ES2189469T3 - Sistema en forma de microfluido para reacciones, y de transferencia. - Google Patents

Sistema en forma de microfluido para reacciones, y de transferencia.

Info

Publication number
ES2189469T3
ES2189469T3 ES99941720T ES99941720T ES2189469T3 ES 2189469 T3 ES2189469 T3 ES 2189469T3 ES 99941720 T ES99941720 T ES 99941720T ES 99941720 T ES99941720 T ES 99941720T ES 2189469 T3 ES2189469 T3 ES 2189469T3
Authority
ES
Spain
Prior art keywords
reactions
chambers
duct
tab
transfer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99941720T
Other languages
English (en)
Inventor
Bruno Colin
Cecile Paris
Jacques Dachaud
Pierre Imbaud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biomerieux SA
Original Assignee
Biomerieux SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9811383A external-priority patent/FR2782934B1/fr
Application filed by Biomerieux SA filed Critical Biomerieux SA
Application granted granted Critical
Publication of ES2189469T3 publication Critical patent/ES2189469T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0015—Diaphragm or membrane valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0023—Constructional types of microvalves; Details of the cutting-off member with ball-shaped valve members
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0605—Valves, specific forms thereof check valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K2099/0071—Microvalves with latching means

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Check Valves (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Fluid-Pressure Circuits (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Control By Computers (AREA)

Abstract

Dispositivo (1) que permite el conducir una reacción de por lo menos dos reacciones en paralelo o en serie, en su seno, el cual se encuentra constituido por: - una superficie superior (2) y una superficie inferior (3), unidas la una con la otra, mediante un borde (4), - por lo menos un canal (5), en el cual, el flujo de fluido (F1 o F2), puede crease mediante medios de transferencia, para permitir el transporte de por lo menos una muestra (6) a tratar y / o a analizar, y, - por lo menos una válvula (8, 18 ó 38) incorporada en cada canal (5), que permite la orientación de cada muestra (6) y, por lo tanto, el control de las transferencias, de las reacciones y de los análisis, en el dispositivo (1), cada válvula (8, 18 ó 38), se encuentra constituida por dos medios (9, 19 ó 39 y 10, 20 ó 40), solidarios del dispositivo (1), siendo el primer medio (9, 19 ó 39), móvil, entre una posición de reposo, en donde la transferencia de fluido (6) es posible, y una posición activa, en donde, la citada transferencia, es imposible, y siendo el segundo medio (19, 20 ó 40), móvil, entre una posición de reposo, en donde éste (10, 20 ó 40) no se encuentra en contacto con el citado primer medio (9, 19 ó 39), y una posición activa en donde, éste, deforma el primer medio (9, 19 ó 39), para que la transferencia (6) sea imposible, y que el citado segundo medio (10, 20 ó 40), se activa mediante un accionador exterior con respecto al dispositivo (1), el cual actúa puntualmente y únicamente en el momento del desplazamiento del segundo medio (10, 20 ó 40), de su posición de reposo, a su posición activa, e inversamente.
ES99941720T 1998-09-08 1999-09-08 Sistema en forma de microfluido para reacciones, y de transferencia. Expired - Lifetime ES2189469T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9811383A FR2782934B1 (fr) 1998-09-08 1998-09-08 Dispositif permettant des reactions, systeme de transfert entre dispositifs et procede de mise en oeuvre d'un tel systeme
FR9907689A FR2782935B3 (fr) 1998-09-08 1999-06-14 Dispositif permettant des reactions, systeme de transfert entre dispositifs et procede de mise en oeuvre d'un tel systeme

Publications (1)

Publication Number Publication Date
ES2189469T3 true ES2189469T3 (es) 2003-07-01

Family

ID=26234541

Family Applications (1)

Application Number Title Priority Date Filing Date
ES99941720T Expired - Lifetime ES2189469T3 (es) 1998-09-08 1999-09-08 Sistema en forma de microfluido para reacciones, y de transferencia.

