ES2393113T3 - Procedimiento para disolver gases con propiedades físicas de corta duración en un líquido - Google Patents
Procedimiento para disolver gases con propiedades físicas de corta duración en un líquido Download PDFInfo
- Publication number
- ES2393113T3 ES2393113T3 ES06754128T ES06754128T ES2393113T3 ES 2393113 T3 ES2393113 T3 ES 2393113T3 ES 06754128 T ES06754128 T ES 06754128T ES 06754128 T ES06754128 T ES 06754128T ES 2393113 T3 ES2393113 T3 ES 2393113T3
- Authority
- ES
- Spain
- Prior art keywords
- gas
- liquid
- membrane
- hyperpolarized
- physical properties
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 78
- 238000000034 method Methods 0.000 title claims abstract description 59
- 230000000704 physical effect Effects 0.000 title claims abstract description 31
- 239000007789 gas Substances 0.000 title description 95
- 239000012528 membrane Substances 0.000 claims abstract description 68
- 229910052724 xenon Inorganic materials 0.000 claims description 39
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 claims description 39
- 230000008569 process Effects 0.000 claims description 25
- 239000012510 hollow fiber Substances 0.000 claims description 20
- 230000005291 magnetic effect Effects 0.000 claims description 15
- 239000002872 contrast media Substances 0.000 claims description 11
- -1 polypropylene Polymers 0.000 claims description 8
- 238000004458 analytical method Methods 0.000 claims description 7
- 229920000098 polyolefin Polymers 0.000 claims description 7
- 230000002209 hydrophobic effect Effects 0.000 claims description 6
- 229920000642 polymer Polymers 0.000 claims description 6
- 239000004743 Polypropylene Substances 0.000 claims description 4
- 210000004369 blood Anatomy 0.000 claims description 4
- 239000008280 blood Substances 0.000 claims description 4
- 229920001155 polypropylene Polymers 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims description 4
- 210000002381 plasma Anatomy 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 229920000306 polymethylpentene Polymers 0.000 claims description 2
- 239000011116 polymethylpentene Substances 0.000 claims description 2
- 229920001296 polysiloxane Polymers 0.000 claims description 2
- 239000004447 silicone coating Substances 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 241001465754 Metazoa Species 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000000243 solution Substances 0.000 description 22
- 238000005481 NMR spectroscopy Methods 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 11
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 9
- 238000004090 dissolution Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 7
- 239000000126 substance Substances 0.000 description 7
- 239000002904 solvent Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 5
- 230000028161 membrane depolarization Effects 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 230000002285 radioactive effect Effects 0.000 description 5
- 238000003325 tomography Methods 0.000 description 5
- 229910052756 noble gas Inorganic materials 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000005187 foaming Methods 0.000 description 3
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 239000011261 inert gas Substances 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 150000002835 noble gases Chemical class 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000010287 polarization Effects 0.000 description 2
- 238000002600 positron emission tomography Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000004611 spectroscopical analysis Methods 0.000 description 2
- 238000004480 129Xe NMR spectroscopy Methods 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 206010010071 Coma Diseases 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 241001267704 Oxyphanes Species 0.000 description 1
- UQVKZNNCIHJZLS-UHFFFAOYSA-N PhIP Chemical compound C1=C2N(C)C(N)=NC2=NC=C1C1=CC=CC=C1 UQVKZNNCIHJZLS-UHFFFAOYSA-N 0.000 description 1
- 239000004695 Polyether sulfone Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 206010053648 Vascular occlusion Diseases 0.000 description 1
- 210000001557 animal structure Anatomy 0.000 description 1
- 239000003633 blood substitute Substances 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000005294 ferromagnetic effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 238000002309 gasification Methods 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 230000000887 hydrating effect Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 229940102213 injectable suspension Drugs 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000006213 oxygenation reaction Methods 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000003058 plasma substitute Substances 0.000 description 1
- 229920000110 poly(aryl ether sulfone) Polymers 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 229920006393 polyether sulfone Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 208000021331 vascular occlusion disease Diseases 0.000 description 1
