ES2170276T3 - Particulas marcadas por un codigo permitiendo el seguimiento de secuencias de procedimientos industriales durante la preparacion de bibliotecas de compuestos de quimica combinatoria. - Google Patents

Particulas marcadas por un codigo permitiendo el seguimiento de secuencias de procedimientos industriales durante la preparacion de bibliotecas de compuestos de quimica combinatoria.

Info

Publication number
ES2170276T3
ES2170276T3 ES96935090T ES96935090T ES2170276T3 ES 2170276 T3 ES2170276 T3 ES 2170276T3 ES 96935090 T ES96935090 T ES 96935090T ES 96935090 T ES96935090 T ES 96935090T ES 2170276 T3 ES2170276 T3 ES 2170276T3
Authority
ES
Spain
Prior art keywords
libraries
sequences
follow
preparation
chemical compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96935090T
Other languages
English (en)
Spanish (es)
Inventor
Paul Henry Kaye
Mark Christopher Tracey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Hertfordshire
Original Assignee
University of Hertfordshire
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10782942&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2170276(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by University of Hertfordshire filed Critical University of Hertfordshire
Application granted granted Critical
Publication of ES2170276T3 publication Critical patent/ES2170276T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047Simultaneous synthesis of different peptide species; Peptide libraries
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/005Beads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/00502Particles of irregular geometry
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547Bar codes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00547Bar codes
    • B01J2219/005492-dimensional
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00554Physical means
    • B01J2219/00556Perforations
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00554Physical means
    • B01J2219/00558Cuts-out
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00554Physical means
    • B01J2219/0056Raised or sunken areas
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00585Parallel processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00592Split-and-pool, mix-and-divide processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00596Solid-phase processes
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B70/00Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Pyrane Compounds (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Powder Metallurgy (AREA)
  • Saccharide Compounds (AREA)
  • Auxiliary Devices For And Details Of Packaging Control (AREA)
  • Manufacture And Refinement Of Metals (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ES96935090T 1995-10-26 1996-10-25 Particulas marcadas por un codigo permitiendo el seguimiento de secuencias de procedimientos industriales durante la preparacion de bibliotecas de compuestos de quimica combinatoria. Expired - Lifetime ES2170276T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9521943.2A GB9521943D0 (en) 1995-10-26 1995-10-26 Coded particles for process sequence tracking in combinatorial compound library preparation

Publications (1)

Publication Number Publication Date
ES2170276T3 true ES2170276T3 (es) 2002-08-01

Family

ID=10782942

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96935090T Expired - Lifetime ES2170276T3 (es) 1995-10-26 1996-10-25 Particulas marcadas por un codigo permitiendo el seguimiento de secuencias de procedimientos industriales durante la preparacion de bibliotecas de compuestos de quimica combinatoria.

Country Status (11)

