ES2168521T3 - Anticuerpo monoclonal frente al complejo de factor xa-inhibidor de la via del factor tisular, y su uso. - Google Patents
Anticuerpo monoclonal frente al complejo de factor xa-inhibidor de la via del factor tisular, y su uso.Info
- Publication number
- ES2168521T3 ES2168521T3 ES96943313T ES96943313T ES2168521T3 ES 2168521 T3 ES2168521 T3 ES 2168521T3 ES 96943313 T ES96943313 T ES 96943313T ES 96943313 T ES96943313 T ES 96943313T ES 2168521 T3 ES2168521 T3 ES 2168521T3
- Authority
- ES
- Spain
- Prior art keywords
- factor
- inhibitor
- tissular
- monoclonal antibody
- antibody against
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/02—Preparation of hybrid cells by fusion of two or more cells, e.g. protoplast fusion
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
- G01N2333/8114—Kunitz type inhibitors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
- G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
- G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
- G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
- G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
- G01N2333/96433—Serine endopeptidases (3.4.21)
- G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
- G01N2333/96444—Factor X (3.4.21.6)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
UN ANTICUERPO MONOCLONAL QUE REACCIONA CON EL COMPLEJO INHIBIDOR DE LA VIA DEL FACTOR TISULAR ON ESPECIFICIDAD, PERO QUE NO REACCIONA CON EL FACTOR X, FACTOR XA LIBRE E INHIBIDOR DE LA VIA DEL FACTOR TISULAR (TFPI), UN HIBRIDOMA QUE SECRETA EL ANTICUERPO MONOCLONAL Y UN METODO PARA MEDIR INMUNOLOGICAMENTE XA TICUERPO MONOCLONAL.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP33922995A JP3681206B2 (ja) | 1995-12-26 | 1995-12-26 | 抗ファクターXa・ティシュファクターパスウェイインヒビター複合体モノクローナル抗体及びその使用 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2168521T3 true ES2168521T3 (es) | 2002-06-16 |
Family
ID=18325482
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96943313T Expired - Lifetime ES2168521T3 (es) | 1995-12-26 | 1996-12-26 | Anticuerpo monoclonal frente al complejo de factor xa-inhibidor de la via del factor tisular, y su uso. |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0812859B1 (es) |
JP (1) | JP3681206B2 (es) |
KR (1) | KR100249314B1 (es) |
AU (1) | AU706547B2 (es) |
DE (1) | DE69619226T2 (es) |
ES (1) | ES2168521T3 (es) |
WO (1) | WO1997023509A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002316999A (ja) * | 2001-04-17 | 2002-10-31 | Dai Ichi Pure Chem Co Ltd | モノクローナル抗体 |
UA112050C2 (uk) * | 2008-08-04 | 2016-07-25 | БАЄР ХЕЛСКЕР ЛЛСі | Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi) |
KR101977846B1 (ko) | 2008-12-19 | 2019-05-14 | 박스알타 인코퍼레이티드 | Tfpi 억제제 및 사용 방법 |
CN102325795B (zh) | 2008-12-22 | 2015-03-25 | 诺沃—诺迪斯克有限公司 | 针对组织因子途径抑制剂的抗体 |
EP3708190A1 (en) * | 2010-02-26 | 2020-09-16 | Novo Nordisk A/S | Stable antibody containing compositions |
NZ602115A (en) * | 2010-03-01 | 2014-12-24 | Bayer Healthcare Llc | Optimized monoclonal antibodies against tissue factor pathway inhibitor (tfpi) |
JP5730983B2 (ja) | 2010-03-19 | 2015-06-10 | バクスター・インターナショナル・インコーポレイテッドBaxter International Incorp0Rated | Tfpi阻害剤および使用方法 |
US20130136733A1 (en) | 2010-05-28 | 2013-05-30 | Novo Nordisk A/S | Stable Multi-Dose Compositions Comprising an Antibody and a Preservative |
NZ629130A (en) | 2012-03-21 | 2016-10-28 | Baxalta Inc | Tfpi inhibitors and methods of use |
WO2016157513A1 (ja) * | 2015-04-03 | 2016-10-06 | 株式会社日立製作所 | 抗原抗体間相互作用量の同定法及び装置 |
-
1995
- 1995-12-26 JP JP33922995A patent/JP3681206B2/ja not_active Expired - Fee Related
-
1996
- 1996-12-26 EP EP96943313A patent/EP0812859B1/en not_active Expired - Lifetime
- 1996-12-26 DE DE69619226T patent/DE69619226T2/de not_active Expired - Lifetime
- 1996-12-26 KR KR1019970705837A patent/KR100249314B1/ko not_active IP Right Cessation
- 1996-12-26 AU AU12089/97A patent/AU706547B2/en not_active Ceased
- 1996-12-26 WO PCT/JP1996/003832 patent/WO1997023509A1/ja active IP Right Grant
- 1996-12-26 ES ES96943313T patent/ES2168521T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP3681206B2 (ja) | 2005-08-10 |
JPH09176199A (ja) | 1997-07-08 |
KR19980702438A (ko) | 1998-07-15 |
KR100249314B1 (ko) | 2000-03-15 |
DE69619226T2 (de) | 2002-08-14 |
WO1997023509A1 (fr) | 1997-07-03 |
EP0812859A1 (en) | 1997-12-17 |
DE69619226D1 (de) | 2002-03-21 |
EP0812859A4 (en) | 2000-04-26 |
AU706547B2 (en) | 1999-06-17 |
AU1208997A (en) | 1997-07-17 |
EP0812859B1 (en) | 2002-02-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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