ES2326083T3 - Tiolactonas como inhibidores de naaladasa. - Google Patents
Tiolactonas como inhibidores de naaladasa. Download PDFInfo
- Publication number
- ES2326083T3 ES2326083T3 ES04716834T ES04716834T ES2326083T3 ES 2326083 T3 ES2326083 T3 ES 2326083T3 ES 04716834 T ES04716834 T ES 04716834T ES 04716834 T ES04716834 T ES 04716834T ES 2326083 T3 ES2326083 T3 ES 2326083T3
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- Spain
- Prior art keywords
- compound
- substituted
- disease
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 32
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 14
- 208000035475 disorder Diseases 0.000 claims abstract 8
- 102000003958 Glutamate Carboxypeptidase II Human genes 0.000 claims abstract 7
- 108090000369 Glutamate Carboxypeptidase II Proteins 0.000 claims abstract 7
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract 7
- 230000005856 abnormality Effects 0.000 claims abstract 6
- 201000010099 disease Diseases 0.000 claims abstract 6
- 230000000694 effects Effects 0.000 claims abstract 6
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims abstract 5
- 229930195712 glutamate Natural products 0.000 claims abstract 5
- 230000001537 neural effect Effects 0.000 claims abstract 5
- 208000010412 Glaucoma Diseases 0.000 claims abstract 4
- 208000017442 Retinal disease Diseases 0.000 claims abstract 4
- 208000017497 prostate disease Diseases 0.000 claims abstract 4
- 208000023105 Huntington disease Diseases 0.000 claims abstract 3
- 206010028980 Neoplasm Diseases 0.000 claims abstract 3
- 208000002193 Pain Diseases 0.000 claims abstract 3
- 230000033115 angiogenesis Effects 0.000 claims abstract 3
- 201000011510 cancer Diseases 0.000 claims abstract 3
- 208000033808 peripheral neuropathy Diseases 0.000 claims abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 3
- 238000009007 Diagnostic Kit Methods 0.000 claims abstract 2
- 125000001424 substituent group Chemical group 0.000 claims 23
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 239000001257 hydrogen Substances 0.000 claims 18
- 150000002431 hydrogen Chemical class 0.000 claims 16
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 12
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000003342 alkenyl group Chemical group 0.000 claims 10
- 125000004419 alkynylene group Chemical group 0.000 claims 10
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims 10
- -1 carboxy, hydroxy Chemical group 0.000 claims 8
- 125000001475 halogen functional group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 7
- 125000002947 alkylene group Chemical group 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- 150000004677 hydrates Chemical class 0.000 claims 6
- 208000012902 Nervous system disease Diseases 0.000 claims 5
- 125000004450 alkenylene group Chemical group 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- 125000005724 cycloalkenylene group Chemical group 0.000 claims 5
- 125000002993 cycloalkylene group Chemical group 0.000 claims 5
- 239000002253 acid Substances 0.000 claims 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 230000004770 neurodegeneration Effects 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 4
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 3
- 125000002529 biphenylenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C12)* 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 2
- 125000004957 naphthylene group Chemical group 0.000 claims 2
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims 1
- LXECNSMYNFWFCZ-UHFFFAOYSA-N 3-(1-oxo-3,4-dihydroisothiochromen-8-yl)benzoic acid Chemical compound OC(=O)C1=CC=CC(C=2C=3C(=O)SCCC=3C=CC=2)=C1 LXECNSMYNFWFCZ-UHFFFAOYSA-N 0.000 claims 1
- OPWFMUIGBAFGOP-UHFFFAOYSA-N 3-(1-oxo-3,4-dihydrothiopyrano[3,4-b]indol-9-yl)benzoic acid Chemical compound OC(=O)C1=CC=CC(N2C3=CC=CC=C3C3=C2C(SCC3)=O)=C1 OPWFMUIGBAFGOP-UHFFFAOYSA-N 0.000 claims 1
