ES2190199T3 - Agentes anti-tumorales. - Google Patents

Agentes anti-tumorales.

Info

Publication number
ES2190199T3
ES2190199T3 ES99909099T ES99909099T ES2190199T3 ES 2190199 T3 ES2190199 T3 ES 2190199T3 ES 99909099 T ES99909099 T ES 99909099T ES 99909099 T ES99909099 T ES 99909099T ES 2190199 T3 ES2190199 T3 ES 2190199T3
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
tumor agents
akanesulphonyloxy
alkanesulphonyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99909099T
Other languages
English (en)
Inventor
Francis Thomas Boyle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of ES2190199T3 publication Critical patent/ES2190199T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/34—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having amino groups and esterified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Un agente anti - tumoral de la fórmula I **(Fórmula)** en la cual R1 es hidrógeno, (1 - 4C)alquilo, (3 - 4C) - alquenilo, (3 - 4C)alquinilo, hidroxi - (1 - 4C)alquilo, (1 - 4C)alcoxi - (1 - 4C)alquilo, amino - (1 - 4C)alquilo, (1 - 4C) - alquilamino - (1 - 4C)alquilo, di [(1 - 4C)alquil]amino - (1 - 4C) - alquilo, pirrolidin - 1 - il - (1 - 4C)alquilo, piperidino - (1 - 4C)alquilo, morfolino - (1 - 4C)alquilo, piperazin - 1 - il - (1 - 4C)alquilo, 4 - (1 - 4C)alquilpiperazin - 1 - il - (1 4C)alquilo, carboxi - (1 - 4C)alquilo, (1 - 4C)alcoxicarbonil - (1 - 4C) - alquilo, carbamoil - (1 - 4C) alquilo, N - (1 - 4C)alquil - carbamoil - (1 - 4C)alquilo, N, N - di - [(1 - 4C)alquil]carbamoil - (1 - 4C)alquilo, amino, (1 - 4C)alquilamino, (3 - 4C)alquenil - amino, (3 - 4C) alquinilamino, di - [(1 - 4C)alquil]amino, di - [(3 4C)alquenil]amino, di - [(3 - 4C)alquinil]amino, pirrol - idin - 1 - ilo, piperidino, morfolino, piperazin - 1 ilo, 4 - (1 - 4C) alquilpiperazin - 1 - ilo, hidroxi - (2 - 4C)alquilamino, (1 - 4C)alcoxi - (2 - 4C)alquilamino, amino - (2 - 4C)alquilamino, (1 - 4C)alquilamino - (2 - 4C)alquilamino, di - [(1 - 4C)alquil]amino - (2 4C)alquilamino, pirrolidin - 1 - il - (2 - 4C)alquilamino, piperidino - (2 - 4C)alquilamino, morfolino (2 - 4C)alquilamino, piperazin - 1 - il - (2 - 4)alquilamino, 4 - (1 - 4)alquil - piperazin - 1 - il - (2 4C)alquilamino, (2 - 4C)alcanoilamino, (2 - 4C)alcanoilamino - (2 - 4C)alquilamino, carboxi - (1 - 4C) alquilamino, (1 - 4C)alcoxicarbonil - (1 - 4C) - alquilamino, carbamoil - (1 - 4C)alquilamino, N - (1 4C)alquilcarbamoil - (1 - 4C)alquilamino, N, N - di - [(1 - 4C)alquil]carbamoil - (1 - 4C) - alquilamino, hidroxi, (1 - 4C) - alcoxi, hidroxi - (2 - 4C) - alcoxi, (1 - 4C)alcoxi - (2 - 4C)alcoxi, amino - (2 - 4C)alcoxi, (1 - 4C)alquilamino - (2 - 4C)alcoxi, di - [(1 - 4C)alquil]amino - (2 - 4C)alcoxi, pirrolidin - 1 - il - (2 4C)alcoxi, piperidino - (2 - 4C)alcoxi, morfolino - (2 - 4C)alcoxi, piperazin - 1 - il - (2 - 4C)alcoxi o 4 -(1 - 4C)alquilpiperazin - 1 - il - (2 - 4C)alcoxi; R2 es hidrógeno, (1 - 4C)alquilo, (3 - 4C)alquenilo, (3 - 4C) - alquinilo, hidroxi - (1 - 4C)alquilo, (1 4C)alcoxi - (1 - 4C) - alquilo, amino - (1 - 4C)alquilo, (1 - 4C)alquilamino - (1 - 4C) - alquilo, di [(1 - 4C)alquil]amino - (1 - 4C)alquilo, pirrolidin - 1 - il - (1 - 4C)alquilo, piperidino - (1 - 4C)alquilo, morfolino - (1 - 4C)alquilo, piperazin - 1 - il - (1 - 4C)alquilo, 4 - (1 - 4C)alquilpiperazin - 1 - il - (1 4C)alquilo, carboxi - (1 - 4C) - alquilo, (1 - 4C)alcoxicarbonil - (1 - 4C)alquilo, carbamoil - (1 - 4C)alquilo, N - (1 - 4C)alquilcarbamoil - (1 - 4C)alquilo, N, N - di - [(1 - 4C)alquil]carbamoil - (1 - 4C)alquilo, amino, (1 - 4C)alquilamino, (3 - 4C)alquenilamino, (3 - 4C)alquinilamino, di - [(1 - 4C)alquil]amino, di - [(3 4C)alquenil]amino, di - [(3 - 4C)alquinil]amino, pirrolidin - 1 - ilo, piperidino, morfolino, piperazin - 1 - ilo, 4 - (1 - 4C)alquilpiperazin - 1 - ilo, hidroxi - (2 - 4C)alquilamino, (1 - 4C)alcoxi- (2 - 4C) - alquilamino, amino - (2 - 4C)alquilamino, (1 - 4C)alquilamino - (2 - 4C)alquilamino, di - [(1 - 4C)alquil]amino (2 - 4C)alquil - amino, pirrolidin - 1 - il - (2 - 4C)alquilamino, piperidino - (2 - 4C)alquilamino, morfolino - (2 - 4C)alquilamino, piperazin - 1 - il - (2 - 4C)alquilamino, 4 - (1 - 4C)alquilpiperazin 1 - il - (2 - 4C)alquilamino, (2 - 4C)alcanoilamino, (2 - 4C)alcanoilamino - (2 - 4C)alquilamino, carboxi (1 - 4C)alquilamino, (1 - 4C) - alcoxicarbonil - (1 - 4C)alquilamino, carbamoil - (1 - 4C)alquil - amino, N - (1 - 4C)alquilcarbamoil - (1 - 4C)alquilamino, , N - di - [(1 - 4C)alquil]carbamoil - (1 - 4C)alquilamino, hidroxi, (1 - 4C)alcoxi, hidroxi - (2 - 4C)alcoxi, (1 - 4C)alcoxi - (2 - 4C) - alcoxi, amino - (2 - 4C)alcoxi, (1 - 4C)alquilamino - (2 - 4C) - alcoxi, di - [(1 - 4C)alquil]amino - (2 - 4C)alcoxi, pirrolidin - 1 - il - (2 4C)alcoxi, piperidino - (2 - 4C)alcoxi, morfolino - (2 - 4C)alcoxi, piperazin - 1 - il - (2 - 4C)alcoxi o 4 - (1 - 4C) - alquilpiperazin - 1 - il - (2 - 4C)alcoxi; R3 es hidrógeno, (1 - 4C)alquilo, (3 - 4C)alquenilo, (3 - 4C) - alquinilo, hidroxi - (1 - 4C)alquilo, (1 4C)alcoxi - (1 - 4C) - alquilo, amino - (1 - 4C)alquilo, (1 - 4C)alquilamino - (1 - 4C) - alquilo, di [(1 - 4C)alquil]amino - (1 - 4C)alquilo, pirrolidin - 1 - il - (1 - 4C)alquilo, piperidino - (1 - 4C)alquilo, morfolino - (1 - 4C)alquilo, piperazin - 1 - il - (1 - 4C)alquilo, 4 - (1 - 4C)alquilpiperazin - 1 - il - (1 4C)alquilo, carboxi - (1 - 4C) - alquilo, (1 - 4C)alcoxicarbonil - (1 - 4C)alquilo, carbamoil - (1 - 4C)alquilo, N - (1 - 4C)alquilcarbamoil - (1 - 4C)alquilo, N, N - di - [(1 - 4C)alquil]carbamoil - (1 - 4C)alquilo, amino, (1 - 4C) - alquilamino, (3 - 4C)alquenilamino, (3 - 