ES2184861T3 - Compuestos peptidicos inhibidores de la liberacion de la metaloproteinasa y del tnf y su utilizacion terapeutica. - Google Patents
Compuestos peptidicos inhibidores de la liberacion de la metaloproteinasa y del tnf y su utilizacion terapeutica.Info
- Publication number
- ES2184861T3 ES2184861T3 ES96915089T ES96915089T ES2184861T3 ES 2184861 T3 ES2184861 T3 ES 2184861T3 ES 96915089 T ES96915089 T ES 96915089T ES 96915089 T ES96915089 T ES 96915089T ES 2184861 T3 ES2184861 T3 ES 2184861T3
- Authority
- ES
- Spain
- Prior art keywords
- tnf
- metaloproteinase
- liberation
- therapeutic use
- peptidic compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Virology (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Hospice & Palliative Care (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
DERIVADOS DE TRIPEPTIDILO QUE POSEEN UN GRUPO SH O ACILS Y QUE SON AMIDAS POSEEN UTILIDAD TERAPEUTICA MEDIANTE LA INHIBICION DE MMP O TNF.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9509434.8A GB9509434D0 (en) | 1995-05-10 | 1995-05-10 | Compounds |
GBGB9525643.4A GB9525643D0 (en) | 1995-12-15 | 1995-12-15 | Compounds |
GBGB9607218.6A GB9607218D0 (en) | 1996-04-04 | 1996-04-04 | Compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2184861T3 true ES2184861T3 (es) | 2003-04-16 |
Family
ID=27267715
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96915089T Expired - Lifetime ES2184861T3 (es) | 1995-05-10 | 1996-05-10 | Compuestos peptidicos inhibidores de la liberacion de la metaloproteinasa y del tnf y su utilizacion terapeutica. |
Country Status (9)
Country | Link |
---|---|
US (1) | US6110896A (es) |
EP (1) | EP0826000B1 (es) |
JP (1) | JPH11504646A (es) |
AT (1) | ATE226592T1 (es) |
AU (1) | AU701279B2 (es) |
CA (1) | CA2217857A1 (es) |
DE (1) | DE69624477T2 (es) |
ES (1) | ES2184861T3 (es) |
WO (1) | WO1996035714A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6406901B1 (en) | 1995-06-08 | 2002-06-18 | Immunex Corporation | TNF-a converting enzyme |
GB9607120D0 (en) * | 1996-04-04 | 1996-06-12 | Chiroscience Ltd | Compounds |
US6953788B1 (en) | 1996-09-19 | 2005-10-11 | Aventis Pharmaceuticals Inc. | 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase |
NZ334897A (en) * | 1996-12-09 | 2001-02-23 | Warner Lambert Co | Medicaments for treating and preventing heart failure and ventricular dilatation |
US6172057B1 (en) | 1997-02-27 | 2001-01-09 | American Cyanamid Company | N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
DE69823019T2 (de) * | 1997-02-27 | 2005-03-31 | Wyeth Holdings Corp. | N-hydroxy-2-(alkyl, aryl oder heteroaryl sulfanyl, sulfinyl oder sulfonyl)-3-substituierte alkyl-, aryl- oder heteroarylamide als matrixmetalloproteinaseinhibitoren |
AU736511B2 (en) | 1998-01-09 | 2001-07-26 | Pfizer Inc. | Matrix metalloprotease inhibitors |
AU735929B2 (en) * | 1998-01-30 | 2001-07-19 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives |
JP2002502848A (ja) * | 1998-02-06 | 2002-01-29 | ダーウィン・ディスカバリー・リミテッド | ヒドロキサム酸およびカルボン酸誘導体 |
US6680338B2 (en) | 1998-02-06 | 2004-01-20 | Darwin Discovery Ltd. | Hydroxamic and carboxylic acid derivatives |
