ES2183726B1 - Compuestos utiles para el tratamiento del alcoholismo. - Google Patents

Compuestos utiles para el tratamiento del alcoholismo.

Info

Publication number
ES2183726B1
ES2183726B1 ES200101642A ES200101642A ES2183726B1 ES 2183726 B1 ES2183726 B1 ES 2183726B1 ES 200101642 A ES200101642 A ES 200101642A ES 200101642 A ES200101642 A ES 200101642A ES 2183726 B1 ES2183726 B1 ES 2183726B1
Authority
ES
Spain
Prior art keywords
alcoholism
treatment
diamine
cyclohexane
bis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES200101642A
Other languages
English (en)
Other versions
ES2183726A1 (es
Inventor
Norberto Bilbeny Lojo
Hernan Garcia Madrid
Maria Belen Font Arellano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Garbil Pharma Investigacion Chile Ltda
Original Assignee
Garbil Pharma Investigacion Chile Ltda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES200101642A priority Critical patent/ES2183726B1/es
Application filed by Garbil Pharma Investigacion Chile Ltda filed Critical Garbil Pharma Investigacion Chile Ltda
Priority to JP2003510421A priority patent/JP2004533480A/ja
Priority to PCT/ES2002/000323 priority patent/WO2003004453A1/es
Priority to CA002451983A priority patent/CA2451983A1/en
Priority to EP02745437A priority patent/EP1403243A1/en
Priority to MXPA03011864A priority patent/MXPA03011864A/es
Priority to US10/482,708 priority patent/US7026514B2/en
Priority to ARP020102506A priority patent/AR036969A1/es
Publication of ES2183726A1 publication Critical patent/ES2183726A1/es
Application granted granted Critical
Publication of ES2183726B1 publication Critical patent/ES2183726B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/132—Amines having two or more amino groups, e.g. spermidine, putrescine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/34—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton
    • C07C211/36—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing at least two amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Compuestos útiles para el tratamiento del alcoholismo. La N,N''- bis(3-aminopropil)ciclohexano-1,4-diamina, de fórmula (I), es un compuesto nuevo que se prepara por hydrogenación con catalizador níquel Raney de N,N''-bis(2-cianoetil)-ciclohexano-1,4-diamina; este último se prepara por reacción entre 1,4-ciclohexanodiamina y acrilonitrilo. La administración oral a ratas genéticamente alcohólicas (provenientes de la cepa UChB de la Universidad de Chile) del monohidrato del tetrametanosulfonato de (1) causa una reducción significativa en el consumo de alcohol. La actividad perdura durante cierto tiempo tras el periodo de tratamiento. Además, el efecto adverso tipo-disulfiram es prácticamente nulo, lo que constituye una ventaja respecto a lo desagradable del uso de algunos agentes anti-alcoholismo, tales como la cianamida cálcica y el propio disulfiram. Por lo tanto, los compuestos de la invención son útiles para la preparación de medicamentos para el tratamiento terapéutico y/o profiláctico delalcoholismo en los mamíferos, incluidos los seres humanos.
ES200101642A 2001-07-05 2001-07-05 Compuestos utiles para el tratamiento del alcoholismo. Expired - Fee Related ES2183726B1 (es)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ES200101642A ES2183726B1 (es) 2001-07-05 2001-07-05 Compuestos utiles para el tratamiento del alcoholismo.
PCT/ES2002/000323 WO2003004453A1 (es) 2001-07-05 2002-07-01 Compuestos utiles para el tratamiento del alcoholismo
CA002451983A CA2451983A1 (en) 2001-07-05 2002-07-01 Compounds used to treat alcoholism
EP02745437A EP1403243A1 (en) 2001-07-05 2002-07-01 Compounds used to treat alcoholism
JP2003510421A JP2004533480A (ja) 2001-07-05 2002-07-01 アルコール中毒を治療するのに有用な化合物
MXPA03011864A MXPA03011864A (es) 2001-07-05 2002-07-01 Compuestos utiles para el tratamiento del alcoholismo.
US10/482,708 US7026514B2 (en) 2001-07-05 2002-07-01 Compounds used to treat alcoholism
ARP020102506A AR036969A1 (es) 2001-07-05 2002-07-04 Compuesto para el tratamiento del alcoholismo en mamiferos, incluidos los seres humanos; procedimiento para la obtencion de ese compuesto y composicion para llevar adelante el tratamiento

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES200101642A ES2183726B1 (es) 2001-07-05 2001-07-05 Compuestos utiles para el tratamiento del alcoholismo.

Publications (2)

Publication Number Publication Date
ES2183726A1 ES2183726A1 (es) 2003-03-16
ES2183726B1 true ES2183726B1 (es) 2004-07-01

Family

ID=8498391

Family Applications (1)

Application Number Title Priority Date Filing Date
ES200101642A Expired - Fee Related ES2183726B1 (es) 2001-07-05 2001-07-05 Compuestos utiles para el tratamiento del alcoholismo.

Country Status (8)

Country Link
US (1) US7026514B2 (es)
EP (1) EP1403243A1 (es)
JP (1) JP2004533480A (es)
AR (1) AR036969A1 (es)
CA (1) CA2451983A1 (es)
ES (1) ES2183726B1 (es)
MX (1) MXPA03011864A (es)
WO (1) WO2003004453A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021211540A1 (en) * 2020-04-14 2021-10-21 The Regents Of The University Of California Diagnosis and treatment of addiction
CN115108924A (zh) * 2022-06-24 2022-09-27 岳阳昌德新材料有限公司 胺类中间体及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5534553A (en) * 1987-06-12 1996-07-09 Hoerrmann; Wilhelm Drug containing fatty amino alcohols or derivatives thereof
DE3727879A1 (de) * 1987-08-21 1989-03-02 Troponwerke Gmbh & Co Kg Verwendung von 2-pyrimidinyl-1-piperazin-derivaten
US5962533A (en) * 1996-02-06 1999-10-05 University Of Florida Research Foundation, Inc. Hydroxy polyamines
US6399662B1 (en) 2000-12-13 2002-06-04 University Of Florida Method and composition for the treatment of diarrhea and gastrointestinal spasms

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Advanced Organic Chemistry, Jerry March, 4ª edición, 1992, John Wiley & Sons, Wiley Interscience, ISBN 0-471-60180-2. Páginas 918-919; reacción 6-27. *

Also Published As

Publication number Publication date
MXPA03011864A (es) 2005-03-07
WO2003004453A1 (es) 2003-01-16
EP1403243A1 (en) 2004-03-31
JP2004533480A (ja) 2004-11-04
US7026514B2 (en) 2006-04-11
AR036969A1 (es) 2004-10-20
US20040180967A1 (en) 2004-09-16
CA2451983A1 (en) 2003-01-16
ES2183726A1 (es) 2003-03-16

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