JP5080457B2 - 液体中に短寿命の物理的特性を有するガスを溶解させることによるコントラスト剤の調製方法 - Google Patents

液体中に短寿命の物理的特性を有するガスを溶解させることによるコントラスト剤の調製方法 Download PDF

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JP5080457B2
JP5080457B2 JP2008515120A JP2008515120A JP5080457B2 JP 5080457 B2 JP5080457 B2 JP 5080457B2 JP 2008515120 A JP2008515120 A JP 2008515120A JP 2008515120 A JP2008515120 A JP 2008515120A JP 5080457 B2 JP5080457 B2 JP 5080457B2
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gas
liquid
membrane
short
hyperpolarized
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Japanese (ja)
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JP2009523116A5 (enExample
JP2009523116A (ja
Inventor
ブリュームラー ペーター
レムケ ホルスト−ディーター
クリーター デトレフ
シュピース ハンス−ヴォルフガング
ヴィーゼ フランク
ツェンカー パウル−フィリップ
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Membrana GmbH
Max Planck Gesellschaft zur Foerderung der Wissenschaften
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Membrana GmbH
Max Planck Gesellschaft zur Foerderung der Wissenschaften
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F23/00—Mixing according to the phases to be mixed, e.g. dispersing or emulsifying
    • B01F23/20—Mixing gases with liquids
    • B01F23/23—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids
    • B01F23/231—Mixing gases with liquids by introducing gases into liquid media, e.g. for producing aerated liquids by bubbling
    • B01F23/23105—Arrangement or manipulation of the gas bubbling devices
    • B01F23/2312—Diffusers
    • B01F23/23124—Diffusers consisting of flexible porous or perforated material, e.g. fabric

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
JP2008515120A 2005-06-09 2006-06-06 液体中に短寿命の物理的特性を有するガスを溶解させることによるコントラスト剤の調製方法 Expired - Fee Related JP5080457B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102005026604.5 2005-06-09
DE102005026604A DE102005026604A1 (de) 2005-06-09 2005-06-09 Verfahren zum Lösen von Gasen mit kurzlebigen physikalischen Eigenschaften in einer Flüssigkeit
PCT/EP2006/005349 WO2006131292A2 (de) 2005-06-09 2006-06-06 Verfahren zum lösen von gasen mit kurzlebigen physikalischen eigenschaften in einer flüssigkeit

Publications (3)

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JP2009523116A JP2009523116A (ja) 2009-06-18
JP2009523116A5 JP2009523116A5 (enExample) 2012-04-19
JP5080457B2 true JP5080457B2 (ja) 2012-11-21

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JP2008515120A Expired - Fee Related JP5080457B2 (ja) 2005-06-09 2006-06-06 液体中に短寿命の物理的特性を有するガスを溶解させることによるコントラスト剤の調製方法

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US (1) US20080199401A1 (enExample)
EP (1) EP1901782B1 (enExample)
JP (1) JP5080457B2 (enExample)
DE (1) DE102005026604A1 (enExample)
ES (1) ES2393113T3 (enExample)
WO (1) WO2006131292A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0804422D0 (en) * 2008-03-10 2008-04-16 Univ Southampton An agent for transporting nuclear spin order and for magnetic resonance imaging
DE102013013197A1 (de) * 2013-08-09 2015-02-12 Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Arbeit, dieses vertreten durch den Präsidenten der Physikalisch-Technischen Bundesanstalt Braunschweig und Berlin Verfahren und Vorrichtung zum kryogenfreien Aufkonzentrieren eines hyperpolarisierten Gases in einem kontinuierlich fließenden Gasstrom und Verwendung
FR3030770B1 (fr) 2014-12-19 2019-08-30 Commissariat A L'energie Atomique Et Aux Energies Alternatives Cellule de mesure de rmn et ensemble de mesure de rmn
CN119086618B (zh) * 2023-09-06 2025-10-03 中国科学院精密测量科学与技术创新研究院 用于超极化129Xe磁共振分子探针流动采样的装置及方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2833493C2 (de) * 1978-07-31 1989-10-12 Akzo Gmbh, 5600 Wuppertal Hohlfäden
US5357959A (en) * 1993-04-16 1994-10-25 Praxair Technology, Inc. Altered dipole moment magnetic resonance imaging method
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
JP2001503646A (ja) * 1996-03-29 2001-03-21 ローレンス バークレー ナショナル ラボラトリィ 過分極化希ガス存在下でのｎｍｒまたはｍｒｉの増強
ATE252916T1 (de) * 1997-08-12 2003-11-15 Bracco Research Sa Verabreichbare formulierugen und ihre anwendung in mri
JPH11179167A (ja) * 1997-12-25 1999-07-06 Nitto Denko Corp スパイラル型膜モジュール
JP3352411B2 (ja) * 1998-03-05 2002-12-03 株式会社東芝 制御システム、電力系統保護制御システムおよびプログラムを記憶した記憶媒体
JP2002507438A (ja) * 1998-03-18 2002-03-12 メディ−フィジックス・インコーポレイテッド 溶解化した極性化１２９Ｘｅを用いる肺および心臓脈管構造の映像化および血流を上昇するＭＲ方法
US6284222B1 (en) * 1998-11-03 2001-09-04 Medi--Physics, Inc. Hyperpolarized helium-3 microbubble gas entrapment methods
CA2401308A1 (en) * 2000-03-13 2001-09-20 Klaus D. Hagspiel Diagnostic procedures using direct injection of gaseous hyperpolarized 129xe and associated systems and products
US6775568B2 (en) * 2000-04-12 2004-08-10 University Of Virginia Patent Foundation Exchange-based NMR imaging and spectroscopy of hyperpolarized xenon-129
US6696040B2 (en) * 2000-07-13 2004-02-24 Medi-Physics, Inc. Diagnostic procedures using 129Xe spectroscopy characteristic chemical shift to detect pathology in vivo
AU2002258961A1 (en) * 2001-04-24 2002-11-05 Medi-Physics, Inc. Methods and devices for moisturizing hyperpolarized noble gases and pharmaceutical products thereof

Also Published As

Publication number Publication date
WO2006131292A3 (de) 2007-02-01
WO2006131292A2 (de) 2006-12-14
DE102005026604A1 (de) 2006-12-14
US20080199401A1 (en) 2008-08-21
EP1901782A2 (de) 2008-03-26
EP1901782B1 (de) 2012-08-15
JP2009523116A (ja) 2009-06-18
ES2393113T3 (es) 2012-12-18

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