GB9823334D0 (en) * | 1998-10-23 | 1998-12-23 | Darwin Discovery Ltd | Enzyme coupling |
MXPA02001349A (es) * | 1999-08-09 | 2002-07-22 | Tripep Ab | Inhibidores de la polimerizacion de proteinas y metodos de uso. |
CA2781858C (en) | 2000-05-12 | 2015-03-31 | Genzyme Corporation | Modulators of tnf-.alpha. signaling |
US20030228320A1 (en) * | 2000-08-18 | 2003-12-11 | Ashdown Martin Leonard | Retroviral immunotherapy |
US6593455B2 (en) | 2001-08-24 | 2003-07-15 | Tripep Ab | Tripeptide amides that block viral infectivity and methods of use thereof |
EP1436317A1 (en) | 2001-09-19 | 2004-07-14 | Tripep Ab | Molecules that block viral infectivity and methods of use thereof |
JP2006516548A (ja) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 迅速ゲル化ポリマー組成物からの薬物送達法 |
US20130324404A1 (en) | 2010-05-31 | 2013-12-05 | Syngenta Participations Ag | 1, 8 -diazaspiro [4.5] decane- 2, 4 -dione derivatives useful as pesticides |
CN103003239A (zh) | 2010-05-31 | 2013-03-27 | 先正达参股股份有限公司 | 基于螺杂环吡咯烷衍生物的杀虫剂 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8311286D0 (en) * | 1983-04-26 | 1983-06-02 | Searle & Co | Carboxyalkyl peptide derivatives |
US4937243A (en) * | 1986-12-24 | 1990-06-26 | Beecham Group P.L.C. | Thiol carboxylic acid derivatives and their use as colagenase inhibitors |
DE3889726T2 (de) * | 1987-03-17 | 1994-10-13 | Res Corp Technologies Inc | Synthetische inhibitoren von säugetier-collagenase. |
DE4311021A1 (de) * | 1993-03-31 | 1994-10-27 | Diagnostikforschung Inst | Bifunktionelle Chelatbildner, deren Technetium- und Rhenium-Komplexe, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Mittel |
EP0715619A4 (en) * | 1993-08-23 | 1997-03-19 | Immunex Corp | INHIBITORS OF TNF-ALPHA SECRETION |
GB9323165D0 (en) * | 1993-11-10 | 1994-01-05 | Chiros Ltd | Compounds |
DK0784629T3 (da) * | 1994-10-05 | 1999-10-25 | Darwin Discovery Ltd | Peptidylforbindelser og deres terapeutiske anvendelse som inhibitorer af metalloproteaser |
-
1996
- 1996-05-10 EP EP96915089A patent/EP0826000B1/en not_active Expired - Lifetime
- 1996-05-10 ES ES96915089T patent/ES2184861T3/es not_active Expired - Lifetime
- 1996-05-10 CA CA002217857A patent/CA2217857A1/en not_active Abandoned
- 1996-05-10 AU AU56980/96A patent/AU701279B2/en not_active Ceased
- 1996-05-10 WO PCT/GB1996/001138 patent/WO1996035714A1/en active IP Right Grant
- 1996-05-10 DE DE69624477T patent/DE69624477T2/de not_active Expired - Fee Related
- 1996-05-10 JP JP8533891A patent/JPH11504646A/ja not_active Ceased
- 1996-05-10 AT AT96915089T patent/ATE226592T1/de not_active IP Right Cessation
- 1996-05-10 US US08/644,797 patent/US6110896A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE226592T1 (de) | 2002-11-15 |
AU701279B2 (en) | 1999-01-21 |
WO1996035714A1 (en) | 1996-11-14 |
EP0826000A1 (en) | 1998-03-04 |
JPH11504646A (ja) | 1999-04-27 |
CA2217857A1 (en) | 1996-11-14 |
AU5698096A (en) | 1996-11-29 |
DE69624477D1 (de) | 2002-11-28 |
EP0826000B1 (en) | 2002-10-23 |
US6110896A (en) | 2000-08-29 |
DE69624477T2 (de) | 2003-06-26 |
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