WO2009082743A3 - Genetic markers for schizophrenia and bipolar disorder - Google Patents

Genetic markers for schizophrenia and bipolar disorder Download PDF

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Publication number
WO2009082743A3
WO2009082743A3 PCT/US2008/088061 US2008088061W WO2009082743A3 WO 2009082743 A3 WO2009082743 A3 WO 2009082743A3 US 2008088061 W US2008088061 W US 2008088061W WO 2009082743 A3 WO2009082743 A3 WO 2009082743A3
Authority
WO
WIPO (PCT)
Prior art keywords
bipolar disorder
schizophrenia
genetic markers
predict
hpcall
Prior art date
Application number
PCT/US2008/088061
Other languages
French (fr)
Other versions
WO2009082743A2 (en
Inventor
Mark David Brennan
Original Assignee
Suregene Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suregene Llc filed Critical Suregene Llc
Priority to US12/523,243 priority Critical patent/US8460868B2/en
Priority to EP08865698.8A priority patent/EP2235209B1/en
Priority to CA2709479A priority patent/CA2709479A1/en
Priority to AU2008340209A priority patent/AU2008340209A1/en
Publication of WO2009082743A2 publication Critical patent/WO2009082743A2/en
Publication of WO2009082743A3 publication Critical patent/WO2009082743A3/en
Priority to IL206617A priority patent/IL206617A0/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
    • G06Q99/00—Subject matter not provided for in other groups of this subclass
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Abstract

The invention provides haplotypes and SNPs of the HPCALl and SV2C genes which predict the risk for developing schizophrenia or bipolar disorder and predict which patients are likely to respond to a given treatment or are more likely to experience negative side effects.
PCT/US2008/088061 2007-12-24 2008-12-22 Genetic markers for schizophrenia and bipolar disorder WO2009082743A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US12/523,243 US8460868B2 (en) 2007-12-24 2008-12-22 Genetic markers for schizophrenia and bipolar disorder
EP08865698.8A EP2235209B1 (en) 2007-12-24 2008-12-22 Genetic markers for schizophrenia and bipolar disorder
CA2709479A CA2709479A1 (en) 2007-12-24 2008-12-22 Genetic markers for schizophrenia and bipolar disorder
AU2008340209A AU2008340209A1 (en) 2007-12-24 2008-12-22 Genetic markers for schizophrenia and bipolar disorder
IL206617A IL206617A0 (en) 2007-12-24 2010-06-24 Genetic markers for scihizophrenia and bipolar disorder

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1656307P 2007-12-24 2007-12-24
US61/016,563 2007-12-24

Publications (2)

Publication Number Publication Date
WO2009082743A2 WO2009082743A2 (en) 2009-07-02
WO2009082743A3 true WO2009082743A3 (en) 2009-11-19

Family

ID=40637705

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/088061 WO2009082743A2 (en) 2007-12-24 2008-12-22 Genetic markers for schizophrenia and bipolar disorder

Country Status (6)

Country Link
US (1) US8460868B2 (en)
EP (1) EP2235209B1 (en)
AU (1) AU2008340209A1 (en)
CA (1) CA2709479A1 (en)
IL (1) IL206617A0 (en)
WO (1) WO2009082743A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2581457A3 (en) 2008-01-17 2013-07-17 Suregene LLC Genetic markers of mental illness
EP2344672B8 (en) 2008-09-25 2014-12-24 SureGene LLC Genetic markers for optimizing treatment for schizophrenia
US7951543B2 (en) * 2009-11-04 2011-05-31 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype
US7951542B2 (en) 2009-11-04 2011-05-31 Surgene, LLC Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype
US7985551B2 (en) 2009-11-04 2011-07-26 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype
US7972793B2 (en) * 2009-11-04 2011-07-05 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the SULT4A1-1 haplotype
US7932042B1 (en) 2010-10-13 2011-04-26 Suregene, Llc Methods and compositions for the treatment of psychotic disorders through the identification of the olanzapine poor response predictor genetic signature
US9265458B2 (en) 2012-12-04 2016-02-23 Sync-Think, Inc. Application of smooth pursuit cognitive testing paradigms to clinical drug development
US9380976B2 (en) 2013-03-11 2016-07-05 Sync-Think, Inc. Optical neuroinformatics
US20200168317A1 (en) 2018-08-22 2020-05-28 Centre For Addiction And Mental Health Tool for assisting individuals experiencing auditory hallucinations to differentiate between hallucinations and ambient sounds
CN115667546A (en) * 2020-02-05 2023-01-31 新加坡科技研究局 Biomarkers for predicting risk of parkinson's disease

Citations (6)

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Publication number Priority date Publication date Assignee Title
WO2001000882A1 (en) * 1999-06-25 2001-01-04 The Trustees Of The University Of Pennsylvania Molecular correlates of schizophrenia and methods of diagnosing schizophrenia via these molecular correlates
EP1266906A1 (en) * 2001-06-13 2002-12-18 Millennium Pharmaceuticals, Inc. 46584, a human transporter family member and uses therefor
WO2004051222A2 (en) * 2002-12-03 2004-06-17 Ucb, S.A. Methods for the identification of agents for the treatment of seizures, neurological diseases, endocrinopathies and hormonal diseases
US20050209181A1 (en) * 2003-11-05 2005-09-22 Huda Akil Compositions and methods for diagnosing and treating mental disorders
WO2007100913A2 (en) * 2006-02-28 2007-09-07 The Regents Of The University Of California Genes differentially expressed in bipolar disorder and/or schizophrenia
WO2007145992A2 (en) * 2006-06-05 2007-12-21 Perlegen Sciences, Inc. Genetic basis of treatment response in depression patients

