ES2179178T3 - Quinasas de la proteina quinasa humana con activacion por citoquina, stress y oncoproteina. - Google Patents

Quinasas de la proteina quinasa humana con activacion por citoquina, stress y oncoproteina.

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Publication number
ES2179178T3
ES2179178T3 ES96905233T ES96905233T ES2179178T3 ES 2179178 T3 ES2179178 T3 ES 2179178T3 ES 96905233 T ES96905233 T ES 96905233T ES 96905233 T ES96905233 T ES 96905233T ES 2179178 T3 ES2179178 T3 ES 2179178T3
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ES
Spain
Prior art keywords
activation
stress
kinasas
cytoquine
oncoprotein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96905233T
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English (en)
Inventor
Roger J Davis
Shashi Gupta
Joel Raingeaud
Benoit Derijard
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Individual
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Individual
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Priority claimed from US08/446,083 external-priority patent/US5804427A/en
Application filed by Individual filed Critical Individual
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Publication of ES2179178T3 publication Critical patent/ES2179178T3/es
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Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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Abstract

SE DESCUBREN ISOFORMAS DE KINASA KINASAS (MKKS) HUMANAS ACTIVADAS POR MITOGENO (MAP). LAS MKKS MEDIAN VIAS DE TRANSDUCCION DE SEÑAL UNICAS QUE ACTIVAN LAS KINASAS MAP HUMANAS P38 Y JNK, LO QUE TIENE COMO RESULTADO LA ACTIVACION DE OTROS FACTORES, INCLUYENDO EL FACTOR ACTIVADOR DE TRANSCRIPCION 2 (ATF2) Y C-JUN. LAS VIAS SE ACTIVAN MEDIANTE DIVERSOS FACTORES, INCLUYENDO CITOQUINAS Y ESTRES AMBIENTAL. SE PROPORCIONAN METODOS PARA IDENTIFICAR REACTIVOS QUE MODULAN LA FUNCION O ACTIVIDAD MKK Y PARA EL USO DE DICHOS REACTIVOS EN EL TRATAMIENTO DE TRASTORNOS MEDIADOS POR MKK.
ES96905233T 1995-05-19 1996-01-26 Quinasas de la proteina quinasa humana con activacion por citoquina, stress y oncoproteina. Expired - Lifetime ES2179178T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/446,083 US5804427A (en) 1995-05-19 1995-05-19 Cytokine-, stress-, and oncoprotein-activated human protein kinase kinases
US08/530,950 US5736381A (en) 1995-05-19 1995-09-19 Cytokine-, stress-, and oncoprotein-activated human protein kinase kinases

Publications (1)

Publication Number Publication Date
ES2179178T3 true ES2179178T3 (es) 2003-01-16

Family

ID=27034496

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96905233T Expired - Lifetime ES2179178T3 (es) 1995-05-19 1996-01-26 Quinasas de la proteina quinasa humana con activacion por citoquina, stress y oncoproteina.

Country Status (11)

Country Link
US (6) US5736381A (es)
EP (2) EP1251177A3 (es)
JP (1) JP3948571B2 (es)
AT (1) ATE220719T1 (es)
AU (1) AU710877B2 (es)
CA (1) CA2219487A1 (es)
DE (1) DE69622405T2 (es)
DK (1) DK0830374T3 (es)
ES (1) ES2179178T3 (es)
PT (1) PT830374E (es)
WO (1) WO1996036642A1 (es)

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US6001622A (en) 1995-12-21 1999-12-14 Sunnybrook Health Science Centre Integrin-linked kinase and its use
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JP2002515744A (ja) * 1996-05-20 2002-05-28 シグナル ファーマシュウティカルズ，インコーポレイテッド マイトジェン活性化プロテインキナーゼｐ３８―２およびその使用方法
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US6376747B1 (en) * 1999-08-27 2002-04-23 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Canada Plant-derived map kinase kinase
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WO2003023362A2 (en) * 2001-09-12 2003-03-20 The Regents Of The University Of California Methods of ameliorating arthritis by modulating jnk signalsome activity
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WO1995028421A1 (en) * 1993-04-15 1995-10-26 National Jewish Center For Immunology And Respiratory Medicine Method and product for regulating cell responsiveness to external signals
SE503628C2 (sv) * 1994-07-05 1996-07-22 Vikthygien Ab Mätdon
US5736381A (en) 1995-05-19 1998-04-07 Davis; Roger J. Cytokine-, stress-, and oncoprotein-activated human protein kinase kinases

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EP1251177A2 (en) 2002-10-23
US6541605B1 (en) 2003-04-01
PT830374E (pt) 2002-11-29
US6174676B1 (en) 2001-01-16
AU4904696A (en) 1996-11-29
DK0830374T3 (da) 2002-10-28
US20020102691A1 (en) 2002-08-01
AU710877B2 (en) 1999-09-30
DE69622405D1 (de) 2002-08-22
ATE220719T1 (de) 2002-08-15
JP3948571B2 (ja) 2007-07-25
EP0830374B1 (en) 2002-07-17
JP2002503946A (ja) 2002-02-05
DE69622405T2 (de) 2003-03-27
EP0830374A4 (en) 1998-10-07
CA2219487A1 (en) 1996-11-21
US5736381A (en) 1998-04-07
WO1996036642A1 (en) 1996-11-21
US20090053231A1 (en) 2009-02-26
US20050272077A1 (en) 2005-12-08
EP1251177A3 (en) 2003-04-23
EP0830374A1 (en) 1998-03-25

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