ES2395137T3 - Derivados de azapéptidos como inhibidores de la proteasa VIH - Google Patents
Derivados de azapéptidos como inhibidores de la proteasa VIH Download PDFInfo
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- ES2395137T3 ES2395137T3 ES09075359T ES09075359T ES2395137T3 ES 2395137 T3 ES2395137 T3 ES 2395137T3 ES 09075359 T ES09075359 T ES 09075359T ES 09075359 T ES09075359 T ES 09075359T ES 2395137 T3 ES2395137 T3 ES 2395137T3
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- Prior art keywords
- compound
- atazanavir
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- 239000003871 white petrolatum Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93420107P | 2007-06-12 | 2007-06-12 | |
| US934201P | 2007-06-12 | ||
| US6762708P | 2008-02-29 | 2008-02-29 | |
| US67627P | 2008-02-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2395137T3 true ES2395137T3 (es) | 2013-02-08 |
Family
ID=39730784
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09075359T Active ES2395137T3 (es) | 2007-06-12 | 2008-06-12 | Derivados de azapéptidos como inhibidores de la proteasa VIH |
| ES11155667T Active ES2394952T3 (es) | 2007-06-12 | 2008-06-12 | Derivados de axapéptido como inhibidores de la proteasa VIH |
| ES08252023T Active ES2356334T3 (es) | 2007-06-12 | 2008-06-12 | Derivados de azapéptidos como inhibidores de la proteasa vih. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11155667T Active ES2394952T3 (es) | 2007-06-12 | 2008-06-12 | Derivados de axapéptido como inhibidores de la proteasa VIH |
| ES08252023T Active ES2356334T3 (es) | 2007-06-12 | 2008-06-12 | Derivados de azapéptidos como inhibidores de la proteasa vih. |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US20090036357A1 (OSRAM) |
| EP (3) | EP2003120B9 (OSRAM) |
| JP (1) | JP2010529196A (OSRAM) |
| KR (2) | KR101185899B1 (OSRAM) |
| CN (2) | CN102424668A (OSRAM) |
| AR (1) | AR066972A1 (OSRAM) |
| AT (2) | ATE447554T1 (OSRAM) |
| AU (1) | AU2008267048C1 (OSRAM) |
| BR (2) | BRPI0823520A2 (OSRAM) |
| CA (1) | CA2692028C (OSRAM) |
| CO (1) | CO6241121A2 (OSRAM) |
| CY (1) | CY1109766T1 (OSRAM) |
| DE (1) | DE602008000255D1 (OSRAM) |
| DK (1) | DK2003120T3 (OSRAM) |
| ES (3) | ES2395137T3 (OSRAM) |
| HR (1) | HRP20100065T1 (OSRAM) |
| MX (1) | MX2009013565A (OSRAM) |
| PL (1) | PL2003120T3 (OSRAM) |
| PT (1) | PT2003120E (OSRAM) |
| RS (1) | RS51226B (OSRAM) |
| RU (2) | RU2448958C2 (OSRAM) |
| SI (1) | SI2003120T1 (OSRAM) |
| TW (1) | TW200908970A (OSRAM) |
| WO (1) | WO2008156632A1 (OSRAM) |
| ZA (1) | ZA200909079B (OSRAM) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TW200835693A (en) * | 2007-02-23 | 2008-09-01 | Auspex Pharmaceuticals Inc | Preparation and utility of non-nucleoside reverse transcriptase inhibitors |
| BRPI0823520A2 (pt) * | 2007-06-12 | 2013-12-17 | Concert Pharmaceuticals Inc | Composto derivado de azapeptídeos e composição farmacêutica contendo o mesmo |
| US9163067B2 (en) * | 2008-10-06 | 2015-10-20 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | HIV-1 integrase derived stimulatory peptides interfering with integrase—Rev protein binding |
| WO2010132663A1 (en) * | 2009-05-13 | 2010-11-18 | Concert Pharmaceticals, Inc. | Pegylated azapeptide derivatives as hiv protease inhibitors |
| WO2010135424A1 (en) * | 2009-05-19 | 2010-11-25 | Glaxosmithkline Llc | Chemical compounds |
| MX2012007210A (es) * | 2009-12-21 | 2012-07-23 | Janssen R & D Ireland | Implante removible degradable para la liberacion sostenida de un compuesto activo. |
| WO2011080562A1 (en) | 2009-12-29 | 2011-07-07 | Hetero Research Foundation | Novel aza-peptides containing 2,2-disubstituted cyclobutyl and/or substituted alkoxy benzyl derivatives as antivirals |
| KR101939546B1 (ko) | 2011-06-20 | 2019-01-16 | 하. 룬드벡 아크티에셀스카브 | 정신 분열증의 치료를 위한 중수소화 1-피페라지노-3-페닐 인단 |
| CN106543073A (zh) * | 2015-09-17 | 2017-03-29 | 宁波杰尔盛化工有限公司 | 2-[4-（2-吡啶基）苄基]-肼羧酸叔丁酯的制备方法 |
| US10603282B2 (en) * | 2015-12-02 | 2020-03-31 | Merck Sharp & Dohme Corp. | Pharmaceutical compositions containing doravirine, tenofovir disoproxil fumarate and lamivudine |
