ES2191314T3 - Procedimiento para la obtencion de bisimidas aromaticas. - Google Patents

Procedimiento para la obtencion de bisimidas aromaticas.

Info

Publication number
ES2191314T3
ES2191314T3 ES98930671T ES98930671T ES2191314T3 ES 2191314 T3 ES2191314 T3 ES 2191314T3 ES 98930671 T ES98930671 T ES 98930671T ES 98930671 T ES98930671 T ES 98930671T ES 2191314 T3 ES2191314 T3 ES 2191314T3
Authority
ES
Spain
Prior art keywords
groups
formula
carbon atoms
mean
same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98930671T
Other languages
English (en)
Inventor
Wolfgang Viergutz
Stefan Koser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Abbott GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott GmbH and Co KG filed Critical Abbott GmbH and Co KG
Application granted granted Critical
Publication of ES2191314T3 publication Critical patent/ES2191314T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Procedimiento para la obtención de bisimidas de la fórmula I **(Fórmula)** en la cual significan R el resto -Alqu1-NH-Alqu2-(NH-Alqu3)a -, representando Alqu1, Alqu2 y Alqu3 restos alquileno con 2 a 6 átomos de carbono y a el número 0 o 1, R1 + R2 significan conjuntamente **(Fórmula)** y R3 + R4 significan conjuntamente **(Fórmula)** donde X1 y X2, que pueden ser iguales o diferentes, significan átomos de hidrógeno o de halógeno, grupos nitro, grupos amino substituidos, en caso dado, por 1 o 2 restos alquilo con 1 a 4 átomos de carbono, grupos hidroxi, grupos mercapto o grupos alquilo con 1 a 4 átomos de carbono, y X3 y X4, que pueden ser iguales o diferentes, significan átomos de hidrógeno o de halógeno, grupos amino substituidos, en caso dado, por 1 o 2 restos alquilo con 1 a 4 átomos de carbono, grupos hidroxi, grupos mercapto o grupos alquilo con 1 a 4 átomos de carbono, mediante reacción de los correspondientes anhídridos del ácido dicarboxílico de las fórmulas II y III R1-CO-O-CO-R2 (II) R3-CO-O-CO-R4 (III), en las cuales tienen R1, R2, R3 y R4 el significado anteriormente indicado, con una amina de la fórmula H2N-R-NH2, significando R lo mismo como antes, caracterizado porque se lleva a cabo la reacción en presencia de una amina terciaria.
ES98930671T 1997-05-16 1998-05-04 Procedimiento para la obtencion de bisimidas aromaticas. Expired - Lifetime ES2191314T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19720803A DE19720803A1 (de) 1997-05-16 1997-05-16 Verfahren zur Herstellung von aromatischen Bisimiden

Publications (1)

Publication Number Publication Date
ES2191314T3 true ES2191314T3 (es) 2003-09-01

Family

ID=7829816

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98930671T Expired - Lifetime ES2191314T3 (es) 1997-05-16 1998-05-04 Procedimiento para la obtencion de bisimidas aromaticas.

Country Status (8)

Country Link
US (1) US6177570B1 (es)
EP (1) EP0983247B1 (es)
JP (1) JP2001527564A (es)
CN (1) CN1124265C (es)
DE (2) DE19720803A1 (es)
DK (1) DK0983247T3 (es)
ES (1) ES2191314T3 (es)
WO (1) WO1998052924A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7947839B2 (en) * 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
CN102702297B (zh) * 2012-06-20 2014-07-02 河南省科学院化学研究所有限公司 胆酸-萘酰亚胺类化合物的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4136489A1 (de) 1991-11-06 1993-05-13 Bayer Ag Neue diethylentriamin-derivate und deren verwendung zu diagnostischen und therapeutischen zwecken
DE69211567T2 (de) * 1991-12-11 1996-10-10 Du Pont Merck Pharma Hochwasserlösliche bis-naphthalimide-derivate nützlich als krebsmittel
US5376664A (en) * 1992-07-27 1994-12-27 The Du Pont Merck Pharmaceutical Company Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents
US5641782A (en) 1995-02-16 1997-06-24 The Dupont Merck Pharmaceutical Company 3-aromatic and 3-heteroaromatic substituted bisnaphthalimides

Also Published As

Publication number Publication date
DK0983247T3 (da) 2003-05-19
EP0983247B1 (de) 2003-01-22
US6177570B1 (en) 2001-01-23
CN1124265C (zh) 2003-10-15
CN1255125A (zh) 2000-05-31
JP2001527564A (ja) 2001-12-25
DE19720803A1 (de) 1998-11-19
DE59807019D1 (de) 2003-02-27
EP0983247A1 (de) 2000-03-08
WO1998052924A1 (de) 1998-11-26

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