ES2176588T3 - Procedimiento para almacenar un ligando dentro de un medio contencion liberable y procedimiento para liberar un ligando del mismo. - Google Patents
Procedimiento para almacenar un ligando dentro de un medio contencion liberable y procedimiento para liberar un ligando del mismo.Info
- Publication number
- ES2176588T3 ES2176588T3 ES97118652T ES97118652T ES2176588T3 ES 2176588 T3 ES2176588 T3 ES 2176588T3 ES 97118652 T ES97118652 T ES 97118652T ES 97118652 T ES97118652 T ES 97118652T ES 2176588 T3 ES2176588 T3 ES 2176588T3
- Authority
- ES
- Spain
- Prior art keywords
- cell
- sample
- matrix
- head
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- 210000004027 cell Anatomy 0.000 abstract 8
- 239000011159 matrix material Substances 0.000 abstract 5
- 239000012530 fluid Substances 0.000 abstract 4
- 239000000523 sample Substances 0.000 abstract 4
- 239000012472 biological sample Substances 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 239000000758 substrate Substances 0.000 abstract 2
- 239000001828 Gelatine Substances 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 210000005056 cell body Anatomy 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 238000005259 measurement Methods 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
- G01N2035/00247—Microvalves
- G01N2035/00267—Meltable plugs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Fertilizers (AREA)
- External Artificial Organs (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Warehouses Or Storage Devices (AREA)
- Basic Packing Technique (AREA)
Abstract
SE DESCRIBE UN PROCEDIMIENTO AUTOMATICO PARA EL TEÑIDO INMUNOCITOQUIMICO DE MATERIALES BIOLOGICOS UTILIZANDO APAREAMIENTO DE LIGANDO. EL APARATO INCLUYE UNA MATRIZ DE CELDAS DE MUESTRA INTERCONECTADAS CON LINEAS DE SUMINISTRO DE REACTIVO Y DRENAJE. CADA CELDA COMPRENDE UNA CAMARA DE FLUIDO EN LA QUE SE INSERTA UN SUSTRATO DE MUESTRA. LA CARA DEL SUSTRATO EN QUE SE MONTA LA MUESTRA BIOLOGICA ESTA ENCARADA A UN POCILLO DE FLUIDO. LA CELDA INCLUYE UNA CABEZA QUE TIENE UNA CAMARA PARA RECIBIR EN ELLA UNA MATRIZ DE SOPORTE SOLIDA QUE CONTIENE EN FORMA LIBERABLE EL LIGANDO QUE HA DE PONERSE EN CONTACTO CON LA MUESTRA. LA CAMARA DE LA CABEZA DE LA CELDA ESTA COMUNICADA CON EL POCILLO DE FLUIDO DE MANERA QUE CUANDO SE LIBERA EL LIGANDO DE LA MATRIZ ESTE FLUYE DENTRO DEL POCILLO DE FLUIDO PONIENDOSE DE ESTA FORMA EN CONTACTO CON LA MUESTRA BIOLOGICA MONTADA. LA MATRIZ DE SOPORTE DEL LIGANDO PUEDE SER GELATINA O CERA. EL CUERPO DE LA CELDA Y LA CABEZA DE LA CELDA SE CALIENTAN O ENFRIAN DIFERENCIALMENTE DE FORMA QUE LA MUESTRA MONTADA PUEDE SER MANTENIDA A LA TEMPERATURA PREFERENTE PARA LA REACCION DE INTERES Y LA CABEZA DE LA CELDA PUEDE SER CALENTADA A UNA TEMPERATURA SUFICIENTE PARA CAUSAR LA DEGRADACION TERMICA DE LA MATRIZ PARA CAUSAR LA LIBERACION DEL LIGANDO. SE PROPORCIONA EL CONTROL ELECTRONICO PARA LA MEDICION Y CONTROL DE LA TEMPERATURA DE LAS DIVERSAS PARTES DE LA CELDA Y EL CONTROL PROGRAMABLE DEL SUMINISTRO DE REACTIVOS A LAS CELDAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1285693A | 1993-02-03 | 1993-02-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2176588T3 true ES2176588T3 (es) | 2002-12-01 |
Family
ID=21757058
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94906107T Expired - Lifetime ES2119166T3 (es) | 1993-02-03 | 1994-02-03 | Sistema de encapsulacion y aparato de histocitoquimica automatica destinados al tratamiento de sustancias biologicas. |