| EP4321513A3 (en) | 2016-03-28 | 2024-05-08 | Incyte Corporation | Pyrrolotriazine compounds as tam inhibitors |
| JOP20180009A1 (ar) | 2017-02-06 | 2019-01-30 | Gilead Sciences Inc | مركبات مثبط فيروس hiv |
| WO2019025250A1 (en) | 2017-08-04 | 2019-02-07 | Basf Se | SUBSTITUTED TRIFLUOROMETHYLOXADIAZOLES FOR COMBATING PHYTOPATHOGENIC FUNGI |
| AU2018342471B2 (en) | 2017-09-27 | 2023-08-24 | Incyte Corporation | Salts of pyrrolotriazine derivatives useful as TAM inhibitors |
| DK3813800T3 (da) | 2018-06-29 | 2025-06-02 | Incyte Corp | Formuleringer af en axl/mer-hæmmer |
| TWI829205B (zh) | 2018-07-30 | 2024-01-11 | 美商基利科學股份有限公司 | 抗hiv化合物 |
| AU2021230385A1 (en) | 2020-03-06 | 2022-09-22 | Incyte Corporation | Combination therapy comprising AXL/MER and PD-1/PD-L1 inhibitors |
| JP2023522210A (ja) * | 2020-04-16 | 2023-05-29 | ザ メディカル カレッジ オブ ウィスコンシン インク | 気道逆流の治療のためのｈｉｖプロテアーゼ阻害剤のエアロゾル化製剤 |
| CN115385983A (zh) * | 2022-01-11 | 2022-11-25 | 嘉兴安谛康生物科技有限公司 | 氮杂双环类化合物及其制备方法、药物组合物和用途 |
| AU2024283382A1 (en) | 2023-05-31 | 2025-11-13 | Gilead Sciences, Inc. | Anti-hiv compounds |
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| PT82580B (pt) | 1985-05-15 | 1989-01-17 | Wellcome Found | Processo para a preparacao de 2',3'- didesoxinucleosidos e de composicoes farmaceuticas que os contem |
| GB8815265D0 (en) | 1988-06-27 | 1988-08-03 | Wellcome Found | Therapeutic nucleosides |
| US5552558A (en) * | 1989-05-23 | 1996-09-03 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| US5304121A (en) | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
| GB9009861D0 (en) | 1990-05-02 | 1990-06-27 | Glaxo Group Ltd | Chemical compounds |
| EP0727419B1 (en) | 1992-12-29 | 2002-02-27 | Abbott Laboratories | Intermediates for the preparation of retroviral protease inhibiting compounds |
| US5886026A (en) | 1993-07-19 | 1999-03-23 | Angiotech Pharmaceuticals Inc. | Anti-angiogenic compositions and methods of use |
| ATE372966T1 (de) | 1994-03-25 | 2007-09-15 | Isotechnika Inc | Verbesserung der effektivität von arzneimitteln duren deuterierung |
| US6221335B1 (en) * | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| TW409125B (en) * | 1996-04-22 | 2000-10-21 | Novartis Ag | Antivirally active heterocyclic azahexane derivatives |
| US5849911A (en) | 1996-04-22 | 1998-12-15 | Novartis Finance Corporation | Antivirally active heterocyclic azahexane derivatives |
| WO1997046514A1 (en) | 1996-05-31 | 1997-12-11 | Novartis Ag | Process for the preparation of hydrazine derivatives useful as intermediates for the preparation of peptide analogues |
| US6087383A (en) * | 1998-01-20 | 2000-07-11 | Bristol-Myers Squibb Company | Bisulfate salt of HIV protease inhibitor |
| US6440710B1 (en) * | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| GB9914821D0 (en) | 1999-06-24 | 1999-08-25 | Glaxo Group Ltd | Compounds |
| GB9925962D0 (en) | 1999-11-02 | 1999-12-29 | Novartis Ag | Organic compounds |
| PT1104760E (pt) * | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Compostos de sulfamoil-heteroarilpirazole como agentes analgesicos e anti-inflamatorios |
| EP1390063B1 (en) | 2001-05-03 | 2004-11-17 | F. Hoffmann-La Roche Ag | Pharmaceutical dosage form of amorphous nelfinavir mesylate |
| US6737042B2 (en) | 2001-05-24 | 2004-05-18 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
| YU12204A (sh) | 2001-08-31 | 2006-08-17 | Bristol Myers Squibb Company | Korišćenje atazanavira u terapiji hiv-a |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| AU2004273773B2 (en) | 2003-02-21 | 2008-01-24 | Jarrow Formulas, Inc. | Methods for treatment of HIV or malaria using combinations of chloroquine and protease inhibitors |
| US20050131017A1 (en) | 2003-12-11 | 2005-06-16 | Degoey David A. | HIV protease inhibiting compounds |
| US20050148523A1 (en) | 2003-12-15 | 2005-07-07 | Colonno Richard J. | Method of treating HIV infection in atazanavir-resistant patients using a combination of atazanavir and another protease inhibitor |
