ES2186055T3 - Fabricacion de un medio destinado a impedir el rechazo del transplante. - Google Patents
Fabricacion de un medio destinado a impedir el rechazo del transplante.Info
- Publication number
- ES2186055T3 ES2186055T3 ES98112821T ES98112821T ES2186055T3 ES 2186055 T3 ES2186055 T3 ES 2186055T3 ES 98112821 T ES98112821 T ES 98112821T ES 98112821 T ES98112821 T ES 98112821T ES 2186055 T3 ES2186055 T3 ES 2186055T3
- Authority
- ES
- Spain
- Prior art keywords
- sub
- rejection
- transplant
- manufacture
- prevent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 3
- 230000036046 immunoreaction Effects 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000001042 pteridinyl group Chemical class N1=C(N=CC2=NC=CN=C12)* 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Uso de derivados de pteridina para la preparación de una composición que elimina la inmunoreacción, en especial se emplean los derivados de pteridina de rechazo a trasplante (I) para la preparación de una composición que elimine la inmunoreacción, en especial el rechazo a trasplante. Los derivados de pteridiana de fórmula (I) o sus sales se emplean en la preparación de una composición que previene la inmunoreacción, en especial el rechazo a trasplante. R{sup,1}, R{sup,3} = H u OH; R{sup,4} = H, metilo, CH{sub,2}OH o CHO; R{sup,2} = H, metilo, CH{sub,2}OH o CHO; alquilo C{sub,1-9}, (CH(OH)){sub,n}-Y'' o (CH(OH)){sub,n}-(CH{sub,2}){sub,m}-W''; Y'' = H o alquilo inferior; W'' = H u OH; y n, m = 1-20.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98112821A EP0978283B1 (de) | 1998-07-10 | 1998-07-10 | Herstellung eines die Transplantatabstossung unterdrückenden Mittels |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2186055T3 true ES2186055T3 (es) | 2003-05-01 |
Family
ID=8232250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98112821T Expired - Lifetime ES2186055T3 (es) | 1998-07-10 | 1998-07-10 | Fabricacion de un medio destinado a impedir el rechazo del transplante. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6114331A (es) |
| EP (1) | EP0978283B1 (es) |
| AT (1) | ATE226077T1 (es) |
| DE (1) | DE59805976D1 (es) |
| ES (1) | ES2186055T3 (es) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4418097A1 (de) * | 1994-05-24 | 1995-11-30 | Cassella Ag | Verwendung von Tetrahydropteridin-Derivaten als Hemmstoffe der NO-Synthase |
-
1998
- 1998-07-10 ES ES98112821T patent/ES2186055T3/es not_active Expired - Lifetime
- 1998-07-10 AT AT98112821T patent/ATE226077T1/de active
- 1998-07-10 EP EP98112821A patent/EP0978283B1/de not_active Expired - Lifetime
- 1998-07-10 DE DE59805976T patent/DE59805976D1/de not_active Expired - Lifetime
-
1999
- 1999-07-07 US US09/348,801 patent/US6114331A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0978283A1 (de) | 2000-02-09 |
| DE59805976D1 (de) | 2002-11-21 |
| EP0978283B1 (de) | 2002-10-16 |
| ATE226077T1 (de) | 2002-11-15 |
| US6114331A (en) | 2000-09-05 |
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