ATE226592T1 - Peptide, die metallproteinasen und die tnf- freisetzung hemmen, und ihre therapeutische verwendung - Google Patents

Peptide, die metallproteinasen und die tnf- freisetzung hemmen, und ihre therapeutische verwendung

Info

Publication number
ATE226592T1
ATE226592T1 AT96915089T AT96915089T ATE226592T1 AT E226592 T1 ATE226592 T1 AT E226592T1 AT 96915089 T AT96915089 T AT 96915089T AT 96915089 T AT96915089 T AT 96915089T AT E226592 T1 ATE226592 T1 AT E226592T1
Authority
AT
Austria
Prior art keywords
metalproteinases
therapeutic use
tnf release
peptides inhibiting
peptides
Prior art date
Application number
AT96915089T
Other languages
English (en)
Inventor
Andrew Douglas Baxter
Road
John Montana
David Alan Owen
Original Assignee
Darwin Discovery Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9509434.8A external-priority patent/GB9509434D0/en
Priority claimed from GBGB9525643.4A external-priority patent/GB9525643D0/en
Priority claimed from GBGB9607218.6A external-priority patent/GB9607218D0/en
Application filed by Darwin Discovery Ltd filed Critical Darwin Discovery Ltd
Application granted granted Critical
Publication of ATE226592T1 publication Critical patent/ATE226592T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT96915089T 1995-05-10 1996-05-10 Peptide, die metallproteinasen und die tnf- freisetzung hemmen, und ihre therapeutische verwendung ATE226592T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9509434.8A GB9509434D0 (en) 1995-05-10 1995-05-10 Compounds
GBGB9525643.4A GB9525643D0 (en) 1995-12-15 1995-12-15 Compounds
GBGB9607218.6A GB9607218D0 (en) 1996-04-04 1996-04-04 Compounds
PCT/GB1996/001138 WO1996035714A1 (en) 1995-05-10 1996-05-10 Peptide compounds which inhibit metalloproteinase and tnf liberation and their therapeutic uses

Publications (1)

Publication Number Publication Date
ATE226592T1 true ATE226592T1 (de) 2002-11-15

Family

ID=27267715

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96915089T ATE226592T1 (de) 1995-05-10 1996-05-10 Peptide, die metallproteinasen und die tnf- freisetzung hemmen, und ihre therapeutische verwendung

Country Status (9)

Country Link
US (1) US6110896A (de)
EP (1) EP0826000B1 (de)
JP (1) JPH11504646A (de)
AT (1) ATE226592T1 (de)
AU (1) AU701279B2 (de)
CA (1) CA2217857A1 (de)
DE (1) DE69624477T2 (de)
ES (1) ES2184861T3 (de)
WO (1) WO1996035714A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406901B1 (en) 1995-06-08 2002-06-18 Immunex Corporation TNF-a converting enzyme
GB9607120D0 (en) * 1996-04-04 1996-06-12 Chiroscience Ltd Compounds
US6953788B1 (en) 1996-09-19 2005-10-11 Aventis Pharmaceuticals Inc. 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase
NZ334897A (en) * 1996-12-09 2001-02-23 Warner Lambert Co Medicaments for treating and preventing heart failure and ventricular dilatation
UA58543C2 (uk) * 1997-02-27 2003-08-15 Амерікан Ціанамід Компані N-гідрокси-2-(алкіл-, арил-, або гетероарилсульфаніл, -сульфініл або -сульфоніл)-3-заміщені алкіл-, арил- або гетероариламіди як інгібітори матричних металопротеїназ
US6172057B1 (en) 1997-02-27 2001-01-09 American Cyanamid Company N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
NZ504683A (en) 1998-01-09 2002-06-28 Pfizer Amide derivatives and pharmaceutical compositions thereof and their use as matrix metalloprotease inhibitors
IL137146A0 (en) * 1998-01-30 2001-07-24 Darwin Discovery Ltd Hydroxamic and carboxylic acid derivatives
EP1053233B1 (de) * 1998-02-06 2003-08-20 Darwin Discovery Limited Hydroxamsäure- und carbonsäurederivative
US6680338B2 (en) 1998-02-06 2004-01-20 Darwin Discovery Ltd. Hydroxamic and carboxylic acid derivatives
GB9823334D0 (en) * 1998-10-23 1998-12-23 Darwin Discovery Ltd Enzyme coupling
CA2378480A1 (en) * 1999-08-09 2001-02-15 Tripep Ab Pharmaceutical compositions containing tripeptides
JP4960565B2 (ja) 2000-05-12 2012-06-27 ジェンザイム コーポレーション ＴＮＦαシグナル伝達のモジュレータ
US20030228320A1 (en) * 2000-08-18 2003-12-11 Ashdown Martin Leonard Retroviral immunotherapy
US6593455B2 (en) 2001-08-24 2003-07-15 Tripep Ab Tripeptide amides that block viral infectivity and methods of use thereof
EP1436317A1 (de) 2001-09-19 2004-07-14 Tripep Ab Moleküle, die die virale infektivität hemmen, und verfahren zu deren anwendung
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
US20130210625A1 (en) 2010-05-31 2013-08-15 Syngenta Crop Protection Llc Spiroheterocyclic pyrrolidine derivatives based pesticides
CN103003276A (zh) 2010-05-31 2013-03-27 先正达参股股份有限公司 作为杀虫剂有用的1,8-二氮杂螺[4.5]癸烷-2,4-二酮衍生物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8311286D0 (en) * 1983-04-26 1983-06-02 Searle & Co Carboxyalkyl peptide derivatives
AU599736B2 (en) * 1986-12-24 1990-07-26 Beecham Group Plc Thiol-carboxylic acid derivatives
EP0358660B1 (de) * 1987-03-17 1994-05-25 Research Corporation Technologies, Inc. Synthetische inhibitoren von säugetier-collagenase
DE4311021A1 (de) * 1993-03-31 1994-10-27 Diagnostikforschung Inst Bifunktionelle Chelatbildner, deren Technetium- und Rhenium-Komplexe, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende radiopharmazeutische Mittel
NZ271893A (en) * 1993-08-23 1997-11-24 Immunex Corp Inhibitors of tnf-alpha secretion
GB9323165D0 (en) * 1993-11-10 1994-01-05 Chiros Ltd Compounds
CN1193978A (zh) * 1994-10-05 1998-09-23 奇罗斯恩有限公司 肽基化合物和它们作为金属蛋白酶抑制剂的医疗用途

Also Published As

Publication number Publication date
ES2184861T3 (es) 2003-04-16
DE69624477T2 (de) 2003-06-26
DE69624477D1 (de) 2002-11-28
AU5698096A (en) 1996-11-29
AU701279B2 (en) 1999-01-21
US6110896A (en) 2000-08-29
WO1996035714A1 (en) 1996-11-14
EP0826000A1 (de) 1998-03-04
EP0826000B1 (de) 2002-10-23
CA2217857A1 (en) 1996-11-14
JPH11504646A (ja) 1999-04-27

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