ES2173170T3 - Construccion de mutantes de pasteurella haemolytica. - Google Patents

Construccion de mutantes de pasteurella haemolytica.

Info

Publication number
ES2173170T3
ES2173170T3 ES95904281T ES95904281T ES2173170T3 ES 2173170 T3 ES2173170 T3 ES 2173170T3 ES 95904281 T ES95904281 T ES 95904281T ES 95904281 T ES95904281 T ES 95904281T ES 2173170 T3 ES2173170 T3 ES 2173170T3
Authority
ES
Spain
Prior art keywords
mutants
construction
pasteurella haemolytica
methyltransferase
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95904281T
Other languages
English (en)
Inventor
Robert E Briggs
Fred M Tatum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biotechnology Research and Development Corp
US Department of Agriculture USDA
Original Assignee
Biotechnology Research and Development Corp
US Department of Agriculture USDA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotechnology Research and Development Corp, US Department of Agriculture USDA filed Critical Biotechnology Research and Development Corp
Application granted granted Critical
Publication of ES2173170T3 publication Critical patent/ES2173170T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C12N9/1092—3-Phosphoshikimate 1-carboxyvinyltransferase (2.5.1.19), i.e. 5-enolpyruvylshikimate-3-phosphate synthase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polyurethanes Or Polyureas (AREA)

Abstract

LA METILACION DE ADN PUEDE SER UN PASO CRITICO EN LA INTRODUCCION DE ADN EN P. HAEMOLYTICA. PARA ESTE PROPOSITO SE HA AISLADO UNA METILTRANSFERASA Y SE HA CLONADO MOLECULARMENTE. EL USO DE LA METILTRANSFERASA HA PERMITIDO LA REALIZACION DE MUTANTES AROA ATENUADOS, DEFINIDOS PARA USO COMO VACUNAS PARA PROTECCION DE GANADO.
ES95904281T 1993-12-06 1994-12-06 Construccion de mutantes de pasteurella haemolytica. Expired - Lifetime ES2173170T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/162,392 US5587305A (en) 1993-12-06 1993-12-06 Pasteurella haemolytica transformants

Publications (1)

Publication Number Publication Date
ES2173170T3 true ES2173170T3 (es) 2002-10-16

Family

ID=22585422

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95904281T Expired - Lifetime ES2173170T3 (es) 1993-12-06 1994-12-06 Construccion de mutantes de pasteurella haemolytica.

Country Status (8)