ES97118652T Expired - Lifetime ES2176588T3 (es) | 1993-02-03 | 1994-02-03 | Procedimiento para almacenar un ligando dentro de un medio contencion liberable y procedimiento para liberar un ligando del mismo. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94906107T Expired - Lifetime ES2119166T3 (es) | 1993-02-03 | 1994-02-03 | Sistema de encapsulacion y aparato de histocitoquimica automatica destinados al tratamiento de sustancias biologicas. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5695942A (es) |
EP (2) | EP0682775B1 (es) |
AT (2) | ATE217973T1 (es) |
AU (1) | AU5997194A (es) |
CA (1) | CA2153677C (es) |
DE (2) | DE69430679T2 (es) |
DK (2) | DK0682775T3 (es) |
ES (2) | ES2119166T3 (es) |
PT (1) | PT826955E (es) |
WO (1) | WO1994018539A2 (es) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0843169B1 (de) * | 1995-02-25 | 2003-03-19 | Roche Diagnostics GmbH | Vorrichtung zur Bearbeitung von Proben auf Objekträgern |
US5959098A (en) | 1996-04-17 | 1999-09-28 | Affymetrix, Inc. | Substrate preparation process |
SE9500777D0 (sv) * | 1995-03-03 | 1995-03-03 | Pharmacia Ab | Provrörshållarinsats |
US6177282B1 (en) * | 1997-08-12 | 2001-01-23 | Mcintyre John A. | Antigens embedded in thermoplastic |
IL134702A (en) * | 1997-09-11 | 2004-03-28 | Bioventures Inc | High density arrays and methods of making the same |
NO306357B1 (no) * | 1997-10-16 | 1999-10-25 | Torstein Ljungmann | Fargemaskin for preparering av vevspröver som er plassert pÕ objektglass |
ATE347098T1 (de) * | 1997-12-23 | 2006-12-15 | Dako Denmark As | Kasette zur bearbeitung einer auf der oberfläche eines trägers angebrachten probe |
US6855559B1 (en) | 1998-09-03 | 2005-02-15 | Ventana Medical Systems, Inc. | Removal of embedding media from biological samples and cell conditioning on automated staining instruments |
US6143512A (en) * | 1998-08-17 | 2000-11-07 | Markovic; Nenad | Cap-pap test |
US6855552B2 (en) | 1998-09-03 | 2005-02-15 | Ventana Medical Systems | Automated immunohistochemical and in situ hybridization assay formulations |
US7410753B2 (en) * | 1998-09-03 | 2008-08-12 | Ventana Medical Systems, Inc. | Removal of embedding media from biological samples and cell conditioning on automated staining instruments |
AU766614B2 (en) * | 1998-09-03 | 2003-10-23 | Ventana Medical Systems, Inc. | Removal of embedding media from biological samples and cell conditioning on automated staining instruments |
US6673620B1 (en) | 1999-04-20 | 2004-01-06 | Cytologix Corporation | Fluid exchange in a chamber on a microscope slide |
DE19932958C2 (de) * | 1999-07-14 | 2003-08-07 | Walter Schubert | Vorrichtung zur Bindung von Molekülen, Molekülgruppen, Molekülteilen und/oder Zellen |
EP1204851A1 (en) | 1999-07-21 | 2002-05-15 | Dako A/S | A method of controlling the temperature of a specimen in or on a solid support member |
FR2806166B1 (fr) * | 2000-03-09 | 2002-11-15 | Genomic Sa | Automate pour traitement, acquisition de signal et analyse de biopuces |
US6465207B1 (en) | 2000-11-03 | 2002-10-15 | Cytologix Corporation | Silver-based staining processes employing non-gelling gelatin |
US6828154B1 (en) | 2000-11-03 | 2004-12-07 | Cytologix Corporation | Staining method with chromic acid precursors |
US6713023B2 (en) * | 2001-06-29 | 2004-03-30 | Agilent Technologies, Inc. | Flow cell for chemical reactions |
US6773677B2 (en) * | 2002-01-09 | 2004-08-10 | Caliper Life Sciences, Inc. | Slide cassette for fluidic injection |
WO2004083824A1 (en) * | 2003-03-20 | 2004-09-30 | Dakocytomation Denmark A/S | System for establishing a sample cover on a substrate |
US7767152B2 (en) | 2003-08-11 | 2010-08-03 | Sakura Finetek U.S.A., Inc. | Reagent container and slide reaction retaining tray, and method of operation |
