ES2269467T3 - Tratamiento de transtornos afectivos por la accion combinada de un agonista del receptor nicotinico y una sustancia monoaminergenica. - Google Patents
Tratamiento de transtornos afectivos por la accion combinada de un agonista del receptor nicotinico y una sustancia monoaminergenica. Download PDFInfo
- Publication number
- ES2269467T3 ES2269467T3 ES01976043T ES01976043T ES2269467T3 ES 2269467 T3 ES2269467 T3 ES 2269467T3 ES 01976043 T ES01976043 T ES 01976043T ES 01976043 T ES01976043 T ES 01976043T ES 2269467 T3 ES2269467 T3 ES 2269467T3
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- Prior art keywords
- treatment
- azabicyclo
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- disorder
- eno
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 5
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Classifications
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- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/16—Halogen atoms; Nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001535 | 2000-10-13 | ||
| DK200001535 | 2000-10-13 | ||
| US24214600P | 2000-10-23 | 2000-10-23 | |
| US242146P | 2000-10-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2269467T3 true ES2269467T3 (es) | 2007-04-01 |
Family
ID=26068892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01976043T Expired - Lifetime ES2269467T3 (es) | 2000-10-13 | 2001-10-10 | Tratamiento de transtornos afectivos por la accion combinada de un agonista del receptor nicotinico y una sustancia monoaminergenica. |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7307087B2 (https=) |
| EP (2) | EP1757600A2 (https=) |
| JP (2) | JP4312456B2 (https=) |
| CN (1) | CN100398103C (https=) |
| AT (1) | ATE334979T1 (https=) |
| AU (2) | AU2001295436B2 (https=) |
| CA (1) | CA2425638C (https=) |
| DE (1) | DE60122015T2 (https=) |
| DK (1) | DK1358177T3 (https=) |
| ES (1) | ES2269467T3 (https=) |
| MX (1) | MXPA03003264A (https=) |
| NZ (1) | NZ524202A (https=) |
| PT (1) | PT1358177E (https=) |
| WO (1) | WO2002030405A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60003911T2 (de) * | 1999-04-26 | 2004-05-27 | Neurosearch A/S | Heteroaryl-diazacycloalkane, ihre herstellung und verwendung |
| CN100522976C (zh) * | 2002-05-07 | 2009-08-05 | 神经研究公司 | 氮杂环乙炔基衍生物 |
| JP2006504634A (ja) * | 2002-05-15 | 2006-02-09 | アボット・ラボラトリーズ | 神経障害性疼痛の治療 |
| JP4750421B2 (ja) * | 2002-12-06 | 2011-08-17 | ノース ショア−ロング アイランド ジュ−イッシュ リサ−チ インスティチュ−ト | α７受容体結合コリン作動性アゴニストを用いる炎症の阻害 |
| WO2004072071A1 (en) * | 2003-02-12 | 2004-08-26 | Neurosearch A/S | 8-aza-bicyclo (3.2.1) octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| US7550485B2 (en) | 2003-10-14 | 2009-06-23 | Wyeth | Substituted N-heterocycle derivatives and methods of their use |
| TW201206425A (en) * | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Treatment of depressive disorders |
| CN101084211A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为治疗剂的用途 |
| AU2005286728A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| AU2005286647A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| BRPI0515482A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
| MX2007003318A (es) | 2004-09-20 | 2007-05-18 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
| BRPI0515500A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados piridazina para inibição de estearoil-coa-desaturase |
| MX2007003332A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa. |
| CA2589106C (en) | 2004-11-02 | 2015-07-21 | Northwestern University | Pyridazine compounds, compositions and methods and their use in treating inflammatory diseases |
| BRPI0519921A2 (pt) | 2004-12-17 | 2009-08-11 | Neurosearch As | composto enanciopuro ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica,e, uso de composto quìmico ou de um sal farmaceuticamente aceitável do mesmo |
| CA2618646A1 (en) | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
| FR2889847B1 (fr) | 2005-08-18 | 2007-10-05 | Sanofi Aventis Sa | Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique. |
| AU2009317348A1 (en) * | 2008-11-18 | 2010-05-27 | Neurosearch A/S | 8-azabicyclo [3.2.1]oct-2-ene derivatives and their use as mono-amine neurotransmitter re-uptake inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9501567D0 (sv) | 1995-04-27 | 1995-04-27 | Astra Ab | A new combination |