Country Link
US (6) US5587305A (es)
EP (2) EP0733114B1 (es)
AT (1) ATE213778T1 (es)
AU (1) AU692817B2 (es)
CA (1) CA2177734C (es)
DE (1) DE69430005T2 (es)
ES (1) ES2173170T3 (es)
WO (1) WO1995016045A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6793927B1 (en) * 1993-12-06 2004-09-21 The United States Of America As Represented By The Secretary Of The Department Of Agriculture Construction of Pasteurella haemolytica vaccines
US5840556A (en) * 1996-05-08 1998-11-24 The United States Of America As Represented By The Department Of Agriculture Molecular genetic construction of vaccine strains of pasteurellaceae
AU767829B2 (en) * 1996-05-08 2003-11-27 Biotechnology Research And Development Corporation Molecular genetic constructions of vaccine strains of pasteurellaceae
US6770275B1 (en) * 1996-05-31 2004-08-03 Akzo Nobel N.V. Live attenuated RTC-producing bacteria of the family
FR2750704B1 (fr) * 1996-07-04 1998-09-25 Rhone Poulenc Rorer Sa Procede de production d'adn therapeutique
US6010705A (en) * 1997-04-11 2000-01-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Attenuated, invasive vaccines against fish pathogens
EP0973865A2 (en) * 1997-04-11 2000-01-26 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Attenuated, invasive vaccines against fish pathogens
WO1998046260A1 (en) * 1997-04-15 1998-10-22 Baylor College Of Medicine Pasteurella haemolytica vaccine
US7138384B1 (en) 1997-08-29 2006-11-21 The Regents Of The University Of California Modulators of DNA cytosine-5 methyltransferase and methods for use thereof
ES2279582T3 (es) 1997-09-25 2007-08-16 Biotechnology Research And Development Corporation Mutante de delecion de lkta de p. hemolitica.
US6936262B2 (en) 1997-09-25 2005-08-30 Biotechnology Research And Development Corporation LktA deletion mutant of P. haemolytica
US7026155B2 (en) 1999-02-02 2006-04-11 Regents Of The University Of California Method of reducing bacterial proliferation
BR0009663A (pt) * 1999-04-09 2002-04-09 Upjohn Co Composições de vacinas antibacterianas
DE10046870A1 (de) * 2000-09-20 2002-03-28 Basf Ag Verfahren zur Veränderung des Genoms von Corynebakterien
DE10152307A1 (de) * 2001-10-26 2003-05-08 Boehringer Ingelheim Vetmed Neue bakterielle Geflügelkrankheit
US7521060B2 (en) * 2001-10-26 2009-04-21 Boehringer Ingelheim Vetmedica S.A. De C.V. Pathogen for bacterial poultry disease
AU2002342485A1 (en) * 2001-11-23 2003-06-10 Universite De Montreal Streptococcus suis avirulent vaccine and uses in antibiotic design
WO2003080149A2 (en) * 2002-03-20 2003-10-02 Mannkind Corporation Inhalation apparatus
US9528107B2 (en) * 2012-01-31 2016-12-27 Pacific Biosciences Of California, Inc. Compositions and methods for selection of nucleic acids
BR112015010364B1 (pt) 2012-11-08 2022-05-03 Boehringer Ingelheim Animal Health USA Inc. Vacinas atenuadas de mannheimia haemolytica e métodos de produção e uso
WO2015066292A1 (en) 2013-11-01 2015-05-07 Merial Limited Attenuated pasteurella multocidavaccines & methods of making & use thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1980000412A1 (en) * 1978-08-24 1980-03-20 N Gilmour Pasteurellosis vaccines
US4388299A (en) * 1980-03-31 1983-06-14 Norden Laboratories, Inc. Modified pasteurella bacteria and vaccines prepared therefrom
US4293545A (en) * 1980-03-31 1981-10-06 Norden Laboratories, Inc. Modified Pasteurella multocida bacteria vaccines
US4335106A (en) * 1980-03-31 1982-06-15 Norden Laboratories Inc. Processes for the growth of a modified Pasteurella multocida bacteria and preparation of a vaccine therefrom
US4735801A (en) * 1982-09-07 1988-04-05 Board Of Trustees Of Leland Stanford Jr. University Novel non-reverting salmonella live vaccines
US5077044A (en) * 1980-05-19 1991-12-31 The Board Of Trustees Of The Leland Stanford Jr. University Novel non-reverting shigella live vaccines
US5210035A (en) * 1980-05-19 1993-05-11 Board Of Trustees Of Leland Stanford Jr. University Non-reventing live vaccines
US4837151A (en) * 1980-05-19 1989-06-06 The Board Of Trustees Of The Leland Stanford Junior University, Stanford University Live vaccines comprising two mutations and foreign antigen
US4626430A (en) * 1981-04-17 1986-12-02 Norden Laboratories, Inc. Processes for growth of modified Pasteurella haemolytica bacteria and preparation of a vaccine therefrom
US4559306A (en) * 1981-04-17 1985-12-17 Norden Laboratories, Inc. Modified Pasteurella multocida bacteria
US4506017A (en) * 1981-04-17 1985-03-19 Norden Laboratories, Inc. Modified Pasteurella haemolytica bacteria
US4888170A (en) * 1981-10-22 1989-12-19 Research Corporation Vaccines obtained from antigenic gene products of recombinant genes
US5165924A (en) * 1986-01-22 1992-11-24 University Of Guelph Serum-free, cell-free vaccine effective against pneumonic pasteurellosis in cattle
US5055400A (en) * 1986-11-26 1991-10-08 University Of Guelph Leukotoxin gene of pasteurella haemolytica
US4957739A (en) * 1987-08-13 1990-09-18 Board Of Regents, The University Of Texas System Pharmaceutical compositions of a 105 kD P. Haemolytica derived antigen useful for treatment of Shipping Fever
IL86583A0 (en) * 1987-06-04 1988-11-15 Molecular Eng Ass Vaccine containing a derivative of a microbe and method for the production thereof
US5468485A (en) * 1987-06-04 1995-11-21 Washington University Avirulent microbes and uses therefor
US4999191A (en) * 1988-05-05 1991-03-12 University Of Georgia Research Foundation, Inc. Pasteurella multocida vaccine
DE69027313T2 (de) * 1989-03-31 1997-01-23 Univ Washington Impfstoffe enthaltende avirulente phop-type mikroorganismen
CA2014033C (en) * 1989-04-07 1993-02-09 Stephen D. Acres Compositions and treatments for pneumonia in animals
US5238823A (en) * 1990-08-22 1993-08-24 Veterinary Infectious Disease Organization Interleukin-2-leukotoxin gene fusions and uses thereof
US5273889A (en) * 1990-08-22 1993-12-28 University Of Saskatchewan Gamma-iterferon-leukotoxin gene fusions and uses thereof
GB9100825D0 (en) * 1991-01-15 1991-02-27 Univ Guelph Pasteurella haemolytica glycoprotease gene and the purified enzyme

Also Published As

Publication number Publication date
DE69430005D1 (de) 2002-04-04
US5587305A (en) 1996-12-24
EP0733114B1 (en) 2002-02-27
US5824525A (en) 1998-10-20
AU1303195A (en) 1995-06-27
ATE213778T1 (de) 2002-03-15
US5849305A (en) 1998-12-15
US5733780A (en) 1998-03-31
US5693777A (en) 1997-12-02
AU692817B2 (en) 1998-06-18
US5683900A (en) 1997-11-04
WO1995016045A1 (en) 1995-06-15
CA2177734A1 (en) 1995-06-15
EP1149587A2 (en) 2001-10-31
EP1149587A3 (en) 2002-03-13
EP0733114A1 (en) 1996-09-25
DE69430005T2 (de) 2002-10-24
CA2177734C (en) 2011-06-21

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