU2010129290/15A RU2525155C2 (ru) | 2010-07-15 | 2010-07-15 | Способ лечения хронической сердечной недостаточности и фармацевтическая композиция для комплексной терапии хронической сердечной недостаточности |
| RU2010129294 | 2010-07-15 | ||
| RU2010129291/15A RU2525156C2 (ru) | 2010-07-15 | 2010-07-15 | Способ лечения и профилактики артериальной гипертензии и фармацевтическая композиция для лечения артериальной гипертензии |
| RU2010129298/15A RU2526153C2 (ru) | 2010-07-15 | 2010-07-15 | Способ повышения фармакологической активности действующего вещества лекарственного средства и фармацевтическая композиция |
| RU2010129290 | 2010-07-15 | ||
| RU2010129295 | 2010-07-15 | ||
| RU2010129294/15A RU2542414C2 (ru) | 2010-07-15 | 2010-07-15 | Лекарственное средство для лечения эректильных дисфункций и способ лечения эректильных дисфункций |
| RU2010130353 | 2010-07-21 | ||
| RU2010130355/15A RU2530638C2 (ru) | 2010-07-21 | 2010-07-21 | Лекарственное средство и способ лечения органических заболеваний нервной системы, психоорганического синдрома и энцефалопатий различного генеза |
| RU2010130348 | 2010-07-21 | ||
| RU2010130348/15A RU2531048C2 (ru) | 2010-07-21 | 2010-07-21 | Лекарственное средство для уменьшения резистентности к инсулину и лечения сахарного диабета и способ повышения эффективности лечения сахарного диабета инсулином и/или гипогликемическими препаратами |
| RU2010130356 | 2010-07-21 | ||
| RU2010130358/15A RU2519695C2 (ru) | 2010-07-21 | 2010-07-21 | Лекарственное средство для лечения синдрома дефицита внимания и способ лечения синдрома дефицита внимания |
| RU2010130353/15A RU2542445C2 (ru) | 2010-07-21 | 2010-07-21 | Лекарственное средство для лечения болезни альцгеймера и способ лечения болезни альцгеймера |
| RU2010130356/15A RU2542453C2 (ru) | 2010-07-21 | 2010-07-21 | Лекарственное средство и способ лечения вегето-сосудистой дистонии, синдрома головокружения различного генеза и кинетозов |
| RU2010130355 | 2010-07-21 | ||
| RU2010130358 | 2010-07-21 | ||
| RU2011110106 | 2011-03-17 | ||
| RU2011110106/15A RU2523451C2 (ru) | 2011-03-17 | 2011-03-17 | Способ лечения хронической сердечной недостаточности и фармацевтическая композиция для лечения хронической сердечной недостаточности |
| RU2011127053/15A RU2565400C2 (ru) | 2011-07-01 | 2011-07-01 | Лекарственное средство для лечения заболеваний мочеполовой системы и способ лечения заболеваний мочеполовой системы |
| RU2011127055 | 2011-07-01 | ||
| RU2011127058/15A RU2536232C2 (ru) | 2011-07-01 | 2011-07-01 | Лекарственное средство для лечения болезни альцгеймера и способ лечения болезни альцгеймера |
| RU2011127052 | 2011-07-01 | ||
| RU2011127055/15A RU2536230C2 (ru) | 2011-07-01 | 2011-07-01 | Лекарственное средство для лечения неврологическо-поведенческих рассторойств развития и способ лечения неврологическо-поведенческих расстройств развития |
| RU2011127051/15A RU2509572C2 (ru) | 2011-07-01 | 2011-07-01 | Лекарственное средство для уменьшения резистентности к инсулину и для лечения сахарного диабета, способ уменьшения резистентности к инсулину, способ лечения сахарного диабета и способ лечения сахарного диабета инсулином и/или гипогликемическими препаратами |
| RU2011127052/15A RU2503462C2 (ru) | 2011-07-01 | 2011-07-01 | Способ лечения головокружения различного генеза, кинетозов и вегето-сосудистой дистонии (варианты) и лекарственное средство |
| RU2011127053 | 2011-07-01 | ||
| RU2011127059 | 2011-07-01 | ||
| RU2011127059/15A RU2536234C2 (ru) | 2011-07-01 | 2011-07-01 | Нейротропное лекарственное средство и способ лечения органических заболеваний нервной системы, психоорганического синдрома и энцефалопатий различного генеза |
| RU2011127051 | 2011-07-01 | ||
| RU2011127058 | 2011-07-01 | ||
