ES2278391T3 - Nuevos inhibidores de anandamida amidasa como agentes analgesicos. - Google Patents
Nuevos inhibidores de anandamida amidasa como agentes analgesicos. Download PDFInfo
- Publication number
- ES2278391T3 ES2278391T3 ES97927958T ES97927958T ES2278391T3 ES 2278391 T3 ES2278391 T3 ES 2278391T3 ES 97927958 T ES97927958 T ES 97927958T ES 97927958 T ES97927958 T ES 97927958T ES 2278391 T3 ES2278391 T3 ES 2278391T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- substituted
- aryl
- heteroaryl
- heterocyclyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- -1 hydroxy, hydroxymethyl Chemical group 0.000 claims abstract description 44
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
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|---|---|---|---|
| US658949 | 1984-10-09 | ||
| US08/658,949 US5688825A (en) | 1996-05-31 | 1996-05-31 | Anandamide amidase inhibitors as analgesic agents |
Publications (1)
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|---|---|
| ES2278391T3 true ES2278391T3 (es) | 2007-08-01 |
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| ES97927958T Expired - Lifetime ES2278391T3 (es) | 1996-05-31 | 1997-05-30 | Nuevos inhibidores de anandamida amidasa como agentes analgesicos. |
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| EP (2) | EP1775286A1 (cg-RX-API-DMAC7.html) |
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| DE (1) | DE69737039T2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2278391T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1997045407A1 (cg-RX-API-DMAC7.html) |
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| US5688825A (en) * | 1996-05-31 | 1997-11-18 | University Of Connecticut | Anandamide amidase inhibitors as analgesic agents |
| WO1999057106A1 (en) * | 1998-05-04 | 1999-11-11 | The University Of Connecticut | Novel analgesic and immunomodulatory cannabinoids |
| DE69920683T2 (de) * | 1998-05-04 | 2005-04-07 | The University Of Connecticut, Farmington | Selektiv auf den CB2-Rezeptor wirkende Cannabinoide |
| US7589220B2 (en) * | 1998-06-09 | 2009-09-15 | University Of Connecticut | Inhibitors of the anandamide transporter |
| US7897598B2 (en) * | 1998-06-09 | 2011-03-01 | Alexandros Makriyannis | Inhibitors of the anandamide transporter |
| WO1999064389A1 (en) * | 1998-06-09 | 1999-12-16 | Alexandros Makriyannis | Inhibitors of the anandamide transporter as analgesic agents |
| US7161016B1 (en) | 1998-11-24 | 2007-01-09 | University Of Connecticut | Cannabimimetic lipid amides as useful medications |
| US7276613B1 (en) * | 1998-11-24 | 2007-10-02 | University Of Connecticut | Retro-anandamides, high affinity and stability cannabinoid receptor ligands |
| ES2325304T3 (es) * | 1999-04-28 | 2009-09-01 | Toray Industries, Inc. | Materiales para eliminar canabinoides y columnas para la eliminacion de canabinoides con el uso de los mismos. |
| GB9923738D0 (en) * | 1999-10-07 | 1999-12-08 | Nestle Sa | Nutritional composition |
| US7119108B1 (en) | 1999-10-18 | 2006-10-10 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
| US6900236B1 (en) * | 1999-10-18 | 2005-05-31 | University Of Connecticut | Cannabimimetic indole derivatives |
| AU778159B2 (en) | 1999-10-18 | 2004-11-18 | University Of Connecticut, The | Peripheral cannabinoid receptor (CB2) selective ligands |
| US8084467B2 (en) * | 1999-10-18 | 2011-12-27 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
| US7393842B2 (en) * | 2001-08-31 | 2008-07-01 | University Of Connecticut | Pyrazole analogs acting on cannabinoid receptors |
| EP1226112A4 (en) * | 1999-10-18 | 2004-10-13 | Univ Connecticut | RETRO-ANANDAMIDES, LIGANDS OF CANNABINOID RECEPTORS WITH HIGH AFFINITY AND STABILITY |
| US7741365B2 (en) * | 1999-10-18 | 2010-06-22 | University Of Connecticut | Peripheral cannabinoid receptor (CB2) selective ligands |
| US6943266B1 (en) * | 1999-10-18 | 2005-09-13 | University Of Connecticut | Bicyclic cannabinoid agonists for the cannabinoid receptor |
| ES2174716B1 (es) * | 2000-07-28 | 2004-08-01 | Universidad Complutense De Madrid | Nuevos derivados de acido araquidonico con afinidad por el transportador de anandamida. |
| ES2181601B2 (es) * | 2001-07-27 | 2004-04-01 | Univ Madrid Complutense | Derivados de acido araquidonico con afinidad por el transportador de anandamida |
| AU2001284061A1 (en) * | 2000-07-28 | 2002-02-18 | Universidad Complutense De Madrid | Novel araquidonic acid derivatives with affinity toward the anandamide transporter |
| JP2004532185A (ja) * | 2001-01-26 | 2004-10-21 | ユニバーシティ オブ コネチカット | 新規なカンナビミメティックリガンド |
| US7173027B2 (en) | 2001-01-29 | 2007-02-06 | University Of Connecticut | Receptor selective cannabimimetic aminoalkylindoles |