NO321928B1 (no) * | 2004-12-23 | 2006-07-24 | Oystein Ljungmann | Fremgangsmate og system for benyttelse av behandlingsvaesker i et apparat for farging av vevsprover pa objektglass |
AU2005322994A1 (en) * | 2004-12-30 | 2006-07-13 | Ventana Medical Systems, Inc. | Low temperature deparaffinization |
CA2535317C (en) | 2005-02-11 | 2010-04-13 | Sakura Finetek U.S.A., Inc. | Reagent container and slide reaction and retaining tray, and method of operation |
US7666358B2 (en) * | 2006-10-20 | 2010-02-23 | Cytyc Corporation | Cell block cassette device |
WO2009099872A2 (en) * | 2008-01-31 | 2009-08-13 | Kacey Med-Vet, Inc. | Automated stainer having stain level detection |
US8975039B2 (en) * | 2008-06-09 | 2015-03-10 | SYFR, Inc. | Automatic sample staining method |
DE102009013534A1 (de) * | 2009-03-19 | 2010-09-23 | Crinotec Gmbh | Verfahren und Vorrichtung zur Bestimmung eines Fremdstoffgehalts in einer Matrix |
JP6013376B2 (ja) * | 2011-02-28 | 2016-10-25 | ダコ・デンマーク・エー/エス | 包埋生体試料の前処置のための2相非混和系 |
US8869666B2 (en) | 2011-03-24 | 2014-10-28 | Sakura Finetek U.S.A., Inc. | Microtome with surface orientation sensor to sense orientation of surface of sample |
US9032854B2 (en) | 2011-12-21 | 2015-05-19 | Sakura Finetek U.S.A., Inc. | Reciprocating microtome drive system |
EP2864754B1 (en) | 2012-06-22 | 2020-08-26 | Leica Biosystems Nussloch GmbH | Tissue sample container |
EP2864467B1 (en) | 2012-06-22 | 2019-04-03 | Leica Biosystems Nussloch GmbH | Biopsy tissue sample transport device |
US9052256B2 (en) | 2013-03-15 | 2015-06-09 | Leica Biosystems Nussloch Gmbh | Method for processing and embedding tissue |
US9389154B2 (en) | 2013-03-15 | 2016-07-12 | Leica Biosystems Nussloch Gmbh | Tissue cassette with biasing element |
US9097629B2 (en) | 2013-03-15 | 2015-08-04 | Leica Biosystems Nussloch Gmbh | Tissue cassette with retractable member |
ES2927121T3 (es) | 2015-05-29 | 2022-11-02 | Illumina Inc | Portamuestras y sistema de ensayo para realizar reacciones designadas |
US20190086303A1 (en) * | 2016-03-21 | 2019-03-21 | Xiamen Talent Biomedical Technology Company, Ltd. | Slide rack device for slide specimen processing |
CA3018633A1 (en) * | 2016-03-21 | 2017-09-28 | Xiamen Talent Biomedical Technology Company, Ltd. | Heat treatment device for slide specimen testing |
US11460383B2 (en) | 2016-06-16 | 2022-10-04 | Nanocytomics, LLC | Automated staining system |
WO2019209290A1 (en) | 2018-04-25 | 2019-10-31 | Hewlett-Packard Development Company, L.P. | Selective release of material in thermally degradable capsule |
WO2023210383A1 (ja) * | 2022-04-28 | 2023-11-02 | 富士フイルム株式会社 | 検査装置 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3495926A (en) * | 1966-11-02 | 1970-02-17 | John F Naz | Method and apparatus for staining microslides |
US3898982A (en) * | 1972-11-13 | 1975-08-12 | Jintan Terumo Co | Capillary tube for blood examination |
US4255411A (en) * | 1978-11-27 | 1981-03-10 | Damon Corporation | Process of determining an immunogenic substance by competition with an antibody in a microcapsule |
US4384193A (en) * | 1981-06-09 | 1983-05-17 | Immulok, Inc. | Incubating device for specimen mounted on glass slides in immunoassays |
FI852736A0 (fi) * | 1985-07-10 | 1985-07-10 | Labsystems Oy | Termosterbar kyvettenhet. |
US4756884A (en) * | 1985-08-05 | 1988-07-12 | Biotrack, Inc. | Capillary flow device |
CA1281283C (en) * | 1985-08-29 | 1991-03-12 | Elazar Rabbani | Method for detecting an analyte moiety by means of signal localization |
US4731335A (en) * | 1985-09-13 | 1988-03-15 | Fisher Scientific Company | Method for treating thin samples on a surface employing capillary flow |