- HNFONZNDOVCFPB-UHFFFAOYSA-N 3-[(1-oxo-3,4-dihydroisothiochromen-8-yl)oxymethyl]benzoic acid Chemical compound OC(=O)C1=CC=CC(COC=2C=3C(=O)SCCC=3C=CC=2)=C1 HNFONZNDOVCFPB-UHFFFAOYSA-N 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 208000016192 Demyelinating disease Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 206010012689 Diabetic retinopathy Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 claims 1
- 208000006011 Stroke Diseases 0.000 claims 1
- 208000030886 Traumatic Brain injury Diseases 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid group Chemical group C(C1=CC=CC=C1)(=O)O WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 230000006931 brain damage Effects 0.000 claims 1
- 231100000874 brain damage Toxicity 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 229960003920 cocaine Drugs 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 208000018631 connective tissue disease Diseases 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000003210 demyelinating effect Effects 0.000 claims 1
- 230000006866 deterioration Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000000893 fibroproliferative effect Effects 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 208000000509 infertility Diseases 0.000 claims 1
- 230000036512 infertility Effects 0.000 claims 1
- 231100000535 infertility Toxicity 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 201000010901 lateral sclerosis Diseases 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229960005181 morphine Drugs 0.000 claims 1
- 208000005264 motor neuron disease Diseases 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 230000000626 neurodegenerative effect Effects 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 229960002715 nicotine Drugs 0.000 claims 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims 1
- 229940005483 opioid analgesics Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000008929 regeneration Effects 0.000 claims 1
- 238000011069 regeneration method Methods 0.000 claims 1
- 201000004193 respiratory failure Diseases 0.000 claims 1
- 231100000241 scar Toxicity 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 210000001550 testis Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000009529 traumatic brain injury Effects 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
- 239000003981 vehicle Substances 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 1
- 201000001119 neuropathy Diseases 0.000 abstract 1
- 230000007823 neuropathy Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US45064803P | 2003-03-03 | 2003-03-03 | |
| US450648P | 2003-03-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2326083T3 true ES2326083T3 (es) | 2009-09-30 |
Family
ID=32962505
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES04716834T Expired - Lifetime ES2326083T3 (es) | 2003-03-03 | 2004-03-03 | Tiolactonas como inhibidores de naaladasa. |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US7125907B2 (enExample) |
| EP (2) | EP1988088A1 (enExample) |
| JP (1) | JP4773951B2 (enExample) |
| AT (1) | ATE433445T1 (enExample) |
| AU (1) | AU2004217969B2 (enExample) |
| CA (1) | CA2518234C (enExample) |
| CY (1) | CY1109356T1 (enExample) |
| DE (1) | DE602004021476D1 (enExample) |
| DK (1) | DK1599461T3 (enExample) |
| ES (1) | ES2326083T3 (enExample) |
| MX (1) | MXPA05009492A (enExample) |
| PL (1) | PL1599461T3 (enExample) |
| PT (1) | PT1599461E (enExample) |
| SI (1) | SI1599461T1 (enExample) |
| WO (1) | WO2004078742A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7125907B2 (en) | 2003-03-03 | 2006-10-24 | Guilford Pharmaceuticals Inc. | Thiolactones |
| US20080287866A1 (en) * | 2007-01-31 | 2008-11-20 | Adam Heller | Methods and compositions for the treatment of pain |
| WO2017029399A1 (en) | 2015-08-20 | 2017-02-23 | Universität Zu Köln | Pain tracking by pet-imaging (pain-trap) |
| WO2021155167A1 (en) * | 2020-01-31 | 2021-08-05 | The Johns Hopkins University | Bile acid-gcpii inhibitor conjugates to treat inflammatory diseases |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4239636A (en) * | 1978-10-23 | 1980-12-16 | Exxon Research & Engineering Co. | Thio-bis-(alkyl lactone acid esters) and thio-bis-(hydrocarbyl diacid esters) are useful additives for lubricating compositions |