| US7829720B2 (en) * | 2004-05-04 | 2010-11-09 | Bristol-Myers Squibb Company | Process for preparing atazanavir bisulfate and novel forms |
| AU2005270124B2 (en) * | 2004-07-06 | 2011-09-08 | Abbvie Inc. | Prodrugs of HIV protease inhibitors |
| KR20070083839A (ko) | 2004-09-29 | 2007-08-24 | 코디스 코포레이션 | 안정한 무정형 라파마이신 유사 화합물의 약학적 투약 형태 |
| CA2588466A1 (en) | 2004-12-03 | 2006-06-08 | Merck & Co., Inc. | Use of atazanavir for improving the pharmacokinetics of drugs metabolized by ugt1a1 |
| EP1934201A1 (en) * | 2005-10-06 | 2008-06-25 | Auspex Pharmaceuticals Inc. | Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties |
| US7750168B2 (en) * | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
| MX2009002398A (es) * | 2006-09-05 | 2009-03-16 | Schering Corp | Combinaciones farmaceuticas para manejo de lipidos y en el tratamiento de aterosclerosis y estatosis hepatica. |
| BRPI0823520A2 (pt) * | 2007-06-12 | 2013-12-17 | Concert Pharmaceuticals Inc | Composto derivado de azapeptídeos e composição farmacêutica contendo o mesmo |
| US20090076097A1 (en) * | 2007-09-14 | 2009-03-19 | Protia, Llc | Deuterium-enriched atazanavir |
| WO2010132663A1 (en) | 2009-05-13 | 2010-11-18 | Concert Pharmaceticals, Inc. | Pegylated azapeptide derivatives as hiv protease inhibitors |
-
2008
- 2008-06-12 BR BRPI0823520-1A patent/BRPI0823520A2/pt not_active IP Right Cessation
- 2008-06-12 EP EP08252023A patent/EP2003120B9/en active Active
- 2008-06-12 RU RU2010100821/04A patent/RU2448958C2/ru not_active IP Right Cessation
- 2008-06-12 ES ES09075359T patent/ES2395137T3/es active Active
- 2008-06-12 DE DE602008000255T patent/DE602008000255D1/de active Active
- 2008-06-12 WO PCT/US2008/007331 patent/WO2008156632A1/en not_active Ceased
- 2008-06-12 CA CA2692028A patent/CA2692028C/en not_active Expired - Fee Related
- 2008-06-12 SI SI200830012T patent/SI2003120T1/sl unknown
- 2008-06-12 MX MX2009013565A patent/MX2009013565A/es active IP Right Grant
- 2008-06-12 AT AT08252023T patent/ATE447554T1/de active
- 2008-06-12 PT PT08252023T patent/PT2003120E/pt unknown
- 2008-06-12 ES ES11155667T patent/ES2394952T3/es active Active
- 2008-06-12 BR BRPI0813911-3A patent/BRPI0813911A2/pt not_active IP Right Cessation
- 2008-06-12 PL PL08252023T patent/PL2003120T3/pl unknown
- 2008-06-12 AT AT09075359T patent/ATE536343T1/de active
- 2008-06-12 KR KR1020107000675A patent/KR101185899B1/ko not_active Expired - Fee Related
- 2008-06-12 TW TW097122018A patent/TW200908970A/zh unknown
- 2008-06-12 JP JP2010512186A patent/JP2010529196A/ja active Pending
- 2008-06-12 CN CN2011102869075A patent/CN102424668A/zh active Pending
- 2008-06-12 KR KR1020127003399A patent/KR20120029480A/ko not_active Withdrawn
- 2008-06-12 US US12/157,712 patent/US20090036357A1/en not_active Abandoned
- 2008-06-12 ES ES08252023T patent/ES2356334T3/es active Active
- 2008-06-12 EP EP11155667A patent/EP2322509B1/en active Active
- 2008-06-12 RS RSP-2010/0034A patent/RS51226B/sr unknown
- 2008-06-12 DK DK08252023.0T patent/DK2003120T3/da active
- 2008-06-12 CN CN2008800216013A patent/CN101711237B/zh not_active Expired - Fee Related
- 2008-06-12 EP EP09075359A patent/EP2116532B1/en active Active
- 2008-06-12 AR ARP080102501A patent/AR066972A1/es unknown
- 2008-06-12 AU AU2008267048A patent/AU2008267048C1/en not_active Ceased
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2009
- 2009-12-11 CO CO09141805A patent/CO6241121A2/es not_active Application Discontinuation
- 2009-12-18 ZA ZA2009/09079A patent/ZA200909079B/en unknown
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2010
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- 2010-02-03 CY CY20101100099T patent/CY1109766T1/el unknown
- 2010-04-06 US US12/755,184 patent/US8158805B2/en not_active Expired - Fee Related
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2012
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- 2012-03-02 US US13/411,089 patent/US8258309B2/en not_active Expired - Fee Related
- 2012-08-27 US US13/595,511 patent/US20130041156A1/en not_active Abandoned
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