Country Status (10)

Country Link
US (1) US6929239B1 (es)
EP (2) EP1201305A3 (es)
JP (1) JP2003525101A (es)
AT (1) ATE228885T1 (es)
AU (1) AU747591B2 (es)
CA (1) CA2342735C (es)
DE (1) DE69904344T2 (es)
ES (1) ES2189469T3 (es)
FR (1) FR2782935B3 (es)
WO (1) WO2000013795A1 (es)

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FR2795518B1 (fr) 1999-06-22 2001-12-21 Biomerieux Sa Dispositif de mise en oeuvre d'une carte d'analyse, carte d'analyse et procede les mettant en oeuvre
FR2806009B1 (fr) 2000-03-07 2002-05-31 Bio Merieux Procede de mise en oeuvre d'une carte d'analyse
FR2813207B1 (fr) * 2000-08-28 2002-10-11 Bio Merieux Carte reactionnelle et utilisation d'une telle carte
EP1334349B1 (en) * 2000-10-18 2012-03-07 Art & Science, Inc. Method for diluting a fluid and detecting analytes within a diluted fluid
FR2817604B1 (fr) 2000-12-01 2004-04-23 Biomerieux Sa Vannes activees par des polymeres electro-actifs ou par des materiaux a memoire de forme, dispositif contenant de telles vannes et procede de mise en oeuvre
WO2002070932A2 (en) * 2001-03-07 2002-09-12 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Microvalve
JP2003094395A (ja) * 2001-09-26 2003-04-03 Olympus Optical Co Ltd アレイ化マイクロ流体素子
US7867193B2 (en) * 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
US7198759B2 (en) * 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
FR2857427B1 (fr) 2003-07-10 2005-08-26 Biomerieux Sa Vanne a commande electrique comprenant une membrane microporeuse
JP4208820B2 (ja) * 2003-11-28 2009-01-14 株式会社東芝 核酸検出カセット
US7867194B2 (en) 2004-01-29 2011-01-11 The Charles Stark Draper Laboratory, Inc. Drug delivery apparatus
CA2583406A1 (en) * 2004-09-20 2007-01-04 Boston Microfluidics Microfluidic device for detecting soluble molecules
RU2008147093A (ru) * 2006-05-01 2010-06-10 Конинклейке Филипс Электроникс Н.В. (Nl) Устройство транспортировки образца текучей среды с уменьшенным мертвым объемом для переработки, контролирования и/или выявления образца текучей среды
US7794665B2 (en) * 2006-07-17 2010-09-14 Industrial Technology Research Institute Fluidic device
US7897113B2 (en) * 2006-07-17 2011-03-01 Industrial Technology Research Institute Fluidic devices and controlling methods thereof
US7959876B2 (en) * 2006-07-17 2011-06-14 Industrial Technology Research Institute Fluidic device
US20080021364A1 (en) * 2006-07-17 2008-01-24 Industrial Technology Research Institute Fluidic device
US9046192B2 (en) 2007-01-31 2015-06-02 The Charles Stark Draper Laboratory, Inc. Membrane-based fluid control in microfluidic devices
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WO2011027832A1 (ja) * 2009-09-04 2011-03-10 国立大学法人北陸先端科学技術大学院大学 有核赤血球濃縮回収用チップ及び有核赤血球濃縮回収方法
WO2011082276A1 (en) * 2009-12-31 2011-07-07 General Electric Company Microvalve
JP6162047B2 (ja) 2011-02-02 2017-07-12 ザ チャールズ スターク ドレイパー ラボラトリー インク 薬物送達装置
FR2973720B1 (fr) * 2011-04-08 2016-02-26 Commissariat Energie Atomique Dispositif de connexion d'une carte microfluidique
US8740177B2 (en) * 2011-07-05 2014-06-03 Rain Bird Corporation Eccentric diaphragm valve
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EP2679307B1 (de) * 2012-06-28 2015-08-12 Thinxxs Microtechnology Ag Mikrospeicher, insbesondere zur Integration in eine mikrofluidische Flusszelle
GB2516675A (en) 2013-07-29 2015-02-04 Atlas Genetics Ltd A valve which depressurises, and a valve system
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KR102233127B1 (ko) * 2014-10-14 2021-03-26 엘지디스플레이 주식회사 가이드 패널 및 이를 포함한 액정 표시 장치
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Also Published As

Publication number Publication date
CA2342735C (fr) 2009-04-21
WO2000013795A1 (fr) 2000-03-16
AU747591B2 (en) 2002-05-16
EP1201305A3 (fr) 2002-11-13
DE69904344D1 (de) 2003-01-16
AU5522999A (en) 2000-03-27
JP2003525101A (ja) 2003-08-26
CA2342735A1 (fr) 2000-03-16
EP1112122B1 (fr) 2002-12-04
DE69904344T2 (de) 2004-04-08
FR2782935A1 (fr) 2000-03-10
EP1201305A2 (fr) 2002-05-02
FR2782935B3 (fr) 2000-10-20
US6929239B1 (en) 2005-08-16
EP1112122A1 (fr) 2001-07-04
ATE228885T1 (de) 2002-12-15

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