| DE69637097T2 (de) * | 1995-10-13 | 2007-09-20 | Neurosearch A/S | 8-Azabicyclo(3.2.1)Oct-2-en-Derivate, deren Herstellung und Anwendung |
| KR100589872B1 (ko) * | 1997-05-30 | 2006-06-15 | 뉴로서치 에이/에스 | 8-아자비사이클로(3,2,1)옥트-2-엔 유도체 및 이의 제조방법 |
| WO1998054182A1 (en) | 1997-05-30 | 1998-12-03 | Neurosearch A/S | 9-AZABICYCLO(3.3.1)NON-2-ENE AND NONANE DERIVATIVES AS CHOLINERGIC LIGANDS AT NICOTINIC ACh RECEPTORS |
| US5948807A (en) * | 1997-09-03 | 1999-09-07 | Regents Of The University Of Minnesota | Spiroindanamines and Spiroindanimides |
| EE04588B1 (et) * | 1997-10-27 | 2006-02-15 | Neurosearch A/S | Heteroarüüldiasatsükloalkaanid kui atsetüülkoliini nikotiinretseptorite kolinergilised ligandid, nende kasutamine ravimitena ning neid sisaldav farmatseutiline kompositsioon |
| JP2002501921A (ja) | 1998-01-28 | 2002-01-22 | ニューロサーチ、アクティーゼルスカブ | 標識された形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体及び標識された及び標識されていない形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体の使用方法 |
| WO1999065492A1 (en) | 1998-06-19 | 1999-12-23 | Eli Lilly And Company | Inhibition of serotonin reuptake |
| SE9803156D0 (sv) | 1998-09-16 | 1998-09-16 | Astra Ab | A new composition |
| SE9803157D0 (sv) | 1998-09-16 | 1998-09-16 | Astra Ab | A new composition |
| SE9803155D0 (sv) | 1998-09-16 | 1998-09-16 | Astra Ab | A new composition |
| SE9803732D0 (sv) | 1998-11-02 | 1998-11-02 | Maria Carlsson | Nicotine treatment for obsessive compulsive disorder |
| ATE259804T1 (de) * | 1998-11-27 | 2004-03-15 | Neurosearch As | 8-azabicyclo(3.2.1)okt-2-en- und -oktanderivate |
| AU2278700A (en) | 1999-01-28 | 2000-08-18 | Neurosearch A/S | Novel azabicyclo derivatives and their use |
| FR2788982B1 (fr) * | 1999-02-02 | 2002-08-02 | Synthelabo | Compositions pharmaceutiques contenant de la nicotine et leur application dans le sevrage tabagique |
| DE60003911T2 (de) * | 1999-04-26 | 2004-05-27 | Neurosearch A/S | Heteroaryl-diazacycloalkane, ihre herstellung und verwendung |
-
2001
- 2001-10-10 CN CNB018168035A patent/CN100398103C/zh not_active Expired - Fee Related
- 2001-10-10 DE DE60122015T patent/DE60122015T2/de not_active Expired - Lifetime
- 2001-10-10 EP EP06116505A patent/EP1757600A2/en not_active Withdrawn
- 2001-10-10 MX MXPA03003264A patent/MXPA03003264A/es active IP Right Grant
- 2001-10-10 CA CA2425638A patent/CA2425638C/en not_active Expired - Fee Related
- 2001-10-10 US US10/380,653 patent/US7307087B2/en not_active Expired - Fee Related
- 2001-10-10 WO PCT/DK2001/000661 patent/WO2002030405A2/en not_active Ceased
- 2001-10-10 PT PT01976043T patent/PT1358177E/pt unknown
- 2001-10-10 AU AU2001295436A patent/AU2001295436B2/en not_active Ceased
- 2001-10-10 AU AU9543601A patent/AU9543601A/xx active Pending
- 2001-10-10 JP JP2002533848A patent/JP4312456B2/ja not_active Expired - Fee Related
- 2001-10-10 EP EP01976043A patent/EP1358177B1/en not_active Expired - Lifetime
- 2001-10-10 AT AT01976043T patent/ATE334979T1/de active
- 2001-10-10 NZ NZ524202A patent/NZ524202A/en unknown
- 2001-10-10 DK DK01976043T patent/DK1358177T3/da active
- 2001-10-10 ES ES01976043T patent/ES2269467T3/es not_active Expired - Lifetime
-
2007
- 2007-07-24 US US11/782,385 patent/US20070265241A1/en not_active Abandoned
-
2008
- 2008-01-21 JP JP2008009961A patent/JP2008156364A/ja active Pending
-
2010
- 2010-05-21 US US12/784,890 patent/US20100267739A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20070265241A1 (en) | 2007-11-15 |
| CN100398103C (zh) | 2008-07-02 |
| AU2001295436B2 (en) | 2006-07-20 |
| WO2002030405A3 (en) | 2002-09-06 |
| WO2002030405A2 (en) | 2002-04-18 |
| CN1635877A (zh) | 2005-07-06 |
| AU2001295436C1 (en) | 2002-04-22 |
| EP1757600A2 (en) | 2007-02-28 |
| DE60122015T2 (de) | 2006-11-23 |
| JP2004510813A (ja) | 2004-04-08 |
| PT1358177E (pt) | 2006-09-29 |
| DE60122015D1 (de) | 2006-09-14 |
| ATE334979T1 (de) | 2006-08-15 |
| MXPA03003264A (es) | 2003-06-06 |
| CA2425638C (en) | 2011-04-05 |
| JP2008156364A (ja) | 2008-07-10 |
| AU9543601A (en) | 2002-04-22 |
| HK1078466A1 (en) | 2006-03-17 |
| CA2425638A1 (en) | 2002-04-18 |
| NZ524202A (en) | 2004-08-27 |
| EP1358177A2 (en) | 2003-11-05 |
| DK1358177T3 (da) | 2006-12-04 |
| US20040092508A1 (en) | 2004-05-13 |
| EP1358177B1 (en) | 2006-08-02 |
| JP4312456B2 (ja) | 2009-08-12 |
| US20100267739A1 (en) | 2010-10-21 |
| US7307087B2 (en) | 2007-12-11 |
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