ES2269206T3 - Ligandos de neurofilina para tratar trastornos oculares. - Google Patents
Ligandos de neurofilina para tratar trastornos oculares. Download PDFInfo
- Publication number
- ES2269206T3 ES2269206T3 ES00980231T ES00980231T ES2269206T3 ES 2269206 T3 ES2269206 T3 ES 2269206T3 ES 00980231 T ES00980231 T ES 00980231T ES 00980231 T ES00980231 T ES 00980231T ES 2269206 T3 ES2269206 T3 ES 2269206T3
- Authority
- ES
- Spain
- Prior art keywords
- piperidinocarboxylate
- oxopentanoyl
- propenyl
- dimethyl
- phenylacetyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Abstract
El uso de un ligando de neurofilina que no muestra actividad inmunosupresora, para la fabricación de un medicamento para el tratamiento de un mamífero que padece de glaucoma, donde el ligando de neurofilina es un derivado de ácido pipecólico que es 1-(3, 3- dimetil-2-oxopentanoil)-2-piperidinocarboxilato de (E)- 3-(3, 4-diclorofenil}-2-propenilo; 1-(3, 3-dimetil-2- oxopentanoil)-2-piperidinocarboxilato de (E)-3-(3, 4, 5- trimetoxifenil)-2-propenilo; 1-(3, 3-dimetil-2- oxopentanoil)-2-piperidinocarboxilato de (E)-3-fenil-2- propenilo; 1-(3, 3-dimetil-2-oxopentanoil)-2- piperidinocarboxilato de (E)-3-((3-(2, 5-dimetoxi)- fenilpropil)fenil)-2-propenilo; 1-(3, 3-dimetil-2- oxopentanoil)-2-piperidinocarboxilato de (E)-3-(1, 3- benzodioxol-5-il)-2-propenilo; 1-(2-oxo-2-fenilacetil)- 2-piperidinocarboxilato de 4-(4-metoxifenil)butilo; 1- (2-oxo-2-fenilacetil)-2-piperidinocarboxilato de 3- fenilpropilo; 1-(2-oxo-2-fenilacetil)-2- piperidinocarboxilato de 3-(3-piridil)propilo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16513799P | 1999-11-12 | 1999-11-12 | |
US165137P | 1999-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2269206T3 true ES2269206T3 (es) | 2007-04-01 |
Family
ID=22597584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES00980231T Expired - Lifetime ES2269206T3 (es) | 1999-11-12 | 2000-10-24 | Ligandos de neurofilina para tratar trastornos oculares. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20060083774A1 (es) |
EP (1) | EP1227859B1 (es) |
JP (1) | JP2003514015A (es) |
AR (1) | AR034103A1 (es) |
AT (1) | ATE335524T1 (es) |
AU (1) | AU784347B2 (es) |
BR (1) | BR0015486A (es) |
CA (1) | CA2386579A1 (es) |
CY (1) | CY1106232T1 (es) |
DE (1) | DE60029985T2 (es) |
DK (1) | DK1227859T3 (es) |
ES (1) | ES2269206T3 (es) |
HK (1) | HK1046108B (es) |
PT (1) | PT1227859E (es) |
TW (1) | TW200511984A (es) |
WO (1) | WO2001035948A2 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021178977A1 (en) * | 2020-03-06 | 2021-09-10 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Compositions and methods for treating ocular disorders |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5260059A (en) * | 1989-04-14 | 1993-11-09 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University | Treatment of open-angle glaucoma by modulation matrix metalloproteinases and their inhibitor |
US5922773A (en) * | 1992-12-04 | 1999-07-13 | The Children's Medical Center Corp. | Glaucoma treatment |
US5798355A (en) * | 1995-06-07 | 1998-08-25 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity |
US5710165A (en) * | 1994-07-06 | 1998-01-20 | Synthelabo | Use of polyamine antagonists for the treatment of glaucoma |
US5696135A (en) * | 1995-06-07 | 1997-12-09 | Gpi Nil Holdings, Inc. | Inhibitors of rotamase enzyme activity effective at stimulating neuronal growth |
US5859031A (en) * | 1995-06-07 | 1999-01-12 | Gpi Nil Holdings, Inc. | Small molecule inhibitors of rotamase enzyme activity |