4C)alquinilamino, di - [(1 - 4C)alquil]amino, di - [(3 4C)alquenil]amino, di - [(3 - 4C)alquinil]amino, pirrolidin - 1 - ilo, piperidino, morfolino, piperazin - 1 - ilo, 4 - (1 - 4C)alquilpiperazin - 1 - ilo, hidroxi - (2 - 4C)alquilamino, (1 - 4C)alcoxi - (2 - 4C)alquilamino, amino - (2 - 4C)alquilamino, (1 - 4C)alquilamino - (2 - 4C)alquilamino, di - [(1 - 4C)alquil]amino (2 - 4C)alquilamino, pirrolidin - 1 - il - (2 - 4C)alquilamino, piperidino - (2 - 4C)alquilamino, morfolino - (2 - 4C)alquilamino, piperazin - 1 - il - (2 - 4C)alquilamino, 4 - (1 - 4C)alquilpiperazin - 1 - il (2 - 4C)alquilamino, (2 - 4C)alcanoilamino, (2 - 4C)alcanoilamino - (2 - 4C)alquilamino, carboxi - (1 4C)alquilamino, (1 - 4C)alcoxicarbonil - (1 - 4C)alquilamino, carbamoil - (1 - 4C)alquilamino, N - (1 4C) - alquilcarbamoil - (1 - 4C)alquilamino, N, N - di - [(1 - 4C) - alquil]carbamoil - (1 - 4C)alquilamino, hidroxi, (1 - 4C)alcoxi, hidroxi - (2 - 4C)alcoxi, (1 - 4C)alcoxi - (2 - 4C)alcoxi, amino - (2 - 4C)alcoxi, (1 - 4C)alquilamino - (2 - 4C)alcoxi, di - [(1 - 4C)alquil]amino - (2 - 4C)alcoxi, pirrolidin - 1 - il - (2 4C)alcoxi, piperidino - (2 - 4C)alcoxi, morfolino - (2 - 4C)alcoxi, piperazin - 1 - il - (2 - 4C)alcoxi o 4 - (1 - 4C)alquilpiperazin - 1 - il - (2 - 4C)alcoxi; R4 es (1 - 4C)alquilo; R5 es (1 - 4C)alquilo; R6 es hidrógeno o (1 - 4C)alquilo; R7 es hidrógeno o (1 - 4C)alquilo; X es oxígeno; m es 1 ó 2 y cada R8 es independientemente hidrógeno, halógeno, hidroxi, (1 - 4C)alcoxi, (2 4C)alqueniloxi, (2 - 4C) - alquiniloxi, (1 - 4C)alquilo, (3 - 4C)alquenilo, (3 - 4C) - alquinilo, amino, (1 - 4C)alquilamino, di - [(1 - 4C)alquil] - amino, ciano, (2 - 4C alcanoilamino, carboxi, (1 - 4C)alcoxi carbonilo, carbamoílo, N - (1 - 4C)alquilcarbamoílo o N, N - di - [(1 - 4C)alquil]carbamoílo; Y1 es halógeno, (1 - 4C)alcanosulfoniloxi, bencenosulfonil - oxi o fenil - (1 - 4C)alcanosulfoniloxi; e Y2 es halógeno, (1 - 4C)alcanosulfoniloxi, bencenosulfonil - oxi o fenil - (1 - 4C)alcanosulfoniloxi; y en la cual cualquier grupo heterocíclico en R1, R2 o R3 está sustituido opcionalmente con 1, 2 ó 3 sustituyentes (1 - 4C)alquilo, y en la cual cualquier grupo fenilo en Y1 o Y2 cuando Y1 e Y2 es bencenosulfoniloxi o fenil - (1 - 4C)alcanosulfoniloxi está sustituido opcionalmente con 1, 2 ó 3 sustituyentes seleccionados de halógeno, nitro, ciano, trifluorometilo, hidroxi, amino, (1 - 4C)alquilo, (1 - 4C)alcoxi, (1 - 4C)alquilamino y di - [(1 - 4C)alquil]amino; o una de sus sales farmacéuticamente aceptables; con la condición de que al menos uno de R1, R2, y R3 es distinto de hidrógeno.
ES99909099T 1998-03-20 1999-03-16 Agentes anti-tumorales. Expired - Lifetime ES2190199T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9805866.2A GB9805866D0 (en) 1998-03-20 1998-03-20 Anti-tumour agents

