ES2171478T3 - Composicion farmaceutica que comprende la hormona de crecimiento y la proteina unidora de la hormona de crecimiento. - Google Patents
Composicion farmaceutica que comprende la hormona de crecimiento y la proteina unidora de la hormona de crecimiento.Info
- Publication number
- ES2171478T3 ES2171478T3 ES95110334T ES95110334T ES2171478T3 ES 2171478 T3 ES2171478 T3 ES 2171478T3 ES 95110334 T ES95110334 T ES 95110334T ES 95110334 T ES95110334 T ES 95110334T ES 2171478 T3 ES2171478 T3 ES 2171478T3
- Authority
- ES
- Spain
- Prior art keywords
- hormone
- binding protein
- growth hormone
- bound
- growth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/61—Growth hormones [GH] (Somatotropin)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Rheumatology (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Neurology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Food Science & Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- General Physics & Mathematics (AREA)
Abstract
UN METODO (LIFA) DE ENSAYO INMUNOFUNCIONAL DE LIGANDO INTERMEDIO PARA DETECTAR LA PRESENCIA Y LA CONCENTRACION DE PROTEINAS DE ENLACE DE HORMONA DE POLIPEPTIDO QUE CONSISTEN EN CAPTURAR LA PROTEINA DE ENLACE CON UN PRIMER ANTICUERPOS ENLAZADO DE FASE SOLIDA, SATURAR LA PROTEINA DE ENLACE DE HORMONA ENLAZADA CON LA HORMONA DE POLIPEPTIDO DE LIGANDO, Y DETECTAR LA HORMONA DE POLIPEPTIDO DE LIGANDO ENLAZADA CON UN SEGUNDO ANTICUERPO DETECTABLEMENTE MARCADO ESPECIFICO PARA LA HORMONA DE POLIPEPTIDO DE LIGANDO. EN AUSENCIA DE HORMONA DE POLIPEPTIDO DE SATURACION AÑADIDA, EL LIFA MIDE LA CANTIDAD DE PROTEINA DE ENLACE DE HORMONA ENLAZADA A LA HORMONA DE POLIPEPTIDO DE LIGANDO ENDOGENO. UN ENSAYO DE PROTEINA DE ENLACE DE HORMONA DE CRECIMIENTO MUESTRA EL METODO DE LA PRESENTE INVENCION. LOS RESULTADOS DE LOS ENSAYOS LIFA INDICAN QUE LA PROTEINA DE ENLACE AUMENTADA AUMENTA SUSTANCIALMENTE LA ACTIVIDAD DE LA HORMONA DE CRECIMIENTO. SE PRESENTAN LOS METODOS DE USO Y LAS FORMULACIONES DE LA PROTEINA DE ENLACE DE HORMONA DE CRECIMIENTO, HORMONA DE CRECIMIENTO, FACTOR-I DE CRECIMIENTO DE INSULINA Y PROTEINA DE ENLACE DE FACTOR DE CRECIMIENTO DE INSULINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/615,538 US5210017A (en) | 1990-11-19 | 1990-11-19 | Ligand-mediated immunofunctional hormone binding protein assay method |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2171478T3 true ES2171478T3 (es) | 2002-09-16 |
Family
ID=24465822
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99123825T Expired - Lifetime ES2324322T3 (es) | 1990-11-19 | 1991-11-19 | Uso de igf-1 solo o combinado con la hormona de crecimiento para estimular el crecimiento. |
ES92901281T Expired - Lifetime ES2090598T3 (es) | 1990-11-19 | 1991-11-19 | Procedimiento de ensayo de proteinas de union de hormonas inmunofuncional mediado por ligando. |
ES95110334T Expired - Lifetime ES2171478T3 (es) | 1990-11-19 | 1991-11-19 | Composicion farmaceutica que comprende la hormona de crecimiento y la proteina unidora de la hormona de crecimiento. |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99123825T Expired - Lifetime ES2324322T3 (es) | 1990-11-19 | 1991-11-19 | Uso de igf-1 solo o combinado con la hormona de crecimiento para estimular el crecimiento. |
ES92901281T Expired - Lifetime ES2090598T3 (es) | 1990-11-19 | 1991-11-19 | Procedimiento de ensayo de proteinas de union de hormonas inmunofuncional mediado por ligando. |
Country Status (12)
Country | Link |
---|---|
US (1) | US5210017A (es) |
EP (3) | EP0995445B1 (es) |
JP (2) | JP2977280B2 (es) |
AT (3) | ATE138739T1 (es) |
AU (1) | AU657109B2 (es) |
CA (1) | CA2093927C (es) |
DE (3) | DE69133614D1 (es) |
DK (3) | DK0681842T3 (es) |
ES (3) | ES2324322T3 (es) |
GR (1) | GR3020505T3 (es) |
HK (1) | HK1007351A1 (es) |
