ES2180439B2 - COSMETIC-DERMATOLOGICAL COMPOSITION. - Google Patents

Abstract

Composition Cosmetic-dermatological.

The composition has the characteristic that presents a series of products in a single unit preparation cosmetic-dermatological doses studied for that there is no interference between their actions. The presentation in a single product greatly facilitates the corporal hygiene. The composition of the invention brings together in a single Product: growth inhibitors or hair removers unwanted body, personal smell masks, body deodorizers by growth inhibition and formation of microorganisms and catabolites, etc.

The composition of the invention is used for the hygiene and treatment of facial or body areas with growth, unwanted capillary.

Description

Composition Cosmetic-dermatological.

Object of the invention

The present invention relates to a product conceived to be used in facial or body areas susceptible to unwanted hair growth.

Background of the invention

Dermatological compositions are known for the care of aesthetics and body hygiene, such as deodorants (inhibitors of the formation of body odors or of its masking), as well as antiperspirants (brakes and sweat production eliminators from sweat glands and excess epidermal fat from of the pilosebaceous glands).

GB-2013493 describes only deodorant products that mask unpleasant odors from certain substances that are part of its composition, for example strontium sulfide used as a depilatory. Your application is only for deodorants.

JP-02056411 refers to to a composition containing zinc and titanium oxides that have application only as deodorants.

WO-9533439 describes depilatory compositions containing sulfur compounds a certain pH It refers only to depilatories.

EP-0183506 refers to to depilatory agents that contain mainly thioglycolate of calcium, product widely used in this type of compositions. Are only depilants

FR-2347040 describes a depilatory cosmetic composition that may contain calcium thioglycolate or strontium sulfide, in addition to imidazolinone-2.

However, no products are known. specific dermatologists that have the aforementioned properties, but which simultaneously inhibit, nullify or destroy hair growth, especially, body hair (axillary, pubic, facial, etc.).

Today to meet this need is you need to have two, three or more products separately, and still in the event that the user used them one after another, it would be in danger of falling into negative interactions between themselves, in a toxicity effect, or in other incompatibilities that They could cause a decrease or nullity of their effects, all this due to chemical, physical or pharmacological ignorance of its effects sets. In addition to the aforementioned danger, there is also the practical inconvenience that it is not easy to find in the same trade all necessary products, resulting in more face the purchase. Time should also be taken into account lost in your multiple application.

Description of the invention

The compositions of the invention resolve and the problems and inconveniences cited are minimized previously.

It is therefore an object of the invention to provide compositions containing a growth inhibitor compound or body hair remover and also contain a product deodorizer and one or more body odor masks.

It is another object of the invention to have The following purposes are combined in a single product: inhibition or hair suppression and body deodorization by inhibition of growth and formation of microorganisms and catabolites.

It is also another object of the invention the provide a product that presents ease of handling, Time savings and economic savings.

The compositions of the invention have the following advantages:

- Prevents the successive application of several different products to achieve the desired effects mean an increase in physical aggression against only one application.

- The required percentage amount of each Active component comes exactly vehiculized in each dose.

- The use of the product subject to the invention sometimes presents the added value of the denaturation of heterologous proteins, which will result in a pharmacological benefit in people affected by a certain type of topical and respiratory allergies. The use of a single product ensures proper administration to positively influence all purposes, since such adequate dosage does not it will depend on the number of products and even less on the criteria Selective dosage of each product by the user. This does not occurs when two or three different products are used in a way successive to achieve the desired purpose, since instead of working with a single transport vehicle is done with two or more vehicles, which would mean a relative percentage decrease of the active ingredients.

The compositions object of the invention contain the following compounds, always referred to a 100% wealth:

to)

lauric bromide isoquinolinic, in a percentage between 0.1 and 8%, as hair inhibitor or suppressant.

b)

triclosan in a percentage between 0.001 and 5%, as deodorizer that acts by inhibition or death of microorganisms and their catabolites

c)

natural perfumes or synthetic, essential oils, or mixtures thereof, in a percentage between 0.02 and 5%, as substances masking body and facial odor.