Publications (1)

Publication Number Publication Date
ES2190199T3 true ES2190199T3 (es) 2003-07-16

Family

ID=10828858

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99909099T Expired - Lifetime ES2190199T3 (es) 1998-03-20 1999-03-16 Agentes anti-tumorales.

Country Status (18)

Country Link
US (1) US6346633B1 (es)
EP (1) EP1064253B1 (es)
JP (1) JP2002507590A (es)
KR (1) KR20010042055A (es)
CN (1) CN1293654A (es)
AT (1) ATE231835T1 (es)
AU (1) AU756651B2 (es)
BR (1) BR9908932A (es)
CA (1) CA2324361A1 (es)
DE (1) DE69905142T2 (es)
DK (1) DK1064253T3 (es)
ES (1) ES2190199T3 (es)
GB (1) GB9805866D0 (es)
IL (1) IL138589A (es)
NO (1) NO20004662L (es)
NZ (1) NZ505856A (es)
WO (1) WO1999048857A1 (es)
ZA (1) ZA200004387B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9805868D0 (en) 1998-03-20 1998-05-13 Zeneca Ltd Anti-tumour agents
US20060099712A1 (en) * 2004-11-08 2006-05-11 Eastman Kodak Company Correlation of anti-cancer activity of dyes with redox potentials
BR112018076639A2 (pt) * 2016-06-27 2019-04-02 Systems Oncology, Llc quimioterapias de combinação
US20220185785A1 (en) * 2019-04-12 2022-06-16 TONIX Pharmaceuticals Holding Corp Inhibitors of cd40-cd154 binding

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2862107D1 (en) 1977-12-02 1982-11-18 Takeda Chemical Industries Ltd Glucosamine-peptide derivatives and their pharmaceutical compositions
JPS58177934A (ja) * 1982-04-13 1983-10-18 Takeda Chem Ind Ltd ベンゾキノン誘導体
NZ240785A (en) * 1991-11-28 1995-08-28 Cancer Res Campaign Tech Substituted nitro aniline derivatives and medicaments
GB9805868D0 (en) 1998-03-20 1998-05-13 Zeneca Ltd Anti-tumour agents

Also Published As

Publication number Publication date
EP1064253A1 (en) 2001-01-03
ATE231835T1 (de) 2003-02-15
DK1064253T3 (da) 2003-06-23
ZA200004387B (en) 2001-10-31
GB9805866D0 (en) 1998-05-13
DE69905142T2 (de) 2003-10-16
EP1064253B1 (en) 2003-01-29
US6346633B1 (en) 2002-02-12
BR9908932A (pt) 2005-10-25
JP2002507590A (ja) 2002-03-12
NZ505856A (en) 2002-09-27
CA2324361A1 (en) 1999-09-30
KR20010042055A (ko) 2001-05-25
NO20004662D0 (no) 2000-09-19
NO20004662L (no) 2000-11-17
AU756651B2 (en) 2003-01-16
DE69905142D1 (de) 2003-03-06
IL138589A (en) 2004-08-31
CN1293654A (zh) 2001-05-02
IL138589A0 (en) 2001-10-31
WO1999048857A1 (en) 1999-09-30
AU2846899A (en) 1999-10-18

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