ES2171993T3 - Derivados de la acridona y procedimiento de preparacion de derivados de 8-hidroxi-imidazoacridinona. - Google Patents

Derivados de la acridona y procedimiento de preparacion de derivados de 8-hidroxi-imidazoacridinona.

Info

Publication number
ES2171993T3
ES2171993T3 ES97939096T ES97939096T ES2171993T3 ES 2171993 T3 ES2171993 T3 ES 2171993T3 ES 97939096 T ES97939096 T ES 97939096T ES 97939096 T ES97939096 T ES 97939096T ES 2171993 T3 ES2171993 T3 ES 2171993T3
Authority
ES
Spain
Prior art keywords
derivatives
dialkylamino
omega
formula
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97939096T
Other languages
English (en)
Inventor
Jerzy Kazimierz Konopa
Marek Tadeusz Konieczny
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
BTG International Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BTG International Ltd filed Critical BTG International Ltd
Application granted granted Critical
Publication of ES2171993T3 publication Critical patent/ES2171993T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE PREPARACION DE UN COMPUESTO DE FORMULA (I), DONDE R 1 Y R 2 SON GRUPOS ALQUILO DE 1 A 4 ATOMOS DE CARBONO, Y N ES DE 2 A 5. DICHO PROCEDIMIENTO CONSISTE EN HACER REACCIONAR UNA 1 - CLORO 7 - (HIDROXILO PROTEGIDO) - 4 - NITROACRIDINA - 9(10H) - ONA, DE FORMULA (IV-P), DONDE A ES UN GRUPO PROTECTOR DE HIDROXILO ELIMINABLE MEDIANTE REDUCCION, CON UNA OM - (DIALQUIL AMINO)ALQ UILAMINA, DE FORMULA: NH 2 (CH 2 ) N NR 1 R SUP,2 , DONDE N, R 1 Y R 2 SON TAL Y COMO SE DEFINIO ANTERIORMENTE, PARA PRODUCIR UN 7 - (HIDROXILO PROTEGIDO) - 4 - NITRO - 1 - [[ OM (DIALQUILAMINO)ALQUIL]AMINO]ACRIDIN - 9(10H) - ONA (III-P); REDUCIR EL COMPUESTO (III-P) A UNA TEMPERATURA DE 15 A 50 °C CON HIDROGENO GASEOSO O CON IONES FORMIATO, EN PRESENCIA DE UN CATALIZADOR DE PALADIO Y DE ACIDO FORMICO; ELIMINAR PRACTICAMENTE LA TOTALIDAD DEL PALADIO RESIDUAL; Y CALENTAR LA MEZCLA DE REACCION RESTANTE PARA REALIZAR LA CICLIZACION DEL COMPUESTO CORRESPONDIENTE DE FORMULA (I). SISE DESEA, TRAS LA ELIMINACION DEL PALADIO, EL INTERMDIARIO 7 - HIDROXI - 4 - N FORMIL - 1 - [[ OM - (DIALQUILAMINO)ALQUIL]AMINO]ACRIDIN 9(10H) - ONA SE PUEDE AISLAR Y POSTERIORMENTE CICLIZARLO MEDIANTE CALENTAMIENTO. DICHOS COMPUESTOS PRESENTAN ACTIVIDAD ANTINEOPLASICA.
ES97939096T 1996-10-07 1997-09-10 Derivados de la acridona y procedimiento de preparacion de derivados de 8-hidroxi-imidazoacridinona. Expired - Lifetime ES2171993T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9620751A GB2317888A (en) 1996-10-07 1996-10-07 Acridone derivatives and preparation of 8-hydroxy-imidazoacridinone derivatives

Publications (1)

Publication Number Publication Date
ES2171993T3 true ES2171993T3 (es) 2002-09-16

Family

ID=10800965

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97939096T Expired - Lifetime ES2171993T3 (es) 1996-10-07 1997-09-10 Derivados de la acridona y procedimiento de preparacion de derivados de 8-hidroxi-imidazoacridinona.

Country Status (11)

Country Link
US (1) US6229015B1 (es)
EP (1) EP0929552B1 (es)
JP (1) JP4138883B2 (es)
AT (1) ATE215542T1 (es)
CA (1) CA2268157C (es)
DE (1) DE69711654T2 (es)
DK (1) DK0929552T3 (es)
ES (1) ES2171993T3 (es)
GB (1) GB2317888A (es)
WO (1) WO1998015554A1 (es)
ZA (1) ZA978960B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1871367A2 (en) * 2005-01-28 2008-01-02 Xanthus Pharmaceuticals, Inc. Compounds for treating inflammatory and demyelinating diseases
US20080108641A1 (en) * 2006-02-08 2008-05-08 Ajami Alfred M Compounds for treating inflammatory disorders, demyelinating disdorders and cancers
WO2007092436A2 (en) * 2006-02-08 2007-08-16 Xanthus Pharmaceuticals, Inc. Compounds for treating inflammatory disorders, demyelinating disorders and cancers
EP3070078B1 (en) 2015-03-20 2017-10-04 Politechnika Gdanska Asymmetric bis-acridines with antitumor activity and use thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9104548D0 (en) * 1991-03-05 1991-04-17 Cholody Wienlaw M Antineoplastic modified imidazoacridines

Also Published As

Publication number Publication date
GB2317888A (en) 1998-04-08
DE69711654D1 (de) 2002-05-08
JP4138883B2 (ja) 2008-08-27
JP2001516339A (ja) 2001-09-25
CA2268157C (en) 2006-01-10
US6229015B1 (en) 2001-05-08
CA2268157A1 (en) 1998-04-16
ZA978960B (en) 1999-04-07
DE69711654T2 (de) 2002-09-19
GB9620751D0 (en) 1996-11-20
ATE215542T1 (de) 2002-04-15
EP0929552B1 (en) 2002-04-03
WO1998015554A1 (en) 1998-04-16
DK0929552T3 (da) 2002-07-22
EP0929552A1 (en) 1999-07-21

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