ES2247820T3 - Analizador de cizallamiento de circulacion para moleculas biologicas activas en capas de liquidos en superficies, procedimiento para los analisis de un liquido y procedimiento para determinar un espesor de una capa de liquido ultrafina. - Google Patents
Analizador de cizallamiento de circulacion para moleculas biologicas activas en capas de liquidos en superficies, procedimiento para los analisis de un liquido y procedimiento para determinar un espesor de una capa de liquido ultrafina.Info
- Publication number
- ES2247820T3 ES2247820T3 ES99936304T ES99936304T ES2247820T3 ES 2247820 T3 ES2247820 T3 ES 2247820T3 ES 99936304 T ES99936304 T ES 99936304T ES 99936304 T ES99936304 T ES 99936304T ES 2247820 T3 ES2247820 T3 ES 2247820T3
- Authority
- ES
- Spain
- Prior art keywords
- liquid
- chamber
- sample
- analyzer
- sample chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 110
- 238000004458 analytical method Methods 0.000 title claims abstract description 28
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- 230000004087 circulation Effects 0.000 title claims description 23
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- 239000012530 fluid Substances 0.000 claims abstract description 39
- 238000001179 sorption measurement Methods 0.000 claims abstract description 30
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- 238000006243 chemical reaction Methods 0.000 claims abstract description 12
- 239000000523 sample Substances 0.000 claims description 66
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 47
- 239000010453 quartz Substances 0.000 claims description 39
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- 102000008946 Fibrinogen Human genes 0.000 description 9
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- 238000010494 dissociation reaction Methods 0.000 description 6
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- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 3
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- LDCYZAJDBXYCGN-VIFPVBQESA-N 5-hydroxy-L-tryptophan Chemical compound C1=C(O)C=C2C(C[C@H](N)C(O)=O)=CNC2=C1 LDCYZAJDBXYCGN-VIFPVBQESA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
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- 229910052724 xenon Inorganic materials 0.000 description 2
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 2
- 102000004506 Blood Proteins Human genes 0.000 description 1
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- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
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- 239000008280 blood Substances 0.000 description 1
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- 230000017531 blood circulation Effects 0.000 description 1
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- 238000005194 fractionation Methods 0.000 description 1
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- 235000011187 glycerol Nutrition 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
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- 150000002500 ions Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052756 noble gas Inorganic materials 0.000 description 1
- 230000010287 polarization Effects 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001296 polysiloxane Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
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- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N13/00—Investigating surface or boundary effects, e.g. wetting power; Investigating diffusion effects; Analysing materials by determining surface, boundary, or diffusion effects
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/405—Concentrating samples by adsorption or absorption
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/117497—Automated chemical analysis with a continuously flowing sample or carrier stream
- Y10T436/118339—Automated chemical analysis with a continuously flowing sample or carrier stream with formation of a segmented stream
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Length Measuring Devices By Optical Means (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19823301 | 1998-05-25 | ||
| DE19823301 | 1998-05-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2247820T3 true ES2247820T3 (es) | 2006-03-01 |
Family
ID=7868841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99936304T Expired - Lifetime ES2247820T3 (es) | 1998-05-25 | 1999-05-25 | Analizador de cizallamiento de circulacion para moleculas biologicas activas en capas de liquidos en superficies, procedimiento para los analisis de un liquido y procedimiento para determinar un espesor de una capa de liquido ultrafina. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6843963B1 (OSRAM) |
| EP (1) | EP1082601B1 (OSRAM) |
| JP (1) | JP3935317B2 (OSRAM) |
| AT (1) | ATE301831T1 (OSRAM) |
| AU (1) | AU760704B2 (OSRAM) |
| CA (1) | CA2333391C (OSRAM) |
| DE (2) | DE59912399D1 (OSRAM) |