| PCT/IB2011/002350 WO2012007845A2 (en) | 2010-07-15 | 2011-07-15 | A method of increasing the effect of an activated-potentiated form of an antibody |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2440393A2 ES2440393A2 (es) | 2014-01-28 |
| ES2440393R1 true ES2440393R1 (es) | 2014-10-10 |
Family
ID=44863151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES201390006A Pending ES2440393R1 (es) | 2010-07-15 | 2011-07-15 | Un método para aumentar el efecto de una forma activada potenciada de un anticuerpo |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US9308275B2 (es) |
| EP (1) | EP2593140A2 (es) |
| JP (2) | JP2013538186A (es) |
| KR (1) | KR20140014059A (es) |
| AR (1) | AR082247A1 (es) |
| AU (1) | AU2011278038B2 (es) |
| BR (1) | BR112013000840A2 (es) |
| CA (1) | CA2804966A1 (es) |
| CZ (1) | CZ2013105A3 (es) |
| DE (1) | DE112011102358T5 (es) |
| DK (1) | DK201370079A (es) |
| EA (1) | EA030566B1 (es) |
| EE (1) | EE201300006A (es) |
| ES (1) | ES2440393R1 (es) |
| FI (1) | FI20135143L (es) |
| FR (1) | FR2962656A1 (es) |
| GB (1) | GB2495884B (es) |
| IT (1) | ITTO20110639A1 (es) |
| LT (1) | LT5988B (es) |
| MX (1) | MX2013000543A (es) |
| NO (1) | NO20130222A1 (es) |
| NZ (1) | NZ606767A (es) |
| PE (1) | PE20130398A1 (es) |
| SG (2) | SG10201505561TA (es) |
| WO (1) | WO2012007845A2 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130064860A1 (en) * | 2010-07-15 | 2013-03-14 | Oleg Iliich Epshtein | Combination pharmaceutical composition and methods of theating genitourinary system disorders |
| US9308275B2 (en) * | 2010-07-15 | 2016-04-12 | Oleg Iliich Epshtein | Method of increasing the effect of an activated-potentiated form of an antibody |
| AU2011281248B2 (en) * | 2010-07-21 | 2017-02-02 | Oleg Lliich Epshtein | Combination pharmaceutical compositions and method of treatment of vertigo, kinetosis and vegetative-vascular dystonia |
| SG187578A1 (en) * | 2010-07-21 | 2013-03-28 | Oleg Iliich Epshtein | A combination pharmaceutical composition and methods of treating diabetes and metabolic disorders |
| EP2450375A1 (en) | 2010-11-09 | 2012-05-09 | Sandoz Gmbh | Cell culture medium and process for protein expression, said medium and process comprising a PAM inhibitor |
| RU2013111962A (ru) * | 2013-03-18 | 2014-09-27 | Олег Ильич Эпштейн | Способ определения выраженности модифицирующей активности, ассоциированной с носителем |
| RU2013111961A (ru) * | 2013-03-18 | 2014-09-27 | Олег Ильич Эпштейн | Способ определения выраженности модифицирующей активности, ассоциированной с носителем |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1466622A1 (en) * | 2001-12-26 | 2004-10-13 | Oleg Iliich Epshtein | Medicinal agent and method for curing diseases accompanied with vascular dystonia |
| EP1547612A1 (en) * | 2002-08-02 | 2005-06-29 | Oleg Iliich Epshtein | Medicinal agent and method for curing erectile dysfunction |
| EP1547611A1 (en) * | 2002-08-02 | 2005-06-29 | Oleg Iliich Epshtein | Medicinal agent and method for curing prostate diseases |
| EP2036574A1 (en) * | 2006-06-06 | 2009-03-18 | Oleg Iliich Epshtein | Medicinal agent for treating fatness, diabetes, and diseases associated with impaired glucose tolerance |
| US20100166762A1 (en) * | 2000-06-20 | 2010-07-01 | Oleg Iliich Epshtein | Method of treating a pathological syndrome |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB750155A (en) | 1953-03-17 | 1956-06-13 | Nat Res Dev | Substituted alanines |
| US3134718A (en) | 1963-12-12 | 1964-05-26 | Schering Corp | Pregna-1,4-dienes and compositions containing same |
| US3901967A (en) | 1973-09-10 | 1975-08-26 | Union Corp | Sustained release of atropine |
