ES2344396A1 - Marcadores geneticos del riesgo de sufrir reestenosis. - Google Patents

Marcadores geneticos del riesgo de sufrir reestenosis. Download PDF

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Publication number
ES2344396A1
ES2344396A1 ES200900507A ES200900507A ES2344396A1 ES 2344396 A1 ES2344396 A1 ES 2344396A1 ES 200900507 A ES200900507 A ES 200900507A ES 200900507 A ES200900507 A ES 200900507A ES 2344396 A1 ES2344396 A1 ES 2344396A1
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ES
Spain
Prior art keywords
suffering
risk
restenosis
genetic markers
determining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES200900507A
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English (en)
Other versions
ES2344396B1 (es
Inventor
Garcia Vicente Andres
Roig Carlos Silvestre
Ferri Patricia Fernandez
Fernandez Pedro Luis Sanchez
Aviles Francisco Fernandez
Martinez Felipe Javier Chaves
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fina Biotech SL
Original Assignee
Fina Biotech SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fina Biotech SL filed Critical Fina Biotech SL
Priority to ES200900507A priority Critical patent/ES2344396B1/es
Priority to JP2011550613A priority patent/JP2012521744A/ja
Priority to PCT/ES2010/070102 priority patent/WO2010097495A1/es
Priority to CA2753460A priority patent/CA2753460A1/en
Priority to EP10745851A priority patent/EP2402458A4/en
Priority to CN2010800088953A priority patent/CN102388147A/zh
Publication of ES2344396A1 publication Critical patent/ES2344396A1/es
Application granted granted Critical
Publication of ES2344396B1 publication Critical patent/ES2344396B1/es
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención contempla un método para la determinación del riesgo de un individuo de sufrir reestenosis tras la implantación de un stent basado en el análisis de una muestra para determinar el genotipo en al menos un polimorfismo de base única (SNP) seleccionado entre rs350099, rs350104, rs164390 y rs875459, en el gen CCNB1, y, opcionalmente de rs2282411 y/o rs733590, en los genes CCNA1 y CDKN1A, respectivamente, donde la presencia de determinados alelos en alguno de estos polimorfismos es indicativa del riesgo de sufrir reestenosis.
ES200900507A 2009-02-24 2009-02-24 Marcadores geneticos del riesgo de sufrir reestenosis. Expired - Fee Related ES2344396B1 (es)

Priority Applications (6)

Application Number Priority Date Filing Date Title
ES200900507A ES2344396B1 (es) 2009-02-24 2009-02-24 Marcadores geneticos del riesgo de sufrir reestenosis.
JP2011550613A JP2012521744A (ja) 2009-02-24 2010-02-24 再狭窄発生リスクの遺伝子マーカー
PCT/ES2010/070102 WO2010097495A1 (es) 2009-02-24 2010-02-24 Marcadores genéticos del riesgo de sufrir reestenosis
CA2753460A CA2753460A1 (en) 2009-02-24 2010-02-24 Genetic markers of the risk of developing restenosis
EP10745851A EP2402458A4 (en) 2009-02-24 2010-02-24 GENETIC MARKERS FOR THE RISK OF RESTENOSIS DISEASE
CN2010800088953A CN102388147A (zh) 2009-02-24 2010-02-24 再狭窄发生风险的遗传标志物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200900507A ES2344396B1 (es) 2009-02-24 2009-02-24 Marcadores geneticos del riesgo de sufrir reestenosis.

Publications (2)

Publication Number Publication Date
ES2344396A1 true ES2344396A1 (es) 2010-08-25
ES2344396B1 ES2344396B1 (es) 2011-06-24

Family

ID=42543362

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200900507A Expired - Fee Related ES2344396B1 (es) 2009-02-24 2009-02-24 Marcadores geneticos del riesgo de sufrir reestenosis.

Country Status (6)

Country Link
EP (1) EP2402458A4 (es)
JP (1) JP2012521744A (es)
CN (1) CN102388147A (es)
CA (1) CA2753460A1 (es)
ES (1) ES2344396B1 (es)
WO (1) WO2010097495A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103865986B (zh) * 2012-12-14 2015-10-28 益善生物技术股份有限公司 Cdkn1a基因突变检测特异性引物和液相芯片
TWI803994B (zh) * 2021-09-29 2023-06-01 國立成功大學 評估罹患動脈粥狀硬化相關疾病或病症風險的方法及套組

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1536001A1 (en) * 2002-08-09 2005-06-01 Nagoya Industrial Science Research Institute Method of diagnosing risk of restenosis after coronary angioplasty
WO2005083127A2 (en) * 2004-02-27 2005-09-09 Applera Corporation Genetic polymorphisms associated with stroke, methods of detection and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007131202A2 (en) * 2006-05-04 2007-11-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Genomics of in-stent restenosis
CN101078025A (zh) * 2006-12-19 2007-11-28 四川大学华西医院 一种检测copd的snp的pcr试剂盒
HUE030996T2 (en) * 2007-02-21 2017-06-28 Decode Genetics Ehf Coronary artery disease and myocardial infarction

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1536001A1 (en) * 2002-08-09 2005-06-01 Nagoya Industrial Science Research Institute Method of diagnosing risk of restenosis after coronary angioplasty
WO2005083127A2 (en) * 2004-02-27 2005-09-09 Applera Corporation Genetic polymorphisms associated with stroke, methods of detection and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Cha et al. "Association of CCR2 polymorphisms with the number of closed coronary artery vessels in coronary artery disease". CLINICA CHIMICA ACTA. 24.05.2007. Vol. 382, Nº. 1-2, páginas 129-133. ISSN 0009-8981. *
Matarin Mar et al. "A genome-wide genotyping study in patients with ischaemic stroke: initial analysis and data release". LANCET NEUROLOGY. 12.04.2007. Vol. 6, Nº. 5, páginas 414-420. ISSN 1474-4422. *
Rodríguez Isabel et al. "Role of the CDKN1A/p21, CDKN1C/p57, and CDKN2A/p16 genes in the risk of atherosclerosis and myocardial infarction". Cell cycle. 01.03.2007. Vol. 6, Nº. 5, páginas 620- 625. ISSN 1551-4005 (Electronic) *
Samani Nilesh J. et al. "Genomewide association analysis of coronary artery disease". The New England journal of medicine. 02.08.2007. Vol. 327, Nº 5, páginas 443-453. ISSN 1533-4406 (Electronic). *

Also Published As

Publication number Publication date
EP2402458A4 (en) 2013-01-02
ES2344396B1 (es) 2011-06-24
EP2402458A1 (en) 2012-01-04
WO2010097495A1 (es) 2010-09-02
JP2012521744A (ja) 2012-09-20
EP2402458A9 (en) 2012-06-13
CN102388147A (zh) 2012-03-21
CA2753460A1 (en) 2010-09-02

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