ES2422275T3 - Derivado del oxindol sustituido y su uso como un modulador del receptor de la vasopresina - Google Patents

Derivado del oxindol sustituido y su uso como un modulador del receptor de la vasopresina

Info

Publication number
ES2422275T3
ES2422275T3 ES07866323T ES07866323T ES2422275T3 ES 2422275 T3 ES2422275 T3 ES 2422275T3 ES 07866323 T ES07866323 T ES 07866323T ES 07866323 T ES07866323 T ES 07866323T ES 2422275 T3 ES2422275 T3 ES 2422275T3
Authority
ES
Spain
Prior art keywords
derived
receptor modulator
vasopressin receptor
substituted oxindole
oxindole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07866323T
Other languages
English (en)
Inventor
Astrid Netz
Thorsten Oost
Herve Geneste
Wilfried Martin Braje
Wolfgang Wernet
Liliane Unger
Wilfried Hornberger
Wilfried Lubisch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Abbott GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott GmbH and Co KG filed Critical Abbott GmbH and Co KG
Application granted granted Critical
Publication of ES2422275T3 publication Critical patent/ES2422275T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)

Abstract

Compuesto de la fórmula general (I) **Fórmula** y las sales farmacéuticamente aceptables y las formas tautoméricas de este.
ES07866323T 2006-12-30 2007-12-28 Derivado del oxindol sustituido y su uso como un modulador del receptor de la vasopresina Active ES2422275T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006062506 2006-12-30
PCT/EP2007/064621 WO2008080972A1 (en) 2006-12-30 2007-12-28 Substituted oxindole derivative and its use as a vasopressin receptor modulator

Publications (1)

Publication Number Publication Date
ES2422275T3 true ES2422275T3 (es) 2013-09-10

Family

ID=39122411

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07866323T Active ES2422275T3 (es) 2006-12-30 2007-12-28 Derivado del oxindol sustituido y su uso como un modulador del receptor de la vasopresina

Country Status (4)

Country Link
EP (1) EP2114922B1 (es)
ES (1) ES2422275T3 (es)
HK (1) HK1132742A1 (es)
WO (1) WO2008080972A1 (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8580842B2 (en) 2003-09-30 2013-11-12 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US20080167286A1 (en) 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
US8486979B2 (en) 2006-12-12 2013-07-16 Abbvie Inc. 1,2,4 oxadiazole compounds and methods of use thereof
UY30846A1 (es) 2006-12-30 2008-07-31 Abbott Gmbh & Amp Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos
US8703774B2 (en) 2007-12-07 2014-04-22 AbbVie Deutschland GmbH & Co. KG Carbamate-substituted oxindole derivatives and use thereof for the treatment of vasopressin-dependent diseases
JP5595926B2 (ja) * 2007-12-07 2014-09-24 アボット ゲーエムベーハー ウント カンパニー カーゲー 5−ハロゲン−置換オキシインドール誘導体およびバソプレッシン依存性疾患の治療へのこれらの使用
WO2009071691A2 (de) * 2007-12-07 2009-06-11 Abbott Gmbh & Co. Kg Oxindol-derivate und ihre verwendung als medikament
MX2010006202A (es) * 2007-12-07 2011-03-04 Abbott Gmbh & Co Kg Derivados de oxindol substituidos por amidometil y el uso de los mismos para el tratamiento de enfermedades dependientes de la vasopresina.
CN102026995B (zh) * 2007-12-07 2014-10-29 Abbvie德国有限责任两合公司 5,6-二取代的羟吲哚衍生物和其用途
WO2010138600A2 (en) 2009-05-29 2010-12-02 Abbott Laboratories Pharmaceutical compositions for the treatment of pain
CA2763931A1 (en) * 2009-06-10 2010-12-16 Abbott Gmbh & Co. Kg Use of substituted oxindole derivatives for the treatment and prophylaxis of pain
US9273036B2 (en) 2013-03-14 2016-03-01 AbbVie Deutschland GmbH & Co. KG Oxindole derivatives carrying an oxetane substituent and use thereof for treating vasopressine-related diseases
CA2903141A1 (en) 2013-03-14 2014-09-18 AbbVie Deutschland GmbH & Co. KG Oxindole derivatives carrying an oxetane substituent and use thereof for treating vasopressine-related diseases
US9862704B2 (en) 2013-12-20 2018-01-09 AbbVie Deutschland GmbH & Co. KG Oxindole derivatives carrying an amine-substituted piperidyl-acetidinyl substituent and use thereof for treating vasopressine-related diseases
WO2015091931A1 (en) 2013-12-20 2015-06-25 AbbVie Deutschland GmbH & Co. KG Oxindole derivatives carrying a piperidyl-substituted azetidinyl substituent and use thereof for treating vasopressine-related diseases
WO2015173392A1 (en) 2014-05-15 2015-11-19 AbbVie Deutschland GmbH & Co. KG Oxindole compounds carrying a co-bound spiro substituent and use thereof for treating vasopressin-related diseases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050070718A1 (en) * 2003-09-30 2005-03-31 Abbott Gmbh & Co. Kg Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
DE102004033834A1 (de) * 2004-07-13 2006-02-02 Abbott Gmbh & Co. Kg Substituierte Oxindol-Derivate und diese enthaltende Arzneimittel
MX2007011693A (es) * 2005-03-24 2008-03-11 Abbott Gmbh & Co Kg Derivados de oxindoles sustituidos, farmacos que contienen dichos derivados y uso de los mismos.
DE102005014904A1 (de) * 2005-03-26 2007-02-01 Abbott Gmbh & Co. Kg Substituierte Oxindol-Derivate, diese enthaltende Arzneimittel und deren Verwendung