Country Link
EP (2) EP1018365A3 (2)
JP (1) JP2000516195A (2)
AT (1) ATE210496T1 (2)
AU (1) AU696505B2 (2)
CA (1) CA2235837A1 (2)
DE (1) DE69618001T2 (2)
DK (1) DK0863797T3 (2)
ES (1) ES2170276T3 (2)
GB (2) GB9521943D0 (2)
PT (1) PT863797E (2)
WO (1) WO1997015390A1 (2)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US6352854B1 (en) 1995-04-25 2002-03-05 Discovery Partners International, Inc. Remotely programmable matrices with memories
US6340588B1 (en) 1995-04-25 2002-01-22 Discovery Partners International, Inc. Matrices with memories
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6284459B1 (en) 1995-04-25 2001-09-04 Discovery Partners International Solid support matrices with memories and combinatorial libraries therefrom
WO1996036436A1 (en) 1995-04-25 1996-11-21 Irori Remotely programmable matrices with memories and uses thereof
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US6025129A (en) 1995-04-25 2000-02-15 Irori Remotely programmable matrices with memories and uses thereof
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US5961923A (en) * 1995-04-25 1999-10-05 Irori Matrices with memories and uses thereof
US5741462A (en) 1995-04-25 1998-04-21 Irori Remotely programmable matrices with memories
US6100026A (en) * 1995-04-25 2000-08-08 Irori Matrices with memories and uses thereof
US6416714B1 (en) * 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US6319668B1 (en) 1995-04-25 2001-11-20 Discovery Partners International Method for tagging and screening molecules
GB2326152B (en) * 1996-03-07 2000-06-28 Imperial College A composite for combinatorial organic synthesis
GB9707741D0 (en) * 1997-04-17 1997-06-04 Zeneca Ltd Process
GB9707742D0 (en) * 1997-04-17 1997-06-04 Zeneca Ltd Methods
GB2337269B (en) * 1997-04-17 2002-10-09 Zeneca Ltd Method for the preparation of a chemical library
US6096496A (en) * 1997-06-19 2000-08-01 Frankel; Robert D. Supports incorporating vertical cavity emitting lasers and tracking apparatus for use in combinatorial synthesis
AU8376998A (en) * 1997-07-24 1999-02-16 Argonaut Technologies, Inc. Compositions for the storage and delivery of solid phase reactive particles and methods of using the same
US6960457B1 (en) * 1997-09-04 2005-11-01 Stanford University Reversible immobilization of arginine-tagged moieties on a silicate surface
GB2334347B (en) * 1998-02-13 2001-02-28 Univ Hertfordshire An improved method of fabricating coded particles
AU2534899A (en) * 1998-02-13 1999-08-30 University Of Hertfordshire An improved method of fabricating coded particles
GB9814259D0 (en) * 1998-07-02 1998-09-02 Univ Hertfordshire Improvements to the fabrication and method of use of coded particles in the field of combinatorial chemistry
EP1062034A1 (en) * 1998-03-13 2000-12-27 Central Research Laboratories Limited Apparatus for, and method of, manufacturing a plurality of uniquely labelled articles
GB9808783D0 (en) * 1998-04-25 1998-06-24 Central Research Lab Ltd Labelling of small articles
JP3662850B2 (ja) 1998-06-24 2005-06-22 イルミナ インコーポレイテッド 微小球を有するアレイセンサーのデコード
GB9820163D0 (en) * 1998-09-17 1998-11-11 Sentec Ltd Micro-fabricated coded labels, reading systems and their applications
EP1169123A1 (en) * 1999-04-09 2002-01-09 Glaxo Group Limited Encoding scheme for solid phase chemical libraries
US6908737B2 (en) 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
