ES2179959T3 - Procedimiento de preparacion de 4'-demetilepipodofilotoxina a partir de podofilotoxina. - Google Patents
Procedimiento de preparacion de 4'-demetilepipodofilotoxina a partir de podofilotoxina.Info
- Publication number
- ES2179959T3 ES2179959T3 ES96942404T ES96942404T ES2179959T3 ES 2179959 T3 ES2179959 T3 ES 2179959T3 ES 96942404 T ES96942404 T ES 96942404T ES 96942404 T ES96942404 T ES 96942404T ES 2179959 T3 ES2179959 T3 ES 2179959T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- podofilotoxina
- demetilepipodofilotoxina
- preparation procedure
- date jun
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE SINTESIS DE 4 DEMETILEPIPODOFILOTOXINA DE FOMULA (II) A PARTIR DE PODOFILOTOXINA DE FORMULA (I). CONSISTE EN TRATARLA CON LA PAREJA DE REACTIVOS: ACIDO FUERTE - SULFURO ALIFATICO, AROMATICO O FUNCIONALIZADO, EN PRESENCIA DE UN ACIDO ORGANICO O MINERAL, O BIEN EN PRESENCIA DE AGUA CON O SIN DISOLVENTE ORGANICO MISCIBLE EN AGUA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9514875A FR2742439B1 (fr) | 1995-12-14 | 1995-12-14 | Procede de preparation de la 4'-demethylepipodophyllotoxine a partir de la podophyllotoxine |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2179959T3 true ES2179959T3 (es) | 2003-02-01 |
Family
ID=9485535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96942404T Expired - Lifetime ES2179959T3 (es) | 1995-12-14 | 1996-12-13 | Procedimiento de preparacion de 4'-demetilepipodofilotoxina a partir de podofilotoxina. |
Country Status (10)
Country | Link |
---|---|
US (1) | US6008382A (es) |
EP (1) | EP0876374B1 (es) |
JP (1) | JP2000501726A (es) |
AT (1) | ATE221072T1 (es) |
AU (1) | AU1179497A (es) |
DE (1) | DE69622589D1 (es) |
ES (1) | ES2179959T3 (es) |
FR (1) | FR2742439B1 (es) |
PT (1) | PT876374E (es) |
WO (1) | WO1997021713A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2869035B1 (fr) | 2004-04-16 | 2006-07-14 | Pierre Fabre Medicament Sa | Derives (poly)aminoalkylaminoacetamide d'epipodophyllotoxine leur procede de preparation et leurs applications en therapeutique comme agent anticancereux |
FR2921368B1 (fr) * | 2007-09-25 | 2012-10-12 | Pf Medicament | Nouveau procede de synthese de derives anticancereux de (poly) aminoalkylaminoacetamide d'epipodophyllotoxine. |
FR2935143B1 (fr) | 2008-08-19 | 2010-12-03 | Pf Medicament | Nouveaus derives (poly)aminoalkylaminoalkylamides, alkyl-urees, ou alkyl-sulfonamides d'epipodophyllotoxine, leur procede de preparation et leur application en therapeuthique comme agent cancereux |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990009788A1 (en) * | 1989-02-23 | 1990-09-07 | The University Of North Carolina At Chapel Hill | Etoposide analogues |
-
1995
- 1995-12-14 FR FR9514875A patent/FR2742439B1/fr not_active Expired - Fee Related
-
1996
- 1996-12-13 ES ES96942404T patent/ES2179959T3/es not_active Expired - Lifetime
- 1996-12-13 EP EP96942404A patent/EP0876374B1/fr not_active Expired - Lifetime
- 1996-12-13 PT PT96942404T patent/PT876374E/pt unknown
- 1996-12-13 DE DE69622589T patent/DE69622589D1/de not_active Expired - Lifetime
- 1996-12-13 AT AT96942404T patent/ATE221072T1/de not_active IP Right Cessation
