ES2336286T3 - Ensayos aglutrimetricos en sangre. - Google Patents
Ensayos aglutrimetricos en sangre. Download PDFInfo
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- ES2336286T3 ES2336286T3 ES98913184T ES98913184T ES2336286T3 ES 2336286 T3 ES2336286 T3 ES 2336286T3 ES 98913184 T ES98913184 T ES 98913184T ES 98913184 T ES98913184 T ES 98913184T ES 2336286 T3 ES2336286 T3 ES 2336286T3
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54346—Nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Nanotechnology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US820999 | 1997-03-20 | ||
| US08/820,999 US5922551A (en) | 1997-03-20 | 1997-03-20 | Agglutrimetric platelet binding assays in blood |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2336286T3 true ES2336286T3 (es) | 2010-04-09 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98913184T Expired - Lifetime ES2336286T3 (es) | 1997-03-20 | 1998-03-20 | Ensayos aglutrimetricos en sangre. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5922551A (https=) |
| EP (1) | EP1012604B1 (https=) |
| JP (1) | JP3881036B2 (https=) |
| AT (1) | ATE452341T1 (https=) |
| AU (1) | AU6779698A (https=) |
| CA (1) | CA2284559C (https=) |
| DE (1) | DE69841387D1 (https=) |
| ES (1) | ES2336286T3 (https=) |
| WO (1) | WO1998041868A1 (https=) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6432715B1 (en) * | 1998-02-24 | 2002-08-13 | Isotag Technology, Inc. | Method for marking items for identification |
| WO2000025140A1 (en) * | 1998-10-23 | 2000-05-04 | Accumetrics, Inc. | Method for determining platelet count |
| WO2000029831A1 (en) * | 1998-11-13 | 2000-05-25 | Bangs Laboratories, Inc. | Labeling microparticles capable of absorbing infrared light and methods of making and using the same |
| AU5044400A (en) * | 1999-05-28 | 2000-12-18 | Sendx Medical, Inc. | Control for methods for determining platelet count and platelet function |
| US6316264B1 (en) * | 1999-12-17 | 2001-11-13 | Bayer Corporation | Test strip for the assay of an analyte in a liquid sample |
| DE10013377A1 (de) * | 2000-03-17 | 2001-09-20 | Dade Behring Marburg Gmbh | Induzierte Aggregation und Agglutination von Plättchen |
| AU2001261020A1 (en) * | 2000-05-09 | 2001-11-20 | Pharmanetics Incorporated | Platelet function assay and reagent therefor |
| GB0015923D0 (en) * | 2000-06-30 | 2000-08-23 | Astrazeneca Ab | Methods |
| DE10038900A1 (de) * | 2000-08-09 | 2002-03-07 | Haemosys Gmbh | Einfache Methode zum drug monitoring von GPIIb/IIIa-Rezeptor-Antagonisten |
| WO2002016506A2 (en) * | 2000-08-24 | 2002-02-28 | Sendx Medical, Inc. | The use of a multiple dye system to enhance the spectral properties of dyed microparticles in an immunoassay |
| US6689615B1 (en) | 2000-10-04 | 2004-02-10 | James Murto | Methods and devices for processing blood samples |
| JP2004069677A (ja) * | 2002-06-13 | 2004-03-04 | Canon Inc | 免疫学的測定方法、免疫学的測定用試薬及びその製造方法 |
| US7655411B2 (en) * | 2002-08-23 | 2010-02-02 | W2 Holdings, Inc. | Thrombospondin fragments and binding agents in the detection, diagnosis and evaluation of cancer |
| AU2003267147A1 (en) * | 2002-09-10 | 2004-04-30 | Placor, Inc. | Method and device for monitoring platelet function |