| AU2002243920A1 (en) * | 2001-02-08 | 2002-08-19 | Nps Pharmaceuticals, Inc. | Methods and compounds for treating neurologic or neuropsychiatric disorders and identifying compounds to treat the same |
| AU2002320430A1 (en) * | 2001-07-13 | 2003-01-29 | University Of Connecticut | Novel bicyclic and tricyclic cannabinoids |
| JP4202250B2 (ja) | 2001-07-25 | 2008-12-24 | バイオマリン ファーマシューティカル インコーポレイテッド | 血液脳関門輸送を調節するための組成物および方法 |
| WO2003035005A2 (en) * | 2001-10-26 | 2003-05-01 | University Of Connecticut | Heteroindanes: a new class of potent cannabimimetic ligands |
| WO2003063847A1 (en) * | 2002-02-01 | 2003-08-07 | Gw Pharma Limited | Compositions comprising cannabinoids for treatment of nausea, vomiting, emesis, motion sickness or like conditions |
| US20040063726A1 (en) * | 2002-02-08 | 2004-04-01 | Artman Linda D | Methods and compounds for treating neurologic or neuropsychiatric disorders and identifying compounds to treat the same |
| IL148244A0 (en) | 2002-02-19 | 2002-09-12 | Yissum Res Dev Co | Anti-nausea and anti-vomiting activity of cannabidiol compounds |
| WO2003092676A1 (en) * | 2002-04-29 | 2003-11-13 | The General Hospital Corporation | Compositions and methods for preventing abuse of orally administered medications |
| US7049329B2 (en) * | 2002-05-16 | 2006-05-23 | Sepracor Inc. | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof |
| EP1509250B1 (en) | 2002-06-06 | 2008-05-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Methods compositions and articles of manufacture for modulating bone growth |
| WO2004017922A2 (en) | 2002-08-23 | 2004-03-04 | University Of Connecticut | Keto cannabinoids with therapeutic indications |
| GB0403864D0 (en) | 2004-02-20 | 2004-03-24 | Ucl Ventures | Modulator |
| CA2789097C (en) | 2005-04-28 | 2017-02-21 | Proteus Digital Health, Inc. | Pharma-informatics system |
| WO2008036682A2 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
| US7781650B2 (en) * | 2007-04-30 | 2010-08-24 | Monsanto Technology Llc | Plants and seeds of corn variety CV202909 |
| EP2203058A4 (en) * | 2007-10-16 | 2011-08-31 | Univ Northeastern | METHODS AND COMPOUNDS FOR MODULATING CANNABINOID ACTIVITY |
| AU2010216512B2 (en) | 2009-02-20 | 2016-06-30 | 2-Bbb Medicines B.V. | Glutathione-based drug delivery system |
| JP2012526144A (ja) | 2009-05-06 | 2012-10-25 | ラボラトリー スキン ケア インコーポレイテッド | 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
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| CN112121852B (zh) * | 2020-08-27 | 2021-09-24 | 中山大学 | 催化剂组合物及催化剂组合物或催化剂用于催化亲核取代反应的用途 |
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| US3577458A (en) * | 1966-11-14 | 1971-05-04 | Allied Chem | Process for the preparation of isocyanates |
| US3465024A (en) * | 1966-11-14 | 1969-09-02 | Allied Chem | Process for the preparation of isocyanates |
| US5804601A (en) * | 1995-04-10 | 1998-09-08 | Takeda Chemical Industries, Ltd. | Aromatic hydroxamic acid compounds, their production and use |
| US5688825A (en) * | 1996-05-31 | 1997-11-18 | University Of Connecticut | Anandamide amidase inhibitors as analgesic agents |
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- 1996-05-31 US US08/658,949 patent/US5688825A/en not_active Expired - Lifetime
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1997
- 1997-05-30 DE DE69737039T patent/DE69737039T2/de not_active Expired - Lifetime
- 1997-05-30 AU AU32290/97A patent/AU3229097A/en not_active Abandoned
- 1997-05-30 ES ES97927958T patent/ES2278391T3/es not_active Expired - Lifetime
- 1997-05-30 EP EP06024572A patent/EP1775286A1/en not_active Withdrawn
- 1997-05-30 EP EP97927958A patent/EP1021406B1/en not_active Expired - Lifetime
- 1997-05-30 CA CA002255620A patent/CA2255620C/en not_active Expired - Fee Related
- 1997-05-30 JP JP09543074A patent/JP2000511540A/ja active Pending
- 1997-05-30 WO PCT/US1997/009613 patent/WO1997045407A1/en not_active Ceased
- 1997-11-12 US US08/967,847 patent/US5874459A/en not_active Expired - Lifetime
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2000
- 2000-04-20 US US09/553,499 patent/US6391909B1/en not_active Expired - Fee Related
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2002
- 2002-02-06 US US10/068,588 patent/US6579900B2/en not_active Expired - Fee Related
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| CA2255620C (en) | 2008-01-29 |
| EP1775286A1 (en) | 2007-04-18 |
| US5874459A (en) | 1999-02-23 |
| DE69737039T2 (de) | 2007-06-21 |
| US5688825A (en) | 1997-11-18 |
| US20020091153A1 (en) | 2002-07-11 |
| DE69737039D1 (de) | 2007-01-11 |
| WO1997045407A1 (en) | 1997-12-04 |
| EP1021406A1 (en) | 2000-07-26 |
| US6391909B1 (en) | 2002-05-21 |
| JP2000511540A (ja) | 2000-09-05 |
| AU3229097A (en) | 1998-01-05 |
| US6579900B2 (en) | 2003-06-17 |
| CA2255620A1 (en) | 1997-12-04 |
| EP1021406B1 (en) | 2006-11-29 |
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