- 1996-12-13 JP JP09521813A patent/JP2000501726A/ja active Pending
- 1996-12-13 US US09/077,303 patent/US6008382A/en not_active Expired - Fee Related
- 1996-12-13 AU AU11794/97A patent/AU1179497A/en not_active Abandoned
- 1996-12-13 WO PCT/FR1996/002000 patent/WO1997021713A1/fr active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
AU1179497A (en) | 1997-07-03 |
FR2742439B1 (fr) | 1998-03-06 |
FR2742439A1 (fr) | 1997-06-20 |
DE69622589D1 (de) | 2002-08-29 |
US6008382A (en) | 1999-12-28 |
PT876374E (pt) | 2002-12-31 |
WO1997021713A1 (fr) | 1997-06-19 |
ATE221072T1 (de) | 2002-08-15 |
EP0876374A1 (fr) | 1998-11-11 |
JP2000501726A (ja) | 2000-02-15 |
EP0876374B1 (fr) | 2002-07-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PT98244A (pt) | Processo de preparacao de um derivado n-fenilacetico de tetra-hidro-tieno{3,2-c}piridina | |
DE59403670D1 (de) | Verfahren zur unterkritischen trocknung von aerogelen | |
EP1362904A4 (en) | WATER-BASED HYDROPHOBIC AGENT FOR TREATING SUBSTRATES | |
BR9610838A (pt) | Processo para tratar um indivìduo tendo uma condição patológica envolvendo neovascularização. | |
AU2001213184A1 (en) | A process of producing polyphenolic adhesive proteins and proteins produced in accordance with the process | |
KR0148212B1 (en) | Phenylalkan (en)oic acids | |
ES2179959T3 (es) | Procedimiento de preparacion de 4'-demetilepipodofilotoxina a partir de podofilotoxina. | |
AU5426599A (en) | Phosphoepoxides, method for making same and uses | |
DE69621835D1 (de) | Verfahren zur herstellung von arylhydrazin durch reduktion von azo-derivate | |
ATE159233T1 (de) | Verfahren zur reinigung von für den menschlichen verbrauch bestimmtem wasser | |
CA2022187A1 (en) | N,n-bis-phosphonomethyl taurine n-oxide and water-soluble salts thereof | |
ES2176758T3 (es) | Procedimiento para la preparacion de 4-ciona-1,2,3-triazxoles. | |
ATE286884T1 (de) | Durch lymphe absorbierbare imidazolderivate | |
AU2001281883A1 (en) | Method for producing 2-alkyl-3-aryl- and -heteroaryloxaziridines and novel 2-alkyl-3-aryloxaziridines | |
GB9017611D0 (en) | Method of decolourising water | |
CA2380227A1 (en) | Improved liquid smoke coloring agent solution made from liquid smoke organic precipitate | |
GB8910374D0 (en) | Chemical compounds | |
EP1092714A3 (en) | Process for the synthesis of benzo[b]thiophenes | |
ATE186737T1 (de) | Ein verbessertes verfahren für die herstellung von seitenketten-derivaten von cyclohexapeptidyl- lipopeptiden | |
KR910000746A (ko) | 1, 1-디옥소페닐실리노일 옥시메틸 d-6-[x-(메틸렌 아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염 | |
BR0112652A (pt) | Processo para preparar um sal de um composto, composto, e, processos para preparar um composto e 4-aminofenilacetamida | |
BR9915484A (pt) | Processo para o isolamento contìnuo de proteìnas ativas | |
ES2139319T3 (es) | Complejo ortohidroximandelato de sodio-fenol-agua, procedimiento de preparacion y utilizacion para el aislamiento de ortohidroximandelato de sodio. | |
DE59901529D1 (de) | Vorrichtung zur Herstellung von kohlesäurehaltigem Wasser | |
HUP0201574A2 (en) | Process for the preparation of fumagillin |