Also Published As

Publication number Publication date
HK1132742A1 (en) 2010-03-05
WO2008080972A1 (en) 2008-07-10
EP2114922A1 (en) 2009-11-11
EP2114922B1 (en) 2013-04-24

Similar Documents

Publication Publication Date Title
ES2422275T3 (es) Derivado del oxindol sustituido y su uso como un modulador del receptor de la vasopresina
DOP2010000047A (es) Compuestos de pirazol y su uso como inhibidores de raf
NI200900040A (es) Derivados de quinazolinona 5-substituidos como agentes antitumorales.
ECSP10010722A (es) Compuestos orgánicos
DK2134691T3 (da) Quinolinonderivativer som parp- og tank-inhibitorer
CL2008002539A1 (es) Compuestos derivados de indol sustituidos; composicion farmaceutica que los comprende; y su uso para el tratamiento de una infeccion viral
HN2006018410A (es) Nuevos derivados del fluoreno, composiciones que los contienen y utilizacion
ECSP11011054A (es) Péptidos antivirales terapéuticos
EA200901109A1 (ru) Применение n-фениламидинов в качестве гербицидов
UY30498A1 (es) Nueva clase de compuestos de benzimidazolilo, sus sales, composiciones farmacéuticas conteniéndolos y aplicaciones
CR10696A (es) Compuestos de n-metilaminometil isoindol, composiciones que las comprenden y metodos que utilizan los mismos
CR11819A (es) Compuestos de isoindolina 5-sustituidos
ATE483707T1 (de) 2-cyclopropylthiazolderivate
EA201000544A1 (ru) Производные спирогетероциклического пирролидиндиона, применимые в качестве пестицидов
UY30881A1 (es) Derivados de fenotiazina, procedimientos y su uso como productos farmacéuticos
DK1907484T3 (da) Naphtalen-amidin-imider
RS52700B (en) SUBSTITUTED OXINDOL DERIVATIVE AND ITS USE AS A VASOPRESIN RECEPTOR LIGAND
CR20110100A (es) Nuevos derivados de sulfamida sustituida
NI200900155A (es) COMPUESTOS DE 2-AMINO PIRIMIDINA. Caso: PC 33441A
ES2572001T3 (es) Derivado de bisfurano antivírico como inhibidor de la proteasa del VIH e intermedios del mismo
BRPI0814772A2 (pt) Indazóis substituídos por 5-piridinona
CR11765A (es) Derivados de iminopiridina y su uso
EA201170585A1 (ru) Производные изохинолинона в качестве антагонистов nk3
EA201000069A1 (ru) Новые гербициды
ECSP10010379A (es) Derivados de oxindol sustituido y su uso para el tratamiento de enfermedades dependientes de la vasopresina