ES2159783T3 - Composicion oftalmologica con tiempo prolongado de residencia en el ojo. - Google Patents

Composicion oftalmologica con tiempo prolongado de residencia en el ojo.

Info

Publication number
ES2159783T3
ES2159783T3 ES97103736T ES97103736T ES2159783T3 ES 2159783 T3 ES2159783 T3 ES 2159783T3 ES 97103736 T ES97103736 T ES 97103736T ES 97103736 T ES97103736 T ES 97103736T ES 2159783 T3 ES2159783 T3 ES 2159783T3
Authority
ES
Spain
Prior art keywords
eye
preserving agent
residence
ammonium salt
dwell time
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97103736T
Other languages
English (en)
Inventor
Gunther Dr Bellmann
Gudrun Dr Claus-Herz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dr Gerhard Mann Chem Pharm Fabrik GmbH
Original Assignee
Dr Gerhard Mann Chem Pharm Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr Gerhard Mann Chem Pharm Fabrik GmbH filed Critical Dr Gerhard Mann Chem Pharm Fabrik GmbH
Application granted granted Critical
Publication of ES2159783T3 publication Critical patent/ES2159783T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

COMPOSICION OFTALMICA CON UN TIEMPO DE RESIDENCIA MAS PROLONGADO EN EL OJO, ESPECIALMENTE EN FORMA DE UN GEL PARA ADMINISTRAR EN FORMA DE GOTAS, DE POMADA O SIMILAR, QUE CONTIENE UN VEHICULO FLUIDIFICABLE CON UNA ELEVADA VISCOSIDAD Y UN CONSERVANTE, ASI COMO EVENTUALMENTE UNO O MAS PRINCIPIOS ACTIVOS Y ADITIVOS HABITUALES, COMO AGENTES QUE PROPORCIONAN ISOTONICIDAD, SUSTANCIAS PARA AJUSTAR EL PH, ETC. SEGUN LA INVENCION, EL CONSERVANTE ESTA CONSTITUIDO ESENCIALMENTE POR UNA SAL DE BENCILLAURILDIMETILAMONIO. ASIMISMO, LA INVENCION SE REFIERE AL USO DE UNA SAL DE BENCILLAURILDIMETILAMONIO COMO CONSERVANTE PARA LA PREPARACION DE COMPOSICIONES OFTALMICAS, QUE SON ADECUADAS PARA UN USO REPETIDO DURANTE UN PERIODO DE TIEMPO MAS LARGO Y/O QUE ESTAN FORMULADAS PARA UN TIEMPO DE RESIDENCIA MAS PROLONGADO EN EL OJO, MEDIANTE LAS CUALES SE PUEDEN EVITAR IRRITACIONES Y/O DAÑOS EN EL TEJIDO DEL OJO.
ES97103736T 1996-04-15 1997-03-06 Composicion oftalmologica con tiempo prolongado de residencia en el ojo. Expired - Lifetime ES2159783T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19614823A DE19614823A1 (de) 1996-04-15 1996-04-15 Ophthalmische Zusammensetzung mit verlängerter Verweilzeit am Auge

Publications (1)

Publication Number Publication Date
ES2159783T3 true ES2159783T3 (es) 2001-10-16

Family

ID=7791310

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97103736T Expired - Lifetime ES2159783T3 (es) 1996-04-15 1997-03-06 Composicion oftalmologica con tiempo prolongado de residencia en el ojo.

Country Status (16)

Country Link
US (2) US6599944B1 (es)
EP (1) EP0801948B1 (es)
JP (1) JP4582822B2 (es)
CN (1) CN1215988A (es)
AT (1) ATE201820T1 (es)
AU (1) AU714093B2 (es)
BR (1) BR9708669A (es)
CA (1) CA2251982C (es)
DE (2) DE19614823A1 (es)
DK (1) DK0801948T3 (es)
ES (1) ES2159783T3 (es)
GR (1) GR3036498T3 (es)
PL (1) PL187339B1 (es)
PT (1) PT801948E (es)
SI (1) SI0801948T1 (es)
WO (1) WO1997038674A1 (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19614823A1 (de) 1996-04-15 1997-10-16 Mann Gerhard Chem Pharm Fab Ophthalmische Zusammensetzung mit verlängerter Verweilzeit am Auge
DE19744113A1 (de) * 1997-10-06 1999-04-15 Mann Gerhard Chem Pharm Fab Dexamethason-Gel
IN185228B (es) * 1999-02-03 2000-12-09 Bakulesh Mafatlal Dr Khamar
DE19918324A1 (de) * 1999-04-22 2000-10-26 Mann Gerhard Chem Pharm Fab Pharmazeutische Zusammensetzung wirksam gegen durch Bakterien, Viren, Pilze, Hefen und Protozoen verursachte Krankheitszustände
DE19938668B4 (de) * 1999-08-14 2006-01-26 Bausch & Lomb Inc. Tränenersatzmittel
DE10132876A1 (de) * 2001-07-06 2003-01-30 Medproject Pharma Entwicklungs Zweiphasige, tropfbare Hydrogele zur Anwendung am Auge
EP2227197A4 (en) * 2007-12-05 2011-06-22 Avedro Inc EYE THERAPY SYSTEM
US8366689B2 (en) * 2008-09-30 2013-02-05 Avedro, Inc. Method for making structural changes in corneal fibrils
WO2011050164A1 (en) 2009-10-21 2011-04-28 Avedro, Inc. Eye therapy
US20110237999A1 (en) * 2010-03-19 2011-09-29 Avedro Inc. Systems and methods for applying and monitoring eye therapy
US9044308B2 (en) 2011-05-24 2015-06-02 Avedro, Inc. Systems and methods for reshaping an eye feature
WO2012167260A2 (en) 2011-06-02 2012-12-06 Avedro, Inc. Systems and methods for monitoring time based photo active agent delivery or photo active marker presence
CN102416011A (zh) * 2011-10-10 2012-04-18 艾硕特生物科技（昆明）有限公司 一种广谱、高效的抗菌洗液
WO2013166408A1 (en) 2012-05-03 2013-11-07 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
US11596599B2 (en) 2012-05-03 2023-03-07 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
EP2844295A1 (en) 2012-05-03 2015-03-11 Kala Pharmaceuticals, Inc. Pharmaceutical nanoparticles showing improved mucosal transport
US9827191B2 (en) 2012-05-03 2017-11-28 The Johns Hopkins University Compositions and methods for ophthalmic and/or other applications
WO2013059837A2 (en) 2012-07-16 2013-04-25 Avedro, Inc. Systems and methods for corneal cross-linking with pulsed light
US9498114B2 (en) 2013-06-18 2016-11-22 Avedro, Inc. Systems and methods for determining biomechanical properties of the eye for applying treatment
US9498122B2 (en) 2013-06-18 2016-11-22 Avedro, Inc. Systems and methods for determining biomechanical properties of the eye for applying treatment
US9308165B2 (en) * 2013-08-22 2016-04-12 Therapeutic Vision, Inc. Composition for treating ocular effects of diabetes
KR102545628B1 (ko) 2014-10-27 2023-06-20 아베드로 인코퍼레이티드 눈의 교차-결합 처리를 위한 시스템 및 방법
US10114205B2 (en) 2014-11-13 2018-10-30 Avedro, Inc. Multipass virtually imaged phased array etalon
EP3285704B1 (en) 2015-04-24 2020-11-18 Avedro Inc. Systems for photoactivating a photosensitizer applied to an eye
US10028657B2 (en) 2015-05-22 2018-07-24 Avedro, Inc. Systems and methods for monitoring cross-linking activity for corneal treatments
US11207410B2 (en) 2015-07-21 2021-12-28 Avedro, Inc. Systems and methods for treatments of an eye with a photosensitizer

