ES2171183T3 - Analogos y conjugados de piperidina con procainamida y napa. - Google Patents
Analogos y conjugados de piperidina con procainamida y napa.Info
- Publication number
- ES2171183T3 ES2171183T3 ES95908752T ES95908752T ES2171183T3 ES 2171183 T3 ES2171183 T3 ES 2171183T3 ES 95908752 T ES95908752 T ES 95908752T ES 95908752 T ES95908752 T ES 95908752T ES 2171183 T3 ES2171183 T3 ES 2171183T3
- Authority
- ES
- Spain
- Prior art keywords
- conjugates
- napa
- procainamide
- derivatives
- piperidine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/9453—Cardioregulators, e.g. antihypotensives, antiarrhythmics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/815—Test for named compound or class of compounds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
SE DESCRIBEN NUEVOS DERIVADOS DE PROCAINAMIDA Y NACETILPROCAINAMIDA (NAPA) QUE TIENEN LA FORMULA (1) EN DONDE: X = HIDROGENO O ACETILO; N = 1 A P DONDE P = MW DE Z/1000; Z = UN POLI(AMINOACIDO) O POLISACARIDO; Y R3 = UN ENLACE O (2) EN DONDE R2 = UN GRUPO ALQUILO, CICLOALQUILO O ARILO QUE TIENE DE 2 A 10 ATOMOS DE CARBONO. LOS DERIVADOS INCLUYEN CONJUGADOS DE MALEIMIDA DE PROTEINAS O POLI(AMINOACIDOS), ENZIMAS, POLIPEPTIDOS DONANTES DE ENZIMA Y SUSTANCIAS DE MARCACION. TAMBIEN SE DESCRIBEN NUEVOS CONJUGADOS ACTIVADOS Y METODOS PARA LA SINTESIS DE LOS INTERMEDIARIOS Y DERIVADOS DE HAPTENO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/190,348 US5525474A (en) | 1994-01-31 | 1994-01-31 | Piperidine analogs and conjugates of procainamide and NAPA |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2171183T3 true ES2171183T3 (es) | 2002-09-01 |
Family
ID=22700969
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95908752T Expired - Lifetime ES2171183T3 (es) | 1994-01-31 | 1995-01-31 | Analogos y conjugados de piperidina con procainamida y napa. |
Country Status (8)
Country | Link |
---|---|
US (1) | US5525474A (es) |
EP (1) | EP0742903B1 (es) |
JP (1) | JP3031636B2 (es) |
AU (1) | AU682931B2 (es) |
CA (1) | CA2181898A1 (es) |
DE (1) | DE69525038T2 (es) |
ES (1) | ES2171183T3 (es) |
WO (1) | WO1995020763A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5439798A (en) * | 1993-12-17 | 1995-08-08 | Boehringer Mannheim Corporation | Maleimide adduct conjugates of procainamide and NAPA |
ES2229341T3 (es) * | 1997-05-27 | 2005-04-16 | Microgenics Corporation | Conjugados e inmunoensayos especificos para el metabolito de la metadona 2-etilidina-1,5-dimetil-3,3-difenil-pirrolidina. |
US6262265B1 (en) | 1999-06-18 | 2001-07-17 | Microgenics Corporation | Non-hydrolyzable analogs of heroin metabolites suitable for use in immunoassay |
US7279340B2 (en) * | 2004-04-07 | 2007-10-09 | Dade Behring Inc. | Synthesis and application of procainamide analogs for use in an immunoassay |
JP6239597B2 (ja) | 2012-05-15 | 2017-11-29 | ソレント・セラピューティクス・インコーポレイテッドSorrento Therapeutics, Inc. | 薬物コンジュゲート、コンジュゲーション方法およびその使用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235969A (en) * | 1978-05-08 | 1980-11-25 | Syva Company | Procainamide antigen conjugates and antibodies |
US4673763A (en) * | 1983-01-03 | 1987-06-16 | Miles Laboratories, Inc. | Alpha-functionalized derivatives and labeled conjugates of procainamide and NAPA |
IL69997A0 (en) * | 1983-01-03 | 1984-01-31 | Miles Lab | Procainamide and n-acetylprocainamide immunogens,antibodies prepared therefrom,labeled conjugates,and the use of such antibodies and labeled conjugates in immunoassays |
EP0199042A1 (en) * | 1985-03-26 | 1986-10-29 | Abbott Laboratories | Procainamide assay, tracers, immunogens and antibodies |
US5439798A (en) * | 1993-12-17 | 1995-08-08 | Boehringer Mannheim Corporation | Maleimide adduct conjugates of procainamide and NAPA |
-
1994
- 1994-01-31 US US08/190,348 patent/US5525474A/en not_active Expired - Fee Related
-
1995
- 1995-01-31 EP EP95908752A patent/EP0742903B1/en not_active Expired - Lifetime
- 1995-01-31 DE DE69525038T patent/DE69525038T2/de not_active Expired - Fee Related
- 1995-01-31 CA CA002181898A patent/CA2181898A1/en not_active Abandoned
- 1995-01-31 ES ES95908752T patent/ES2171183T3/es not_active Expired - Lifetime
- 1995-01-31 JP JP07520245A patent/JP3031636B2/ja not_active Expired - Fee Related
- 1995-01-31 WO PCT/US1995/001249 patent/WO1995020763A1/en active IP Right Grant
- 1995-01-31 AU AU16970/95A patent/AU682931B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP0742903B1 (en) | 2002-01-16 |
DE69525038D1 (de) | 2002-02-21 |
CA2181898A1 (en) | 1995-08-03 |
WO1995020763A1 (en) | 1995-08-03 |
JPH09508393A (ja) | 1997-08-26 |
EP0742903A1 (en) | 1996-11-20 |
US5525474A (en) | 1996-06-11 |
JP3031636B2 (ja) | 2000-04-10 |
AU682931B2 (en) | 1997-10-23 |
AU1697095A (en) | 1995-08-15 |
DE69525038T2 (de) | 2002-08-29 |
EP0742903A4 (en) | 2000-04-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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