| SE393532B (sv) | 1974-05-02 | 1977-05-16 | Draco Ab | Sett att framstella en farmaceutisk zinkberedning for astadkommande av en smaklig, fordragbar, peroral zinklosning innehallande ett zinkkomplex |
| US4311897A (en) | 1979-08-28 | 1982-01-19 | Union Carbide Corporation | Plasma arc torch and nozzle assembly |
| US4963367A (en) | 1984-04-27 | 1990-10-16 | Medaphore, Inc. | Drug delivery compositions and methods |
| US4839341A (en) | 1984-05-29 | 1989-06-13 | Eli Lilly And Company | Stabilized insulin formulations |
| SU1331508A1 (ru) | 1985-08-14 | 1987-08-23 | Киевский Кабельный Завод "Укркабель" | Устройство дл пневматического массажа урогенитальной сферы человека |
| FI101344B1 (fi) | 1988-03-31 | 1998-06-15 | Tanabe Seiyaku Co | Menetelmä valmistaa valmiste, josta kontrolloidusti vapautuu farmaseuttisesti aktiivista ainetta |
| US4987127A (en) | 1989-01-31 | 1991-01-22 | Dal Sirany | Method of treating a virus outbreak |
| SU1730144A1 (ru) | 1989-02-24 | 1992-04-30 | Научный Центр По Разработке И Внедрению Современных Методов Молекулярной Диагностики | Способ подавлени репродукции вирусов |
| US5733572A (en) | 1989-12-22 | 1998-03-31 | Imarx Pharmaceutical Corp. | Gas and gaseous precursor filled microspheres as topical and subcutaneous delivery vehicles |
| US5698195A (en) | 1991-03-18 | 1997-12-16 | New York University Medical Center | Methods of treating rheumatoid arthritis using chimeric anti-TNF antibodies |
| RU2007989C1 (ru) | 1991-11-12 | 1994-02-28 | Акционерное общество "Трейдис" | Способ габович подбора гомеопатических препаратов и их разовой дозы |
| EP0663836B1 (en) | 1992-10-08 | 1997-07-09 | The Kennedy Institute Of Rheumatology | Treatment of autoimmune and inflammatory disorders |
| DK140992D0 (da) | 1992-11-24 | 1992-11-24 | Ole Buchardt | Fremgangsmaade til frembringelse af antistoffer mod haptener og andre b-celle-antigener, antistoffer opnaaet ved fremgangsmaaden og anvendelse af disse antistoffer til fremstilling af vacciner, isaer til veterinaermedicinsk brug |
| US5879677A (en) | 1992-12-09 | 1999-03-09 | The Scripps Research Institute | Method for inhibition of cerebral tissue factor mediated reperfusion damage |
| WO1994022846A1 (en) | 1993-03-30 | 1994-10-13 | Pfizer Inc. | Compounds enhancing antitumor activity of other cytotoxic agents |
| RU2033784C1 (ru) | 1993-05-28 | 1995-04-30 | Индивидуальное частное предприятие "Диалог" | Устройство для репродуцирования гомеопатических и изопатических препаратов |
| US5895783A (en) | 1993-07-16 | 1999-04-20 | Schering Aktiengesellschaft | Treatment of preeclampsia and preterm labor with combination of progestational agent and a nitric oxide synthase substrate and/or donor |
| IT1261849B (it) | 1993-09-02 | 1996-06-03 | Avantgarde Spa | Dispositivo medico per la somministrazione di principi attivi o farmaci a bassissimo dosaggio, in particolare di farmaci omeopatici. |
| EP0652014A1 (en) | 1993-11-10 | 1995-05-10 | National Institute Of Immunology | Treatment of prostatic hypertrophy |
| NZ278607A (en) | 1994-02-07 | 1999-05-28 | Knoll Ag | Use of tnf antagonists for treating disorders involving elevated serum levels of il-6 wherein the serum levels are 500pg/ml or above |
| WO1995026325A2 (en) | 1994-03-25 | 1995-10-05 | Isotechnika Inc. | Enhancement of the efficacy of drugs by deuteration |
| US5629286A (en) | 1994-03-31 | 1997-05-13 | Brewitt; Barbara | Homeopathic dilutions of growth factors |
| IL110035A0 (en) | 1994-06-16 | 1994-10-07 | Tapuach Natural Technologies 1 | Homeopathic formulations |
| RU2137483C1 (ru) | 1995-08-02 | 1999-09-20 | Божедомов Владимир Александрович | Способ лечения урогенитальной хламидийной, уреаплазменной и микоплазменной инфекции |
| US6379669B1 (en) | 1995-08-04 | 2002-04-30 | Akhouri A. Sinha | Targeting of organs by immunoconjugates |
