ES2398096T3 - Anticuerpo que enlaza con la integrina alfa4beta7 y su uso para tratar la enfermedad intestinal inflamatoria - Google Patents

Anticuerpo que enlaza con la integrina alfa4beta7 y su uso para tratar la enfermedad intestinal inflamatoria Download PDF

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Publication number
ES2398096T3
ES2398096T3 ES01925028T ES01925028T ES2398096T3 ES 2398096 T3 ES2398096 T3 ES 2398096T3 ES 01925028 T ES01925028 T ES 01925028T ES 01925028 T ES01925028 T ES 01925028T ES 2398096 T3 ES2398096 T3 ES 2398096T3
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ES
Spain
Prior art keywords
antigen
binds
days
fragment
day
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01925028T
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English (en)
Spanish (es)
Inventor
Lee R. Brettman
Judith A. Fox
David Edward Allison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Millennium Pharmaceuticals Inc
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Genentech Inc
Millennium Pharmaceuticals Inc
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Filing date
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Publication of ES2398096T3 publication Critical patent/ES2398096T3/es
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Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Emergency Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
ES01925028T 2000-04-14 2001-04-13 Anticuerpo que enlaza con la integrina alfa4beta7 y su uso para tratar la enfermedad intestinal inflamatoria Expired - Lifetime ES2398096T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US55008200A 2000-04-14 2000-04-14
US550082 2000-04-14
US748960 2000-12-27
US09/748,960 US20010046496A1 (en) 2000-04-14 2000-12-27 Method of administering an antibody
PCT/US2001/012234 WO2001078779A2 (en) 2000-04-14 2001-04-13 Antibody alpha4beta7 integrin and its use to treat inflammatory bowel disease

Publications (1)

Publication Number Publication Date
ES2398096T3 true ES2398096T3 (es) 2013-03-13

Family

ID=27069332

Family Applications (2)

Application Number Title Priority Date Filing Date
ES01925028T Expired - Lifetime ES2398096T3 (es) 2000-04-14 2001-04-13 Anticuerpo que enlaza con la integrina alfa4beta7 y su uso para tratar la enfermedad intestinal inflamatoria
ES10010997.4T Expired - Lifetime ES2609689T3 (es) 2000-04-14 2001-04-13 Anticuerpo que enlaza con la integrina alfa4beta7 y su uso para tratar la enfermedad intestinal inflamatoria

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES10010997.4T Expired - Lifetime ES2609689T3 (es) 2000-04-14 2001-04-13 Anticuerpo que enlaza con la integrina alfa4beta7 y su uso para tratar la enfermedad intestinal inflamatoria

Country Status (15)

Country Link
US (5) US20010046496A1 (OSRAM)
EP (3) EP1278543B1 (OSRAM)
JP (3) JP2003531129A (OSRAM)
AU (1) AU2001251629A1 (OSRAM)
BE (1) BE2017C009I2 (OSRAM)
CA (1) CA2406220C (OSRAM)
CY (3) CY1113489T1 (OSRAM)
DK (2) DK1278543T3 (OSRAM)
ES (2) ES2398096T3 (OSRAM)
FR (1) FR14C0080I2 (OSRAM)
LU (1) LUC00014I2 (OSRAM)
MX (1) MXPA02010059A (OSRAM)
NL (1) NL300702I1 (OSRAM)
PT (1) PT2298348T (OSRAM)
WO (1) WO2001078779A2 (OSRAM)

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Publication number Publication date
CY2014046I2 (el) 2016-04-13
AU2001251629A1 (en) 2001-10-30
MXPA02010059A (es) 2004-08-19
LUC00014I2 (OSRAM) 2017-06-19
US20140186345A1 (en) 2014-07-03
HK1054320A1 (en) 2003-11-28
DK2298348T3 (en) 2017-01-30
WO2001078779A2 (en) 2001-10-25
ES2609689T3 (es) 2017-04-21
CY2014046I1 (el) 2016-04-13
EP1278543A2 (en) 2003-01-29
CY1113489T1 (el) 2016-04-13
LUC00014I1 (OSRAM) 2017-04-18
EP3167902A1 (en) 2017-05-17
EP2298348A1 (en) 2011-03-23
EP3167902B1 (en) 2020-07-29
US20120034243A1 (en) 2012-02-09
EP2298348B1 (en) 2016-10-12
EP2298348B9 (en) 2017-02-15
BE2017C009I2 (OSRAM) 2017-09-22
DK1278543T3 (da) 2013-01-14
EP1278543B1 (en) 2012-09-19
NL300702I2 (OSRAM) 2016-01-28
CA2406220C (en) 2019-02-12
WO2001078779A3 (en) 2002-07-04
JP2015083603A (ja) 2015-04-30
US20050095238A1 (en) 2005-05-05
JP2003531129A (ja) 2003-10-21
FR14C0080I2 (fr) 2015-10-30
PT2298348T (pt) 2017-01-04
US20010046496A1 (en) 2001-11-29
NL300702I1 (OSRAM) 2016-01-28
US20200002423A1 (en) 2020-01-02
JP2012184241A (ja) 2012-09-27
JP5764524B2 (ja) 2015-08-19
CA2406220A1 (en) 2001-10-25
CY1118429T1 (el) 2017-06-28
JP6021959B2 (ja) 2016-11-09
FR14C0080I1 (OSRAM) 2014-12-19

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