ES2240345T3 - Derivados de amidinofenilalanina como inhibidores de trombina. - Google Patents

Derivados de amidinofenilalanina como inhibidores de trombina.

Info

Publication number
ES2240345T3
ES2240345T3 ES01272199T ES01272199T ES2240345T3 ES 2240345 T3 ES2240345 T3 ES 2240345T3 ES 01272199 T ES01272199 T ES 01272199T ES 01272199 T ES01272199 T ES 01272199T ES 2240345 T3 ES2240345 T3 ES 2240345T3
Authority
ES
Spain
Prior art keywords
formula
methyl
compound
hydrazino
pip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01272199T
Other languages
English (en)
Spanish (es)
Inventor
Uros Urleb
Anamarija Zega
Mojca Stegnar
Bakija Alenka Trampus
Tomaz Solmajer
Gregor Mlinsek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lek Pharmaceuticals dd
Univerza Ljubljana v Fakulteta za Farmazijo
Original Assignee
Univerza Ljubljana v Fakulteta za Farmazijo
Lek Pharmaceuticals and Chemical Co dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univerza Ljubljana v Fakulteta za Farmazijo, Lek Pharmaceuticals and Chemical Co dd filed Critical Univerza Ljubljana v Fakulteta za Farmazijo
Application granted granted Critical
Publication of ES2240345T3 publication Critical patent/ES2240345T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/48—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom
    • C07C311/49—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups having nitrogen atoms of sulfonamide groups further bound to another hetero atom to nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES01272199T 2000-12-22 2001-12-20 Derivados de amidinofenilalanina como inhibidores de trombina. Expired - Lifetime ES2240345T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI200000326A SI20743A (sl) 2000-12-22 2000-12-22 Novi trombinski inhibitorji
SI200000326 2000-12-22

Publications (1)

Publication Number Publication Date
ES2240345T3 true ES2240345T3 (es) 2005-10-16

Family

ID=20432799

Family Applications (1)

Application Number Title Priority Date Filing Date
ES01272199T Expired - Lifetime ES2240345T3 (es) 2000-12-22 2001-12-20 Derivados de amidinofenilalanina como inhibidores de trombina.

Country Status (10)

Country Link
US (2) US7285547B2 (enExample)
EP (1) EP1355894B1 (enExample)
JP (1) JP4390453B2 (enExample)
AT (1) ATE291016T1 (enExample)
DE (1) DE60109498T2 (enExample)
DK (1) DK1355894T3 (enExample)
ES (1) ES2240345T3 (enExample)
PT (1) PT1355894E (enExample)
SI (1) SI20743A (enExample)
WO (1) WO2002051824A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
GB0523539D0 (en) * 2005-11-18 2005-12-28 Lek Tovarna Farmacevtskih New use of organic compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9322976D0 (en) * 1993-11-08 1994-01-05 Pfizer Ltd Therapeutic agents

Also Published As

Publication number Publication date
WO2002051824A1 (en) 2002-07-04
PT1355894E (pt) 2005-08-31
US20080004256A1 (en) 2008-01-03
DK1355894T3 (da) 2005-07-11
DE60109498T2 (de) 2006-04-13
EP1355894B1 (en) 2005-03-16
EP1355894A1 (en) 2003-10-29
JP4390453B2 (ja) 2009-12-24
DE60109498D1 (en) 2005-04-21
ATE291016T1 (de) 2005-04-15
JP2004516317A (ja) 2004-06-03
US7285547B2 (en) 2007-10-23
SI20743A (sl) 2002-06-30
US20040048851A1 (en) 2004-03-11

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