WO (1) | WO1992008985A2 (es) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5866350A (en) * | 1985-03-19 | 1999-02-02 | Helen Hwai-An Lee | Method for the immunological determination of a biological material in a sample |
WO1994003198A1 (en) * | 1992-07-31 | 1994-02-17 | Genentech, Inc. | Human growth hormone aqueous formulation |
US5981485A (en) | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
US5593844A (en) * | 1990-11-19 | 1997-01-14 | Genentech, Inc. | Ligand-mediated immunofunctional hormone binding protein assay method |
US6326154B1 (en) * | 1990-11-19 | 2001-12-04 | Genentech, Inc. | Ligand-mediated immunofunctional hormone binding protein assay method |
US5464757A (en) * | 1991-01-15 | 1995-11-07 | The Salk Institute For Biological Studies | DNA encoding CRF binding protein |
US6087188A (en) * | 1992-11-13 | 2000-07-11 | Alk A/S | Two-site immunoassay for an antibody with chemiluminescent label and biotin bound ligand |
EP0974663A1 (en) * | 1993-06-25 | 2000-01-26 | Smithkline Beecham Plc | Lipoprotein associated phospholipase A2, inhibitors thereof and use of same in diagnosis and therapy |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
AUPN801296A0 (en) * | 1996-02-12 | 1996-03-07 | Csl Limited | Stabilised growth hormone formulation and method of preparation thereof |
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
AU762351B2 (en) * | 1999-01-06 | 2003-06-26 | Genentech Inc. | Insulin-like growth factor (IGF) I mutant variants |
ES2301547T3 (es) * | 2000-05-16 | 2008-07-01 | Genentech, Inc. | Tratamiento de trastornos del cartilago. |
US7108993B2 (en) * | 2002-07-19 | 2006-09-19 | Bayer Healthcare Llc | Use of dual conjugated labels in the elimination of serum interference in immunochromatographic assays |
SE0300959D0 (sv) * | 2002-12-19 | 2003-04-02 | Pharmacia Ab | Methods for predicting therapeutic response to agents acting on the growth hormone receptor |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
EP1667521B1 (en) | 2003-09-12 | 2011-12-07 | Tercica, Inc. | Methods for treatment of insulin-like growth factor-1 (igf-1) deficiency |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
WO2006127694A2 (en) | 2004-07-13 | 2006-11-30 | Dexcom, Inc. | Analyte sensor |
US20060020192A1 (en) | 2004-07-13 | 2006-01-26 | Dexcom, Inc. | Transcutaneous analyte sensor |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE263537C (es) * | ||||
NL7501215A (nl) * | 1975-02-01 | 1976-08-03 | Akzo Nv | Methode voor het aantonen en bepalen van een antigeen of antilichaam. |
US4486530A (en) * | 1980-08-04 | 1984-12-04 | Hybritech Incorporated | Immunometric assays using monoclonal antibodies |
US4476228A (en) * | 1982-11-08 | 1984-10-09 | Abbott Laboratories | Determination of unsaturated thyroxine binding protein sites using fluorescence polarization techniques |
US4622293A (en) * | 1983-07-05 | 1986-11-11 | Miles Laboratories, Inc. | Iodothyronine immunoassays employing HMS as TBP blocking agent |
US4594327A (en) * | 1983-11-02 | 1986-06-10 | Syntex (U.S.A.) Inc. | Assay method for whole blood samples |
IL74201A0 (en) * | 1984-01-30 | 1985-04-30 | Icrf Patents Limited | Polypeptides for the detection and control of mammalian cell growth |
US4737456A (en) * | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
JPS63273496A (ja) * | 1987-05-01 | 1988-11-10 | Sumitomo Pharmaceut Co Ltd | モノクロ−ナル抗体、ハイブリド−マおよびヒト成長ホルモン測定方法 |
DD263537A1 (de) * | 1987-09-01 | 1989-01-04 | Akad Wissenschaften Ddr | Verfahren zur herstellung von monoklonalen antikoerpern gegen humanes wachstumshormon |
US4956302A (en) * | 1987-09-11 | 1990-09-11 | Abbott Laboratories | Lateral flow chromatographic binding assay device |
EP0404783A4 (en) * | 1988-01-28 | 1991-01-23 | E.I. Du Pont De Nemours And Company | Immunoassays using monoclonal antibodies directed against natural binding proteins |
