ES2188828T3 - Complejos de s-(+)-adenosilmetionina y 3'-azido-2-3'-didesoxinucleoxido como inhibidores potentes de la replicacion del vih. - Google Patents

Complejos de s-(+)-adenosilmetionina y 3'-azido-2-3'-didesoxinucleoxido como inhibidores potentes de la replicacion del vih.

Info

Publication number
ES2188828T3
ES2188828T3 ES97114113T ES97114113T ES2188828T3 ES 2188828 T3 ES2188828 T3 ES 2188828T3 ES 97114113 T ES97114113 T ES 97114113T ES 97114113 T ES97114113 T ES 97114113T ES 2188828 T3 ES2188828 T3 ES 2188828T3
Authority
ES
Spain
Prior art keywords
azido
complexes
didesoxinucleoxido
adenosilmetionina
hiv replication
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97114113T
Other languages
English (en)
Inventor
Kurt Zimmermann
Henrich H Paradies
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Symbio Herborn Group GmbH and Co
Original Assignee
Symbio Herborn Group GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symbio Herborn Group GmbH and Co filed Critical Symbio Herborn Group GmbH and Co
Application granted granted Critical
Publication of ES2188828T3 publication Critical patent/ES2188828T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE PREPARAN COMPLEJOS MOLECULARES, QUE INCLUYEN LA S (+) SE DEMUESTRA QUE POSEEN EFECTOS SINERGICOS INHIBITORIOS SOBRE LA REPLICACION DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA 1 Y 2 IN VITRO E IN VIVO, EN PARTICULAR SOBRE LA TRANSCRIPTASA INVERSA, Y PRESENTAN UN ELEVADO INDICE TERAPEUTICO.
ES97114113T 1996-08-14 1997-08-14 Complejos de s-(+)-adenosilmetionina y 3'-azido-2-3'-didesoxinucleoxido como inhibidores potentes de la replicacion del vih. Expired - Lifetime ES2188828T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19632823A DE19632823C1 (de) 1996-08-14 1996-08-14 Komplexe zwischen S-(+)-Adenosylmethionin und 3'-Azido-2',3'-didesoxynucleosid als potente Inhibitoren der HIV-Replikation

Publications (1)

Publication Number Publication Date
ES2188828T3 true ES2188828T3 (es) 2003-07-01

Family

ID=7802653

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97114113T Expired - Lifetime ES2188828T3 (es) 1996-08-14 1997-08-14 Complejos de s-(+)-adenosilmetionina y 3'-azido-2-3'-didesoxinucleoxido como inhibidores potentes de la replicacion del vih.

Country Status (9)

Country Link
US (1) US6117849A (es)
EP (1) EP0827964B1 (es)
JP (1) JP3202179B2 (es)
AT (1) ATE229030T1 (es)
CA (1) CA2213099C (es)
DE (2) DE19632823C1 (es)
DK (1) DK0827964T3 (es)
ES (1) ES2188828T3 (es)
PT (1) PT827964E (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6759395B2 (en) * 2000-12-18 2004-07-06 Orchid Chemicals & Pharmaceuticals, Ltd. Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same
US6914052B2 (en) 2001-03-15 2005-07-05 The Trustees Of Boston College Selective anti-viral nucleoside chain terminators
ITMI20012462A1 (it) * 2001-11-22 2003-05-22 Gnosis Srl Processo per la preparazione di compresse comprendenti s-adenosilmetionina
SI1325740T1 (en) * 2001-12-12 2004-08-31 Chemistry & Health International B.V. Stable granulates containing S-Adenosylmethionine and process for the preparation thereof
US20050272687A1 (en) * 2004-06-08 2005-12-08 Hebert Rolland F Stable S-adenosyl-l-methionine
US20090012036A1 (en) * 2005-05-24 2009-01-08 Hebert Rolland F Stable S-adenosyl-L-methionine
CN102924549A (zh) * 2005-09-26 2013-02-13 吉利德制药有限责任公司 作为抗病毒剂的修饰的4'-核苷
US20100004191A1 (en) * 2008-07-01 2010-01-07 Rolland F Hebert Compositions of S-adenosyl-L-methionine.
KR102186066B1 (ko) 2013-01-16 2020-12-04 허버트 샘-이 엘엘씨 S-아데노실-l-메티오닌의 안정한 인돌-3-프로피오네이트염
KR102229211B1 (ko) * 2020-05-04 2021-03-17 권재훈 바이러스 전파방지를 위한 공용 시설 버튼을 누르기위한 누름장치

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2001976B (en) * 1977-08-03 1982-03-10 Yamasa Shoyu Kk S-adenosyl-l-methionine compositions and production thereof
US4724232A (en) * 1985-03-16 1988-02-09 Burroughs Wellcome Co. Treatment of human viral infections
US4880782A (en) * 1986-11-21 1989-11-14 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. Method of treating viral infections in humans and compositions therefor
DE4005275A1 (de) * 1990-02-20 1991-08-22 Grundmann Ewald Verwendung von s-adenosylmethionin als mittel gegen virale infektionen durch retroviren
IT1243859B (it) * 1990-10-23 1994-06-28 Bioresearch Spa Composizioni farmaceutiche comprendenti associazioni fra sali di s-adenosil-l-metionina e acido 5-metil (o 5-formil)-tetraidrofolico per la terapia di complicanze neurologiche negli ammalati di aids.
DE19628514C1 (de) * 1996-07-05 1997-09-25 E Dr Grundmann Kombination von S-Adenosylmethionin und Azidothymidin zur Hemmung der HIV-Replikation

Also Published As

Publication number Publication date
EP0827964A3 (en) 1998-07-29
ATE229030T1 (de) 2002-12-15
CA2213099C (en) 2003-10-28
JPH10139795A (ja) 1998-05-26
PT827964E (pt) 2003-04-30
EP0827964A2 (en) 1998-03-11
DE19632823C1 (de) 1997-11-20
EP0827964B1 (en) 2002-12-04
DE69717568T2 (de) 2003-09-04
JP3202179B2 (ja) 2001-08-27
DK0827964T3 (da) 2003-03-17
CA2213099A1 (en) 1998-02-14
US6117849A (en) 2000-09-12
DE69717568D1 (de) 2003-01-16

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