ES2162550A1 - Procedimiento de preparacion de 3-hidroximetilquinuclidina. - Google Patents

Procedimiento de preparacion de 3-hidroximetilquinuclidina.

Info

Publication number
ES2162550A1
ES2162550A1 ES009900709A ES9900709A ES2162550A1 ES 2162550 A1 ES2162550 A1 ES 2162550A1 ES 009900709 A ES009900709 A ES 009900709A ES 9900709 A ES9900709 A ES 9900709A ES 2162550 A1 ES2162550 A1 ES 2162550A1
Authority
ES
Spain
Prior art keywords
quinuclidine
formula
hydroxymethyl
production
converting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES009900709A
Other languages
English (en)
Other versions
ES2162550B1 (es
Inventor
Yves Guminski
Thierry Imbert
Aprick Lesimple
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Publication of ES2162550A1 publication Critical patent/ES2162550A1/es
Application granted granted Critical
Publication of ES2162550B1 publication Critical patent/ES2162550B1/es
Anticipated expiration legal-status Critical
Withdrawn - After Issue legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Procedimiento de preparación de 3-hidroximetilquinuclidina, utilizable para la preparación de mequitazina. Este procedimiento consiste o bien en preparar el 3-metoximetil-3-quinuclidinol a partir de la 3-quinuclidinona, transformarlo en 3- formilquinuclidina, y reducirlo a 3-hidroximetilquinuclidina, o bien en preparar la 3-cianoquinuclidina, hidrolizarla y reducir el ácido obtenido a 3-hidroximetilquinuclidina.
ES009900709A 1998-04-09 1999-04-08 Procedimiento de preparacion de 3-hidroximetilquinuclidina. Withdrawn - After Issue ES2162550B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9804451A FR2777278B1 (fr) 1998-04-09 1998-04-09 Nouveau procede de preparation de la 3-hydroxymethyl quinuclidine, intermediaire de synthese de la mequitazine

Publications (2)

Publication Number Publication Date
ES2162550A1 true ES2162550A1 (es) 2001-12-16
ES2162550B1 ES2162550B1 (es) 2003-04-01

Family

ID=9525062

Family Applications (1)

Application Number Title Priority Date Filing Date
ES009900709A Withdrawn - After Issue ES2162550B1 (es) 1998-04-09 1999-04-08 Procedimiento de preparacion de 3-hidroximetilquinuclidina.

Country Status (3)

Country Link
AR (1) AR014977A1 (es)
ES (1) ES2162550B1 (es)
FR (1) FR2777278B1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2911606B1 (fr) 2007-01-18 2009-04-17 Pierre Fabre Medicament Sa Nouveau derive de la quinuclidine utile dans la preparation de la mequitazine

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0089860A1 (fr) * 1982-03-05 1983-09-28 Pharmuka Laboratoires Isomère lévogyre de la méquitazine, son procédé de préparation et médicaments le contenant
EP0102283A1 (fr) * 1982-08-17 1984-03-07 Pharmuka Laboratoires Nouveau procédé de préparation de dérivés de la quinuclidine substitués en position 3
EP0354301A2 (de) * 1988-08-10 1990-02-14 Rütgerswerke Aktiengesellschaft Verfahren zur Herstellung von Chinuclidin-3-methanol

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5137895A (en) * 1991-04-29 1992-08-11 A. H. Robins Company, Incorporated 3-[N-aroyl(or thioaroyl)aminomethyl]-3-quinuclidinols

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0089860A1 (fr) * 1982-03-05 1983-09-28 Pharmuka Laboratoires Isomère lévogyre de la méquitazine, son procédé de préparation et médicaments le contenant
EP0102283A1 (fr) * 1982-08-17 1984-03-07 Pharmuka Laboratoires Nouveau procédé de préparation de dérivés de la quinuclidine substitués en position 3
EP0354301A2 (de) * 1988-08-10 1990-02-14 Rütgerswerke Aktiengesellschaft Verfahren zur Herstellung von Chinuclidin-3-methanol

Also Published As

Publication number Publication date
FR2777278A1 (fr) 1999-10-15
ES2162550B1 (es) 2003-04-01
FR2777278B1 (fr) 2000-06-30
AR014977A1 (es) 2001-04-11

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