DK131988A (da) * | 1988-03-11 | 1989-09-12 | Erasmus University | Igf-bindingsprotein, dna-struktur, der koder for igf-bindingsproteinet og vektor indeholdende denne dna-struktur |
WO1989009792A1 (en) * | 1988-04-12 | 1989-10-19 | Synergen, Inc. | Method for potentiating and inhibiting insulin-like growth factor activity |
CA1341598C (en) * | 1988-07-15 | 2009-09-29 | Central Sydney Area Health Service | Acid-labile sub-unit (als) of insulin-like growth factor binding proteincomplex |
GB8826451D0 (en) * | 1988-11-11 | 1988-12-14 | Sandoz Ltd | Improvements in/relating to organic compounds |
CA2033176C (en) * | 1989-06-09 | 1999-12-14 | Julian Richard Este Wells | Growth hormone fusion proteins |
US5126324A (en) * | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
-
1990
- 1990-11-19 US US07/615,538 patent/US5210017A/en not_active Expired - Lifetime
-
1991
- 1991-11-19 AT AT92901281T patent/ATE138739T1/de not_active IP Right Cessation
- 1991-11-19 DE DE69133614T patent/DE69133614D1/de not_active Expired - Lifetime
- 1991-11-19 ES ES99123825T patent/ES2324322T3/es not_active Expired - Lifetime
- 1991-11-19 DK DK95110334T patent/DK0681842T3/da active
- 1991-11-19 DK DK92901281.3T patent/DK0558647T3/da active
- 1991-11-19 ES ES92901281T patent/ES2090598T3/es not_active Expired - Lifetime
- 1991-11-19 JP JP4501539A patent/JP2977280B2/ja not_active Expired - Lifetime
- 1991-11-19 EP EP99123825A patent/EP0995445B1/en not_active Expired - Lifetime
- 1991-11-19 EP EP95110334A patent/EP0681842B1/en not_active Expired - Lifetime
- 1991-11-19 WO PCT/US1991/008664 patent/WO1992008985A2/en active IP Right Grant
- 1991-11-19 AT AT99123825T patent/ATE425764T1/de not_active IP Right Cessation
- 1991-11-19 AT AT95110334T patent/ATE213165T1/de not_active IP Right Cessation
- 1991-11-19 DE DE69119911T patent/DE69119911T2/de not_active Expired - Lifetime
- 1991-11-19 DK DK99123825T patent/DK0995445T3/da active
- 1991-11-19 AU AU91067/91A patent/AU657109B2/en not_active Expired
- 1991-11-19 EP EP92901281A patent/EP0558647B1/en not_active Expired - Lifetime
- 1991-11-19 CA CA002093927A patent/CA2093927C/en not_active Expired - Lifetime
- 1991-11-19 ES ES95110334T patent/ES2171478T3/es not_active Expired - Lifetime
- 1991-11-19 DE DE69132931T patent/DE69132931T2/de not_active Expired - Lifetime
-
1996
- 1996-07-10 GR GR960401874T patent/GR3020505T3/el unknown
-
1998
- 1998-06-25 HK HK98106559A patent/HK1007351A1/xx not_active IP Right Cessation
-
1999
- 1999-05-10 JP JP12859899A patent/JP3159966B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ES2090598T3 (es) | 1996-10-16 |
ATE213165T1 (de) | 2002-02-15 |
DE69119911D1 (de) | 1996-07-04 |
AU9106791A (en) | 1992-06-11 |
DK0681842T3 (da) | 2002-06-03 |
EP0995445A3 (en) | 2004-01-07 |
ATE138739T1 (de) | 1996-06-15 |
EP0681842B1 (en) | 2002-02-13 |
JPH11346765A (ja) | 1999-12-21 |
CA2093927A1 (en) | 1992-05-20 |
DE69132931D1 (de) | 2002-03-21 |
DE69119911T2 (de) | 1996-11-21 |
EP0681842A2 (en) | 1995-11-15 |
DE69133614D1 (de) | 2009-04-30 |
ATE425764T1 (de) | 2009-04-15 |
DK0995445T3 (da) | 2009-07-06 |
EP0558647B1 (en) | 1996-05-29 |
JP3159966B2 (ja) | 2001-04-23 |
EP0995445A2 (en) | 2000-04-26 |
US5210017A (en) | 1993-05-11 |
DK0558647T3 (da) | 1996-08-19 |
JPH06502724A (ja) | 1994-03-24 |
ES2324322T3 (es) | 2009-08-04 |
GR3020505T3 (en) | 1996-10-31 |
DE69132931T2 (de) | 2002-11-28 |
EP0681842A3 (en) | 1998-06-10 |
WO1992008985A2 (en) | 1992-05-29 |
AU657109B2 (en) | 1995-03-02 |
EP0995445B1 (en) | 2009-03-18 |
HK1007351A1 (en) | 1999-04-09 |
CA2093927C (en) | 2000-07-18 |
JP2977280B2 (ja) | 1999-11-15 |
EP0558647A1 (en) | 1993-09-08 |
WO1992008985A3 (en) | 1992-10-29 |
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