- 238000004457 water analysis Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
- B01F23/20—Mixing gases with liquids
- B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
- B01F23/231—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids by bubbling
- B01F23/23105—Arrangement or manipulation of the gas bubbling devices
- B01F23/2312—Diffusers
- B01F23/23124—Diffusers consisting of flexible porous or perforated material, e.g. fabric
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005026604 | 2005-06-09 | ||
| DE102005026604A DE102005026604A1 (de) | 2005-06-09 | 2005-06-09 | Verfahren zum Lösen von Gasen mit kurzlebigen physikalischen Eigenschaften in einer Flüssigkeit |
| PCT/EP2006/005349 WO2006131292A2 (de) | 2005-06-09 | 2006-06-06 | Verfahren zum lösen von gasen mit kurzlebigen physikalischen eigenschaften in einer flüssigkeit |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2393113T3 true ES2393113T3 (es) | 2012-12-18 |
Family
ID=37398693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06754128T Active ES2393113T3 (es) | 2005-06-09 | 2006-06-06 | Procedimiento para disolver gases con propiedades físicas de corta duración en un líquido |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20080199401A1 (enExample) |
| EP (1) | EP1901782B1 (enExample) |
| JP (1) | JP5080457B2 (enExample) |
| DE (1) | DE102005026604A1 (enExample) |
| ES (1) | ES2393113T3 (enExample) |
| WO (1) | WO2006131292A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0804422D0 (en) * | 2008-03-10 | 2008-04-16 | Univ Southampton | An agent for transporting nuclear spin order and for magnetic resonance imaging |
| DE102013013197A1 (de) * | 2013-08-09 | 2015-02-12 | Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Arbeit, dieses vertreten durch den Präsidenten der Physikalisch-Technischen Bundesanstalt Braunschweig und Berlin | Verfahren und Vorrichtung zum kryogenfreien Aufkonzentrieren eines hyperpolarisierten Gases in einem kontinuierlich fließenden Gasstrom und Verwendung |
| FR3030770B1 (fr) | 2014-12-19 | 2019-08-30 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Cellule de mesure de rmn et ensemble de mesure de rmn |
| CN119086618B (zh) * | 2023-09-06 | 2025-10-03 | 中国科学院精密测量科学与技术创新研究院 | 用于超极化129Xe磁共振分子探针流动采样的装置及方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2833493C2 (de) * | 1978-07-31 | 1989-10-12 | Akzo Gmbh, 5600 Wuppertal | Hohlfäden |
| US5357959A (en) * | 1993-04-16 | 1994-10-25 | Praxair Technology, Inc. | Altered dipole moment magnetic resonance imaging method |
| US5545396A (en) * | 1994-04-08 | 1996-08-13 | The Research Foundation Of State University Of New York | Magnetic resonance imaging using hyperpolarized noble gases |
| JP2001503646A (ja) * | 1996-03-29 | 2001-03-21 | ローレンス バークレー ナショナル ラボラトリィ | 過分極化希ガス存在下でのｎｍｒまたはｍｒｉの増強 |
| ATE252916T1 (de) * | 1997-08-12 | 2003-11-15 | Bracco Research Sa | Verabreichbare formulierugen und ihre anwendung in mri |
| JPH11179167A (ja) * | 1997-12-25 | 1999-07-06 | Nitto Denko Corp | スパイラル型膜モジュール |
| JP3352411B2 (ja) * | 1998-03-05 | 2002-12-03 | 株式会社東芝 | 制御システム、電力系統保護制御システムおよびプログラムを記憶した記憶媒体 |
| JP2002507438A (ja) * | 1998-03-18 | 2002-03-12 | メディ−フィジックス・インコーポレイテッド | 溶解化した極性化１２９Ｘｅを用いる肺および心臓脈管構造の映像化および血流を上昇するＭＲ方法 |
| US6284222B1 (en) * | 1998-11-03 | 2001-09-04 | Medi--Physics, Inc. | Hyperpolarized helium-3 microbubble gas entrapment methods |
| CA2401308A1 (en) * | 2000-03-13 | 2001-09-20 | Klaus D. Hagspiel | Diagnostic procedures using direct injection of gaseous hyperpolarized 129xe and associated systems and products |
| US6775568B2 (en) * | 2000-04-12 | 2004-08-10 | University Of Virginia Patent Foundation | Exchange-based NMR imaging and spectroscopy of hyperpolarized xenon-129 |
| US6696040B2 (en) * | 2000-07-13 | 2004-02-24 | Medi-Physics, Inc. | Diagnostic procedures using 129Xe spectroscopy characteristic chemical shift to detect pathology in vivo |
| AU2002258961A1 (en) * | 2001-04-24 | 2002-11-05 | Medi-Physics, Inc. | Methods and devices for moisturizing hyperpolarized noble gases and pharmaceutical products thereof |
-
2005
- 2005-06-09 DE DE102005026604A patent/DE102005026604A1/de not_active Withdrawn
-
2006
- 2006-06-06 WO PCT/EP2006/005349 patent/WO2006131292A2/de not_active Ceased
- 2006-06-06 EP EP06754128A patent/EP1901782B1/de not_active Not-in-force
- 2006-06-06 US US11/916,662 patent/US20080199401A1/en not_active Abandoned
- 2006-06-06 JP JP2008515120A patent/JP5080457B2/ja not_active Expired - Fee Related
- 2006-06-06 ES ES06754128T patent/ES2393113T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006131292A3 (de) | 2007-02-01 |
| WO2006131292A2 (de) | 2006-12-14 |
| DE102005026604A1 (de) | 2006-12-14 |
| US20080199401A1 (en) | 2008-08-21 |
| EP1901782A2 (de) | 2008-03-26 |
| EP1901782B1 (de) | 2012-08-15 |
| JP5080457B2 (ja) | 2012-11-21 |
| JP2009523116A (ja) | 2009-06-18 |
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