The compositions of the invention may have different forms of presentation, such as: creams or milks, lotions or tonics, sprays, sticks, gels, masks and sludge (sludge), etc. In all of them the components specific to the invention are accompanied by suitable compounds for the different forms of presentation.

The invention also covers all product formulations for cosmetic or dermatological use that incorporate in their formulations the products of the invention, even if accompanied by other products with shares  different, such as moisturizing, nourishing, refreshing, tense, relaxing, firming, wrinkle, anti-technical, depigmenting, anti-stain, anti-stretch marks, anti-cellulite or any other quality Cosmetic-dermatological-medical.

The joint presence in the composition object of the invention of hair inhibitor components and of deodorizers, it is not done randomly and indiscriminately, but it is the result of detailed studies conducted to  find the ideal mixture of hair inhibitor and deodorizer have good effects cosmetic-dermatological and good stability Chemical and pharmacological.

So, after relating all the agents normally used depilatories and other possible candidates, are He proceeded to enumerate and study them, and then move on to selection process. Once documented each of them and contrasted its effects described in the bibliographic studies and live, it was observed that one of these products, Cetrimide, belonging to the group of quaternary ammoniums, there were demonstrated an excellent growth inhibitory power of cancer cells in patients who had been practiced radical surgery (as described in: Martindale, The extra Pharmacopeia, 26th edition, page 173 "Effect of implantation of cancer cells "and in G.R. Gibson, F.O. Stephens; Lancet, ii / 1966, 678: "Irrigation with Cetrimide"). It is known that both pilosebaceous gland cells (among others) and cells carcinogens continue to grow and increase as long as they receive nutrition, so the quaternary ammonium group was selected  as the beginning of the investigation for inhibition. During the selection process Cetrimide was discarded due to its effects toxicological and, after testing and checking others compounds of the same group, it was concluded that a bromide salt of this group of quaternary ammoniums satisfied all the tests of efficacy initiated and corroborated by the results of laboratory. For this reason, lauric bromide was selected isoquinolinic

Subsequently, once the isoquinoline lauryl bromide was selected, studies were carried out to enhance the growth inhibitory effect. Effectiveness tests were performed in vivo with a statistically significant number of people by the officially accepted double-blind method, resulting in a positive inhibitory effect of progressive growth.

Triclosan was added to the formulation for its bactericidal and preservative effects and the test was performed again in vivo by the same double blind method, obtaining even better results in the inhibitory power of hair growth, since the time elapsed in the hair appearance was clearly superior.

These results indicated that the composition object of the invention has a growth inhibitory effect of hair and that this is enhanced with a synergistically positively and significantly by adding Triclosan It is not a hair inhibitor by itself.

As for the stability of the composition, it It has been shown to be longer than 30 months. These compositions they do not present pharmacological incompatibilities or variations rheological or organoleptic.

Examples

Descriptively, but not limitatively, it They describe the following examples.

Example 1 Cosmetic form: Emulsions (Milk or Cream)

In an unchanging reactor or tank and resistant, equipped with good agitation and prepared to be heated, phases A, B and C are prepared, with the following components and proportions, expressed parts by weight and referred to a wealth of 100% of the products used as Try milks or creams:

         \ catcode` \ # = 12 \ nobreak \ centering \ small \ begin {tabular} {lll}
 Phase A \ + Milks \ + Creams \\ Peg-8
Stearate \ + 4.62 parts \ + 7.92 parts \\ Glycol Stearate \ +
1,4 \; \; \; \; '' \ + 2,4 \; \; \; \; '' \\ Peg-40
stearate \ + 0.98 \; \; '' \ + 1.68 \; \; '' \\ Liquid paraffin
\ + 7.0 \; \; \; '' \ + 15.0 \; \; '' \\ Isopropyl palmitate \ + 5,0
\; \; \; '' \ + 10.0 \; \; '' \\ Polyethylene glycol (BHT) \ + 0.1
\; \; \; '' \ + 0,1 \; \; \; \; '' \\ Triclosan \ + 0.2 \; \; \; '' \ +
0.2 \; \; \; \; '' \\ Dimeticone \ + 0.8 \; \; \; '' \ + 0.8 \; \; \; \; ''
\\ \ + \ + \\ Phase B \ + \ + \\ Water
\ + \ multicolumn {2} {l} {sufficient quantity for 100%} \\
\ + \ multicolumn {2} {l} {of A + B + C} \\ Glycerin \ + 8.0 parts \ + 10.0
parts \\ Allantoin \ + 0.2 \; \; \; \; '' \ + 0.15 \; \; \; '' \\
Lauric bromide \ + \ + \\ isoquinolinic \ + 0.4 \; \; \; \; '' \ + 2.0
\; \; \; \; \; '' \\ Methylparaben \ + 0.2 \; \; \; \; '' \ + 0.2
\; \; \; \; \; '' \\ Propilparaben \ + 0,05 \; \; \ '' \ + 0,05 \; \; \; ''
\\ \ + \ + \\ Phase C \ + \ + \\ Perfume \ + 0.15 parts \ +
0.3 parts
\\\ end {tabular} \ par \ vskip.5 \ baselineskip
      

Phases A and B homogenize well by heating each at 70-80 ° C, and phase A is poured over the phase B, with good agitation, allowing to cool slowly. When they reach 40-45 ° C phase C is added, leaving the stirring until it reaches room temperature.

These cosmetic forms can also marketed in container with Roll on ball, tube, jar, spray (after adding the appropriate propellant), natural spray, wipes, tampons, etc.

Example 2 Cosmetic form: Stick

In some devices like the ones in the example the previous phases are prepared A, B and C, with the following components and proportions:

         \ dotable {\ tabskip \ tabcolsep # \ hfil \ + # \ hfil \ tabskip0ptplus1fil \ dddarstrut \ cr} {
  Phase A \ + \ cr Water \ + Enough quantity for \ cr \ +
complete 100% of A + B + C \ cr Sodium hydroxide \ + 0.84 parts \ cr \ + \ cr
  Phase B \ + \ cr Dipropylene Glycol \ + 40 parts \ cr
Propylene Glycol \ + 20 \; \; \; \; '' \ cr Glycerin \ + 20 \; \; \; \; '' \ cr
Stearic acid \ + 6.5 \; \; \; '' \ cr Triclosan \ + 0.15 \; '' \ cr
\ + \ cr Phase C \ + \ cr Lauric bromide \ + \ isoquinolinic cr \ +
3.0 \; \; '' \ cr Dimethicone copoliol \ + 1,0 \; \; '' \ cr Perfume \ +
0.4 \; \;
'' \ cr}
      

For the preparation, the Phase is well homogenized A heating at 75-80 ° C and pouring over Phase B, also homogenized and heated at 75-80 ° C, with a  Good agitation Stirring continues while the temperature. At 65-70 ° C they are added one by one Phase C components with good agitation and maintaining that temperature. The product is packaged in the mold or container corresponding when it is at 65 ° C, and then allowed to cool at 15-25 ° C.

This cosmetic form can be marketed using a bar with rotating dosing wheel.

Claims (5)

1. Cosmetic-dermatological composition, to be used in body areas susceptible to unwanted hair growth, characterized in that it contains isoquinoline lauric bromide, triclosan and one or more masking substances of body and facial odor with adequate concentrations so that there is no interference in their actions . 2. Cosmetic-dermatological composition according to claim 1, characterized in that the percentage of isoquinoline lauric bromide is between 0.1 and 8%. 3. Cosmetic-dermatological composition according to claim 1, characterized in that the percentage of triclosan is comprised between

 \ hbox {0.001 and 5%} 

. 4. Cosmetic-dermatological composition according to claim 1, characterized in that as a masking substance of body and facial odor it contains, in a percentage comprised between 0.02 and 5%, natural or synthetic perfumes, essential oils or mixtures thereof. 5. Use of cosmetic-dermatological compositions according to claims 1 to 4 for the preparation of cosmetic-dermatological formulations characterized in that they are presented in the form of a single product formulated as a solution, emulsion, cream, gel, stick or other forms of presentation, which can be used for the hygienic treatment of facial or body areas susceptible to unwanted hair growth.