US5614547A (en) * | 1995-06-07 | 1997-03-25 | Guilford Pharmaceuticals Inc. | Small molecule inhibitors of rotamase enzyme |
US5856329A (en) * | 1995-06-28 | 1999-01-05 | Allergan | Method of using (2-imidazolin-2-ylamino) quinoxalines in treating ocular neural injury |
US5786378A (en) * | 1996-09-25 | 1998-07-28 | Gpi Nil Holdings, Inc. | Heterocyclic thioesters |
US5801187A (en) * | 1996-09-25 | 1998-09-01 | Gpi-Nil Holdings, Inc. | Heterocyclic esters and amides |
US5780484A (en) * | 1996-11-13 | 1998-07-14 | Vertex Pharmaceuticals Incorporated | Methods for stimulating neurite growth with piperidine compounds |
US5840736A (en) * | 1996-11-13 | 1998-11-24 | Vertex Pharmaceuticals Incorporated | Methods and compositions for stimulating neurite growth |
US5811434A (en) * | 1996-11-13 | 1998-09-22 | Vertex Pharmacueticals Incorporated | Methods and compositions for stimulating neurite growth |
US5721256A (en) * | 1997-02-12 | 1998-02-24 | Gpi Nil Holdings, Inc. | Method of using neurotrophic sulfonamide compounds |
US5846979A (en) * | 1997-02-28 | 1998-12-08 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic esters, amides, thioesters, and ketones |
US5877211A (en) * | 1997-11-21 | 1999-03-02 | Allergan | EP2 receptor agonists as neuroprotective agents for the eye |
DE69907418T2 (de) * | 1998-02-23 | 2003-11-13 | Fujisawa Pharmaceutical Co | Verwendung von makroliden zur behandlung von glaukom |
US6399648B1 (en) * | 1998-08-14 | 2002-06-04 | Gpi Nil Holdings, Inc. | N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders |
JP4503180B2 (ja) * | 1998-08-14 | 2010-07-14 | ジーピーアイ ニル ホールディングス インコーポレイテッド | 視覚および記憶障害のための組成物および使用法 |
-
2000
- 2000-10-24 EP EP00980231A patent/EP1227859B1/en not_active Expired - Lifetime
- 2000-10-24 BR BR0015486-5A patent/BR0015486A/pt not_active Application Discontinuation
- 2000-10-24 AT AT00980231T patent/ATE335524T1/de active
- 2000-10-24 PT PT00980231T patent/PT1227859E/pt unknown
- 2000-10-24 WO PCT/US2000/029320 patent/WO2001035948A2/en active IP Right Grant
- 2000-10-24 DE DE60029985T patent/DE60029985T2/de not_active Expired - Lifetime
- 2000-10-24 DK DK00980231T patent/DK1227859T3/da active
- 2000-10-24 AU AU17522/01A patent/AU784347B2/en not_active Ceased
- 2000-10-24 JP JP2001537941A patent/JP2003514015A/ja active Pending
- 2000-10-24 CA CA002386579A patent/CA2386579A1/en not_active Abandoned
- 2000-10-24 AR ARP000105596A patent/AR034103A1/es unknown
- 2000-10-24 ES ES00980231T patent/ES2269206T3/es not_active Expired - Lifetime
- 2000-11-10 TW TW093138914A patent/TW200511984A/zh unknown
-
2002
- 2002-09-26 HK HK02107121.5A patent/HK1046108B/zh not_active IP Right Cessation
-
2005
- 2005-12-06 US US11/295,033 patent/US20060083774A1/en not_active Abandoned
-
2006
- 2006-11-02 CY CY20061101579T patent/CY1106232T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
TW200511984A (en) | 2005-04-01 |
PT1227859E (pt) | 2006-12-29 |
WO2001035948A3 (en) | 2002-01-17 |
AU784347B2 (en) | 2006-03-16 |
ATE335524T1 (de) | 2006-09-15 |
AR034103A1 (es) | 2004-02-04 |
DE60029985D1 (de) | 2006-09-21 |
EP1227859A2 (en) | 2002-08-07 |
AU1752201A (en) | 2001-05-30 |
DK1227859T3 (da) | 2006-12-11 |
JP2003514015A (ja) | 2003-04-15 |
US20060083774A1 (en) | 2006-04-20 |
WO2001035948A2 (en) | 2001-05-25 |
EP1227859B1 (en) | 2006-08-09 |
CA2386579A1 (en) | 2001-05-25 |
BR0015486A (pt) | 2002-07-02 |
HK1046108A1 (en) | 2002-12-27 |
CY1106232T1 (el) | 2011-06-08 |
DE60029985T2 (de) | 2007-02-01 |
HK1046108B (zh) | 2007-01-05 |
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