WO2000063419A1 (en) * 1999-04-15 2000-10-26 Virtual Arrays, Inc. Combinatorial chemical library supports having indicia at coding positions and methods of use
US7253435B2 (en) 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US8939376B1 (en) 1999-04-16 2015-01-27 Mycartis Nv Encoding of microcarriers
US6919009B2 (en) 1999-10-01 2005-07-19 Nanoplex Technologies, Inc. Method of manufacture of colloidal rod particles as nanobarcodes
US7045049B1 (en) 1999-10-01 2006-05-16 Nanoplex Technologies, Inc. Method of manufacture of colloidal rod particles as nanobar codes
US7225082B1 (en) 1999-10-01 2007-05-29 Oxonica, Inc. Colloidal rod particles as nanobar codes
AU2001293381B2 (en) * 2000-04-19 2005-09-15 3D Molecular Sciences Limited A method of fabricating coded particles
JP2004537712A (ja) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
US7811768B2 (en) * 2001-01-26 2010-10-12 Aviva Biosciences Corporation Microdevice containing photorecognizable coding patterns and methods of using and producing the same
US7015047B2 (en) 2001-01-26 2006-03-21 Aviva Biosciences Corporation Microdevices having a preferential axis of magnetization and uses thereof
GB0109746D0 (en) * 2001-04-18 2001-06-13 Scient Generics Ltd Chemical libraries based on coded particles
GB0109545D0 (en) * 2001-04-18 2001-06-06 Scient Generics Ltd Chemical libraries based on coded particles
US7572642B2 (en) 2001-04-18 2009-08-11 Ambrigen, Llc Assay based on particles, which specifically bind with targets in spatially distributed characteristic patterns
GB0111470D0 (en) * 2001-05-10 2001-07-04 Scient Generics Ltd Homogenous photoresist functionalisation
CA2466164A1 (en) * 2001-10-30 2003-05-08 Nanomics Biosystems Pty, Ltd. Device and methods for directed synthesis of chemical libraries
CA2488797C (en) * 2002-06-21 2011-04-19 Stephen D. Nightingale Multi-functional product markers and methods for making and using the same
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7441703B2 (en) 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US20040058457A1 (en) * 2002-08-29 2004-03-25 Xueying Huang Functionalized nanoparticles
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
US20100255603A9 (en) 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
CA2498933C (en) 2002-09-12 2012-08-28 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
AU2003270726A1 (en) 2002-09-12 2004-04-30 Cidra Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7361821B2 (en) 2002-09-20 2008-04-22 Intel Corporation Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading
AU2003278852A1 (en) 2002-09-20 2004-05-13 Intel Corporation Controlled alignment of nano-barcodes encoding specific information for scanning probe microscopy (spm) reading
US8791053B2 (en) 2002-09-27 2014-07-29 Mpm-Holding Aps Spatially encoded polymer matrix
GB2393785B (en) 2002-10-03 2005-08-31 Toshiba Res Europ Ltd Method of making a free standing structure
GB2393784B (en) * 2002-10-03 2005-06-15 Toshiba Res Europ Ltd An identification tag and method of making an identification tag
US7312257B2 (en) 2003-01-23 2007-12-25 General Electric Company Polymer encapsulation of high aspect ratio materials and methods of making same
GB2405013B (en) * 2003-08-11 2006-02-15 Toshiba Res Europ Ltd A security marker and security marking method
US7488451B2 (en) 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
CA2550902C (en) 2003-12-22 2013-06-25 Versamatrix A/S Apparatus and methods for analysis and sorting of particles such as polymer beads