| WO1997009056A1 (fr) | 1995-09-07 | 1997-03-13 | L'oreal | Extrait d'iridacees et compositions le contenant |
| KR19990082461A (ko) | 1996-02-12 | 1999-11-25 | 올레그 일리치 엡슈타인 | 약제 및 생물체를 약제로 치료하는 방법 |
| IL118096A0 (en) | 1996-05-01 | 1996-09-12 | Yeda Res & Dev | Antibodies against interferon alpha/beta receptor |
| US6150500A (en) | 1996-07-12 | 2000-11-21 | Salerno; John C. | Activators of endothelial nitric oxide synthase |
| SE9604341D0 (sv) | 1996-11-26 | 1996-11-26 | Ferring Bv | Hepta-peptide oxytocin analogue |
| RU2104032C1 (ru) | 1997-03-11 | 1998-02-10 | Общество с ограниченной ответственностью "Снежный барс" | Способ усиления лечебного эффекта лекарственных средств |
| US5849528A (en) | 1997-08-21 | 1998-12-15 | Incyte Pharmaceuticals, Inc.. | Polynucleotides encoding a human S100 protein |
| DE19746868A1 (de) | 1997-10-23 | 1999-04-29 | Knoll Ag | Verwendung von TNF-Antagonisten als Arzneimittel zur Behandlung von septischen Erkrankungen |
| WO1999026657A1 (en) | 1997-11-25 | 1999-06-03 | Musc Foundation For Research Development | Inhibitors of nitric oxide synthase |
| RU2122858C1 (ru) | 1997-12-29 | 1998-12-10 | Яковлева Людмила Борисовна | Гомеопатическое лекарственное средство седативного действия "вернисон" |
| US6326360B1 (en) | 1998-03-11 | 2001-12-04 | Grelan Pharmaceuticals Co., Ltd. | Bubbling enteric coated preparations |
| RU2187334C2 (ru) | 1998-05-22 | 2002-08-20 | Эпштейн Олег Ильич | Способ коррекции нарушенного иммунного гомеостаза и лекарственное средство |
| US6933272B1 (en) | 1998-09-22 | 2005-08-23 | Erik Helmerhorst | Use of non-peptidyl compounds for the treatment of insulin related ailments |
| RU2144370C1 (ru) | 1999-01-06 | 2000-01-20 | Титиева Наталья Михайловна | Гомеопатическое лекарственное средство для лечения гипертрофии предстательной железы |
| RU2156621C1 (ru) | 1999-03-04 | 2000-09-27 | Эпштейн Олег Ильич | Нейротропное лекарственное средство |
| RU2177795C1 (ru) | 2001-02-15 | 2002-01-10 | Эпштей Олег Ильич | Гомеопатическое лекарственное средство для лечения и профилактики аденовирусных инфекций у детей |
| RU2192882C1 (ru) | 2001-04-18 | 2002-11-20 | Эпштейн Олег Ильич | Лекарственное средство и способ лечения патологического синдрома, обусловленного нарушением кроветворения |
| RU2199345C1 (ru) | 2001-12-26 | 2003-02-27 | Эпштейн Олег Ильич | Лекарственное средство и способ регуляции углеводного и жирового обмена |
| UA76638C2 (en) | 2002-08-02 | 2006-08-15 | Oleh Illich Epshtein | Homeopathic medication based on anti-interferon antibodies and method for treating a pathological syndrome associated with interferon |
| UA76640C2 (uk) | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Спосіб корекції патологічних імунних реакцій та гомеопатичний лікарський засіб |
| US7229648B2 (en) | 2003-03-14 | 2007-06-12 | Dreyer Lee R | Homeopathic formulations useful for treating pain and/or inflammation |
| RU2253478C1 (ru) | 2003-10-01 | 2005-06-10 | Эпштейн Олег Ильич | Средство для потенцирования лечебных эффектов - усиления действия лекарственного вещества |
| JP2007518692A (ja) * | 2004-01-20 | 2007-07-12 | アステラス製薬株式会社 | 勃起不全治療方法 |
| BRPI0514903A (pt) * | 2004-09-03 | 2008-06-24 | Hansens Lab | proteìnas vegetais ou leite fermentado compreendendo ligando de receptor e uso dos mesmos |
| RU2309732C1 (ru) | 2006-03-13 | 2007-11-10 | Олег Ильич Эпштейн | Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата |
| MX2008012549A (es) * | 2006-04-04 | 2009-01-14 | Dong A Pharm Co Ltd | Agente para la prevencion y tratamiento de hiperplasia prostatica que comprende compuesto de pirazolopirimidinona. |