| JPH0532659A (ja) * | 1991-08-01 | 1993-02-09 | Tsumura & Co | 糖尿病治療剤 |
| GB9218810D0 (en) | 1992-09-04 | 1992-10-21 | Univ Birmingham | Antiviral pyrimidine nucleosides |
| US6011021A (en) | 1996-06-17 | 2000-01-04 | Guilford Pharmaceuticals Inc. | Methods of cancer treatment using naaladase inhibitors |
| GB9602721D0 (en) | 1996-02-09 | 1996-04-10 | Pharmacia Spa | Biologically active ureido derivatives useful in the treatment of multiple sclerosis |
| US5795877A (en) | 1996-12-31 | 1998-08-18 | Guilford Pharmaceuticals Inc. | Inhibitors of NAALADase enzyme activity |
| US5804602A (en) | 1996-06-17 | 1998-09-08 | Guilford Pharmaceuticals Inc. | Methods of cancer treatment using naaladase inhibitors |
| US5902817A (en) | 1997-04-09 | 1999-05-11 | Guilford Pharmaceuticals Inc. | Certain sulfoxide and sulfone derivatives |
| US6384022B1 (en) | 1996-06-17 | 2002-05-07 | Guilford Pharmaceuticals Inc. | Prodrugs of NAALAdase inhibitors |
| US6046180A (en) | 1996-06-17 | 2000-04-04 | Guilford Pharmaceuticals Inc. | NAALADase inhibitors |
| US5824662A (en) | 1996-09-27 | 1998-10-20 | Guilford Pharmaceuticals Inc. | Treatment of global and focal ischemia using naaladase inhibitors |
| US6025345A (en) | 1996-06-17 | 2000-02-15 | Guilford Pharmaceuticals Inc. | Inhibitors of NAALADase enzyme activity |
| US5863536A (en) | 1996-12-31 | 1999-01-26 | Guilford Pharmaceuticals Inc. | Phosphoramidate derivatives |
| TR199802638T2 (xx) | 1996-06-17 | 1999-03-22 | Guilford Pharmaceuticals, Inc. | Kanser tedavisinde naaladase inhibit�rleri kullan�m�. |
| US6017903A (en) | 1996-09-27 | 2000-01-25 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors |
| US5977090A (en) | 1996-09-27 | 1999-11-02 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of treating compulsive disorders using NAALADase inhibitors |
| US6071965A (en) | 1996-06-17 | 2000-06-06 | Guilford Pharmaceuticals Inc. | Phosphinic alkanoic acid derivatives |
| US6025344A (en) | 1996-06-17 | 2000-02-15 | Guilford Pharmaceuticals Inc. | Certain dioic acid derivatives useful as NAALADase inhibitors |
| US6054444A (en) | 1997-04-24 | 2000-04-25 | Guilford Pharmaceuticals Inc. | Phosphonic acid derivatives |
| US5672592A (en) | 1996-06-17 | 1997-09-30 | Guilford Pharmaceuticals Inc. | Certain phosphonomethyl-pentanedioic acid derivatives thereof |
| GB9615202D0 (en) | 1996-07-19 | 1996-09-04 | Smithkline Beecham Plc | Pharmaceuticals |
| PL332413A1 (en) | 1996-09-27 | 1999-09-13 | Guilford Pharm Inc | Compositions containing inhibitors of naaladase as well as methods of treating glutamatic anomaly and influencing neuronic functions among animals |
| US5962521A (en) | 1997-04-04 | 1999-10-05 | Guilford Pharmaceuticals Inc. | Hydroxamic acid derivatives |
| US5981209A (en) | 1997-12-04 | 1999-11-09 | Guilford Pharmaceuticals Inc. | Use of NAALADase activity to identify prostate cancer and benign prostatic hyperplasia |
| US6028216A (en) | 1997-12-31 | 2000-02-22 | Guilford Pharmaceuticals Inc. | Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives |
| US6121252A (en) | 1998-03-30 | 2000-09-19 | Guilford Pharmaceuticals Inc. | Phosphinic acid derivatives |
| US6395718B1 (en) | 1998-07-06 | 2002-05-28 | Guilford Pharmaceuticals Inc. | Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors |
| EP1093453B1 (en) * | 1998-07-06 | 2005-09-28 | Guilford Pharmaceuticals Inc. | Naaladase inhibitors useful as pharmaceutical compounds and compositions |
| US6265609B1 (en) * | 1998-07-06 | 2001-07-24 | Guilford Pharmaceuticals Inc. | Thio-substituted pentanedioic acid derivatives |
| US6444657B1 (en) | 1998-12-31 | 2002-09-03 | Guilford Pharmaceuticals Inc. | Methods for treating certain diseases using naaladase inhibitors |
| US6479470B1 (en) * | 1999-04-28 | 2002-11-12 | Georgetown University | Ligands for metabotropic glutamate receptors and inhibitors of NAALAdase |
| US6228888B1 (en) * | 1999-07-01 | 2001-05-08 | Guilford Pharmaceuticals Inc. | Methods for treating anxiety, anxiety disorders and memory impairment using naaladase inhibitors |