WO2005061094A1 (en) 2003-12-22 2005-07-07 Versamatrix A/S Identification of encoded beads
US7433123B2 (en) 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US20050277710A1 (en) * 2004-06-14 2005-12-15 Joyce Richard P Tagged resin, method of making a tagged resin, and articles made therefrom
WO2006020363A2 (en) 2004-07-21 2006-02-23 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
ATE459933T1 (de) 2004-11-16 2010-03-15 Illumina Inc Verfahren und vorrichtung zum lesen von kodierten mikrokugeln
US7602952B2 (en) 2004-11-16 2009-10-13 Illumina, Inc. Scanner having spatial light modulator
US7604173B2 (en) 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
WO2006061600A1 (en) * 2004-12-07 2006-06-15 University Of Southampton Particles for use as a solid support and process for their preparation
GB2422686A (en) * 2004-12-07 2006-08-02 Univ Southampton Preparation of solid support particles for chemical reactions
US8592136B2 (en) 2005-09-13 2013-11-26 Affymetrix, Inc. Methods for producing codes for microparticles
US8178278B2 (en) 2005-09-13 2012-05-15 Affymetrix, Inc. Miniaturized microparticles
US7623624B2 (en) 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
US20090032592A1 (en) 2006-01-11 2009-02-05 Novo Nordisk A/S Spherical encoded beads
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
JP4803125B2 (ja) * 2007-05-10 2011-10-26 ソニー株式会社 ビーズ群と該ビーズ群の作製方法、並びにビーズ群を用いる方法
EP1995329B1 (en) 2007-05-10 2013-09-25 Sony Corporation Method for sequencing nucleic acids
JP4973993B2 (ja) * 2007-07-23 2012-07-11 財団法人生産技術研究奨励会 マイクロビーズの配列装置における解放装置及びその解放装置の設定方法
GB0725306D0 (en) * 2007-12-28 2008-02-06 Pronostics Ltd Improved microparticles
JP2009174954A (ja) * 2008-01-23 2009-08-06 Fujitsu Ltd コード化粒子
JP4582224B2 (ja) 2008-05-02 2010-11-17 ソニー株式会社 マイクロビーズ作製方法及びマイクロビーズ
US9182406B2 (en) 2008-08-04 2015-11-10 Biodesy, Inc. Nonlinear optical detection of molecules comprising an unnatural amino acid possessing a hyperpolarizability
EP2312393A1 (en) * 2009-10-14 2011-04-20 Biocartis SA Method for producing microparticles
US9428789B2 (en) 2011-03-21 2016-08-30 Biodesy, Inc. Classification of kinase inhibitors using nonlinear optical techniques
US9139863B2 (en) 2012-03-16 2015-09-22 Genentech, Inc. Engineered conformationally-stabilized proteins
JP6198807B2 (ja) 2012-03-16 2017-09-20 ジェネンテック, インコーポレイテッド 操作され立体構造的に安定化されたタンパク質
GB2517857A (en) 2012-04-25 2015-03-04 Biodesy Inc Methods for detecting allosteric modulators of proteins
US10436778B2 (en) 2013-03-15 2019-10-08 Plexbio Co., Ltd. Methods and systems for multiplex assays
SG10202003996YA (en) 2014-05-05 2020-06-29 Regeneron Pharma Humanized c5 and c3 animals
EP3237906B8 (en) 2014-12-23 2020-10-28 Bluelight Therapeutics, Inc. Attachment of proteins to interfaces for use in nonlinear optical detection
TWI737614B (zh) 2015-06-11 2021-09-01 博錸生技股份有限公司 已編碼微載體及其製造方法以及用以進行多工分析之包含該等已編碼微載體之套件
JP2019502753A (ja) 2015-12-23 2019-01-31 ムーンショット ファーマ エルエルシー ナンセンス変異依存mRNA分解機構の抑制による免疫応答の誘導法
US11796535B2 (en) 2016-09-16 2023-10-24 Plexbio Co., Ltd. Methods and systems for multiplex assays
US10765762B2 (en) 2017-02-27 2020-09-08 Regeneron Pharmaceuticals, Inc. Humanized model of kidney and liver disorders
EP3641752A4 (en) 2017-06-22 2021-03-17 Moonshot Pharma LLC METHOD OF TREATMENT OF CANCER WITH COMPOSITIONS WITH AMLEXANOX AND IMMUNE MODULATORS
EP4293568B1 (en) * 2019-01-23 2025-08-27 BGI Shenzhen Microbead