| RU2438707C2 (ru) | 2006-06-06 | 2012-01-10 | Олег Ильич Эпштейн | Лекарственное средство для перорального лечения сахарного диабета и других заболеваний, сопровождающихся нарушением толерантности к глюкозе, и способ получения твердой лекарственной формы для пероральной терапии сахарного диабета и других заболеваний, сопровождающихся нарушением толерантности к глюкозе |
| EP2040756A4 (en) * | 2006-07-13 | 2013-01-09 | Mazence Inc | COMPOSITION CONTAINING ACIDIC AMINO ACID CHELATE AND METAL ACCELERATING METAL ABSORPTION |
| GB0812019D0 (en) | 2008-07-02 | 2008-08-06 | Asterion Ltd | Insulin |
| US20130189707A1 (en) | 2010-01-26 | 2013-07-25 | Svetlana Alexandrovna Sergeeva | Method of determination of autoantibody level by means of enzyme immunoassay |
| US9308275B2 (en) * | 2010-07-15 | 2016-04-12 | Oleg Iliich Epshtein | Method of increasing the effect of an activated-potentiated form of an antibody |
| US20130064860A1 (en) * | 2010-07-15 | 2013-03-14 | Oleg Iliich Epshtein | Combination pharmaceutical composition and methods of theating genitourinary system disorders |
| CA2804964C (en) | 2010-07-15 | 2016-06-28 | Oleg Iliich Epshtein | Combination pharmaceutical composition and methods of treating functional diseases or conditions of gastrointestinal tract |
| EA029436B1 (ru) | 2010-07-15 | 2018-03-30 | Олег Ильич ЭПШТЕЙН | Комбинированная фармацевтическая композиция для лечения рассеянного склероза и инфекционных заболеваний, сопровождающихся нейротоксическими нарушениями, и способы лечения указанных заболеваний |
| AU2011278040B2 (en) | 2010-07-15 | 2016-06-02 | Oleg Iliich Epshtein | Pharmaceutical compositions and methods of treatment |
| EP2593482A2 (en) | 2010-07-15 | 2013-05-22 | Oleg Iliich Epshtein | A combination pharmaceutical composition and methods of treating diseases or conditions associated with the cardiovascular system |
| AU2011281248B2 (en) * | 2010-07-21 | 2017-02-02 | Oleg Lliich Epshtein | Combination pharmaceutical compositions and method of treatment of vertigo, kinetosis and vegetative-vascular dystonia |
| WO2012014078A2 (en) * | 2010-07-21 | 2012-02-02 | Olge Iliich Epshtein | Method of treatment of organic diseases of nervous system, psychoorganic syndrome and encephalopathy |
| EP2596019A2 (en) * | 2010-07-21 | 2013-05-29 | Oleg Iliich Epshtein | A method of treating attention deficit hyperactivity disorder |
| AU2011281247B2 (en) | 2010-07-21 | 2015-07-30 | Oleg Iliich Epshtein | Combination pharmaceutical composition and methods of treating diseases or conditions associated with respiratory disease or condition |
| SG187578A1 (en) * | 2010-07-21 | 2013-03-28 | Oleg Iliich Epshtein | A combination pharmaceutical composition and methods of treating diabetes and metabolic disorders |
| CN103119060A (zh) * | 2010-07-21 | 2013-05-22 | 奥列格·伊里奇·爱泼斯坦 | 治疗阿尔兹海默病的方法 |
| RU2535033C2 (ru) | 2010-08-06 | 2014-12-10 | Олег Ильич Эпштейн | Лекарственное средство и способ профилактики инфицирования вич, профилактики и лечения заболеваний, вызываемых вич или ассоциированных с вич, в том числе спида |
| US20120263725A1 (en) | 2010-08-06 | 2012-10-18 | Epshtein Oleg Iiiich | Pharmaceutical composition and methods of treating and preventing the diseases caused by HIV or associated with HIV |
| RU2517084C2 (ru) | 2010-08-06 | 2014-05-27 | Олег Ильич Эпштейн | Способ и средство для ингибирования продукции или усиления элиминации белка р24 |
| SG187732A1 (en) | 2010-08-06 | 2013-03-28 | Oleg Iliich Epshtein | Combination pharmaceutical composition and methods of treating and preventing the infectious diseases |
| RU2535034C2 (ru) | 2010-08-06 | 2014-12-10 | Олег Ильич Эпштейн | Лекарственное средство и способ профилактики инфицирования вич, профилактики и лечения заболеваний, вызываемых вич или ассоциированных с вич, в том числе спида |
