ES2192141B1 - Formulaciones acrilicas de curado en frio con activadores derivados de diaminodifenilcarbinol de baja toxicidad. - Google Patents
Formulaciones acrilicas de curado en frio con activadores derivados de diaminodifenilcarbinol de baja toxicidad.Info
- Publication number
- ES2192141B1 ES2192141B1 ES200200312A ES200200312A ES2192141B1 ES 2192141 B1 ES2192141 B1 ES 2192141B1 ES 200200312 A ES200200312 A ES 200200312A ES 200200312 A ES200200312 A ES 200200312A ES 2192141 B1 ES2192141 B1 ES 2192141B1
- Authority
- ES
- Spain
- Prior art keywords
- cement
- low toxicity
- formulations
- acrylic
- cold curing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 231100000053 low toxicity Toxicity 0.000 title abstract 3
- 239000012190 activator Substances 0.000 title abstract 2
- 239000002639 bone cement Substances 0.000 abstract 3
- 239000004568 cement Substances 0.000 abstract 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 206010067484 Adverse reaction Diseases 0.000 abstract 1
- 230000006838 adverse reaction Effects 0.000 abstract 1
- 238000013267 controlled drug release Methods 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- VWLLGOHTYLKBJE-UHFFFAOYSA-N o-[amino(diphenyl)methyl]hydroxylamine Chemical compound C=1C=CC=CC=1C(N)(ON)C1=CC=CC=C1 VWLLGOHTYLKBJE-UHFFFAOYSA-N 0.000 abstract 1
- 230000000399 orthopedic effect Effects 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000001356 surgical procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A61K6/083—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
Landscapes
- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Surgery (AREA)
- Materials For Medical Uses (AREA)
Abstract
Formulaciones acrílicas de curado en frío con activadores derivados de diaminodifenilcarbinol de baja toxicidad. La presente invención está relacionada con el desarrollo de formulaciones acrílicas de curado en frío para su uso como composiciones precursoras de cementos óseos de baja toxicidad y buena biocompatibilidad. Los cementos óseos poliméricos se vienen empleando durante las últimas décadas como soportes de liberación controlada de medicamentos y en cirugía ortopédica y traumatología para la fijación de prótesis de articulaciones siendo la función del cemento óseo la inmovilización de la prótesis. Sin embargo, se han descrito ciertas reacciones adversas producidas por el cemento a medio y largo plazo que se relacionan principalmente con la composición química del cemento y/o sus propiedades físicas.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200200312A ES2192141B1 (es) | 2002-02-08 | 2002-02-08 | Formulaciones acrilicas de curado en frio con activadores derivados de diaminodifenilcarbinol de baja toxicidad. |
PCT/ES2003/000055 WO2003066117A1 (es) | 2002-02-08 | 2003-01-31 | Formulaciones acrílicas de curado en frío con activadores derivados de diaminodifenilcarbinol de baja toxicidad |
AU2003208725A AU2003208725A1 (en) | 2002-02-08 | 2003-01-31 | Cold-curing acrylic formulations comprising low toxicity activators derived from diaminodiphenylcarbinol |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200200312A ES2192141B1 (es) | 2002-02-08 | 2002-02-08 | Formulaciones acrilicas de curado en frio con activadores derivados de diaminodifenilcarbinol de baja toxicidad. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2192141A1 ES2192141A1 (es) | 2003-09-16 |
ES2192141B1 true ES2192141B1 (es) | 2005-02-16 |
Family
ID=27675918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200200312A Expired - Fee Related ES2192141B1 (es) | 2002-02-08 | 2002-02-08 | Formulaciones acrilicas de curado en frio con activadores derivados de diaminodifenilcarbinol de baja toxicidad. |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2003208725A1 (es) |
ES (1) | ES2192141B1 (es) |
WO (1) | WO2003066117A1 (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110339395A (zh) * | 2018-04-03 | 2019-10-18 | 暨南大学 | 一种pmma基的水合骨水泥及其制备方法与应用 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10332680A1 (de) * | 2003-07-18 | 2005-02-17 | Biomet Deutschland Gmbh | Verwendung von antiseptischen Wirkstoffen in PMMA-Knochenzementen |
CN107041970B (zh) * | 2016-12-20 | 2020-12-15 | 中山大学 | 一种高无机组分的复合型骨水泥及其制备方法和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08245329A (ja) * | 1995-03-13 | 1996-09-24 | G C:Kk | 義歯床用裏装材 |
GB9928837D0 (en) * | 1999-12-06 | 2000-02-02 | Abonetics Ltd | Novel bone cement |
-
2002
- 2002-02-08 ES ES200200312A patent/ES2192141B1/es not_active Expired - Fee Related
-
2003
- 2003-01-31 WO PCT/ES2003/000055 patent/WO2003066117A1/es not_active Application Discontinuation
- 2003-01-31 AU AU2003208725A patent/AU2003208725A1/en not_active Abandoned
Non-Patent Citations (3)
Title |
---|
DEB, S. et al.: Water absortion characteristics and cytotoxic and biological evaluation of bone cements formulated with a novel activator. J. of Biomedical Materials Research, 1999, Vol. 48, nº 5, páginas 719-725, resumen, tabla I. * |
RÉTHY, E. et al.: Sinthetische lineare polimere V. Die-wirkung der tetra alkyldiamino- diaryl-aktivatoren auf die polymerisation der monomer- polymer-mischungen des methyl methacrylates in anwesenheit von benzoylperoxyd. Macromol. Chem., 1958, Vol. 25, páginas 176-185. \\ Y 3-6,9,10 * |
VÁZQUEZ, B. et al.: "Application of long chain amine activator in conventional acrylic bone cement". J. of Biomedical Materials Research, 1998, Vol. 43, nº 2, páginas 131-139, resumen, tabla I. * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110339395A (zh) * | 2018-04-03 | 2019-10-18 | 暨南大学 | 一种pmma基的水合骨水泥及其制备方法与应用 |
CN110339395B (zh) * | 2018-04-03 | 2021-09-21 | 暨南大学 | 一种pmma基的水合骨水泥及其制备方法与应用 |
Also Published As
Publication number | Publication date |
---|---|
AU2003208725A1 (en) | 2003-09-02 |
ES2192141A1 (es) | 2003-09-16 |
WO2003066117A1 (es) | 2003-08-14 |
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Legal Events
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