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053628A (en) * 1971-05-12 1977-10-11 Fisons Limited Composition
GB1399834A (en) * 1971-05-12 1975-07-02 Fisons Ltd Pharmaceutical compositions
AU499860B2 (en) * 1975-04-24 1979-05-03 Honda Giken Kogyo Kabushiki Kaisha Deflector plate to equalise fuel distribution in induction gas flow
JPS5313588A (en) * 1976-07-23 1978-02-07 Alcon Lab Inc Ophthalmic solution
GB2013084B (en) * 1978-01-25 1982-07-28 Alcon Lab Inc Ophthalmic drug dosage
US4271143A (en) * 1978-01-25 1981-06-02 Alcon Laboratories, Inc. Sustained release ophthalmic drug dosage
DE3415663A1 (de) * 1984-04-27 1985-10-31 Sandoz-Patent-GmbH, 7850 Lörrach Eine neue ophthalmologische verabreichungsform
US4738851A (en) * 1985-09-27 1988-04-19 University Of Iowa Research Foundation, Inc. Controlled release ophthalmic gel formulation
US5032392A (en) * 1986-09-04 1991-07-16 Vision Pharmaceuticals Aqueous ophthalmic solutions for the treatment of dryness and/or irritation of human or animal eyes
FR2665635A1 (fr) 1990-08-10 1992-02-14 Merck Sharp & Dohme Composition pharmaceutique fluide a base d'un complexe metallique et son procede de preparation.
FR2678832B1 (fr) * 1991-07-10 1995-03-17 Europhta Sa Laboratoire Nouvelles compositions ophtalmiques a resorption amelioree et leurs procedes de preparation.
FR2679773A1 (fr) * 1991-07-30 1993-02-05 Merck Sharp & Dohme Preparation ophtalmique contenant un agent osmotique acceptable antimicrobien.
WO1994010976A1 (en) * 1992-11-16 1994-05-26 Ciba Vision Ag, Hettlingen Polyvinyl alcohol/borate ophthalmic drug delivery system
WO1994015597A1 (en) * 1993-01-11 1994-07-21 Allergan, Inc. Ophthalmic compositions comprising benzyllauryldimethylammonium chloride
DE19614823A1 (de) 1996-04-15 1997-10-16 Mann Gerhard Chem Pharm Fab Ophthalmische Zusammensetzung mit verlängerter Verweilzeit am Auge

Also Published As

Publication number Publication date
DE59703711D1 (de) 2001-07-12
BR9708669A (pt) 1999-08-03
EP0801948A1 (de) 1997-10-22
AU2024697A (en) 1997-11-07
CN1215988A (zh) 1999-05-05
CA2251982C (en) 2008-01-29
PL328656A1 (en) 1999-02-15
WO1997038674A1 (de) 1997-10-23
SI0801948T1 (en) 2001-10-31
JP4582822B2 (ja) 2010-11-17
US20040071778A1 (en) 2004-04-15
DK0801948T3 (da) 2001-09-10
GR3036498T3 (en) 2001-11-30
PL187339B1 (pl) 2004-06-30
ATE201820T1 (de) 2001-06-15
PT801948E (pt) 2001-10-31
EP0801948B1 (de) 2001-06-06
DE19614823A1 (de) 1997-10-16
CA2251982A1 (en) 1997-10-23
US6599944B1 (en) 2003-07-29
AU714093B2 (en) 1999-12-16
JP2000508646A (ja) 2000-07-11

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