| US20130171161A1 (en) | 2010-12-23 | 2013-07-04 | Oleg Iliich Epshtein | Method and composition for the treatment of diseases caused by or associated with hiv |
| JP5418549B2 (ja) * | 2011-07-06 | 2014-02-19 | アイシン精機株式会社 | 車両のドアアウタハンドル装置 |
-
2011
- 2011-07-15 US US13/135,901 patent/US9308275B2/en active Active
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- 2011-07-15 ES ES201390006A patent/ES2440393R1/es active Pending
- 2011-07-15 PE PE2013000076A patent/PE20130398A1/es not_active Application Discontinuation
- 2011-07-15 KR KR1020137003861A patent/KR20140014059A/ko not_active Application Discontinuation
- 2011-07-15 BR BR112013000840A patent/BR112013000840A2/pt not_active IP Right Cessation
- 2011-07-15 FR FR1156482A patent/FR2962656A1/fr not_active Withdrawn
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- 2011-07-15 DE DE112011102358T patent/DE112011102358T5/de not_active Withdrawn
- 2011-07-15 IT IT000639A patent/ITTO20110639A1/it unknown
- 2011-07-15 GB GB1302649.7A patent/GB2495884B/en not_active Expired - Fee Related
- 2011-07-15 WO PCT/IB2011/002350 patent/WO2012007845A2/en active Application Filing
- 2011-07-15 EA EA201300126A patent/EA030566B1/ru not_active IP Right Cessation
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- 2011-07-15 JP JP2013519175A patent/JP2013538186A/ja active Pending
- 2011-07-15 CA CA2804966A patent/CA2804966A1/en not_active Abandoned
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- 2011-07-15 AU AU2011278038A patent/AU2011278038B2/en not_active Ceased
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- 2013-02-08 NO NO20130222A patent/NO20130222A1/no not_active Application Discontinuation
- 2013-02-14 LT LT2013016A patent/LT5988B/lt not_active IP Right Cessation
- 2013-02-14 DK DKPA201370079A patent/DK201370079A/da not_active Application Discontinuation
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- 2016-03-03 US US15/060,202 patent/US20160251448A1/en not_active Abandoned
- 2016-03-03 US US15/060,157 patent/US20160244531A1/en not_active Abandoned
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100166762A1 (en) * | 2000-06-20 | 2010-07-01 | Oleg Iliich Epshtein | Method of treating a pathological syndrome |
| EP1466622A1 (en) * | 2001-12-26 | 2004-10-13 | Oleg Iliich Epshtein | Medicinal agent and method for curing diseases accompanied with vascular dystonia |
| EP1547612A1 (en) * | 2002-08-02 | 2005-06-29 | Oleg Iliich Epshtein | Medicinal agent and method for curing erectile dysfunction |
| EP1547611A1 (en) * | 2002-08-02 | 2005-06-29 | Oleg Iliich Epshtein | Medicinal agent and method for curing prostate diseases |
| EP2036574A1 (en) * | 2006-06-06 | 2009-03-18 | Oleg Iliich Epshtein | Medicinal agent for treating fatness, diabetes, and diseases associated with impaired glucose tolerance |
Non-Patent Citations (4)
| Title |
|---|
| Jonas W. B. et al. A critical overview of homeopathy. Ann. Intern. Med. 2003, Vol. 138, páginas 393-399 (todo el documento) * |
| Markel A. L. et al . Hypotensive activity of ultralow doses of antibodies to factors involved in the regulation of vascular tone. Bulletin of Experimental Biology and Medicine. Supplement 1, 2003 (todo el documento) * |
| Shang A. et al. Are the clinical effects of homoeopathy placebo effects? Comparative study of placebo-controlled trials of homoeopathy and allopathy. The Lancet. 27.08.2005, Vol. 366, páginas 726-732 (todo el documento) * |
| Vickers A. J. et al. Clinical Trials of Homeopathy and Placebo: Analysis of a Scientific Debate. The Journal of Alternative and Complementary Medicine. 2000, Vol. 6, Nº 1, páginas 49-56 (todo el documento) * |
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