US5068198A (en) * | 1986-03-26 | 1991-11-26 | Syntex (U.S.A.) Inc. | Liquid single reagent for assays involving confining gels |
DE3786875D1 (de) * | 1986-10-23 | 1993-09-09 | Behringwerke Ag | Bioaffine poroese festphasen, ein verfahren zur herstellung von bioaffinen poroesen festphasen und ihre verwendung. |
USH349H (en) * | 1987-03-12 | 1987-10-06 | The United States Of America As Represented By The Secretary Of The Army | Inert solid compositions which become chemically reactive when molten |
US4847208A (en) * | 1987-07-29 | 1989-07-11 | Bogen Steven A | Apparatus for immunohistochemical staining and method of rinsing a plurality of slides |
GB8722902D0 (en) * | 1987-09-30 | 1987-11-04 | Shandon Southern Prod | Tissue &c processing |
US4985082A (en) * | 1987-11-20 | 1991-01-15 | Lafayette Applied Chemistry, Inc. | Microporous granular starch matrix compositions |
US4908319A (en) * | 1988-03-16 | 1990-03-13 | Smyczek Peter J | Laboratory apparatus |
GB8813628D0 (en) * | 1988-06-09 | 1988-07-13 | Shandon Southern Prod | Immunostaining |
CA2028804C (en) * | 1989-11-21 | 2000-06-20 | Howard J. Buttery | Biomosaic polymers and method for preparing same |
US5273905A (en) * | 1991-02-22 | 1993-12-28 | Amoco Corporation | Processing of slide mounted material |
DE4117830A1 (de) * | 1991-05-29 | 1992-12-03 | Medite Ges Fuer Medizintechnik | Trog fuer behandlungsstationen einer vorrichtung zur faerbung von auf objekttraegern in objekttraegerhaltern angeordneten histologischen praeparaten |
US5413924A (en) * | 1992-02-13 | 1995-05-09 | Kosak; Kenneth M. | Preparation of wax beads containing a reagent for release by heating |
-
1994
- 1994-02-03 ES ES94906107T patent/ES2119166T3/es not_active Expired - Lifetime
- 1994-02-03 EP EP94906107A patent/EP0682775B1/en not_active Expired - Lifetime
- 1994-02-03 DE DE69430679T patent/DE69430679T2/de not_active Expired - Lifetime
- 1994-02-03 ES ES97118652T patent/ES2176588T3/es not_active Expired - Lifetime
- 1994-02-03 WO PCT/CA1994/000061 patent/WO1994018539A2/en active IP Right Grant
- 1994-02-03 PT PT97118652T patent/PT826955E/pt unknown
- 1994-02-03 AT AT97118652T patent/ATE217973T1/de not_active IP Right Cessation
- 1994-02-03 DK DK94906107T patent/DK0682775T3/da active
- 1994-02-03 AT AT94906107T patent/ATE165917T1/de not_active IP Right Cessation
- 1994-02-03 DK DK97118652T patent/DK0826955T3/da active
- 1994-02-03 US US08/387,813 patent/US5695942A/en not_active Expired - Lifetime
- 1994-02-03 DE DE69410084T patent/DE69410084T2/de not_active Expired - Lifetime
- 1994-02-03 CA CA002153677A patent/CA2153677C/en not_active Expired - Lifetime
- 1994-02-03 EP EP97118652A patent/EP0826955B1/en not_active Expired - Lifetime
- 1994-02-03 AU AU59971/94A patent/AU5997194A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE69430679T2 (de) | 2002-12-19 |
AU5997194A (en) | 1994-08-29 |
EP0826955B1 (en) | 2002-05-22 |
WO1994018539A3 (en) | 1994-09-29 |
US5695942A (en) | 1997-12-09 |
EP0826955A3 (en) | 1999-03-03 |
DE69430679D1 (de) | 2002-06-27 |
CA2153677A1 (en) | 1994-08-18 |
ES2119166T3 (es) | 1998-10-01 |
DE69410084D1 (de) | 1998-06-10 |
EP0826955A2 (en) | 1998-03-04 |
DK0682775T3 (da) | 1999-02-15 |
ATE217973T1 (de) | 2002-06-15 |
PT826955E (pt) | 2002-09-30 |
ATE165917T1 (de) | 1998-05-15 |
EP0682775B1 (en) | 1998-05-06 |
EP0682775A1 (en) | 1995-11-22 |
WO1994018539A2 (en) | 1994-08-18 |
DE69410084T2 (de) | 1999-01-21 |
DK0826955T3 (da) | 2002-08-19 |
CA2153677C (en) | 2005-01-04 |
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