| US20070243632A1 (en) * | 2003-07-08 | 2007-10-18 | Coller Barry S | Methods for measuring platelet reactivity of patients that have received drug eluting stents |
| ATE536889T1 (de) * | 2003-07-08 | 2011-12-15 | Accumetrics Inc | Kontrollierte thrombozyten-aktivierung zur überwachung der behandlung von adp-antagonisten |
| ES2340378T3 (es) * | 2003-12-16 | 2010-06-02 | Dynabyte Informationssysteme Gmbh | Dispositivo de cartucho para el analisis de sangre. |
| EP2187201B1 (en) | 2003-12-16 | 2012-02-15 | Dynabyte Informationssysteme GmbH | Cartridge device for blood analysis |
| US7439069B2 (en) * | 2004-02-27 | 2008-10-21 | Nippoldt Douglas D | Blood coagulation test cartridge, system, and method |
| US7422905B2 (en) * | 2004-02-27 | 2008-09-09 | Medtronic, Inc. | Blood coagulation test cartridge, system, and method |
| US7399637B2 (en) * | 2004-04-19 | 2008-07-15 | Medtronic, Inc. | Blood coagulation test cartridge, system, and method |
| CA2623142C (en) * | 2004-09-22 | 2016-01-19 | The Regents Of The University Of Colorado, A Body Corporate | Methods for a global assay of coagulation and fibrinolysis |
| EP1875232A2 (en) * | 2005-04-25 | 2008-01-09 | PlaCor, Inc. | Methods and devices for monitoring platelet function |
| US7595169B2 (en) * | 2005-04-27 | 2009-09-29 | Accumetrics, Inc. | Method for determining percent platelet aggregation |
| US7205115B2 (en) * | 2005-04-28 | 2007-04-17 | Accumetrics, Inc. | Method and system for stabilization of arachidonic acid for use in platelet function assay |
| US7932021B2 (en) * | 2005-07-28 | 2011-04-26 | American Diagnostica, Inc. | Lupus anticoagulant testing |
| US20080081379A1 (en) * | 2006-07-13 | 2008-04-03 | Sigler Gerald F | Homogeneous double receptor agglutination assay for immunosuppressant drugs |
| US20100099130A1 (en) * | 2006-10-25 | 2010-04-22 | Placor Inc. | Methods and devices for monitoring platelet function |
| US8197420B2 (en) | 2006-12-18 | 2012-06-12 | Magnolia Medical Technologies, Inc. | Systems and methods for parenterally procuring bodily-fluid samples with reduced contamination |
| EP2153235B1 (en) * | 2007-05-03 | 2012-05-16 | Accumetrics, Inc. | Methods of measuring inhibition of platelet aggregation by thrombin receptor antagonists |
| JP4853666B2 (ja) * | 2007-05-30 | 2012-01-11 | Jsr株式会社 | 標的物質の検出方法、混合粒子、および標的物質の検出試薬 |
| US8448499B2 (en) | 2008-12-23 | 2013-05-28 | C A Casyso Ag | Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method |
| US20110165595A1 (en) * | 2009-07-13 | 2011-07-07 | Catanzaro Brian E | Apparatus and methods for processing a whole blood sample |
| US8535241B2 (en) | 2011-10-13 | 2013-09-17 | Magnolia Medical Technologies, Inc. | Fluid diversion mechanism for bodily-fluid sampling |
| US8864684B2 (en) | 2011-10-13 | 2014-10-21 | Magnolia Medical Technologies, Inc. | Fluid diversion mechanism for bodily-fluid sampling |
| US9022951B2 (en) | 2012-05-30 | 2015-05-05 | Magnolia Medical Technologies, Inc. | Fluid diversion mechanism for bodily-fluid sampling |
| US9060724B2 (en) | 2012-05-30 | 2015-06-23 | Magnolia Medical Technologies, Inc. | Fluid diversion mechanism for bodily-fluid sampling |