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053433A (en) * 1975-02-19 1977-10-11 Minnesota Mining And Manufacturing Company Method of tagging with color-coded microparticles
CA1056653A (en) * 1975-11-10 1979-06-19 Edward J. Stevens Color-coded identifier microparticles
US4390452A (en) * 1979-08-20 1983-06-28 Minnesota Mining & Manufacturing Company Microparticles with visual identifying means
US4631211A (en) * 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
US4767205A (en) * 1986-01-28 1988-08-30 Flow Cytometry Standards Corporation Composition and method for hidden identification
JP2001524926A (ja) * 1991-09-18 2001-12-04 アフィマックス テクノロジーズ ナームロゼ フェンノートシャップ オリゴマーの雑多ライブラリーの集合体を合成する方法
NZ257077A (en) * 1992-11-06 1997-05-26 Chiron Mimotopes Pty Ltd Support for synthesis of modular polymers
US5429392A (en) * 1993-06-18 1995-07-04 Loving; Charles D. Composite microdot and method
GB2289150B (en) * 1994-04-25 1998-07-15 Univ Hertfordshire Coded items for labelling objects

Also Published As

Publication number Publication date
GB9622249D0 (en) 1996-12-18
DE69618001T2 (de) 2002-08-14
GB2306484B (en) 1997-09-24
EP1018365A8 (en) 2001-03-28
AU696505B2 (en) 1998-09-10
GB2306484A (en) 1997-05-07
PT863797E (pt) 2002-05-31
ATE210496T1 (de) 2001-12-15
DK0863797T3 (da) 2002-04-15
EP1018365A9 (en) 2001-05-16
EP1018365A3 (en) 2000-10-11
EP0863797A1 (en) 1998-09-16
DE69618001D1 (de) 2002-01-24
AU7318496A (en) 1997-05-15
EP1018365A2 (en) 2000-07-12
CA2235837A1 (en) 1997-05-01
JP2000516195A (ja) 2000-12-05
GB9521943D0 (en) 1996-01-03
WO1997015390A1 (en) 1997-05-01
EP0863797B1 (en) 2001-12-12

Similar Documents

Publication Publication Date Title
ES2170276T3 (es) Particulas marcadas por un codigo permitiendo el seguimiento de secuencias de procedimientos industriales durante la preparacion de bibliotecas de compuestos de quimica combinatoria.
ZA941968B (en) Process for the purification of taxoids
MX9303585A (es) 3,4-dimetil-2,5,6-tris(p-sulfonatofenil)-1-fosfanorbornadieno, procedimiento para su preparacion y procedimiento para la hidroformilacion de compuestos olefinicamente insaturados.
AR042345A2 (es) Un procedimiento para la preparacion de una composicion farmaceutica para el tratamiento de aterosclerosis que contiene 8.9 - dehidroesterona o sus sales de la misma
FI964520L (fi) Atsabisykloyhdisteet
FR2709125B1 (fr) Procédé de métathèse des oléfines mettant en Óoeuvre un catalyseur au rhénium amélioré.
NO921256D0 (no) Aminosyre-beta-lyaseenzyminhibitor som deodoranter
ES2096974T3 (es) Proceso de condensacion y/o equilibrio de compuestos organicos de silicio.
IT8921705A0 (it) Copolimero contenente fluoro utile come veicolo per vernice.
ES2171748T3 (es) Procedimiento de fabricacion de compuestos de tipo monazita, dopados o no con actinidos y uso de los mismos para acondicionar residuos radiactivos enriquecidos con actinidos y lantanidos.
NO901452L (no) Blandinger inneholdende 2-tiocyano-metyltio-benzotiazol for anvendelse som industrielle mikrobiocider.
ES2091285T3 (es) 2-hidroxi-1,2,3-propanotricarboxilato de 3-((5-metil-2-furanil)-metil)-n-(4-piperidinil)-3h-imidazo-(4,5-b)-piridin-2-amina.
AU1779188A (en) Guanidine-related compounds comprising a substituted tetraphenylborate ion, process for obtaining these compounds, and use of the compounds
ES2125938T3 (es) Procedimiento para la reactivacion de proteinas membranales purificadas.
DE69108358D1 (de) Heptamethyl-Indanverbindung.
IT8820799A0 (it) Procedimento per la inertizzazione degli scarti industriali di amianto crisotilo.
ATE179638T1 (de) Pneumatischer vibrator
BR9812229A (pt) Processo para a purificação de antitrombina iii
BR9003672A (pt) Processo para fabricacao descontinua de l-carnitina por via microbiologica
DE69706933D1 (de) Verfahren zur Reinigung von 1,1,1-Tris(4-Hydroxyphenyl)alkanen
BR9405186A (pt) Processo para a preparação de 2,4,5-tribromopirrol-3-carbonitrila
RU95112778A (ru) Инструмент для прессования полосы
DK0667184T3 (da) Fremgangsmåde til skeletisomerisering af lineære olefiner
ATE78598T1 (de) Immunassay unter benutzung der mikropartikelneutralisierung.
ATE198881T1 (de) Trennung von 4-cyano-4-(3,4-dimethoxyphenyl)-5- methylexancarbonsäure

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 863797

Country of ref document: ES