| ES (1) | ES2247820T3 (OSRAM) |
| WO (1) | WO1999061896A1 (OSRAM) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1383603B1 (en) * | 2001-04-26 | 2006-08-23 | Vrije Universiteit Brussel | Method for accelaration and intensification of target-receptor binding and device therefor |
| DE10258048A1 (de) | 2002-12-11 | 2004-06-24 | Man Roland Druckmaschinen Ag | Gummituchzylinder für Offset-Druckmaschinen |
| US7417737B2 (en) * | 2003-12-02 | 2008-08-26 | Fujilfilm Corporation | Method for measuring surface plasmon resonance |
| JP4664298B2 (ja) | 2004-08-24 | 2011-04-06 | 富士フイルム株式会社 | 表面プラズモン共鳴分析における解離定数の算出方法 |
| US7449343B2 (en) | 2004-09-07 | 2008-11-11 | Fujifilm Corporation | Method for measuring surface plasmon resonance |
| US20070202609A1 (en) * | 2004-11-09 | 2007-08-30 | Roper D K | Apparatus and methods for increasing lateral mass transfer over molecule sensors |
| US7955864B2 (en) * | 2005-08-22 | 2011-06-07 | Life Technologies Corporation | Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other |
| DE102007012866A1 (de) | 2007-03-09 | 2008-09-18 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Flusskanalsystem und Verfahren zum Anbinden von Analyten an Liganden |
| JP5033820B2 (ja) * | 2009-02-03 | 2012-09-26 | 株式会社日立ハイテクノロジーズ | 全反射顕微鏡装置、及び蛍光試料分析方法 |
| DE102010041426A1 (de) * | 2010-09-27 | 2012-05-03 | Siemens Aktiengesellschaft | Messeinheit und Verfahren zur optischen Untersuchung einer Flüssigkeit zur Bestimmung einer Analyt-Konzentration |
| DE102012102983A1 (de) * | 2012-04-05 | 2013-10-10 | Carl Zeiss Microscopy Gmbh | Verfahren und Vorrichtung zum Bestimmen eines kritischen Winkels eines Anregungslichtstrahls |
| EP2677037B1 (en) * | 2012-06-21 | 2016-04-13 | Synapse B.V. | Simultaneous measurement of thrombin generation and clot strength in plasma and whole blood |
| ES3055651T3 (en) | 2016-07-28 | 2026-02-13 | Otsuka Pharma Co Ltd | Detection chip, detection system, and detection method |
| ES2947300T3 (es) * | 2017-02-15 | 2023-08-04 | Otsuka Pharma Co Ltd | Chip de inspección y sistema de inspección |
| DE102017115661A1 (de) * | 2017-07-12 | 2019-01-17 | Endress+Hauser Conducta Gmbh+Co. Kg | Optischer Sensor |
| CN109580482A (zh) * | 2018-12-04 | 2019-04-05 | 华北电力大学 | 一种纳米颗粒强化气液传质过程中微观状态观测装置及其方法 |
| US20220326234A1 (en) * | 2019-09-24 | 2022-10-13 | Otsuka Pharmaceutical Co., Ltd. | Detection method and detection device |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4028056A (en) * | 1976-04-20 | 1977-06-07 | Technicon Instruments Corporation | Substance separation technique |
| US4413505A (en) * | 1981-03-09 | 1983-11-08 | Environmental Sciences Associates, Inc. | Electrochemical flow cell, particularly use with liquid chromatography |
| DE3168903D1 (en) * | 1980-08-28 | 1985-03-28 | Du Pont | Flow analysis |
| AU557816B2 (en) * | 1981-09-18 | 1987-01-08 | Prutec Ltd. | Method for the determination of species in solution with an optical wave-guide |
| DE3588124T2 (de) * | 1984-06-13 | 1997-02-20 | Applied Research Systems | Vorrichtung, mit Verwendung in chemischen Prüfverfahren |
| GB8829942D0 (en) * | 1988-12-22 | 1989-02-15 | Isis Innovations Ltd | Method |
| RU2095787C1 (ru) * | 1994-09-27 | 1997-11-10 | Московский областной научно-исследовательский клинический институт | Оптическая кювета для исследования жидкости в тонком слое |
| US5716852A (en) * | 1996-03-29 | 1998-02-10 | University Of Washington | Microfabricated diffusion-based chemical sensor |
| US6184978B1 (en) * | 1996-05-15 | 2001-02-06 | International Remote Imaging Systems, Inc. | Method and apparatus for verifying uniform flow of a fluid sample through a flow cell and distribution on a slide |
-
1999
- 1999-05-25 EP EP99936304A patent/EP1082601B1/de not_active Expired - Lifetime
- 1999-05-25 ES ES99936304T patent/ES2247820T3/es not_active Expired - Lifetime
- 1999-05-25 WO PCT/DE1999/001529 patent/WO1999061896A1/de not_active Ceased
- 1999-05-25 DE DE59912399T patent/DE59912399D1/de not_active Expired - Lifetime
- 1999-05-25 DE DE19980961T patent/DE19980961D2/de not_active Expired - Lifetime
- 1999-05-25 AU AU51494/99A patent/AU760704B2/en not_active Ceased
- 1999-05-25 JP JP2000551244A patent/JP3935317B2/ja not_active Expired - Fee Related
- 1999-05-25 AT AT99936304T patent/ATE301831T1/de active
- 1999-05-25 CA CA2333391A patent/CA2333391C/en not_active Expired - Fee Related
- 1999-05-25 US US09/701,066 patent/US6843963B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE59912399D1 (de) | 2005-09-15 |
| AU760704B2 (en) | 2003-05-22 |
| EP1082601B1 (de) | 2005-08-10 |
| JP3935317B2 (ja) | 2007-06-20 |
| AU5149499A (en) | 1999-12-13 |
| ATE301831T1 (de) | 2005-08-15 |
| DE19980961D2 (de) | 2002-01-03 |
| EP1082601A1 (de) | 2001-03-14 |
| CA2333391A1 (en) | 1999-12-02 |
| CA2333391C (en) | 2012-01-31 |
| JP2002516993A (ja) | 2002-06-11 |
| US6843963B1 (en) | 2005-01-18 |
| WO1999061896A1 (de) | 1999-12-02 |
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