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
US5474796A (en) * 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US5800998A (en) * 1996-11-12 1998-09-01 Millennium Pharmaceuticals, Inc. Assays for diagnosing type II diabetes in a subject
WO2003039234A2 (en) * 2001-11-06 2003-05-15 David Pickar Pharmacogenomics-based system for clinical applications
CA2592473A1 (en) * 2004-12-30 2006-07-06 University Of Louisville Research Foundation, Inc. Genetic markers of schizophrenia
WO2009008896A1 (en) 2007-07-06 2009-01-15 University Of Louisville Research Foundation, Inc. Genetic markers of schizophrenia

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001000882A1 (en) * 1999-06-25 2001-01-04 The Trustees Of The University Of Pennsylvania Molecular correlates of schizophrenia and methods of diagnosing schizophrenia via these molecular correlates
EP1266906A1 (en) * 2001-06-13 2002-12-18 Millennium Pharmaceuticals, Inc. 46584, a human transporter family member and uses therefor
WO2004051222A2 (en) * 2002-12-03 2004-06-17 Ucb, S.A. Methods for the identification of agents for the treatment of seizures, neurological diseases, endocrinopathies and hormonal diseases
US20050209181A1 (en) * 2003-11-05 2005-09-22 Huda Akil Compositions and methods for diagnosing and treating mental disorders
WO2007100913A2 (en) * 2006-02-28 2007-09-07 The Regents Of The University Of California Genes differentially expressed in bipolar disorder and/or schizophrenia
WO2007145992A2 (en) * 2006-06-05 2007-12-21 Perlegen Sciences, Inc. Genetic basis of treatment response in depression patients

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BERNSTEIN HANS-GERT ET AL: "Brain region-specific changes in the expression of calcium sensor proteins after repeated applications of ketamine to rats.", NEUROSCIENCE LETTERS, vol. 339, no. 2, 20 March 2003 (2003-03-20), pages 95 - 98, XP002529795, ISSN: 0304-3940 *
CICHON S ET AL: "Pharmacogenetics of schizophrenia.", AMERICAN JOURNAL OF MEDICAL GENETICS SPRING 2000, vol. 97, no. 1, April 2000 (2000-04-01), pages 98 - 106, XP002529793, ISSN: 0148-7299 *
DATABASE GENECARDS [online] "HPCAL 1, HIPPOCALCIN-LIKE 1", XP002529796, retrieved from HTTP://WWW.GENECARDS.ORG/CGI-BIN/CARDDISP.PL?GENE=HPCAL1&SEARCH=HPCAL1&SNP=751#SNP Database accession no. GC02P010393 *
DATABASE GENECARDS [online] "SV2C synaptic vesicle glycoprotein 2C", XP002545132, retrieved from HTTP://WWW.GENECARDS.ORG/CGI-BIN/CARDDISP.PL?GENE=SV2C&SEARCH=SV2C&SNP=1499#SNP Database accession no. GC05P075414 *
FREUDENBERG-HUA Y ET AL: "Systematic investigation of genetic variability in 111 human genes-implications for studying variable drug response.", THE PHARMACOGENOMICS JOURNAL 2005, vol. 5, no. 3, 2005, pages 183 - 192, XP008106631, ISSN: 1470-269X *
HANS-GERT BERNSTEIN ET AL: "Increased number of nitric oxide synthase immunoreactive Purkinje cells and dentate nucleus neurons in schizophrenia", JOURNAL OF NEUROCYTOLOGY, KLUWER ACADEMIC PUBLISHERS, BO, vol. 30, no. 8, 1 August 2001 (2001-08-01), pages 661 - 670, XP019214056, ISSN: 1573-7381 *
MARCHECO-TERUEL B ET AL: "A genome-wide linkage search for bipolar disorder susceptibility loci in a large and complex pedigree from the eastern part of Cuba.", AMERICAN JOURNAL OF MEDICAL GENETICS. PART B, NEUROPSYCHIATRIC GENETICS : THE OFFICIAL PUBLICATION OF THE INTERNATIONAL SOCIETY OF PSYCHIATRIC GENETICS, vol. 141B, no. 8, 5 December 2006 (2006-12-05), pages 833 - 843, XP002545160, ISSN: 1552-4841 *
SHERRINGTON R ET AL: "LOCALIZATION OF A SUSCEPTIBILITY LOCUS FOR SCHIZOPHRENIA ON CHROMOSOME 5", NATURE, vol. 336, no. 6195, 1988, LONDON, pages 164 - 167, XP002545159, ISSN: 0028-0836 *
STÖBER GERALD ET AL: "Association study of 5'-UTR polymorphisms of the human dopamine transporter gene with manic depression.", BIPOLAR DISORDERS OCT 2006, vol. 8, no. 5 Pt 1, October 2006 (2006-10-01), pages 490 - 495, XP002529794, ISSN: 1398-5647 *
ZHANG AIPING ET AL: "Dopamine transporter polymorphisms and risperidone response in Chinese schizophrenia patients: an association study.", PHARMACOGENOMICS OCT 2007, vol. 8, no. 10, October 2007 (2007-10-01), pages 1337 - 1345, XP008106676, ISSN: 1744-8042 *

Also Published As

Publication number Publication date
AU2008340209A1 (en) 2009-07-02
US20100151461A1 (en) 2010-06-17
EP2235209B1 (en) 2014-02-12
US8460868B2 (en) 2013-06-11
IL206617A0 (en) 2010-12-30
CA2709479A1 (en) 2009-07-02
WO2009082743A2 (en) 2009-07-02
EP2235209A2 (en) 2010-10-06

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