| WO2014022275A1 (en) | 2012-08-01 | 2014-02-06 | Magnolia Medical Technologies, Inc. | Fluid diversion mechanism for bodily-fluid sampling |
| EP3906952A1 (en) | 2012-10-11 | 2021-11-10 | Magnolia Medical Technologies, Inc. | Systems and methods for delivering a fluid to a patient with reduced contamination |
| EP3498168B1 (en) | 2012-11-30 | 2021-01-20 | Magnolia Medical Technologies, Inc. | Syringe based fluid diversion mechanism for bodily-fluid sampling |
| US10772548B2 (en) | 2012-12-04 | 2020-09-15 | Magnolia Medical Technologies, Inc. | Sterile bodily-fluid collection device and methods |
| CA2932536C (en) | 2012-12-04 | 2023-02-28 | Magnolia Medical Technologies, Inc. | Sterile bodily-fluid collection device and methods |
| JP6437515B2 (ja) | 2013-03-12 | 2018-12-12 | マグノリア メディカル テクノロジーズ,インコーポレイテッド | 針の内腔を選択的に閉塞するための方法及び装置 |
| US9360433B1 (en) | 2013-05-21 | 2016-06-07 | Indevr, Inc. | Detection of agglutination by optical density measurement |
| US10123783B2 (en) | 2014-03-03 | 2018-11-13 | Magnolia Medical Technologies, Inc. | Apparatus and methods for disinfection of a specimen container |
| FR3019900B1 (fr) * | 2014-04-09 | 2017-12-22 | Bio-Rad Innovations | Utilisation de particules absorbantes pour ameliorer la detection du signal dans un procede d'analyse |
| US10539579B2 (en) | 2014-09-29 | 2020-01-21 | C A Casyso Gmbh | Blood testing system and method |
| US10816559B2 (en) | 2014-09-29 | 2020-10-27 | Ca Casyso Ag | Blood testing system and method |
| EP3769681B1 (en) | 2015-06-12 | 2022-03-02 | Magnolia Medical Technologies, Inc. | Bodily-fluid sampling and transfer device |
| EP3733067B1 (en) | 2015-09-03 | 2023-06-14 | Magnolia Medical Technologies, Inc. | System for maintaining sterility of a specimen container |
| JP7121756B2 (ja) * | 2017-02-10 | 2022-08-18 | シー2エヌ ダイアグノスティクス リミテッド ライアビリティ カンパニー | 生物流体中の生体分子の濃度を測定するための方法 |
| EP4249118B1 (en) | 2017-06-09 | 2024-12-11 | Magnolia Medical Technologies, Inc. | Fluid control devices |
| JP7204742B2 (ja) | 2017-09-12 | 2023-01-16 | マグノリア メディカル テクノロジーズ,インコーポレイテッド | 流体制御デバイス及び流体制御デバイスを使用する方法 |
| CN111771054B (zh) | 2017-12-07 | 2022-09-23 | 木兰医药技术股份有限公司 | 流体控制装置及其使用方法 |
| US11786155B2 (en) | 2019-02-08 | 2023-10-17 | Magnolia Medical Technologies, Inc. | Devices and methods for bodily fluid collection and distribution |
| EP3938108B1 (en) | 2019-03-11 | 2023-08-02 | Magnolia Medical Technologies, Inc. | Fluid control devices |
| US12543980B2 (en) | 2021-06-21 | 2026-02-10 | Instrumentation Laboratory Company | Determining a platelet aggregation value |
| CN114935488A (zh) * | 2022-03-23 | 2022-08-23 | 哈尔滨医科大学附属第一医院 | 涡旋混匀法纠正edta依赖性假性血小板减少的方法 |
| CN116625777B (zh) * | 2023-07-21 | 2023-10-13 | 山东新华医疗器械股份有限公司 | 低水平冻干态糖化血红蛋白质控品及其制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54108693A (en) * | 1978-02-14 | 1979-08-25 | Mitsubishi Chem Ind | Method and device for optically measuring antigennantibody reaction |
| US4879219A (en) * | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US4973669A (en) * | 1980-09-19 | 1990-11-27 | Massachusetts General Hospital | Monoclonal IgM antibody with specificity against hepatitis B surface antigen |
| US4793180A (en) * | 1981-10-14 | 1988-12-27 | Agm Cargo-Ties, Inc. | Delayed action irreversible humidity indicator |