| US6313159B1 (en) | 1999-08-20 | 2001-11-06 | Guilford Pharmaceuticals Inc. | Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors |
| US6348464B1 (en) | 1999-11-12 | 2002-02-19 | Guilford Pharmaceuticals, Inc. | Pyrrolecarbonylimino derivatives as naaladase inhibitors |
| AU6661901A (en) | 2000-05-30 | 2001-12-11 | Guilford Pharm Inc | Naaladase inhibitors for treating retinal disorders and glaucoma |
| WO2001091738A2 (en) * | 2000-05-30 | 2001-12-06 | Guilford Pharmaceuticals Inc. | Naaladase inhibitors for treating amyotrophic lateral sclerosis |
| WO2001092273A2 (en) | 2000-05-30 | 2001-12-06 | Guilford Pharmaceuticals Inc. | Benzenedicarboxylic acid derivatives |
| ES2288550T3 (es) * | 2001-01-08 | 2008-01-16 | Pathway Intermediates Limited | Compuestos autoinductores y sus utilizaciones. |
| FR2819253B1 (fr) | 2001-01-11 | 2004-12-03 | Servier Lab | Nouveaux derives d'acide hydroxamique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP4234430B2 (ja) * | 2001-01-17 | 2009-03-04 | エムジーアイ ジーピー インコーポレイティッド | チオールを含むｎａａｌａｄアーゼ抑制物質 |
| JP4625236B2 (ja) | 2001-05-11 | 2011-02-02 | エーザイ インコーポレーテッド | ＮＡＡＬＡＤａｓｅ阻害剤としてのヒドロキサム酸およびアシルヒドロキサミン |
| PT1406867E (pt) | 2001-05-30 | 2009-02-25 | Eisai Corp North America | Derivados do ácido tiolalquilbenzóico |
| US20050080139A1 (en) | 2001-12-28 | 2005-04-14 | Slusher Barbara S. | Naaladase inhibitors for treating huntington's disease |
| WO2004078180A2 (en) | 2003-03-03 | 2004-09-16 | Guilford Pharmaceuticals Inc. | Naaladase inhibitors for treating opioid tolerance |
| US7125907B2 (en) | 2003-03-03 | 2006-10-24 | Guilford Pharmaceuticals Inc. | Thiolactones |
-
2004
- 2004-03-03 US US10/791,278 patent/US7125907B2/en not_active Expired - Fee Related
- 2004-03-03 DK DK04716834T patent/DK1599461T3/da active
- 2004-03-03 EP EP08013761A patent/EP1988088A1/en not_active Withdrawn
- 2004-03-03 AU AU2004217969A patent/AU2004217969B2/en not_active Ceased
- 2004-03-03 PL PL04716834T patent/PL1599461T3/pl unknown
- 2004-03-03 PT PT04716834T patent/PT1599461E/pt unknown
- 2004-03-03 ES ES04716834T patent/ES2326083T3/es not_active Expired - Lifetime
- 2004-03-03 CA CA2518234A patent/CA2518234C/en not_active Expired - Fee Related
- 2004-03-03 AT AT04716834T patent/ATE433445T1/de active
- 2004-03-03 SI SI200431195T patent/SI1599461T1/sl unknown
- 2004-03-03 MX MXPA05009492A patent/MXPA05009492A/es active IP Right Grant
- 2004-03-03 DE DE602004021476T patent/DE602004021476D1/de not_active Expired - Lifetime
- 2004-03-03 EP EP04716834A patent/EP1599461B1/en not_active Expired - Lifetime
- 2004-03-03 WO PCT/US2004/006178 patent/WO2004078742A1/en not_active Ceased
- 2004-03-03 JP JP2006508945A patent/JP4773951B2/ja not_active Expired - Fee Related
-
2006
- 2006-10-02 US US11/537,979 patent/US20070037798A1/en not_active Abandoned
-
2007
- 2007-07-30 US US11/830,737 patent/US7553866B2/en not_active Expired - Fee Related
-
2009
- 2009-05-26 US US12/472,251 patent/US7968593B2/en not_active Expired - Fee Related
- 2009-08-28 CY CY20091100904T patent/CY1109356T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004217969A1 (en) | 2004-09-16 |
| PL1599461T3 (pl) | 2009-10-30 |
| US7125907B2 (en) | 2006-10-24 |
| EP1599461B1 (en) | 2009-06-10 |
| CA2518234A1 (en) | 2004-09-16 |
| US7968593B2 (en) | 2011-06-28 |
| US20050004203A1 (en) | 2005-01-06 |
| US20080004334A1 (en) | 2008-01-03 |
| ATE433445T1 (de) | 2009-06-15 |
| JP2006519858A (ja) | 2006-08-31 |
| DK1599461T3 (da) | 2009-08-17 |
| MXPA05009492A (es) | 2005-12-14 |
| CA2518234C (en) | 2012-11-13 |
| CY1109356T1 (el) | 2014-07-02 |
| US20100048667A1 (en) | 2010-02-25 |
| WO2004078742A1 (en) | 2004-09-16 |
| EP1599461A1 (en) | 2005-11-30 |
| AU2004217969B2 (en) | 2011-03-03 |
| EP1988088A1 (en) | 2008-11-05 |
| US7553866B2 (en) | 2009-06-30 |
| PT1599461E (pt) | 2009-07-20 |
| US20070037798A1 (en) | 2007-02-15 |
| SI1599461T1 (sl) | 2009-10-31 |
| JP4773951B2 (ja) | 2011-09-14 |
| DE602004021476D1 (de) | 2009-07-23 |
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