| US4760030A (en) * | 1984-09-10 | 1988-07-26 | Syntex (U.S.A.) Inc. | Quantitative opaque particle agglutination assay |
| US5004923A (en) * | 1985-08-05 | 1991-04-02 | Biotrack, Inc. | Capillary flow device |
| US5110727A (en) * | 1987-04-03 | 1992-05-05 | Cardiovascular Diagnostics, Inc. | Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles |
| US5114842A (en) * | 1987-07-08 | 1992-05-19 | The Scripps Research Institute | Peptides and antibodies that inhibit platelet adhesion |
| US5529901A (en) * | 1987-11-19 | 1996-06-25 | Staat Der Nederlanden | Method for determining the presence or amount of analyte using a stable colloidal carbon sol |
| US5252459A (en) * | 1988-09-23 | 1993-10-12 | Abbott Laboratories | Indicator reagents, diagnostic assays and test kits employing organic polymer latex particles |
| JPH03123861A (ja) * | 1989-10-06 | 1991-05-27 | Mitsubishi Kasei Corp | ハプテンの免疫化学的測定法 |
| US5252496A (en) * | 1989-12-18 | 1993-10-12 | Princeton Biomeditech Corporation | Carbon black immunochemical label |
| US5246832A (en) * | 1990-06-20 | 1993-09-21 | University Of Massachusetts Medical Center | Platelet analysis in whole blood |
| US5427913A (en) * | 1992-12-03 | 1995-06-27 | Alberta Cancer Board | Methods for determining platelet function |
| US5455228A (en) * | 1993-07-02 | 1995-10-03 | The Research Foundation Of State University Of New York | Peptidase resistant thrombin receptor peptide ligand |
| US6238931B1 (en) * | 1993-09-24 | 2001-05-29 | Biosite Diagnostics, Inc. | Fluorescence energy transfer in particles |
| US5763199A (en) * | 1994-09-29 | 1998-06-09 | Mount Sinai School Of Medicine Of The City University Of New York | Platelet blockade assay |
| JP3249919B2 (ja) * | 1996-07-30 | 2002-01-28 | 株式会社堀場製作所 | 免疫測定方法 |
| US6016712A (en) * | 1997-09-18 | 2000-01-25 | Accumetrics | Device for receiving and processing a sample |
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1997
- 1997-03-20 US US08/820,999 patent/US5922551A/en not_active Expired - Lifetime
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1998
- 1998-03-20 WO PCT/US1998/006044 patent/WO1998041868A1/en not_active Ceased
- 1998-03-20 DE DE69841387T patent/DE69841387D1/de not_active Expired - Lifetime
- 1998-03-20 CA CA002284559A patent/CA2284559C/en not_active Expired - Lifetime
- 1998-03-20 AT AT98913184T patent/ATE452341T1/de not_active IP Right Cessation
- 1998-03-20 ES ES98913184T patent/ES2336286T3/es not_active Expired - Lifetime
- 1998-03-20 AU AU67796/98A patent/AU6779698A/en not_active Abandoned
- 1998-03-20 EP EP98913184A patent/EP1012604B1/en not_active Expired - Lifetime
- 1998-03-20 JP JP54086998A patent/JP3881036B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69841387D1 (de) | 2010-01-28 |
| EP1012604A1 (en) | 2000-06-28 |
| JP2002511925A (ja) | 2002-04-16 |
| AU6779698A (en) | 1998-10-12 |
| EP1012604B1 (en) | 2009-12-16 |
| JP3881036B2 (ja) | 2007-02-14 |
| ATE452341T1 (de) | 2010-01-15 |
| US5922551A (en) | 1999-07-13 |
| CA2284559C (en) | 2009-05-12 |
| WO1998041868A1 (en) | 1998-09-24 |
| CA2284559A1 (en) | 1998-09-24 |
| EP1012604A4 (en) | 2002-01-02 |
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